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Identification
NameWarfarin
Accession NumberDB00682  (APRD00341)
TypeSmall Molecule
GroupsApproved
DescriptionWarfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally, including its ability to cross the placental barrier during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death. Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use. Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors.
Structure
Thumb
Synonyms
4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin
Coumafene
Zoocoumarin
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
CoumadinTablet7.5 mg/1OralCardinal Health2009-01-01Not applicableUs
CoumadinTablet7.5 mg/1OralPhysicians Total Care, Inc.1995-07-31Not applicableUs
CoumadinTablet7.5 mg/1OralREMEDYREPACK INC.2013-04-01Not applicableUs
CoumadinTablet3 mg/1OralBristol Myers Squibb Pharma Company2009-01-01Not applicableUs
CoumadinTablet5 mg/1OralREMEDYREPACK INC.2013-05-14Not applicableUs
CoumadinTablet10 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-01-01Not applicableUs
CoumadinTablet6 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-01-01Not applicableUs
CoumadinTablet6 mg/1OralREMEDYREPACK INC.2013-03-04Not applicableUs
CoumadinTablet5 mg/1OralBristol Myers Squibb Pharma Company2009-01-01Not applicableUs
CoumadinTablet1 mg/1OralA S Medication Solutions Llc2009-01-01Not applicableUs
CoumadinTablet2.5 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-26Not applicableUs
CoumadinTablet2 mg/1OralCardinal Health2009-01-01Not applicableUs
CoumadinTablet4 mg/1OralBristol Myers Squibb Pharma Company2009-01-01Not applicableUs
CoumadinTablet10 mg/1OralCardinal Health2009-01-01Not applicableUs
CoumadinTablet4 mg/1OralPhysicians Total Care, Inc.2000-11-21Not applicableUs
CoumadinTablet10 mg/1OralREMEDYREPACK INC.2013-04-01Not applicableUs
CoumadinTablet6 mg/1OralBristol Myers Squibb Pharma Company2009-01-01Not applicableUs
CoumadinTablet2.5 mg/1OralREMEDYREPACK INC.2013-05-14Not applicableUs
CoumadinTablet3 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-01-01Not applicableUs
CoumadinTablet4 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-01-01Not applicableUs
CoumadinTablet1 mg/1OralREMEDYREPACK INC.2013-03-01Not applicableUs
CoumadinTablet7.5 mg/1OralBristol Myers Squibb Pharma Company2009-01-01Not applicableUs
CoumadinPowder, for solution5 mgIntravenousBristol Myers Squibb Canada1997-09-022006-05-29Canada
CoumadinTablet5 mg/1OralPhysicians Total Care, Inc.2004-11-15Not applicableUs
CoumadinTablet5 mg/1OralA S Medication Solutions Llc2009-01-01Not applicableUs
CoumadinTablet2.5 mg/1OralCardinal Health2009-01-01Not applicableUs
CoumadinTablet1 mg/1OralBristol Myers Squibb Pharma Company2009-01-01Not applicableUs
CoumadinTablet3 mg/1OralCardinal Health2009-01-01Not applicableUs
CoumadinTablet6 mg/1OralPhysicians Total Care, Inc.2005-03-23Not applicableUs
CoumadinTablet5 mg/1OralREMEDYREPACK INC.2013-02-26Not applicableUs
CoumadinInjection, powder, lyophilized, for solution2 mg/mLIntravenousBristol Myers Squibb Holdings Pharma, Ltd. Liability Company2009-01-012016-11-30Us
CoumadinTablet2 mg/1OralA S Medication Solutions Llc2009-01-01Not applicableUs
CoumadinTablet1 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-01-01Not applicableUs
CoumadinTablet2.5 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-01-01Not applicableUs
CoumadinTablet10 mg/1OralREMEDYREPACK INC.2013-04-03Not applicableUs
CoumadinTablet10 mg/1OralBristol Myers Squibb Pharma Company2009-01-01Not applicableUs
CoumadinTablet5 mg/1OralCardinal Health2009-01-01Not applicableUs
CoumadinTablet1 mg/1OralPhysicians Total Care, Inc.2004-09-27Not applicableUs
CoumadinTablet3 mg/1OralREMEDYREPACK INC.2013-02-28Not applicableUs
CoumadinTablet2 mg/1OralBristol Myers Squibb Pharma Company2009-01-01Not applicableUs
CoumadinTablet4 mg/1OralCardinal Health2009-01-01Not applicableUs
CoumadinTablet5 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-01-01Not applicableUs
CoumadinTablet2 mg/1OralREMEDYREPACK INC.2013-03-04Not applicableUs
CoumadinTablet7.5 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-01-01Not applicableUs
CoumadinTablet1 mg/1OralCardinal Health2009-01-01Not applicableUs
CoumadinTablet5 mg/1OralA S Medication Solutions Llc2009-01-01Not applicableUs
CoumadinTablet2.5 mg/1OralBristol Myers Squibb Pharma Company2009-01-01Not applicableUs
CoumadinTablet2 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-01-01Not applicableUs
CoumadinTablet2 mg/1OralREMEDYREPACK INC.2013-03-27Not applicableUs
Coumadin Tab 10mgTablet10 mgOralBristol Myers Squibb Canada1957-12-31Not applicableCanada
Coumadin Tab 1mgTablet1 mgOralBristol Myers Squibb Canada1957-12-31Not applicableCanada
Coumadin Tab 2.5mgTablet2.5 mgOralBristol Myers Squibb Canada1992-12-31Not applicableCanada
Coumadin Tab 2mgTablet2 mgOralBristol Myers Squibb Canada1993-12-31Not applicableCanada
Coumadin Tab 3mgTablet3 mgOralBristol Myers Squibb Canada1999-08-25Not applicableCanada
Coumadin Tab 4mgTablet4 mgOralBristol Myers Squibb Canada1992-12-31Not applicableCanada
Coumadin Tab 5mgTablet5 mgOralBristol Myers Squibb Canada1957-12-31Not applicableCanada
Coumadin Tab 6 mgTablet6 mgOralBristol Myers Squibb Canada2000-09-29Not applicableCanada
Mylan-warfarinTablet10 mgOralMylan Pharmaceuticals Ulc2001-12-18Not applicableCanada
Mylan-warfarinTablet2.5 mgOralMylan Pharmaceuticals Ulc2001-12-18Not applicableCanada
Mylan-warfarinTablet3 mgOralMylan Pharmaceuticals Ulc2006-10-21Not applicableCanada
Mylan-warfarinTablet4 mgOralMylan Pharmaceuticals Ulc2001-12-18Not applicableCanada
Mylan-warfarinTablet6 mgOralMylan Pharmaceuticals Ulc2006-10-21Not applicableCanada
Mylan-warfarinTablet1 mgOralMylan Pharmaceuticals Ulc2001-12-18Not applicableCanada
Mylan-warfarinTablet5 mgOralMylan Pharmaceuticals Ulc2001-12-18Not applicableCanada
Mylan-warfarinTablet7.5 mgOralMylan Pharmaceuticals Ulc2006-10-21Not applicableCanada
Mylan-warfarinTablet2 mgOralMylan Pharmaceuticals Ulc2001-12-18Not applicableCanada
Novo-warfarinTablet10 mgOralNovopharm LimitedNot applicableNot applicableCanada
Novo-warfarinTablet2 mgOralNovopharm Limited2005-02-232015-10-26Canada
Novo-warfarinTablet5 mgOralNovopharm Limited2005-02-232015-10-26Canada
Novo-warfarinTablet2.5 mgOralNovopharm Limited2005-02-232015-10-26Canada
Novo-warfarinTablet6 mgOralNovopharm LimitedNot applicableNot applicableCanada
Novo-warfarinTablet3 mgOralNovopharm Limited2005-02-232015-10-26Canada
Novo-warfarinTablet7.5 mgOralNovopharm LimitedNot applicableNot applicableCanada
Novo-warfarinTablet4 mgOralNovopharm Limited2005-02-232015-10-26Canada
Novo-warfarinTablet1 mgOralNovopharm Limited2005-02-232015-10-26Canada
Nu-warfarinTablet1 mgOralNu Pharm IncNot applicableNot applicableCanada
Nu-warfarinTablet4.0 mgOralNu Pharm IncNot applicableNot applicableCanada
Nu-warfarinTablet2 mgOralNu Pharm IncNot applicableNot applicableCanada
Nu-warfarinTablet5.0 mgOralNu Pharm IncNot applicableNot applicableCanada
Nu-warfarinTablet2.5 mgOralNu Pharm IncNot applicableNot applicableCanada
Nu-warfarinTablet10.0 mgOralNu Pharm IncNot applicableNot applicableCanada
Nu-warfarinTablet3.0 mgOralNu Pharm IncNot applicableNot applicableCanada
Taro-warfarinTablet10 mgOralTaro Pharmaceuticals Inc2000-08-09Not applicableCanada
Taro-warfarinTablet3 mgOralTaro Pharmaceuticals Inc2000-08-09Not applicableCanada
Taro-warfarinTablet1 mgOralTaro Pharmaceuticals Inc2000-08-09Not applicableCanada
Taro-warfarinTablet7.5 mgOralTaro Pharmaceuticals Inc2000-08-09Not applicableCanada
Taro-warfarinTablet4 mgOralTaro Pharmaceuticals Inc2000-08-09Not applicableCanada
Taro-warfarinTablet2 mgOralTaro Pharmaceuticals Inc2000-08-09Not applicableCanada
Taro-warfarinTablet5 mgOralTaro Pharmaceuticals Inc2000-08-09Not applicableCanada
Taro-warfarinTablet2.5 mgOralTaro Pharmaceuticals Inc2000-08-09Not applicableCanada
Taro-warfarinTablet6 mgOralTaro Pharmaceuticals Inc2000-08-09Not applicableCanada
WarfarinTablet2.5 mgOralSanis Health Inc2010-02-252014-08-01Canada
WarfarinTablet6 mgOralSanis Health Inc2010-02-252014-08-01Canada
WarfarinTablet3 mgOralSanis Health Inc2010-02-252014-08-01Canada
WarfarinTablet7.5 mgOralSanis Health Inc2010-02-252014-08-01Canada
WarfarinTablet4 mgOralSanis Health Inc2010-03-222014-08-01Canada
WarfarinTablet1 mgOralSanis Health Inc2010-02-252014-08-01Canada
WarfarinTablet10 mgOralSanis Health Inc2010-02-252014-08-01Canada
WarfarinTablet5 mgOralSanis Health Inc2010-02-252014-08-01Canada
WarfarinTablet2 mgOralSanis Health Inc2010-02-252014-08-01Canada
Warfilone Tab 5mgTablet5 mgOralMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1963-12-312000-08-03Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-warfarinTablet10 mgOralApotex Inc2000-10-16Not applicableCanada
Apo-warfarinTablet2 mgOralApotex Inc2000-10-16Not applicableCanada
Apo-warfarinTablet3 mgOralApotex Inc2002-04-23Not applicableCanada
Apo-warfarinTablet2.5 mgOralApotex Inc2000-10-16Not applicableCanada
Apo-warfarinTablet4 mgOralApotex Inc2000-10-16Not applicableCanada
Apo-warfarinTablet1 mgOralApotex Inc2000-10-16Not applicableCanada
Apo-warfarinTablet5 mgOralApotex Inc2000-10-16Not applicableCanada
JantovenTablet4 mg/1OralREMEDYREPACK INC.2013-05-242016-04-05Us
JantovenTablet2.5 mg/1OralCardinal Health2010-02-23Not applicableUs
JantovenTablet6 mg/1OralUpsher Smith Laboratories, Inc.2010-02-23Not applicableUs
JantovenTablet2.5 mg/1OralUpsher Smith Laboratories, Inc.2010-02-23Not applicableUs
JantovenTablet3 mg/1OralREMEDYREPACK INC.2013-05-172016-04-05Us
JantovenTablet5 mg/1OralREMEDYREPACK INC.2013-05-282016-04-05Us
JantovenTablet5 mg/1OralCardinal Health2010-02-23Not applicableUs
JantovenTablet7.5 mg/1OralREMEDYREPACK INC.2013-05-162016-04-05Us
JantovenTablet7.5 mg/1OralUpsher Smith Laboratories, Inc.2010-02-23Not applicableUs
JantovenTablet10 mg/1OralREMEDYREPACK INC.2013-03-272016-04-05Us
JantovenTablet3 mg/1OralUpsher Smith Laboratories, Inc.2010-02-23Not applicableUs
JantovenTablet4 mg/1OralREMEDYREPACK INC.2013-05-172016-04-05Us
JantovenTablet10 mg/1OralREMEDYREPACK INC.2011-12-07Not applicableUs
JantovenTablet7.5 mg/1OralCardinal Health2010-02-23Not applicableUs
JantovenTablet1 mg/1OralUpsher Smith Laboratories, Inc.2010-02-23Not applicableUs
JantovenTablet6 mg/1OralREMEDYREPACK INC.2013-05-292016-04-05Us
JantovenTablet1 mg/1OralREMEDYREPACK INC.2013-05-172016-04-05Us
JantovenTablet10 mg/1OralUpsher Smith Laboratories, Inc.2010-02-23Not applicableUs
JantovenTablet4 mg/1OralUpsher Smith Laboratories, Inc.2010-02-23Not applicableUs
JantovenTablet6 mg/1OralREMEDYREPACK INC.2013-05-222016-04-05Us
JantovenTablet2 mg/1OralCardinal Health2010-02-23Not applicableUs
JantovenTablet2 mg/1OralUpsher Smith Laboratories, Inc.2010-02-23Not applicableUs
JantovenTablet2 mg/1OralREMEDYREPACK INC.2013-05-172016-04-05Us
JantovenTablet5 mg/1OralUpsher Smith Laboratories, Inc.2010-02-23Not applicableUs
Warfarin SodiumTablet4 mg/1OralCadila Healthcare Limited2006-06-19Not applicableUs
Warfarin SodiumTablet10 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-06-19Not applicableUs
Warfarin SodiumTablet2 mg/1OralTeva Pharmaceuticals Usa, Inc.2015-03-16Not applicableUs
Warfarin SodiumTablet3 mg/1OralTeva Pharmaceuticals Usa, Inc.1998-11-122018-01-31Us
Warfarin SodiumTablet4 mg/1OralREMEDYREPACK INC.2012-01-19Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralPhysicians Total Care, Inc.2000-11-14Not applicableUs
Warfarin SodiumTablet10 mg/1OralREMEDYREPACK INC.2011-10-192016-11-05Us
Warfarin SodiumTablet1 mg/1OralExelan Pharmaceuticals Inc.2015-04-08Not applicableUs
Warfarin SodiumTablet5 mg/1OralMed Health Pharma, LLC2011-02-09Not applicableUs
Warfarin SodiumTablet2 mg/1OralAphena Pharma Solutions Tennessee, Llc2015-04-08Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralA S Medication Solutions2015-04-07Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralProficient Rx LP2015-04-07Not applicableUs
Warfarin SodiumTablet5 mg/1OralCamber Pharmaceuticals2011-11-01Not applicableUs
Warfarin SodiumTablet3 mg/1OralA S Medication Solutions2011-11-01Not applicableUs
Warfarin SodiumTablet2 mg/1OralRebel Distributors Corp2006-05-30Not applicableUs
Warfarin SodiumTablet4 mg/1OralAphena Pharma Solutions Tennessee, Llc1999-07-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralClinical Solutions Wholesale1999-07-15Not applicableUs
Warfarin SodiumTablet2 mg/1OralSt Marys Medical Park Pharmacy2013-08-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralReady Meds1999-07-15Not applicableUs
Warfarin SodiumTablet2.5 mg/1Oralbryant ranch prepack2006-06-19Not applicableUs
Warfarin SodiumTablet5 mg/1OralAmneal Pharmaceuticals, LLC2010-08-16Not applicableUs
Warfarin SodiumTablet1 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-06-19Not applicableUs
Warfarin SodiumTablet1 mg/1OralTeva Pharmaceuticals Usa, Inc.1997-07-252018-01-31Us
Warfarin SodiumTablet4 mg/1OralREMEDYREPACK INC.2013-05-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralREMEDYREPACK INC.2011-09-282016-11-11Us
Warfarin SodiumTablet3 mg/1OralCitron Pharma LLC2011-11-01Not applicableUs
Warfarin SodiumTablet1 mg/1OralUnit Dose Services2006-06-19Not applicableUs
Warfarin SodiumTablet10 mg/1OralExelan Pharmaceuticals Inc.2015-04-08Not applicableUs
Warfarin SodiumTablet5 mg/1OralA S Medication Solutions2006-06-19Not applicableUs
Warfarin SodiumTablet6 mg/1OralUnit Dose Services2015-07-22Not applicableUs
Warfarin SodiumTablet2 mg/1OralREMEDYREPACK INC.2011-03-092016-10-26Us
Warfarin SodiumTablet6 mg/1OralTaro Pharmaceuticals U.S.A., Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet3 mg/1OralKAISER FOUNDATION HOSPITALS2015-12-04Not applicableUs
Warfarin SodiumTablet1 mg/1OralNu Care Pharmaceuticals, Inc.2006-06-19Not applicableUs
Warfarin SodiumTablet2 mg/1OralLake Erie Medical DBA Quality Care Products LLC2006-05-30Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralCardinal Health2010-03-292016-02-25Us
Warfarin SodiumTablet6 mg/1OralClinical Solutions Wholesale, Llc2015-03-16Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralGolden State Medical Supply, Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralTaro Pharmaceuticals U.S.A., Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet1 mg/1OralAidarex Pharmaceuticals LLC1999-07-15Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralA S Medication Solutions2015-04-07Not applicableUs
Warfarin SodiumTablet10 mg/1OralRebel Distributors Corp2006-05-30Not applicableUs
Warfarin SodiumTablet10 mg/1OralAphena Pharma Solutions Tennessee, Llc1999-07-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralPd Rx Pharmaceuticals, Inc.2010-03-29Not applicableUs
Warfarin SodiumTablet5 mg/1OralClinical Solutions Wholesale1999-07-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralDIRECT RX2015-01-01Not applicableUs
Warfarin SodiumTablet2 mg/1OralAmneal Pharmaceuticals, LLC2010-08-16Not applicableUs
Warfarin SodiumTablet10 mg/1OralCadila Healthcare Limited2006-06-19Not applicableUs
Warfarin SodiumTablet6 mg/1OralTeva Pharmaceuticals Usa, Inc.2015-03-16Not applicableUs
Warfarin SodiumTablet10 mg/1OralAidarex Pharmaceuticals LLC2006-06-19Not applicableUs
Warfarin SodiumTablet2 mg/1OralREMEDYREPACK INC.2014-04-15Not applicableUs
Warfarin SodiumTablet6 mg/1OralPhysicians Total Care, Inc.2003-08-06Not applicableUs
Warfarin SodiumTablet3 mg/1OralUnit Dose Services2006-06-19Not applicableUs
Warfarin SodiumTablet4 mg/1OralExelan Pharmaceuticals Inc.2015-04-08Not applicableUs
Warfarin SodiumTablet1 mg/1OralNorthwind Pharmaceuticals, LLC2015-03-10Not applicableUs
Warfarin SodiumTablet3 mg/1OralAphena Pharma Solutions Tennessee, Llc2015-04-08Not applicableUs
Warfarin SodiumTablet2 mg/1OralUnit Dose Services2015-05-05Not applicableUs
Warfarin SodiumTablet10 mg/1OralA S Medication Solutions1999-07-15Not applicableUs
Warfarin SodiumTablet3 mg/1OralA S Medication Solutions2006-06-19Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralCamber Pharmaceuticals2011-11-01Not applicableUs
Warfarin SodiumTablet10 mg/1OralA S Medication Solutions2011-11-01Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralSTAT Rx USA LLC1999-07-15Not applicableUs
Warfarin SodiumTablet1 mg/1OralSTAT Rx USA LLC2011-11-04Not applicableUs
Warfarin SodiumTablet1 mg/1OralCardinal Health2010-03-292016-02-25Us
Warfarin SodiumTablet2 mg/1OralClinical Solutions Wholesale1999-07-15Not applicableUs
Warfarin SodiumTablet6 mg/1OralGolden State Medical Supply, Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet10 mg/1Oralbryant ranch prepack1999-07-15Not applicableUs
Warfarin SodiumTablet1 mg/1OralCadila Healthcare Limited2006-06-19Not applicableUs
Warfarin SodiumTablet5 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-06-19Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralREMEDYREPACK INC.2016-03-11Not applicableUs
Warfarin SodiumTablet10 mg/1OralTeva Pharmaceuticals Usa, Inc.1997-07-252018-02-28Us
Warfarin SodiumTablet7.5 mg/1OralREMEDYREPACK INC.2009-09-16Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Warfarin SodiumTablet1 mg/1OralREMEDYREPACK INC.2011-12-06Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralCitron Pharma LLC2011-11-01Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralMed Health Pharma, LLC2011-02-09Not applicableUs
Warfarin SodiumTablet5 mg/1OralREMEDYREPACK INC.2016-02-10Not applicableUs
Warfarin SodiumTablet3 mg/1OralSt Marys Medical Park Pharmacy2013-08-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralTYA Pharmaceuticals2006-06-19Not applicableUs
Warfarin SodiumTablet5 mg/1OralCadila Healthcare Limited2006-06-19Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-06-19Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralTeva Pharmaceuticals Usa, Inc.2015-03-16Not applicableUs
Warfarin SodiumTablet6 mg/1OralTeva Pharmaceuticals Usa, Inc.1998-11-162018-02-28Us
Warfarin SodiumTablet6 mg/1OralREMEDYREPACK INC.2013-05-22Not applicableUs
Warfarin SodiumTablet4 mg/1OralPhysicians Total Care, Inc.2000-11-15Not applicableUs
Warfarin SodiumTablet6 mg/1OralREMEDYREPACK INC.2011-11-30Not applicableUs
Warfarin SodiumTablet2 mg/1OralExelan Pharmaceuticals Inc.2015-04-08Not applicableUs
Warfarin SodiumTablet6 mg/1OralMed Health Pharma, LLC2011-02-09Not applicableUs
Warfarin SodiumTablet5 mg/1OralAphena Pharma Solutions Tennessee, Llc2015-04-08Not applicableUs
Warfarin SodiumTablet4 mg/1OralA S Medication Solutions2011-11-01Not applicableUs
Warfarin SodiumTablet10 mg/1OralProficient Rx LP2015-05-12Not applicableUs
Warfarin SodiumTablet6 mg/1OralCamber Pharmaceuticals2011-11-01Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralA S Medication Solutions2011-11-01Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralRebel Distributors Corp2006-05-30Not applicableUs
Warfarin SodiumTablet5 mg/1OralAphena Pharma Solutions Tennessee, Llc1999-07-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralClinical Solutions Wholesale1999-07-15Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralClinical Solutions Wholesale, Llc2015-03-16Not applicableUs
Warfarin SodiumTablet3 mg/1OralGolden State Medical Supply, Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet1 mg/1Oralbryant ranch prepack2006-06-19Not applicableUs
Warfarin SodiumTablet6 mg/1OralAmneal Pharmaceuticals, LLC2010-08-16Not applicableUs
Warfarin SodiumTablet2 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-06-19Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralTeva Pharmaceuticals Usa, Inc.1997-07-252017-08-31Us
Warfarin SodiumTablet1 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Warfarin SodiumTablet5 mg/1OralREMEDYREPACK INC.2011-09-282016-11-10Us
Warfarin SodiumTablet4 mg/1OralCitron Pharma LLC2011-11-01Not applicableUs
Warfarin SodiumTablet2 mg/1OralUnit Dose Services2006-06-19Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralREMEDYREPACK INC.2016-01-27Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralA S Medication Solutions2006-06-19Not applicableUs
Warfarin SodiumTablet5 mg/1OralUnit Dose Services2015-04-07Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralTaro Pharmaceuticals U.S.A., Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet4 mg/1OralKAISER FOUNDATION HOSPITALS2015-12-04Not applicableUs
Warfarin SodiumTablet5 mg/1OralREMEDYREPACK INC.2011-05-03Not applicableUs
Warfarin SodiumTablet1 mg/1OralLake Erie Medical DBA Quality Care Products LLC2006-05-30Not applicableUs
Warfarin SodiumTablet3 mg/1OralCardinal Health2010-03-292016-02-25Us
Warfarin SodiumTablet4 mg/1OralAphena Pharma Solutions Tennessee, Llc2015-04-08Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralUnit Dose Services2015-04-07Not applicableUs
Warfarin SodiumTablet3 mg/1OralTaro Pharmaceuticals U.S.A., Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet2 mg/1OralAidarex Pharmaceuticals LLC1999-07-15Not applicableUs
Warfarin SodiumTablet3 mg/1OralREMEDYREPACK INC.2011-12-02Not applicableUs
Warfarin SodiumTablet10 mg/1OralRebel Distributors Corp2006-05-30Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralAphena Pharma Solutions Tennessee, Llc1999-07-15Not applicableUs
Warfarin SodiumTablet6 mg/1OralLake Erie Medical DBA Quality Care Products LLC2013-05-22Not applicableUs
Warfarin SodiumTablet5 mg/1OralNew Horizon Rx Group, LLC2013-08-25Not applicableUs
Warfarin SodiumTablet2 mg/1OralAmerican Health Packaging2012-04-02Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralAmneal Pharmaceuticals, LLC2010-08-16Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralCadila Healthcare Limited2006-06-19Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralTeva Pharmaceuticals Usa, Inc.2015-03-16Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralAidarex Pharmaceuticals LLC2010-08-16Not applicableUs
Warfarin SodiumTablet1 mg/1OralCitron Pharma LLC2011-11-01Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralPhysicians Total Care, Inc.2003-10-21Not applicableUs
Warfarin SodiumTablet4 mg/1OralUnit Dose Services2006-06-19Not applicableUs
Warfarin SodiumTablet5 mg/1OralExelan Pharmaceuticals Inc.2015-04-08Not applicableUs
Warfarin SodiumTablet4 mg/1OralNorthwind Pharmaceuticals, LLC2015-03-10Not applicableUs
Warfarin SodiumTablet10 mg/1OralCitron Pharma LLC2011-11-01Not applicableUs
Warfarin SodiumTablet3 mg/1OralMed Health Pharma, LLC2011-02-09Not applicableUs
Warfarin SodiumTablet6 mg/1OralREMEDYREPACK INC.2016-02-12Not applicableUs
Warfarin SodiumTablet2 mg/1OralA S Medication Solutions1997-07-25Not applicableUs
Warfarin SodiumTablet4 mg/1OralA S Medication Solutions2006-06-19Not applicableUs
Warfarin SodiumTablet3 mg/1OralCamber Pharmaceuticals2011-11-01Not applicableUs
Warfarin SodiumTablet1 mg/1OralA S Medication Solutions2011-11-01Not applicableUs
Warfarin SodiumTablet5 mg/1OralSTAT Rx USA LLC1999-07-15Not applicableUs
Warfarin SodiumTablet4 mg/1OralPd Rx Pharmaceuticals, Inc.2010-03-29Not applicableUs
Warfarin SodiumTablet6 mg/1OralCardinal Health2010-03-292016-02-25Us
Warfarin SodiumTablet5 mg/1OralClinical Solutions Wholesale1999-07-15Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralGolden State Medical Supply, Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet4 mg/1Oralbryant ranch prepack1997-07-25Not applicableUs
Warfarin SodiumTablet2 mg/1OralCadila Healthcare Limited2006-06-19Not applicableUs
Warfarin SodiumTablet6 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-06-19Not applicableUs
Warfarin SodiumTablet5 mg/1OralProficient Rx LP2015-04-07Not applicableUs
Warfarin SodiumTablet2 mg/1OralTeva Pharmaceuticals Usa, Inc.1997-07-252018-02-28Us
Warfarin SodiumTablet2 mg/1OralREMEDYREPACK INC.2011-06-30Not applicableUs
Warfarin SodiumTablet5 mg/1OralPhysicians Total Care, Inc.2000-10-09Not applicableUs
Warfarin SodiumTablet5 mg/1OralClinical Solutions Wholesale1999-07-15Not applicableUs
Warfarin SodiumTablet4 mg/1OralSt Marys Medical Park Pharmacy2013-08-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralTYA Pharmaceuticals1997-07-25Not applicableUs
Warfarin SodiumTablet6 mg/1OralCadila Healthcare Limited2006-06-19Not applicableUs
Warfarin SodiumTablet2 mg/1OralREMEDYREPACK INC.2016-01-14Not applicableUs
Warfarin SodiumTablet3 mg/1OralTeva Pharmaceuticals Usa, Inc.2015-03-16Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralREMEDYREPACK INC.2014-04-14Not applicableUs
Warfarin SodiumTablet2 mg/1OralPhysicians Total Care, Inc.2000-11-15Not applicableUs
Warfarin SodiumTablet6 mg/1OralREMEDYREPACK INC.2011-12-192016-10-28Us
Warfarin SodiumTablet2.5 mg/1OralExelan Pharmaceuticals Inc.2015-04-08Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralMed Health Pharma, LLC2011-02-09Not applicableUs
Warfarin SodiumTablet1 mg/1OralAphena Pharma Solutions Tennessee, Llc2015-04-08Not applicableUs
Warfarin SodiumTablet1 mg/1OralA S Medication Solutions2011-11-01Not applicableUs
Warfarin SodiumTablet1 mg/1OralTaro Pharmaceuticals U.S.A., Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralCamber Pharmaceuticals2011-11-01Not applicableUs
Warfarin SodiumTablet4 mg/1OralA S Medication Solutions2011-11-01Not applicableUs
Warfarin SodiumTablet3 mg/1OralRebel Distributors Corp2006-05-30Not applicableUs
Warfarin SodiumTablet3 mg/1OralAphena Pharma Solutions Tennessee, Llc1999-07-15Not applicableUs
Warfarin SodiumTablet3 mg/1OralLake Erie Medical DBA Quality Care Products LLC2006-05-30Not applicableUs
Warfarin SodiumTablet4 mg/1OralCardinal Health2010-03-292016-02-25Us
Warfarin SodiumTablet10 mg/1OralClinical Solutions Wholesale, Llc2015-03-16Not applicableUs
Warfarin SodiumTablet4 mg/1OralGolden State Medical Supply, Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet2 mg/1Oralbryant ranch prepack2010-03-29Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralAmneal Pharmaceuticals, LLC2010-08-16Not applicableUs
Warfarin SodiumTablet3 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-06-19Not applicableUs
Warfarin SodiumTablet5 mg/1OralPd Rx Pharmaceuticals, Inc.2015-04-07Not applicableUs
Warfarin SodiumTablet5 mg/1OralTeva Pharmaceuticals Usa, Inc.1997-07-252018-01-31Us
Warfarin SodiumTablet10 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralREMEDYREPACK INC.2011-10-032016-11-16Us
Warfarin SodiumTablet5 mg/1OralCitron Pharma LLC2011-11-01Not applicableUs
Warfarin SodiumTablet1 mg/1OralMed Health Pharma, LLC2011-02-09Not applicableUs
Warfarin SodiumTablet3 mg/1OralREMEDYREPACK INC.2016-01-28Not applicableUs
Warfarin SodiumTablet2 mg/1OralA S Medication Solutions2006-06-19Not applicableUs
Warfarin SodiumTablet6 mg/1OralA S Medication Solutions2006-06-19Not applicableUs
Warfarin SodiumTablet1 mg/1OralCamber Pharmaceuticals2011-11-01Not applicableUs
Warfarin SodiumTablet10 mg/1OralTaro Pharmaceuticals U.S.A., Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet10 mg/1OralKAISER FOUNDATION HOSPITALS2015-12-04Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralREMEDYREPACK INC.2011-05-16Not applicableUs
Warfarin SodiumTablet2 mg/1OralCitron Pharma LLC2011-11-01Not applicableUs
Warfarin SodiumTablet10 mg/1OralPhysicians Total Care, Inc.2005-04-04Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralUnit Dose Services2006-06-19Not applicableUs
Warfarin SodiumTablet6 mg/1OralExelan Pharmaceuticals Inc.2015-04-08Not applicableUs
Warfarin SodiumTablet5 mg/1OralNorthwind Pharmaceuticals, LLC2015-03-10Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralAphena Pharma Solutions Tennessee, Llc2015-04-08Not applicableUs
Warfarin SodiumTablet3 mg/1OralUnit Dose Services2015-07-14Not applicableUs
Warfarin SodiumTablet4 mg/1OralTaro Pharmaceuticals U.S.A., Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralAidarex Pharmaceuticals LLC1999-07-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralNu Care Pharmaceuticals, Inc2015-04-07Not applicableUs
Warfarin SodiumTablet10 mg/1OralRebel Distributors Corp2006-05-30Not applicableUs
Warfarin SodiumTablet1 mg/1OralAphena Pharma Solutions Tennessee, Llc1999-07-15Not applicableUs
Warfarin SodiumTablet4 mg/1OralClinical Solutions Wholesale, Llc2015-03-16Not applicableUs
Warfarin SodiumTablet1 mg/1OralGolden State Medical Supply, Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralAmerican Health Packaging2012-04-02Not applicableUs
Warfarin SodiumTablet3 mg/1OralAmneal Pharmaceuticals, LLC2010-08-16Not applicableUs
Warfarin SodiumTablet2 mg/1OralAphena Pharma Solutions Tennessee, Llc1999-07-15Not applicableUs
Warfarin SodiumTablet10 mg/1OralTeva Pharmaceuticals Usa, Inc.2015-03-16Not applicableUs
Warfarin SodiumTablet3 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Warfarin SodiumTablet4 mg/1OralTeva Pharmaceuticals Usa, Inc.1997-07-252018-02-28Us
Warfarin SodiumTablet10 mg/1OralREMEDYREPACK INC.2011-11-14Not applicableUs
Warfarin SodiumTablet1 mg/1OralPhysicians Total Care, Inc.2000-11-15Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralREMEDYREPACK INC.2011-05-23Not applicableUs
Warfarin SodiumTablet5 mg/1OralREMEDYREPACK INC.2015-06-15Not applicableUs
Warfarin SodiumTablet4 mg/1OralMed Health Pharma, LLC2011-02-09Not applicableUs
Warfarin SodiumTablet3 mg/1OralREMEDYREPACK INC.2016-03-04Not applicableUs
Warfarin SodiumTablet5 mg/1OralA S Medication Solutions2011-11-01Not applicableUs
Warfarin SodiumTablet10 mg/1OralA S Medication Solutions2006-06-19Not applicableUs
Warfarin SodiumTablet4 mg/1OralCamber Pharmaceuticals2011-11-01Not applicableUs
Warfarin SodiumTablet2 mg/1OralA S Medication Solutions2011-11-01Not applicableUs
Warfarin SodiumTablet1 mg/1OralRebel Distributors Corp2006-05-30Not applicableUs
Warfarin SodiumTablet1 mg/1OralPd Rx Pharmaceuticals, Inc.1997-07-25Not applicableUs
Warfarin SodiumTablet5 mg/1OralClinical Solutions Wholesale1999-07-15Not applicableUs
Warfarin SodiumTablet10 mg/1OralGolden State Medical Supply, Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet3 mg/1Oralbryant ranch prepack2006-06-19Not applicableUs
Warfarin SodiumTablet3 mg/1OralCadila Healthcare Limited2006-06-19Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-06-19Not applicableUs
Warfarin SodiumTablet1 mg/1OralTeva Pharmaceuticals Usa, Inc.2015-03-16Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralAphena Pharma Solutions Tennessee, Llc1999-07-15Not applicableUs
Warfarin SodiumTablet1 mg/1OralPd Rx Pharmaceuticals, Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralClinical Solutions Wholesale1999-07-15Not applicableUs
Warfarin SodiumTablet6 mg/1OralSt Marys Medical Park Pharmacy2014-05-22Not applicableUs
Warfarin SodiumTablet1 mg/1OralAmneal Pharmaceuticals, LLC2010-08-16Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralCadila Healthcare Limited2006-06-19Not applicableUs
Warfarin SodiumTablet4 mg/1OralTeva Pharmaceuticals Usa, Inc.2015-03-16Not applicableUs
Warfarin SodiumTablet4 mg/1OralREMEDYREPACK INC.2013-05-292016-04-05Us
Warfarin SodiumTablet10 mg/1OralREMEDYREPACK INC.2014-04-14Not applicableUs
Warfarin SodiumTablet3 mg/1OralPhysicians Total Care, Inc.2003-08-06Not applicableUs
Warfarin SodiumTablet4 mg/1OralLake Erie Medical DBA Quality Care Products LLC2015-03-10Not applicableUs
Warfarin SodiumTablet3 mg/1OralExelan Pharmaceuticals Inc.2015-04-08Not applicableUs
Warfarin SodiumTablet10 mg/1OralMed Health Pharma, LLC2011-02-09Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralAphena Pharma Solutions Tennessee, Llc2015-04-08Not applicableUs
Warfarin SodiumTablet1 mg/1OralUnit Dose Services2015-10-19Not applicableUs
Warfarin SodiumTablet2 mg/1OralTaro Pharmaceuticals U.S.A., Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet10 mg/1OralCamber Pharmaceuticals2011-11-01Not applicableUs
Warfarin SodiumTablet5 mg/1OralA S Medication Solutions2011-11-01Not applicableUs
Warfarin SodiumTablet5 mg/1OralRebel Distributors Corp2006-05-30Not applicableUs
Warfarin SodiumTablet6 mg/1OralA S Medication Solutions2011-11-01Not applicableUs
Warfarin SodiumTablet1 mg/1OralKAISER FOUNDATION HOSPITALS2015-12-04Not applicableUs
Warfarin SodiumTablet2 mg/1OralAidarex Pharmaceuticals LLC2015-05-05Not applicableUs
Warfarin SodiumTablet2 mg/1OralSTAT Rx USA LLC2011-11-04Not applicableUs
Warfarin SodiumTablet5 mg/1OralCardinal Health2010-03-292016-02-25Us
Warfarin SodiumTablet5 mg/1OralClinical Solutions Wholesale1999-07-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralGolden State Medical Supply, Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet7.5 mg/1Oralbryant ranch prepack2006-06-19Not applicableUs
Warfarin SodiumTablet10 mg/1OralAmneal Pharmaceuticals, LLC2010-08-16Not applicableUs
Warfarin SodiumTablet4 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-06-19Not applicableUs
Warfarin SodiumTablet1 mg/1OralPd Rx Pharmaceuticals, Inc.2015-03-16Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralTeva Pharmaceuticals Usa, Inc.1997-07-25Not applicableUs
Warfarin SodiumTablet3 mg/1OralREMEDYREPACK INC.2009-09-29Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Warfarin SodiumTablet5 mg/1OralREMEDYREPACK INC.2011-11-03Not applicableUs
Warfarin SodiumTablet6 mg/1OralCitron Pharma LLC2011-11-01Not applicableUs
Warfarin SodiumTablet2 mg/1OralMed Health Pharma, LLC2011-02-09Not applicableUs
Warfarin SodiumTablet1 mg/1OralREMEDYREPACK INC.2016-01-28Not applicableUs
Warfarin SodiumTablet1 mg/1OralA S Medication Solutions2006-06-19Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralA S Medication Solutions2006-06-19Not applicableUs
Warfarin SodiumTablet2 mg/1OralCamber Pharmaceuticals2011-11-01Not applicableUs
Warfarin SodiumTablet5 mg/1OralTeva Pharmaceuticals Usa, Inc.2015-03-16Not applicableUs
Warfarin SodiumTablet2 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralCitron Pharma LLC2011-11-01Not applicableUs
Warfarin SodiumTablet2 mg/1OralCardinal Health2010-03-292016-02-25Us
Warfarin SodiumTablet5 mg/1OralUnit Dose Services2006-06-19Not applicableUs
Warfarin SodiumTablet7.5 mg/1OralExelan Pharmaceuticals Inc.2015-04-08Not applicableUs
Warfarin SodiumTablet10 mg/1OralREMEDYREPACK INC.2013-05-132016-04-05Us
Warfarin SodiumTablet10 mg/1OralAphena Pharma Solutions Tennessee, Llc2015-04-08Not applicableUs
Warfarin SodiumTablet4 mg/1OralUnit Dose Services2015-06-09Not applicableUs
Warfarin SodiumTablet5 mg/1OralTaro Pharmaceuticals U.S.A., Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralLake Erie Medical DBA Quality Care Products LLC2006-05-30Not applicableUs
Warfarin SodiumTablet4 mg/1OralNu Care Pharmaceuticals, Inc.2015-06-09Not applicableUs
Warfarin SodiumTablet1 mg/1OralREMEDYREPACK INC.2013-03-272016-04-05Us
Warfarin SodiumTablet6 mg/1OralAphena Pharma Solutions Tennessee, Llc1999-07-15Not applicableUs
Warfarin SodiumTablet5 mg/1OralClinical Solutions Wholesale, Llc2015-03-16Not applicableUs
Warfarin SodiumTablet2 mg/1OralGolden State Medical Supply, Inc.1999-07-15Not applicableUs
Warfarin SodiumTablet5 mg/1Oralbryant ranch prepack1999-07-15Not applicableUs
Warfarin SodiumTablet4 mg/1OralAmneal Pharmaceuticals, LLC2010-08-16Not applicableUs
Warfarin SodiumTablet2.5 mg/1OralAmerican Health Packaging2012-04-02Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
LawarinNot Available
MarevanNot Available
WaranNot Available
WarfantNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Warfarin potassium
2610-86-8
Thumb
  • InChI Key: WSHYKIAQCMIPTB-UHFFFAOYSA-M
  • Monoisotopic Mass: 346.06074045
  • Average Mass: 346.423
DBSALT001410
Warfarin sodium
129-06-6
Thumb
  • InChI Key: KYITYFHKDODNCQ-UHFFFAOYNA-M
  • Monoisotopic Mass: 330.086803643
  • Average Mass: 330.3098
DBSALT000278
Categories
UNII5Q7ZVV76EI
CAS number81-81-2
WeightAverage: 308.3279
Monoisotopic: 308.104859
Chemical FormulaC19H16O4
InChI KeyPJVWKTKQMONHTI-UHFFFAOYNA-N
InChI
InChI=1/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3
IUPAC Name
4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
SMILES
CC(=O)CC(C1=CC=CC=C1)C1=C(O)C2=C(OC1=O)C=CC=C2
Pharmacology
IndicationFor the treatment of retinal vascular occlusion, pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, transient cerebral ischaemia, arterial embolism and thrombosis.
Structured Indications
PharmacodynamicsWarfarin, a coumarin anticoagulant, is a racemic mixture of two active isomers. It is used in the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF).
Mechanism of actionWarfarin inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decreased prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
TargetKindPharmacological actionActionsOrganismUniProt ID
Vitamin K epoxide reductase complex subunit 1Proteinyes
inhibitor
HumanQ9BQB6 details
Related Articles
AbsorptionRapidly absorbed following oral administration with considerable interindividual variations. Also absorbed percutaneously.
Volume of distribution
  • 0.14 L/kg
Protein binding99% bound primarily to albumin
Metabolism

Metabolized stereo- and regio-selectively by hepatic microsomal enzymes. S-warfarin is predominantly metabolized by cytochrome P450 (CYP) 2C9 to yield the 6- and 7-hydroxylated metabolites. R-warfarin is metabolized by CYP1A1, 1A2, and 3A4 to yield 6-, 8-, and 10-hydroxylated metabolites. Hydroxylated metabolites may be further conjugated prior to excretion into bile and urine. UGT1A1 appears to be responsible for producing the 6-O-glucuronide of warfarin, with a possibly contribution from UGT1A10. Five UGT1As may be involved in the formation of 7-O-glucuronide warfarin. S-warfarin has higher potency than R-warfarin and genetic polymorphisms in CYP2C9 may dramatically decrease clearance of and increase toxicity of the medication.

SubstrateEnzymesProduct
Warfarin
S-6-HydroxywarfarinDetails
Warfarin
S-4'-HydroxywarfarinDetails
Warfarin
R-4'-HydroxywarfarinDetails
Warfarin
R-6-HydroxywarfarinDetails
Warfarin
R-10-HydroxywarfarinDetails
Warfarin
R-8-HydroxywarfarinDetails
Warfarin
R-7-HydroxywarfarinDetails
Warfarin
S-7-HydroxywarfarinDetails
Route of eliminationThe elimination of warfarin is almost entirely by metabolism. Very little warfarin is excreted unchanged in urine. The metabolites are principally excreted into the urine; and to a lesser extent into the bile.
Half lifeR-warfarin t1/2=37-89 hours; S-warfarin t1/2=21-43 hours.
Clearance
  • 0.065 +/- 0.025 mL/min/kg [CYP2C9 Genotype 1/1]
  • 0.041 +/- 0.021 [CYP2C9 Genotype 1/2 or 1/3]
  • 0.020 +/- 0.011 [CYP2C9 Genotype 2/2, 2/3, or 3/3]
ToxicityLD50=374 (orally in mice)
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Warfarin Action PathwayDrug actionSMP00268
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Cytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
rs1799853 CYP2C9*2T AllelePoor drug metabolizer, lower dose requirements15608560
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-Bromoepiandrosterone16-Bromoepiandrosterone may increase the anticoagulant activities of Warfarin.Investigational
19-norandrostenedione19-norandrostenedione may increase the anticoagulant activities of Warfarin.Experimental, Illicit
4-Androstenedione4-Androstenedione may increase the anticoagulant activities of Warfarin.Experimental, Illicit
5-androstenedione5-androstenedione may increase the anticoagulant activities of Warfarin.Experimental, Illicit
AbciximabAbciximab may increase the anticoagulant activities of Warfarin.Approved
AbirateroneThe serum concentration of Warfarin can be increased when it is combined with Abiraterone.Approved
AceclofenacAceclofenac may increase the anticoagulant activities of Warfarin.Approved
AcenocoumarolWarfarin may increase the anticoagulant activities of Acenocoumarol.Approved
AcetaminophenAcetaminophen may increase the anticoagulant activities of Warfarin.Approved
AcetohexamideAcetohexamide may increase the anticoagulant activities of Warfarin.Withdrawn
AcetovanilloneAcetovanillone may increase the anticoagulant activities of Warfarin.Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
AdalimumabThe serum concentration of Warfarin can be decreased when it is combined with Adalimumab.Approved
AdapaleneAdapalene may increase the anticoagulant activities of Warfarin.Approved
AlclometasoneAlclometasone may increase the anticoagulant activities of Warfarin.Approved
AldosteroneAldosterone may increase the anticoagulant activities of Warfarin.Experimental
AllopurinolAllopurinol may increase the anticoagulant activities of Warfarin.Approved
AllylestrenolThe therapeutic efficacy of Warfarin can be decreased when used in combination with Allylestrenol.Approved
AlprostadilAlprostadil may increase the anticoagulant activities of Warfarin.Approved, Investigational
AlteplaseAlteplase may increase the anticoagulant activities of Warfarin.Approved
AltrenogestThe therapeutic efficacy of Warfarin can be decreased when used in combination with Altrenogest.Vet Approved
ALX-0081ALX-0081 may increase the anticoagulant activities of Warfarin.Investigational
AmcinonideAmcinonide may increase the anticoagulant activities of Warfarin.Approved
AmdinocillinAmdinocillin may increase the anticoagulant activities of Warfarin.Withdrawn
AmineptineAmineptine may increase the anticoagulant activities of Warfarin.Illicit, Withdrawn
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Warfarin.Approved
AmiodaroneAmiodarone may increase the anticoagulant activities of Warfarin.Approved, Investigational
AmitriptylineAmitriptyline may increase the anticoagulant activities of Warfarin.Approved
AmobarbitalThe metabolism of Warfarin can be increased when combined with Amobarbital.Approved, Illicit
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Warfarin.Approved
AmoxicillinAmoxicillin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
AmpicillinAmpicillin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Warfarin.Approved
AncrodWarfarin may increase the anticoagulant activities of Ancrod.Investigational
AnecortaveAnecortave may increase the anticoagulant activities of Warfarin.Investigational
AnisodamineAnisodamine may increase the anticoagulant activities of Warfarin.Investigational
AnistreplaseAnistreplase may increase the anticoagulant activities of Warfarin.Approved
AntipyrineAntipyrine may increase the anticoagulant activities of Warfarin.Approved
Antithrombin III humanWarfarin may increase the anticoagulant activities of Antithrombin III human.Approved
ApixabanApixaban may increase the anticoagulant activities of Warfarin.Approved
ApremilastApremilast may increase the anticoagulant activities of Warfarin.Approved, Investigational
AprepitantThe serum concentration of Warfarin can be decreased when it is combined with Aprepitant.Approved, Investigational
AprotininThe therapeutic efficacy of Warfarin can be decreased when used in combination with Aprotinin.Approved, Withdrawn
ArdeparinArdeparin may increase the anticoagulant activities of Warfarin.Approved, Withdrawn
ArgatrobanArgatroban may increase the anticoagulant activities of Warfarin.Approved, Investigational
ArmodafinilThe metabolism of Warfarin can be decreased when combined with Armodafinil.Approved, Investigational
AstaxanthinAstaxanthin may increase the anticoagulant activities of Warfarin.Investigational
AtazanavirThe serum concentration of Warfarin can be increased when it is combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Warfarin can be decreased when combined with Atomoxetine.Approved
AtorvastatinAtorvastatin may increase the anticoagulant activities of Warfarin.Approved
AzapropazoneAzapropazone may increase the anticoagulant activities of Warfarin.Withdrawn
AzathioprineAzathioprine may decrease the anticoagulant activities of Warfarin.Approved
AzelastineAzelastine may increase the anticoagulant activities of Warfarin.Approved
AzidocillinAzidocillin may increase the anticoagulant activities of Warfarin.Approved
AzithromycinThe metabolism of Warfarin can be decreased when combined with Azithromycin.Approved
AzlocillinAzlocillin may increase the anticoagulant activities of Warfarin.Approved
BacampicillinBacampicillin may increase the anticoagulant activities of Warfarin.Approved
BalsalazideBalsalazide may increase the anticoagulant activities of Warfarin.Approved, Investigational
BarbexacloneThe metabolism of Warfarin can be increased when combined with Barbexaclone.Experimental
BarbitalThe metabolism of Warfarin can be increased when combined with Barbital.Illicit
BatroxobinBatroxobin may increase the anticoagulant activities of Warfarin.Experimental
BazedoxifeneBazedoxifene may decrease the anticoagulant activities of Warfarin.Approved, Investigational
BecaplerminBecaplermin may increase the anticoagulant activities of Warfarin.Approved, Investigational
BeclomethasoneBeclomethasone may increase the anticoagulant activities of Warfarin.Investigational
Beclomethasone dipropionateBeclomethasone dipropionate may increase the anticoagulant activities of Warfarin.Approved, Investigational
BemiparinBemiparin may increase the anticoagulant activities of Warfarin.Approved
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Warfarin.Withdrawn
Benzathine benzylpenicillinBenzathine benzylpenicillin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
BenzylpenicillinBenzylpenicillin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
Benzylpenicillin PotassiumBenzylpenicillin Potassium may increase the anticoagulant activities of Warfarin.Approved
Benzylpenicilloyl PolylysineBenzylpenicilloyl Polylysine may increase the anticoagulant activities of Warfarin.Approved
BeraprostBeraprost may increase the anticoagulant activities of Warfarin.Investigational
BetamethasoneBetamethasone may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
Betulinic AcidBetulinic Acid may increase the anticoagulant activities of Warfarin.Investigational
BexaroteneThe serum concentration of Warfarin can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateBezafibrate may increase the anticoagulant activities of Warfarin.Approved
BicalutamideThe serum concentration of Warfarin can be increased when it is combined with Bicalutamide.Approved
BivalirudinBivalirudin may increase the anticoagulant activities of Warfarin.Approved, Investigational
BoceprevirThe serum concentration of Warfarin can be decreased when it is combined with Boceprevir.Approved
BortezomibThe metabolism of Warfarin can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe metabolism of Warfarin can be increased when combined with Bosentan.Approved, Investigational
BromfenacBromfenac may increase the anticoagulant activities of Warfarin.Approved
BucillamineBucillamine may increase the anticoagulant activities of Warfarin.Investigational
BudesonideBudesonide may increase the anticoagulant activities of Warfarin.Approved
ButylphthalideButylphthalide may increase the anticoagulant activities of Warfarin.Investigational
CaffeineThe metabolism of Warfarin can be decreased when combined with Caffeine.Approved
CangrelorCangrelor may increase the anticoagulant activities of Warfarin.Approved
CapecitabineThe serum concentration of Warfarin can be increased when it is combined with Capecitabine.Approved, Investigational
CarbamazepineThe serum concentration of Warfarin can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbenicillinCarbenicillin may increase the anticoagulant activities of Warfarin.Approved
CarbimazoleCarbimazole may decrease the anticoagulant activities of Warfarin.Approved
CarbomycinThe serum concentration of Warfarin can be increased when it is combined with Carbomycin.Vet Approved
CarindacillinCarindacillin may increase the anticoagulant activities of Warfarin.Approved
CarprofenCarprofen may increase the anticoagulant activities of Warfarin.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may increase the anticoagulant activities of Warfarin.Experimental
CefacetrileCefacetrile may increase the anticoagulant activities of Warfarin.Approved
CefaclorCefaclor may increase the anticoagulant activities of Warfarin.Approved
CefadroxilCefadroxil may increase the anticoagulant activities of Warfarin.Approved, Vet Approved, Withdrawn
CefalotinCefalotin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
CefamandoleCefamandole may increase the anticoagulant activities of Warfarin.Approved
CefapirinCefapirin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
CefazolinCefazolin may increase the anticoagulant activities of Warfarin.Approved
CefiximeCefixime may increase the anticoagulant activities of Warfarin.Approved
CefmenoximeCefmenoxime may increase the anticoagulant activities of Warfarin.Approved
CefmetazoleCefmetazole may increase the anticoagulant activities of Warfarin.Approved
CefminoxCefminox may increase the anticoagulant activities of Warfarin.Approved
CefonicidCefonicid may increase the anticoagulant activities of Warfarin.Approved
CefoperazoneCefoperazone may increase the anticoagulant activities of Warfarin.Approved
CeforanideCeforanide may increase the anticoagulant activities of Warfarin.Approved
CefotaximeCefotaxime may increase the anticoagulant activities of Warfarin.Approved
CefotetanCefotetan may increase the anticoagulant activities of Warfarin.Approved
CefotiamCefotiam may increase the anticoagulant activities of Warfarin.Approved
CefoxitinCefoxitin may increase the anticoagulant activities of Warfarin.Approved
CefpodoximeCefpodoxime may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
CefradineCefradine may increase the anticoagulant activities of Warfarin.Approved
CefroxadineCefroxadine may increase the anticoagulant activities of Warfarin.Approved
CeftazidimeCeftazidime may increase the anticoagulant activities of Warfarin.Approved
CeftizoximeCeftizoxime may increase the anticoagulant activities of Warfarin.Approved
CeftriaxoneCeftriaxone may increase the anticoagulant activities of Warfarin.Approved
CefuroximeCefuroxime may increase the anticoagulant activities of Warfarin.Approved
CelecoxibCelecoxib may increase the anticoagulant activities of Warfarin.Approved, Investigational
CephalexinCephalexin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
CephaloglycinCephaloglycin may increase the anticoagulant activities of Warfarin.Approved
CephaloridineCephaloridine may increase the anticoagulant activities of Warfarin.Approved, Withdrawn
CeritinibThe serum concentration of Warfarin can be increased when it is combined with Ceritinib.Approved
CerivastatinCerivastatin may increase the anticoagulant activities of Warfarin.Withdrawn
CertoparinWarfarin may increase the anticoagulant activities of Certoparin.Approved
Chloral hydrateThe serum concentration of Warfarin can be increased when it is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChloramphenicolChloramphenicol may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
ChloroquineChloroquine may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Warfarin.Withdrawn
ChlorpropamideChlorpropamide may increase the anticoagulant activities of Warfarin.Approved
ChlortetracyclineChlortetracycline may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
CholecalciferolThe metabolism of Warfarin can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CholestyramineCholestyramine can cause a decrease in the absorption of Warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Chondroitin sulfateChondroitin sulfate may increase the anticoagulant activities of Warfarin.Approved, Nutraceutical
CiclesonideCiclesonide may increase the anticoagulant activities of Warfarin.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Warfarin.Approved
CimetidineCimetidine may increase the anticoagulant activities of Warfarin.Approved
CinoxacinCinoxacin may increase the anticoagulant activities of Warfarin.Approved, Withdrawn
CiprofibrateCiprofibrate may increase the anticoagulant activities of Warfarin.Approved
CiprofloxacinCiprofloxacin may increase the anticoagulant activities of Warfarin.Approved, Investigational
CitalopramThe metabolism of Warfarin can be decreased when combined with Citalopram.Approved
Citric AcidWarfarin may increase the anticoagulant activities of Citric Acid.Nutraceutical, Vet Approved
ClarithromycinThe metabolism of Warfarin can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Warfarin can be decreased when combined with Clemastine.Approved
ClobetasolClobetasol may increase the anticoagulant activities of Warfarin.Investigational
Clobetasol propionateClobetasol propionate may increase the anticoagulant activities of Warfarin.Approved
ClocortoloneClocortolone may increase the anticoagulant activities of Warfarin.Approved
ClofibrateClofibrate may increase the anticoagulant activities of Warfarin.Approved
ClomipramineClomipramine may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
ClonixinClonixin may increase the anticoagulant activities of Warfarin.Approved
ClopidogrelClopidogrel may increase the anticoagulant activities of Warfarin.Approved, Nutraceutical
ClotrimazoleThe metabolism of Warfarin can be decreased when combined with Clotrimazole.Approved, Vet Approved
CloxacillinCloxacillin may decrease the anticoagulant activities of Warfarin.Approved, Vet Approved
CobicistatThe serum concentration of Warfarin can be increased when it is combined with Cobicistat.Approved
Coenzyme Q10Coenzyme Q10 may decrease the anticoagulant activities of Warfarin.Experimental
ColesevelamColesevelam can cause a decrease in the absorption of Warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
CollagenaseThe risk or severity of adverse effects can be increased when Warfarin is combined with Collagenase.Approved
ConivaptanThe serum concentration of Warfarin can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensConjugated Equine Estrogens may decrease the anticoagulant activities of Warfarin.Approved
Cortisone acetateCortisone acetate may increase the anticoagulant activities of Warfarin.Approved
CranberryCranberry may increase the anticoagulant activities of Warfarin.Approved
CrizotinibThe metabolism of Warfarin can be decreased when combined with Crizotinib.Approved
CurcuminCurcumin may increase the anticoagulant activities of Warfarin.Investigational
CyclacillinCyclacillin may increase the anticoagulant activities of Warfarin.Approved
CyclobenzaprineCyclobenzaprine may increase the anticoagulant activities of Warfarin.Approved
CyclosporineThe metabolism of Warfarin can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Warfarin can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
D-LimoneneD-Limonene may increase the anticoagulant activities of Warfarin.Investigational
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Warfarin.Approved
DabrafenibThe serum concentration of Warfarin can be decreased when it is combined with Dabrafenib.Approved
DalteparinWarfarin may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidWarfarin may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DapoxetineDapoxetine may increase the anticoagulant activities of Warfarin.Investigational
DarunavirThe serum concentration of Warfarin can be decreased when it is combined with Darunavir.Approved
DasatinibDasatinib may increase the anticoagulant activities of Warfarin.Approved, Investigational
DeferasiroxThe serum concentration of Warfarin can be decreased when it is combined with Deferasirox.Approved, Investigational
DefibrotideDefibrotide may increase the anticoagulant activities of Warfarin.Approved, Investigational
dehydroepiandrosterone sulfatedehydroepiandrosterone sulfate may increase the anticoagulant activities of Warfarin.Investigational
DelavirdineThe metabolism of Warfarin can be decreased when combined with Delavirdine.Approved
DemeclocyclineDemeclocycline may increase the anticoagulant activities of Warfarin.Approved
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Warfarin is combined with Deoxycholic Acid.Approved
dersalazinedersalazine may increase the anticoagulant activities of Warfarin.Investigational
DesipramineDesipramine may increase the anticoagulant activities of Warfarin.Approved
DesirudinWarfarin may increase the anticoagulant activities of Desirudin.Approved
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Warfarin.Investigational
DesogestrelDesogestrel may decrease the anticoagulant activities of Warfarin.Approved
DesoximetasoneDesoximetasone may increase the anticoagulant activities of Warfarin.Approved
Desoxycorticosterone acetateDesoxycorticosterone acetate may increase the anticoagulant activities of Warfarin.Approved
Desoxycorticosterone PivalateDesoxycorticosterone Pivalate may increase the anticoagulant activities of Warfarin.Experimental, Vet Approved
DesvenlafaxineThe risk or severity of adverse effects can be increased when Desvenlafaxine is combined with Warfarin.Approved
DexamethasoneDexamethasone may increase the anticoagulant activities of Warfarin.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateDexamethasone isonicotinate may increase the anticoagulant activities of Warfarin.Vet Approved
DexmethylphenidateThe serum concentration of Warfarin can be increased when it is combined with Dexmethylphenidate.Approved
DextranWarfarin may increase the anticoagulant activities of Dextran.Approved, Vet Approved
Dextran 40Warfarin may increase the anticoagulant activities of Dextran 40.Approved
Dextran 70Warfarin may increase the anticoagulant activities of Dextran 70.Approved
Dextran 75Warfarin may increase the anticoagulant activities of Dextran 75.Approved
DiclofenacDiclofenac may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
DicloxacillinDicloxacillin may decrease the anticoagulant activities of Warfarin.Approved, Vet Approved
DicoumarolDicoumarol may increase the anticoagulant activities of Warfarin.Approved
DienestrolDienestrol may decrease the anticoagulant activities of Warfarin.Approved
DienogestDienogest may decrease the anticoagulant activities of Warfarin.Approved
DiethylstilbestrolDiethylstilbestrol may decrease the anticoagulant activities of Warfarin.Approved
DiflorasoneDiflorasone may increase the anticoagulant activities of Warfarin.Approved
DiflunisalDiflunisal may increase the anticoagulant activities of Warfarin.Approved
DifluocortoloneDifluocortolone may increase the anticoagulant activities of Warfarin.Approved
DifluprednateDifluprednate may increase the anticoagulant activities of Warfarin.Approved
DihydroergotamineThe metabolism of Warfarin can be decreased when combined with Dihydroergotamine.Approved
DihydrotestosteroneDihydrotestosterone may increase the anticoagulant activities of Warfarin.Illicit
DiltiazemThe metabolism of Warfarin can be decreased when combined with Diltiazem.Approved
DipyridamoleDipyridamole may increase the anticoagulant activities of Warfarin.Approved
DisulfiramThe serum concentration of Warfarin can be increased when it is combined with Disulfiram.Approved
DitazoleDitazole may increase the anticoagulant activities of Warfarin.Approved, Withdrawn
DosulepinDosulepin may increase the anticoagulant activities of Warfarin.Approved
DoxepinDoxepin may increase the anticoagulant activities of Warfarin.Approved
DoxycyclineThe metabolism of Warfarin can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe serum concentration of Warfarin can be increased when it is combined with Dronedarone.Approved
DrospirenoneDrospirenone may decrease the anticoagulant activities of Warfarin.Approved
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Warfarin.Approved, Investigational, Withdrawn
DroxicamDroxicam may increase the anticoagulant activities of Warfarin.Approved
DuloxetineDuloxetine may increase the anticoagulant activities of Warfarin.Approved
DuvelisibDuvelisib may increase the anticoagulant activities of Warfarin.Investigational
DydrogesteroneThe therapeutic efficacy of Warfarin can be decreased when used in combination with Dydrogesterone.Approved, Withdrawn
E6201E6201 may increase the anticoagulant activities of Warfarin.Investigational
EbselenEbselen may increase the anticoagulant activities of Warfarin.Investigational
EconazoleThe serum concentration of Warfarin can be increased when it is combined with Econazole.Approved
Edetic AcidWarfarin may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanEdoxaban may increase the anticoagulant activities of Warfarin.Approved
EfavirenzThe serum concentration of Warfarin can be decreased when it is combined with Efavirenz.Approved, Investigational
ElvitegravirThe serum concentration of Warfarin can be decreased when it is combined with Elvitegravir.Approved
EnoxacinEnoxacin may increase the anticoagulant activities of Warfarin.Approved
EnoxaparinWarfarin may increase the anticoagulant activities of Enoxaparin.Approved
EnzalutamideThe serum concentration of Warfarin can be decreased when it is combined with Enzalutamide.Approved
EpinastineEpinastine may increase the anticoagulant activities of Warfarin.Approved, Investigational
EpirizoleEpirizole may increase the anticoagulant activities of Warfarin.Approved
eplivanserineeplivanserine may increase the anticoagulant activities of Warfarin.Investigational
EpoprostenolEpoprostenol may increase the anticoagulant activities of Warfarin.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Warfarin.Approved, Investigational
EquileninEquilenin may increase the anticoagulant activities of Warfarin.Experimental
EquilinEquilin may increase the anticoagulant activities of Warfarin.Approved
ErlotinibThe serum concentration of Warfarin can be increased when it is combined with Erlotinib.Approved, Investigational
ErythromycinThe metabolism of Warfarin can be decreased when combined with Erythromycin.Approved, Vet Approved
ErythromycinThe serum concentration of Warfarin can be increased when it is combined with Erythromycin.Approved, Vet Approved
EscitalopramEscitalopram may increase the anticoagulant activities of Warfarin.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Warfarin can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineEsmirtazapine may increase the anticoagulant activities of Warfarin.Investigational
EsomeprazoleThe serum concentration of Warfarin can be increased when it is combined with Esomeprazole.Approved, Investigational
EstradiolEstradiol may decrease the anticoagulant activities of Warfarin.Approved, Investigational, Vet Approved
EstramustineEstramustine may decrease the anticoagulant activities of Warfarin.Approved
EstriolEstriol may decrease the anticoagulant activities of Warfarin.Approved, Vet Approved
Estrogens, esterifiedEstrogens, esterified may decrease the anticoagulant activities of Warfarin.Approved
EstroneEstrone may increase the anticoagulant activities of Warfarin.Approved
Estrone sulfateEstrone sulfate may increase the anticoagulant activities of Warfarin.Approved
Etacrynic acidThe serum concentration of Warfarin can be increased when it is combined with Etacrynic acid.Approved
EtanerceptEtanercept may increase the anticoagulant activities of Warfarin.Approved, Investigational
EthanolThe serum concentration of Warfarin can be decreased when it is combined with Ethanol.Approved
Ethinyl EstradiolEthinyl Estradiol may decrease the anticoagulant activities of Warfarin.Approved
EthotoinEthotoin may increase the anticoagulant activities of Warfarin.Approved
Ethyl biscoumacetateWarfarin may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
Ethynodiol diacetateEthynodiol diacetate may decrease the anticoagulant activities of Warfarin.Approved
EtodolacEtodolac may increase the anticoagulant activities of Warfarin.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the anticoagulant activities of Warfarin.Approved
EtofibrateEtofibrate may increase the anticoagulant activities of Warfarin.Approved
EtonogestrelEtonogestrel may decrease the anticoagulant activities of Warfarin.Approved, Investigational
EtoperidoneEtoperidone may increase the anticoagulant activities of Warfarin.Approved
EtoposideEtoposide may increase the anticoagulant activities of Warfarin.Approved
EtoricoxibEtoricoxib may increase the anticoagulant activities of Warfarin.Approved, Investigational
EtravirineThe serum concentration of Warfarin can be decreased when it is combined with Etravirine.Approved
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Warfarin.Approved
ExenatideExenatide may increase the anticoagulant activities of Warfarin.Approved, Investigational
exisulindexisulind may increase the anticoagulant activities of Warfarin.Investigational
FelodipineThe metabolism of Warfarin can be decreased when combined with Felodipine.Approved, Investigational
FenbufenFenbufen may increase the anticoagulant activities of Warfarin.Approved
FenofibrateFenofibrate may increase the anticoagulant activities of Warfarin.Approved
FenoprofenFenoprofen may increase the anticoagulant activities of Warfarin.Approved
FibrinolysinFibrinolysin may increase the anticoagulant activities of Warfarin.Approved
FleroxacinFleroxacin may increase the anticoagulant activities of Warfarin.Approved
FloctafenineFloctafenine may increase the anticoagulant activities of Warfarin.Approved, Withdrawn
FloxuridineThe metabolism of Warfarin can be decreased when combined with Floxuridine.Approved
fluasteronefluasterone may increase the anticoagulant activities of Warfarin.Investigational
FlucloxacillinFlucloxacillin may decrease the anticoagulant activities of Warfarin.Approved
FluconazoleThe serum concentration of Warfarin can be increased when it is combined with Fluconazole.Approved
FludrocortisoneFludrocortisone may increase the anticoagulant activities of Warfarin.Approved
FluindioneWarfarin may increase the anticoagulant activities of Fluindione.Investigational
FlumequineFlumequine may increase the anticoagulant activities of Warfarin.Withdrawn
FlumethasoneFlumethasone may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
FlunisolideFlunisolide may increase the anticoagulant activities of Warfarin.Approved, Investigational
FlunixinFlunixin may increase the anticoagulant activities of Warfarin.Vet Approved
Fluocinolone AcetonideFluocinolone Acetonide may increase the anticoagulant activities of Warfarin.Approved, Investigational, Vet Approved
FluocinonideFluocinonide may increase the anticoagulant activities of Warfarin.Approved, Investigational
FluocortoloneFluocortolone may increase the anticoagulant activities of Warfarin.Approved, Withdrawn
FluorometholoneFluorometholone may increase the anticoagulant activities of Warfarin.Approved
FluorouracilThe serum concentration of Warfarin can be increased when it is combined with Fluorouracil.Approved
FluorouracilThe metabolism of Warfarin can be decreased when combined with Fluorouracil.Approved
FluoxetineThe metabolism of Warfarin can be decreased when combined with Fluoxetine.Approved, Vet Approved
FluoxymesteroneFluoxymesterone may increase the anticoagulant activities of Warfarin.Approved, Illicit
FluprednideneFluprednidene may increase the anticoagulant activities of Warfarin.Approved, Withdrawn
FluprednisoloneFluprednisolone may increase the anticoagulant activities of Warfarin.Approved
FlurandrenolideFlurandrenolide may increase the anticoagulant activities of Warfarin.Approved
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Warfarin.Approved, Investigational
Fluticasone furoateFluticasone furoate may increase the anticoagulant activities of Warfarin.Approved
Fluticasone PropionateFluticasone Propionate may increase the anticoagulant activities of Warfarin.Approved
FluvastatinThe metabolism of Warfarin can be decreased when combined with Fluvastatin.Approved
FluvoxamineThe metabolism of Warfarin can be decreased when combined with Fluvoxamine.Approved, Investigational
FondaparinuxWarfarin may increase the anticoagulant activities of Fondaparinux.Investigational
Fondaparinux sodiumFondaparinux sodium may increase the anticoagulant activities of Warfarin.Approved, Investigational
FormestaneFormestane may increase the anticoagulant activities of Warfarin.Approved, Investigational, Withdrawn
FosamprenavirThe serum concentration of Warfarin can be increased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Warfarin can be decreased when it is combined with Fosaprepitant.Approved
FosphenytoinFosphenytoin may increase the anticoagulant activities of Warfarin.Approved
Fusidic AcidThe serum concentration of Warfarin can be increased when it is combined with Fusidic Acid.Approved
GabexateWarfarin may increase the anticoagulant activities of Gabexate.Investigational
GarenoxacinGarenoxacin may increase the anticoagulant activities of Warfarin.Investigational
GatifloxacinGatifloxacin may increase the anticoagulant activities of Warfarin.Approved, Investigational
GefitinibGefitinib may increase the anticoagulant activities of Warfarin.Approved, Investigational
GemcitabineGemcitabine may increase the anticoagulant activities of Warfarin.Approved
GemfibrozilThe metabolism of Warfarin can be decreased when combined with Gemfibrozil.Approved
GemifloxacinGemifloxacin may increase the anticoagulant activities of Warfarin.Approved, Investigational
GenisteinGenistein may decrease the anticoagulant activities of Warfarin.Investigational
GestodeneGestodene may decrease the anticoagulant activities of Warfarin.Approved
GestrinoneThe therapeutic efficacy of Warfarin can be decreased when used in combination with Gestrinone.Approved
Ginkgo bilobaThe risk or severity of adverse effects can be increased when Ginkgo biloba is combined with Warfarin.Approved, Nutraceutical
GlibornurideGlibornuride may increase the anticoagulant activities of Warfarin.Withdrawn
GliclazideGliclazide may increase the anticoagulant activities of Warfarin.Approved
GlimepirideGlimepiride may increase the anticoagulant activities of Warfarin.Approved
GlipizideGlipizide may increase the anticoagulant activities of Warfarin.Approved
GliquidoneGliquidone may increase the anticoagulant activities of Warfarin.Approved
GlisoxepideGlisoxepide may increase the anticoagulant activities of Warfarin.Approved
Glucagon recombinantGlucagon recombinant may increase the anticoagulant activities of Warfarin.Approved
GlucosamineGlucosamine may increase the anticoagulant activities of Warfarin.Approved
GlutethimideThe metabolism of Warfarin can be increased when combined with Glutethimide.Approved, Illicit
GlyburideGlyburide may increase the anticoagulant activities of Warfarin.Approved
GrepafloxacinGrepafloxacin may increase the anticoagulant activities of Warfarin.Withdrawn
GriseofulvinThe serum concentration of Warfarin can be decreased when it is combined with Griseofulvin.Approved, Vet Approved
HE3286HE3286 may increase the anticoagulant activities of Warfarin.Investigational
HeminHemin may increase the anticoagulant activities of Warfarin.Approved
HeparinWarfarin may increase the anticoagulant activities of Heparin.Approved, Investigational
HexestrolHexestrol may decrease the anticoagulant activities of Warfarin.Withdrawn
HexobarbitalThe metabolism of Warfarin can be increased when combined with Hexobarbital.Approved
HigenamineHigenamine may increase the anticoagulant activities of Warfarin.Investigational
HirulogWarfarin may increase the anticoagulant activities of Hirulog.Experimental
HMPL-004HMPL-004 may increase the anticoagulant activities of Warfarin.Investigational
HydrocortisoneHydrocortisone may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
Hydroxyprogesterone caproateThe therapeutic efficacy of Warfarin can be decreased when used in combination with Hydroxyprogesterone caproate.Approved
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Warfarin is combined with Ibritumomab tiuxetan.Approved
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Warfarin.Approved
IbudilastIbudilast may increase the anticoagulant activities of Warfarin.Approved, Investigational
IbuprofenIbuprofen may increase the anticoagulant activities of Warfarin.Approved
IbuproxamIbuproxam may increase the anticoagulant activities of Warfarin.Withdrawn
IcatibantIcatibant may increase the anticoagulant activities of Warfarin.Approved
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Warfarin.Approved, Nutraceutical
IdelalisibThe serum concentration of Warfarin can be increased when it is combined with Idelalisib.Approved
idraparinuxWarfarin may increase the anticoagulant activities of idraparinux.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Warfarin.Approved, Withdrawn
IfosfamideIfosfamide may increase the anticoagulant activities of Warfarin.Approved
IloprostIloprost may increase the anticoagulant activities of Warfarin.Approved, Investigational
ImatinibImatinib may increase the anticoagulant activities of Warfarin.Approved
ImipramineImipramine may increase the anticoagulant activities of Warfarin.Approved
IndalpineIndalpine may increase the anticoagulant activities of Warfarin.Investigational, Withdrawn
IndinavirThe metabolism of Warfarin can be decreased when combined with Indinavir.Approved
IndobufenIndobufen may increase the anticoagulant activities of Warfarin.Investigational
IndomethacinIndomethacin may increase the anticoagulant activities of Warfarin.Approved, Investigational
IndoprofenIndoprofen may increase the anticoagulant activities of Warfarin.Withdrawn
IrbesartanThe metabolism of Warfarin can be decreased when combined with Irbesartan.Approved, Investigational
IsavuconazoniumThe metabolism of Warfarin can be decreased when combined with Isavuconazonium.Approved, Investigational
IsoniazidThe metabolism of Warfarin can be decreased when combined with Isoniazid.Approved
IsoxicamIsoxicam may increase the anticoagulant activities of Warfarin.Withdrawn
IsradipineThe metabolism of Warfarin can be decreased when combined with Isradipine.Approved
IstaroximeIstaroxime may increase the anticoagulant activities of Warfarin.Investigational
ItraconazoleThe serum concentration of Warfarin can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Warfarin can be increased when it is combined with Ivacaftor.Approved
IvermectinIvermectin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
JosamycinThe serum concentration of Warfarin can be increased when it is combined with Josamycin.Approved
Kct 0809Kct 0809 may increase the anticoagulant activities of Warfarin.Investigational
KebuzoneKebuzone may increase the anticoagulant activities of Warfarin.Experimental
KetanserinKetanserin may increase the anticoagulant activities of Warfarin.Investigational
KetoconazoleThe metabolism of Warfarin can be decreased when combined with Ketoconazole.Approved, Investigational
KetoconazoleThe serum concentration of Warfarin can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoprofenKetoprofen may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
KetorolacKetorolac may increase the anticoagulant activities of Warfarin.Approved
KitasamycinThe serum concentration of Warfarin can be increased when it is combined with Kitasamycin.Experimental
L-CarnitineL-Carnitine may increase the anticoagulant activities of Warfarin.Approved
LansoprazoleThe serum concentration of Warfarin can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe metabolism of Warfarin can be decreased when combined with Lapatinib.Approved, Investigational
LeflunomideLeflunomide may increase the anticoagulant activities of Warfarin.Approved, Investigational
LepirudinLepirudin may increase the anticoagulant activities of Warfarin.Approved
LevofloxacinLevofloxacin may increase the anticoagulant activities of Warfarin.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Levomilnacipran is combined with Warfarin.Approved
LevonorgestrelLevonorgestrel may decrease the anticoagulant activities of Warfarin.Approved, Investigational
LevothyroxineLevothyroxine may increase the anticoagulant activities of Warfarin.Approved
LidocaineThe metabolism of Warfarin can be decreased when combined with Lidocaine.Approved, Vet Approved
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Warfarin.Approved
LiothyronineLiothyronine may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
LiotrixLiotrix may increase the anticoagulant activities of Warfarin.Approved
LisofyllineLisofylline may increase the anticoagulant activities of Warfarin.Investigational
LixisenatideLixisenatide can cause a decrease in the absorption of Warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
LomefloxacinLomefloxacin may increase the anticoagulant activities of Warfarin.Approved
LomitapideThe serum concentration of Warfarin can be increased when it is combined with Lomitapide.Approved
LopinavirThe serum concentration of Warfarin can be decreased when it is combined with Lopinavir.Approved
LornoxicamLornoxicam may increase the anticoagulant activities of Warfarin.Approved
LosartanThe metabolism of Warfarin can be decreased when combined with Losartan.Approved
LovastatinThe metabolism of Warfarin can be decreased when combined with Lovastatin.Approved, Investigational
LoxoprofenLoxoprofen may increase the anticoagulant activities of Warfarin.Approved
LuliconazoleThe serum concentration of Warfarin can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Warfarin can be increased when it is combined with Lumacaftor.Approved
LumiracoxibLumiracoxib may increase the anticoagulant activities of Warfarin.Approved, Investigational
LynestrenolLynestrenol may decrease the anticoagulant activities of Warfarin.Investigational
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Warfarin.Approved
MasoprocolMasoprocol may increase the anticoagulant activities of Warfarin.Approved
ME-609ME-609 may increase the anticoagulant activities of Warfarin.Investigational
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
MedrogestoneThe therapeutic efficacy of Warfarin can be decreased when used in combination with Medrogestone.Approved
Medroxyprogesterone acetateMedroxyprogesterone acetate may decrease the anticoagulant activities of Warfarin.Approved, Investigational
MedrysoneMedrysone may increase the anticoagulant activities of Warfarin.Approved
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Warfarin.Approved
Megestrol acetateThe therapeutic efficacy of Warfarin can be decreased when used in combination with Megestrol acetate.Approved, Vet Approved
MelengestrolMelengestrol may increase the anticoagulant activities of Warfarin.Vet Approved
MeloxicamMeloxicam may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
MercaptopurineMercaptopurine may decrease the anticoagulant activities of Warfarin.Approved
MesalazineMesalazine may increase the anticoagulant activities of Warfarin.Approved
MestranolMestranol may decrease the anticoagulant activities of Warfarin.Approved
MetamizoleMetamizole may increase the anticoagulant activities of Warfarin.Withdrawn
MethallenestrilMethallenestril may decrease the anticoagulant activities of Warfarin.Experimental
MethimazoleMethimazole may decrease the anticoagulant activities of Warfarin.Approved
MethohexitalThe metabolism of Warfarin can be increased when combined with Methohexital.Approved
MethylphenidateThe serum concentration of Warfarin can be increased when it is combined with Methylphenidate.Approved, Investigational
MethylphenobarbitalThe metabolism of Warfarin can be increased when combined with Methylphenobarbital.Approved
MethylprednisoloneMethylprednisolone may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
MethyltestosteroneMethyltestosterone may increase the anticoagulant activities of Warfarin.Approved
MeticillinMeticillin may increase the anticoagulant activities of Warfarin.Approved
MetreleptinThe serum concentration of Warfarin can be decreased when it is combined with Metreleptin.Approved
MetronidazoleThe serum concentration of Warfarin can be increased when it is combined with Metronidazole.Approved
MevastatinMevastatin may increase the anticoagulant activities of Warfarin.Experimental
MexiletineThe metabolism of Warfarin can be decreased when combined with Mexiletine.Approved
MezlocillinMezlocillin may increase the anticoagulant activities of Warfarin.Approved
MiconazoleThe serum concentration of Warfarin can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MifepristoneThe serum concentration of Warfarin can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Milnacipran is combined with Warfarin.Approved
MilrinoneMilrinone may increase the anticoagulant activities of Warfarin.Approved
MinocyclineMinocycline may increase the anticoagulant activities of Warfarin.Approved, Investigational
MirtazapineMirtazapine may increase the anticoagulant activities of Warfarin.Approved
MitotaneThe serum concentration of Warfarin can be decreased when it is combined with Mitotane.Approved
MizoribineMizoribine may increase the anticoagulant activities of Warfarin.Investigational
MoclobemideThe metabolism of Warfarin can be decreased when combined with Moclobemide.Approved
ModafinilThe serum concentration of Warfarin can be decreased when it is combined with Modafinil.Approved, Investigational
MometasoneMometasone may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
MoxifloxacinMoxifloxacin may increase the anticoagulant activities of Warfarin.Approved, Investigational
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Warfarin.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Warfarin.Approved
NabumetoneNabumetone may increase the anticoagulant activities of Warfarin.Approved
NadroparinWarfarin may increase the anticoagulant activities of Nadroparin.Approved
NafamostatNafamostat may increase the anticoagulant activities of Warfarin.Investigational
NafcillinNafcillin may decrease the anticoagulant activities of Warfarin.Approved
NaftifineNaftifine may increase the anticoagulant activities of Warfarin.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Warfarin.Investigational
Nalidixic AcidNalidixic Acid may increase the anticoagulant activities of Warfarin.Approved
NaproxenNaproxen may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
NCX 1022NCX 1022 may increase the anticoagulant activities of Warfarin.Investigational
NCX 4016NCX 4016 may increase the anticoagulant activities of Warfarin.Investigational
NefazodoneThe metabolism of Warfarin can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Warfarin can be decreased when it is combined with Nelfinavir.Approved
NemonoxacinNemonoxacin may increase the anticoagulant activities of Warfarin.Investigational
NeomycinNeomycin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
NepafenacNepafenac may increase the anticoagulant activities of Warfarin.Approved
NetupitantThe serum concentration of Warfarin can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Warfarin can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Warfarin can be decreased when combined with Nicardipine.Approved
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Warfarin.Approved
NilotinibThe metabolism of Warfarin can be decreased when combined with Nilotinib.Approved, Investigational
NimesulideNimesulide may increase the anticoagulant activities of Warfarin.Approved, Withdrawn
NintedanibThe risk or severity of adverse effects can be increased when Warfarin is combined with Nintedanib.Approved
NitroaspirinNitroaspirin may increase the anticoagulant activities of Warfarin.Investigational
NomegestrolThe therapeutic efficacy of Warfarin can be decreased when used in combination with Nomegestrol.Approved
NorelgestrominNorelgestromin may decrease the anticoagulant activities of Warfarin.Approved
NorethisteroneThe therapeutic efficacy of Warfarin can be decreased when used in combination with Norethisterone.Approved
NorfloxacinNorfloxacin may increase the anticoagulant activities of Warfarin.Approved
NorgestimateNorgestimate may decrease the anticoagulant activities of Warfarin.Approved
NorgestrelNorgestrel may decrease the anticoagulant activities of Warfarin.Approved
NortriptylineNortriptyline may increase the anticoagulant activities of Warfarin.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Warfarin is combined with Obinutuzumab.Approved
OfloxacinOfloxacin may increase the anticoagulant activities of Warfarin.Approved
OlaparibThe metabolism of Warfarin can be decreased when combined with Olaparib.Approved
OleandomycinThe serum concentration of Warfarin can be increased when it is combined with Oleandomycin.Vet Approved
Oleoyl estroneOleoyl estrone may increase the anticoagulant activities of Warfarin.Investigational
OlopatadineOlopatadine may increase the anticoagulant activities of Warfarin.Approved
OlsalazineOlsalazine may increase the anticoagulant activities of Warfarin.Approved
Omacetaxine mepesuccinateThe risk or severity of adverse effects can be increased when Warfarin is combined with Omacetaxine mepesuccinate.Approved
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Warfarin.Approved
OmeprazoleThe serum concentration of Warfarin can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OpipramolOpipramol may increase the anticoagulant activities of Warfarin.Investigational
OrgoteinOrgotein may increase the anticoagulant activities of Warfarin.Vet Approved
OritavancinThe serum concentration of Warfarin can be increased when it is combined with Oritavancin.Approved, Investigational
OrlistatOrlistat may increase the anticoagulant activities of Warfarin.Approved, Investigational
OsimertinibThe serum concentration of Warfarin can be increased when it is combined with Osimertinib.Approved
OtamixabanWarfarin may increase the anticoagulant activities of Otamixaban.Investigational
OxacillinOxacillin may increase the anticoagulant activities of Warfarin.Approved
OxandroloneOxandrolone may increase the anticoagulant activities of Warfarin.Approved, Investigational
OxaprozinOxaprozin may increase the anticoagulant activities of Warfarin.Approved
OxymetholoneOxymetholone may increase the anticoagulant activities of Warfarin.Approved, Illicit
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Warfarin.Withdrawn
OxytetracyclineOxytetracycline may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
PalbociclibThe serum concentration of Warfarin can be increased when it is combined with Palbociclib.Approved
PantoprazoleThe metabolism of Warfarin can be decreased when combined with Pantoprazole.Approved
ParamethasoneParamethasone may increase the anticoagulant activities of Warfarin.Approved
ParecoxibParecoxib may increase the anticoagulant activities of Warfarin.Approved
ParnaparinParnaparin may increase the anticoagulant activities of Warfarin.Approved
ParoxetineParoxetine may increase the anticoagulant activities of Warfarin.Approved, Investigational
PazufloxacinPazufloxacin may increase the anticoagulant activities of Warfarin.Investigational
PefloxacinPefloxacin may increase the anticoagulant activities of Warfarin.Approved
Peginterferon alfa-2bThe serum concentration of Warfarin can be increased when it is combined with Peginterferon alfa-2b.Approved
PentobarbitalThe metabolism of Warfarin can be increased when combined with Pentobarbital.Approved, Vet Approved
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Warfarin.Approved
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Warfarin.Approved, Investigational
PhenindionePhenindione may increase the anticoagulant activities of Warfarin.Approved
PhenobarbitalThe metabolism of Warfarin can be increased when combined with Phenobarbital.Approved
PhenoxymethylpenicillinPhenoxymethylpenicillin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
PhenprocoumonWarfarin may increase the anticoagulant activities of Phenprocoumon.Approved
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
PhenytoinPhenytoin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
PhylloquinonePhylloquinone may decrease the anticoagulant activities of Warfarin.Approved
PimecrolimusPimecrolimus may increase the anticoagulant activities of Warfarin.Approved, Investigational
PioglitazoneThe metabolism of Warfarin can be decreased when combined with Pioglitazone.Approved, Investigational
PiperacillinPiperacillin may increase the anticoagulant activities of Warfarin.Approved
PirfenidonePirfenidone may increase the anticoagulant activities of Warfarin.Investigational
PiroxicamPiroxicam may increase the anticoagulant activities of Warfarin.Approved, Investigational
PitavastatinPitavastatin may increase the anticoagulant activities of Warfarin.Approved
PivampicillinPivampicillin may increase the anticoagulant activities of Warfarin.Approved
PivmecillinamPivmecillinam may increase the anticoagulant activities of Warfarin.Approved
PlasminPlasmin may increase the anticoagulant activities of Warfarin.Investigational
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Warfarin.Approved
PosaconazoleThe serum concentration of Warfarin can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PrasteronePrasterone may increase the anticoagulant activities of Warfarin.Approved, Nutraceutical
PrasugrelPrasugrel may increase the anticoagulant activities of Warfarin.Approved
PravastatinPravastatin may increase the anticoagulant activities of Warfarin.Approved
PrednicarbatePrednicarbate may increase the anticoagulant activities of Warfarin.Approved
PrednisolonePrednisolone may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
PrednisonePrednisone may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
PregnenolonePregnenolone may increase the anticoagulant activities of Warfarin.Experimental
PrimidoneThe metabolism of Warfarin can be increased when combined with Primidone.Approved, Vet Approved
Procaine benzylpenicillinProcaine benzylpenicillin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
ProgesteroneThe therapeutic efficacy of Warfarin can be decreased when used in combination with Progesterone.Approved, Vet Approved
ProguanilProguanil may increase the anticoagulant activities of Warfarin.Approved
PromestrienePromestriene may decrease the anticoagulant activities of Warfarin.Investigational
PropacetamolPropacetamol may increase the anticoagulant activities of Warfarin.Approved
PropafenoneThe serum concentration of Warfarin can be increased when it is combined with Propafenone.Approved
PropylthiouracilPropylthiouracil may decrease the anticoagulant activities of Warfarin.Approved
Protein CWarfarin may increase the anticoagulant activities of Protein C.Approved
Protein S humanWarfarin may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeWarfarin may increase the anticoagulant activities of Protocatechualdehyde.Approved
ProtriptylineProtriptyline may increase the anticoagulant activities of Warfarin.Approved
PrulifloxacinPrulifloxacin may increase the anticoagulant activities of Warfarin.Investigational
PTC299PTC299 may increase the anticoagulant activities of Warfarin.Investigational
PyrimethamineThe metabolism of Warfarin can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuinestrolQuinestrol may decrease the anticoagulant activities of Warfarin.Approved
QuinidineQuinidine may increase the anticoagulant activities of Warfarin.Approved
QuinineQuinine may increase the anticoagulant activities of Warfarin.Approved
RabeprazoleThe metabolism of Warfarin can be decreased when combined with Rabeprazole.Approved, Investigational
RamatrobanRamatroban may increase the anticoagulant activities of Warfarin.Investigational
RanitidineThe serum concentration of Warfarin can be increased when it is combined with Ranitidine.Approved
RanolazineThe metabolism of Warfarin can be decreased when combined with Ranolazine.Approved, Investigational
RegorafenibThe risk or severity of adverse effects can be increased when Warfarin is combined with Regorafenib.Approved
ResveratrolResveratrol may increase the anticoagulant activities of Warfarin.Experimental, Investigational
ReteplaseReteplase may increase the anticoagulant activities of Warfarin.Approved
ReviparinWarfarin may increase the anticoagulant activities of Reviparin.Approved
RidogrelRidogrel may increase the anticoagulant activities of Warfarin.Approved
RifabutinThe metabolism of Warfarin can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Warfarin can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Warfarin can be increased when combined with Rifapentine.Approved
RimexoloneRimexolone may increase the anticoagulant activities of Warfarin.Approved
RitonavirThe serum concentration of Warfarin can be decreased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanWarfarin may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the anticoagulant activities of Warfarin.Investigational, Withdrawn
RomidepsinRomidepsin may increase the anticoagulant activities of Warfarin.Approved, Investigational
RopiniroleThe metabolism of Warfarin can be decreased when combined with Ropinirole.Approved, Investigational
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Warfarin.Approved, Investigational
RosoxacinRosoxacin may increase the anticoagulant activities of Warfarin.Approved
RosuvastatinRosuvastatin may increase the anticoagulant activities of Warfarin.Approved
S EquolS Equol may decrease the anticoagulant activities of Warfarin.Investigational
SalicylamideSalicylamide may increase the anticoagulant activities of Warfarin.Approved
Salicylic acidSalicylic acid may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
SalsalateSalsalate may increase the anticoagulant activities of Warfarin.Approved
SaquinavirThe serum concentration of Warfarin can be increased when it is combined with Saquinavir.Approved, Investigational
SCH-530348SCH-530348 may increase the anticoagulant activities of Warfarin.Investigational
SecobarbitalThe metabolism of Warfarin can be increased when combined with Secobarbital.Approved, Vet Approved
SecoisolariciresinolSecoisolariciresinol may decrease the anticoagulant activities of Warfarin.Investigational
SelexipagSelexipag may increase the anticoagulant activities of Warfarin.Approved
SeratrodastSeratrodast may increase the anticoagulant activities of Warfarin.Approved, Investigational
SertralineThe metabolism of Warfarin can be decreased when combined with Sertraline.Approved
SevofluraneSevoflurane may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
SildenafilThe metabolism of Warfarin can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Warfarin can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Warfarin can be increased when it is combined with Simeprevir.Approved
SimvastatinSimvastatin may increase the anticoagulant activities of Warfarin.Approved
SitaxentanThe serum concentration of Warfarin can be increased when it is combined with Sitaxentan.Approved, Investigational, Withdrawn
SolithromycinThe serum concentration of Warfarin can be increased when it is combined with Solithromycin.Investigational
SorafenibSorafenib may increase the anticoagulant activities of Warfarin.Approved, Investigational
SparfloxacinSparfloxacin may increase the anticoagulant activities of Warfarin.Approved
SRT501SRT501 may increase the anticoagulant activities of Warfarin.Investigational
St. John's WortThe metabolism of Warfarin can be increased when combined with St. John's Wort.Nutraceutical
StanozololStanozolol may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
StiripentolThe serum concentration of Warfarin can be increased when it is combined with Stiripentol.Approved
StreptokinaseStreptokinase may increase the anticoagulant activities of Warfarin.Approved
SucralfateSucralfate may decrease the anticoagulant activities of Warfarin.Approved
SugammadexSugammadex may increase the anticoagulant activities of Warfarin.Approved
SulbactamSulbactam may increase the anticoagulant activities of Warfarin.Approved
SulfadiazineThe metabolism of Warfarin can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleSulfamethoxazole may increase the anticoagulant activities of Warfarin.Approved
SulfasalazineSulfasalazine may increase the anticoagulant activities of Warfarin.Approved
SulfinpyrazoneThe metabolism of Warfarin can be decreased when combined with Sulfinpyrazone.Approved
SulfisoxazoleThe metabolism of Warfarin can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulindacSulindac may increase the anticoagulant activities of Warfarin.Approved
SulodexideWarfarin may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SultamicillinSultamicillin may increase the anticoagulant activities of Warfarin.Investigational
SuprofenSuprofen may increase the anticoagulant activities of Warfarin.Approved, Withdrawn
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Warfarin.Approved
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Warfarin.Approved
TamoxifenThe serum concentration of Warfarin can be increased when it is combined with Tamoxifen.Approved
TazobactamTazobactam may increase the anticoagulant activities of Warfarin.Approved
TegafurThe serum concentration of Warfarin can be increased when it is combined with Tegafur.Approved
TelaprevirThe serum concentration of Warfarin can be decreased when it is combined with Telaprevir.Approved
TelithromycinThe metabolism of Warfarin can be decreased when combined with Telithromycin.Approved
TemafloxacinTemafloxacin may increase the anticoagulant activities of Warfarin.Withdrawn
TenecteplaseTenecteplase may increase the anticoagulant activities of Warfarin.Approved
TenofovirThe metabolism of Warfarin can be decreased when combined with Tenofovir.Approved, Investigational
TenoxicamTenoxicam may increase the anticoagulant activities of Warfarin.Approved
TepoxalinTepoxalin may increase the anticoagulant activities of Warfarin.Vet Approved
TeriflunomideThe serum concentration of Warfarin can be decreased when it is combined with Teriflunomide.Approved
TesmilifeneTesmilifene may increase the anticoagulant activities of Warfarin.Investigational
TestosteroneTestosterone may increase the anticoagulant activities of Warfarin.Approved, Investigational
TetracyclineTetracycline may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
TheophyllineThe metabolism of Warfarin can be decreased when combined with Theophylline.Approved
ThiamylalThe metabolism of Warfarin can be increased when combined with Thiamylal.Approved, Vet Approved
ThiopentalThe metabolism of Warfarin can be increased when combined with Thiopental.Approved, Vet Approved
Thyroid, porcineThyroid, porcine may increase the anticoagulant activities of Warfarin.Approved
TianeptineTianeptine may increase the anticoagulant activities of Warfarin.Approved
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Warfarin.Approved
TiboloneTibolone may increase the anticoagulant activities of Warfarin.Approved
TicagrelorThe metabolism of Warfarin can be decreased when combined with Ticagrelor.Approved
TicarcillinTicarcillin may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
TiclopidineThe metabolism of Warfarin can be decreased when combined with Ticlopidine.Approved
TigecyclineThe serum concentration of Warfarin can be increased when it is combined with Tigecycline.Approved
TinoridineTinoridine may increase the anticoagulant activities of Warfarin.Investigational
TinzaparinTinzaparin may increase the anticoagulant activities of Warfarin.Approved
TipranavirTipranavir may increase the anticoagulant activities of Warfarin.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Warfarin.Approved
TixocortolTixocortol may increase the anticoagulant activities of Warfarin.Approved
TocilizumabThe serum concentration of Warfarin can be decreased when it is combined with Tocilizumab.Approved
TolazamideTolazamide may increase the anticoagulant activities of Warfarin.Approved
TolbutamideThe metabolism of Warfarin can be decreased when combined with Tolbutamide.Approved
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Warfarin.Approved
TolmetinTolmetin may increase the anticoagulant activities of Warfarin.Approved
TolterodineTolterodine may increase the anticoagulant activities of Warfarin.Approved, Investigational
TopiramateThe metabolism of Warfarin can be decreased when combined with Topiramate.Approved
TorasemideThe serum concentration of Warfarin can be increased when it is combined with Torasemide.Approved
ToremifeneToremifene may increase the anticoagulant activities of Warfarin.Approved, Investigational
TositumomabThe risk or severity of adverse effects can be increased when Warfarin is combined with Tositumomab.Approved
TramadolTramadol may increase the anticoagulant activities of Warfarin.Approved, Investigational
TranilastTranilast may increase the anticoagulant activities of Warfarin.Approved, Investigational
TranilastThe risk or severity of adverse effects can be increased when Tranilast is combined with Warfarin.Approved, Investigational
TranylcypromineThe metabolism of Warfarin can be decreased when combined with Tranylcypromine.Approved
TrapidilTrapidil may increase the anticoagulant activities of Warfarin.Approved
TrazodoneTrazodone may decrease the anticoagulant activities of Warfarin.Approved, Investigational
TreprostinilTreprostinil may increase the anticoagulant activities of Warfarin.Approved, Investigational
TriamcinoloneTriamcinolone may increase the anticoagulant activities of Warfarin.Approved, Vet Approved
TriflusalTriflusal may increase the anticoagulant activities of Warfarin.Approved
TrimethoprimThe metabolism of Warfarin can be decreased when combined with Trimethoprim.Approved, Vet Approved
TrimipramineTrimipramine may increase the anticoagulant activities of Warfarin.Approved
Trisalicylate-cholineTrisalicylate-choline may increase the anticoagulant activities of Warfarin.Approved
TroleandomycinThe serum concentration of Warfarin can be increased when it is combined with Troleandomycin.Approved
TrovafloxacinTrovafloxacin may increase the anticoagulant activities of Warfarin.Approved, Withdrawn
TylosinThe serum concentration of Warfarin can be increased when it is combined with Tylosin.Vet Approved
UrokinaseUrokinase may increase the anticoagulant activities of Warfarin.Approved, Investigational, Withdrawn
ValdecoxibValdecoxib may increase the anticoagulant activities of Warfarin.Investigational, Withdrawn
Valproic AcidThe metabolism of Warfarin can be decreased when combined with Valproic Acid.Approved, Investigational
ValsartanThe metabolism of Warfarin can be decreased when combined with Valsartan.Approved, Investigational
VemurafenibThe serum concentration of Warfarin can be increased when it is combined with Vemurafenib.Approved
VenlafaxineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Warfarin.Approved
VerapamilThe metabolism of Warfarin can be decreased when combined with Verapamil.Approved
Vitamin EVitamin E may increase the anticoagulant activities of Warfarin.Approved, Nutraceutical, Vet Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Warfarin.Approved
VoriconazoleThe serum concentration of Warfarin can be increased when it is combined with Voriconazole.Approved, Investigational
VorinostatVorinostat may increase the anticoagulant activities of Warfarin.Approved, Investigational
XimelagatranWarfarin may increase the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
Ym150Warfarin may increase the anticoagulant activities of Ym150.Investigational
ZafirlukastThe serum concentration of Warfarin can be increased when it is combined with Zafirlukast.Approved, Investigational
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Warfarin.Approved
ZeranolZeranol may decrease the anticoagulant activities of Warfarin.Vet Approved
ZileutonThe serum concentration of Warfarin can be increased when it is combined with Zileuton.Approved, Investigational, Withdrawn
ZimelidineZimelidine may increase the anticoagulant activities of Warfarin.Withdrawn
ZiprasidoneThe metabolism of Warfarin can be decreased when combined with Ziprasidone.Approved
ZomepiracZomepirac may increase the anticoagulant activities of Warfarin.Withdrawn
Food Interactions
  • Avoid alcohol.
  • Avoid drastic changes in dietary habit.
  • Avoid St. John's Wort.
  • Consult your doctor before ingesting large amounts of dietary Vitamin K (e.g. from green leafy vegetables).
  • Limit garlic, ginger, gingko, and horse chestnut.
References
Synthesis Reference

Nasri W. Badran, “Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin (warfarin) and methods of making.” U.S. Patent US4113744, issued April, 1960.

US4113744
General References
  1. Ansell J, Hirsh J, Poller L, Bussey H, Jacobson A, Hylek E: The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004 Sep;126(3 Suppl):204S-233S. [PubMed:15383473 ]
  2. Whitlon DS, Sadowski JA, Suttie JW: Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition. Biochemistry. 1978 Apr 18;17(8):1371-7. [PubMed:646989 ]
  3. Li T, Chang CY, Jin DY, Lin PJ, Khvorova A, Stafford DW: Identification of the gene for vitamin K epoxide reductase. Nature. 2004 Feb 5;427(6974):541-4. [PubMed:14765195 ]
  4. Rost S, Fregin A, Ivaskevicius V, Conzelmann E, Hortnagel K, Pelz HJ, Lappegard K, Seifried E, Scharrer I, Tuddenham EG, Muller CR, Strom TM, Oldenburg J: Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature. 2004 Feb 5;427(6974):537-41. [PubMed:14765194 ]
  5. Hirsh J, Fuster V, Ansell J, Halperin JL: American Heart Association/American College of Cardiology Foundation guide to warfarin therapy. J Am Coll Cardiol. 2003 May 7;41(9):1633-52. [PubMed:12742309 ]
  6. Holbrook AM, Pereira JA, Labiris R, McDonald H, Douketis JD, Crowther M, Wells PS: Systematic overview of warfarin and its drug and food interactions. Arch Intern Med. 2005 May 23;165(10):1095-106. [PubMed:15911722 ]
  7. Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G: Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008 Jun;133(6 Suppl):160S-198S. doi: 10.1378/chest.08-0670. [PubMed:18574265 ]
  8. Freedman MD: Oral anticoagulants: pharmacodynamics, clinical indications and adverse effects. J Clin Pharmacol. 1992 Mar;32(3):196-209. [PubMed:1564123 ]
  9. Warfarin. (2007). In Human Developmental Toxicants: Aspects of Toxicology and Chemistry (pp. 193–4). CRC Press. [ISBN:1420006754 ]
  10. Loftus, Christopher M. (1995). Fetal toxicity of common neurosurgical drugs. In Neurosurgical Aspects of Pregnancy (pp. 11–13). American Association of Neurological Surgeons. [ISBN:1879284367 ]
External Links
ATC CodesB01AA03
AHFS Codes
  • 20:12.04.08
PDB EntriesNot Available
FDA labelDownload (641 KB)
MSDSDownload (59.5 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9109
Blood Brain Barrier+0.9124
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.5502
P-glycoprotein inhibitor INon-inhibitor0.8782
P-glycoprotein inhibitor IINon-inhibitor0.8382
Renal organic cation transporterNon-inhibitor0.8863
CYP450 2C9 substrateNon-substrate0.678
CYP450 2D6 substrateSubstrate0.5658
CYP450 3A4 substrateNon-substrate0.6007
CYP450 1A2 substrateNon-inhibitor0.714
CYP450 2C9 inhibitorInhibitor0.7657
CYP450 2D6 inhibitorNon-inhibitor0.9286
CYP450 2C19 inhibitorNon-inhibitor0.9161
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8785
Ames testNon AMES toxic0.6844
CarcinogenicityNon-carcinogens0.9352
BiodegradationNot ready biodegradable0.7474
Rat acute toxicity4.1700 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8768
hERG inhibition (predictor II)Non-inhibitor0.9615
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Pharmaceutical research assoc inc
  • Bristol myers squibb pharma co
  • Usl pharma inc
  • Abbott laboratories pharmaceutical products div
  • Barr laboratories inc
  • Mylan pharmaceuticals inc
  • Pliva inc
  • Sandoz inc
  • Taro pharmaceuticals inc
  • Watson laboratories inc
  • Zydus pharmaceuticals usa inc
Packagers
Dosage forms
FormRouteStrength
Injection, powder, lyophilized, for solutionIntravenous2 mg/mL
Powder, for solutionIntravenous5 mg
TabletOral10 mg
TabletOral1 mg
TabletOral2.5 mg
TabletOral2 mg
TabletOral3 mg
TabletOral4 mg
TabletOral5 mg
TabletOral6 mg
TabletOral10.0 mg
TabletOral3.0 mg
TabletOral4.0 mg
TabletOral5.0 mg
TabletOral7.5 mg
TabletOral1 mg/1
TabletOral10 mg/1
TabletOral2 mg/1
TabletOral2.5 mg/1
TabletOral3 mg/1
TabletOral4 mg/1
TabletOral5 mg/1
TabletOral6 mg/1
TabletOral7.5 mg/1
Prices
Unit descriptionCostUnit
Warfarin sodium powder54.53USD g
Coumadin 5 mg vial34.07USD vial
Coumadin 10 mg tablet2.01USD tablet
Coumadin 7.5 mg tablet1.97USD tablet
Coumadin 6 mg tablet1.94USD tablet
Coumadin 3 mg tablet1.51USD tablet
Coumadin 5 mg tablet1.51USD tablet
Coumadin 4 mg tablet1.49USD tablet
Coumadin 2.5 mg tablet1.46USD tablet
Coumadin 2 mg tablet1.4USD tablet
Coumadin 1 mg tablet1.37USD tablet
Warfarin sodium 10 mg tablet1.0USD tablet
Warfarin sodium 7.5 mg tablet0.96USD tablet
Jantoven 10 mg tablet0.76USD tablet
Jantoven 7.5 mg tablet0.74USD tablet
Jantoven 6 mg tablet0.72USD tablet
Warfarin sodium 6 mg tablet0.68USD tablet
Warfarin sodium 3 mg tablet0.66USD tablet
Warfarin sodium 4 mg tablet0.66USD tablet
Warfarin sodium 2.5 mg tablet0.65USD tablet
Warfarin sodium 5 mg tablet0.65USD tablet
Warfarin sodium 2 mg tablet0.63USD tablet
Warfarin sodium 1 mg tablet0.61USD tablet
Jantoven 5 mg tablet0.59USD tablet
Jantoven 2 mg tablet0.56USD tablet
Jantoven 4 mg tablet0.56USD tablet
Jantoven 2.5 mg tablet0.53USD tablet
Jantoven 3 mg tablet0.53USD tablet
Coumadin 10 mg Tablet0.5USD tablet
Jantoven 1 mg tablet0.49USD tablet
Coumadin 3 mg Tablet0.43USD tablet
Coumadin 4 mg Tablet0.43USD tablet
Coumadin 2 mg Tablet0.35USD tablet
Coumadin 1 mg Tablet0.33USD tablet
Taro-Warfarin 7.5 mg Tablet0.33USD tablet
Taro-Warfarin 6 mg Tablet0.31USD tablet
Apo-Warfarin 10 mg Tablet0.28USD tablet
Coumadin 2.5 mg Tablet0.28USD tablet
Coumadin 5 mg Tablet0.28USD tablet
Mylan-Warfarin 10 mg Tablet0.28USD tablet
Taro-Warfarin 10 mg Tablet0.28USD tablet
Warfarin 10 mg Tablet0.28USD tablet
Apo-Warfarin 3 mg Tablet0.24USD tablet
Apo-Warfarin 4 mg Tablet0.24USD tablet
Mylan-Warfarin 3 mg Tablet0.24USD tablet
Mylan-Warfarin 4 mg Tablet0.24USD tablet
Novo-Warfarin 3 mg Tablet0.24USD tablet
Novo-Warfarin 4 mg Tablet0.24USD tablet
Taro-Warfarin 3 mg Tablet0.24USD tablet
Taro-Warfarin 4 mg Tablet0.24USD tablet
Warfarin 3 mg Tablet0.24USD tablet
Warfarin 4 mg Tablet0.24USD tablet
Apo-Warfarin 2 mg Tablet0.19USD tablet
Mylan-Warfarin 2 mg Tablet0.19USD tablet
Novo-Warfarin 2 mg Tablet0.19USD tablet
Taro-Warfarin 2 mg Tablet0.19USD tablet
Warfarin 2 mg Tablet0.19USD tablet
Apo-Warfarin 1 mg Tablet0.18USD tablet
Mylan-Warfarin 1 mg Tablet0.18USD tablet
Novo-Warfarin 1 mg Tablet0.18USD tablet
Taro-Warfarin 1 mg Tablet0.18USD tablet
Warfarin 1 mg Tablet0.18USD tablet
Apo-Warfarin 5 mg Tablet0.16USD tablet
Mylan-Warfarin 5 mg Tablet0.16USD tablet
Novo-Warfarin 5 mg Tablet0.16USD tablet
Taro-Warfarin 5 mg Tablet0.16USD tablet
Warfarin 5 mg Tablet0.16USD tablet
Apo-Warfarin 2.5 mg Tablet0.15USD tablet
Mylan-Warfarin 2.5 mg Tablet0.15USD tablet
Novo-Warfarin 2.5 mg Tablet0.15USD tablet
Taro-Warfarin 2.5 mg Tablet0.15USD tablet
Warfarin 2.5 mg Tablet0.15USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point161 °CPhysProp
water solubility17 mg/L (at 20 °C)TOMLIN,C (1997)
logP2.70HANSCH,C ET AL. (1995)
logS-3.89ADME Research, USCD
Caco2 permeability-4.68ADME Research, USCD
pKa5.08Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0472 mg/mLALOGPS
logP2.41ALOGPS
logP2.74ChemAxon
logS-3.8ALOGPS
pKa (Strongest Acidic)6.33ChemAxon
pKa (Strongest Basic)-6.6ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area63.6 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity86.86 m3·mol-1ChemAxon
Polarizability31.93 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (8.72 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 4-hydroxycoumarins. These are coumarins that contain one or more hydroxyl groups attached to C4-position the coumarin skeleton.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassCoumarins and derivatives
Sub ClassHydroxycoumarins
Direct Parent4-hydroxycoumarins
Alternative Parents
Substituents
  • 4-hydroxycoumarin
  • 1-benzopyran
  • Benzopyran
  • Pyranone
  • Benzenoid
  • Pyran
  • Monocyclic benzene moiety
  • Heteroaromatic compound
  • Vinylogous acid
  • Lactone
  • Ketone
  • Oxacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Vitamin-k-epoxide reductase (warfarin-sensitive) activity
Specific Function:
Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
Gene Name:
VKORC1
Uniprot ID:
Q9BQB6
Molecular Weight:
18234.3 Da
References
  1. Gebauer M: Synthesis and structure-activity relationships of novel warfarin derivatives. Bioorg Med Chem. 2007 Mar 15;15(6):2414-20. Epub 2007 Jan 17. [PubMed:17275317 ]
  2. Zhu Y, Shennan M, Reynolds KK, Johnson NA, Herrnberger MR, Valdes R Jr, Linder MW: Estimation of warfarin maintenance dose based on VKORC1 (-1639 G>A) and CYP2C9 genotypes. Clin Chem. 2007 Jul;53(7):1199-205. Epub 2007 May 17. [PubMed:17510308 ]
  3. Yin T, Miyata T: Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1 - rationale and perspectives. Thromb Res. 2007;120(1):1-10. Epub 2006 Dec 11. [PubMed:17161452 ]
  4. Osman A, Enstrom C, Lindahl TL: Plasma S/R ratio of warfarin co-varies with VKORC1 haplotype. Blood Coagul Fibrinolysis. 2007 Apr;18(3):293-6. [PubMed:17413769 ]
  5. Limdi NA, McGwin G, Goldstein JA, Beasley TM, Arnett DK, Adler BK, Baird MF, Acton RT: Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin. Clin Pharmacol Ther. 2008 Feb;83(2):312-21. Epub 2007 Jul 25. [PubMed:17653141 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP2C18
Uniprot ID:
P33260
Molecular Weight:
55710.075 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Yamasaki K, Maruyama T, Kragh-Hansen U, Otagiri M: Characterization of site I on human serum albumin: concept about the structure of a drug binding site. Biochim Biophys Acta. 1996 Jul 18;1295(2):147-57. [PubMed:8695640 ]
  2. Joseph KS, Hage DS: The effects of glycation on the binding of human serum albumin to warfarin and L-tryptophan. J Pharm Biomed Anal. 2010 Nov 2;53(3):811-8. doi: 10.1016/j.jpba.2010.04.035. Epub 2010 May 6. [PubMed:20537832 ]
  3. Wybranowski T, Cyrankiewicz M, Ziomkowska B, Kruszewski S: The HSA affinity of warfarin and flurbiprofen determined by fluorescence anisotropy measurements of camptothecin. Biosystems. 2008 Dec;94(3):258-62. doi: 10.1016/j.biosystems.2008.05.034. Epub 2008 Jul 31. [PubMed:18721856 ]
  4. Bertucci C, Wainer IW: Improved chromatographic performance of a modified human albumin based stationary phase. Chirality. 1997;9(4):335-40. [PubMed:9275312 ]
Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Gene Name:
ORM1
Uniprot ID:
P02763
Molecular Weight:
23511.38 Da
References
  1. Hazai E, Visy J, Fitos I, Bikadi Z, Simonyi M: Selective binding of coumarin enantiomers to human alpha1-acid glycoprotein genetic variants. Bioorg Med Chem. 2006 Mar 15;14(6):1959-65. Epub 2005 Nov 15. [PubMed:16290938 ]
  2. Nakagawa T, Kishino S, Itoh S, Sugawara M, Miyazaki K: Differential binding of disopyramide and warfarin enantiomers to human alpha(1)-acid glycoprotein variants. Br J Clin Pharmacol. 2003 Dec;56(6):664-9. [PubMed:14616427 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on December 08, 2016 11:47