Streptococcal Pharyngitis

Also known as: Streptococcal pharyngitis / Septic pharyngitis / Streptococcal sore throat / Pharyngitis streptococcal

DrugDrug NameDrug Description
DB01060AmoxicillinA broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxicillin is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it is susceptible to beta-lacatamase degradation.
DB00833CefaclorSemisynthetic, broad-spectrum antibiotic derivative of cephalexin.
DB01140CefadroxilLong-acting, broad-spectrum, water-soluble, cephalexin derivative.
DB00535CefdinirCefdinir (marketed by Abbott Laboratories under the brand name Omnicef) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat, and skin. It was approved by the U.S. Food and Drug Administration (FDA) in December of 1997.
DB01066CefditorenCefditoren is a third-generation cephalosporin antibiotic for oral use. It is commonly marketed under the trade name Spectracef by Cornerstone BioPharma.
DB00671CefiximeCefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.
DB01416CefpodoximeCefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
DB01150CefprozilCefprozil is a cephalosporin antibiotic. It can be used to treat bronchitis, ear infections, skin infections, and other bacterial infections.
DB01415CeftibutenCeftibuten is a third-generation cephalosporin antibiotic. It is an orally-administered agent. Cefalexin is used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis.
DB01211ClarithromycinClarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB01190ClindamycinClindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB00417PhenoxymethylpenicillinPhenoxymethylpenicillin (Penicillin V) is narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (S. agalactiae), S. viridans, and Enterococcus faecalis. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as Bacillus anthracis, Corynebacterium diphtheriae, and Erysipelothrix rhusiopathiae. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by Neisseria meningitidis and Pasteurella. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
DrugDrug NameTargetType
DB01060AmoxicillinPenicillin-binding protein 1Atarget
DB01060AmoxicillinCytochrome P450 2C19enzyme
DB01060AmoxicillinSolute carrier family 15 member 1transporter
DB01060AmoxicillinSolute carrier family 15 member 2transporter
DB01060AmoxicillinSolute carrier family 22 member 6transporter
DB00833CefaclorPenicillin-binding protein 1Atarget
DB00833CefaclorSolute carrier family 15 member 1transporter
DB00833CefaclorSolute carrier family 15 member 2transporter
DB00833CefaclorPenicillin-binding protein 3target
DB00833CefaclorMyeloperoxidaseenzyme
DB00833CefaclorSolute carrier family 22 member 8transporter
DB01140CefadroxilSolute carrier family 22 member 5transporter
DB01140CefadroxilSolute carrier family 15 member 1transporter
DB01140CefadroxilSolute carrier family 15 member 2transporter
DB01140CefadroxilSolute carrier family 22 member 6transporter
DB01140CefadroxilSolute carrier family 22 member 8transporter
DB01140CefadroxilPenicillin-binding protein 3target
DB01140CefadroxilPenicillin-binding protein 1Atarget
DB01140CefadroxilPenicillin-binding protein 1btarget
DB01140CefadroxilPenicillin-binding protein 2Btarget
DB00535CefdinirMyeloperoxidasetarget
DB00535CefdinirPenicillin-binding protein 2target
DB00535CefdinirPBP3target
DB00535CefdinirSolute carrier family 22 member 5transporter
DB00535CefdinirSolute carrier family 15 member 1transporter
DB00535CefdinirSolute carrier family 15 member 2transporter
DB00535CefdinirSolute carrier family 22 member 6transporter
DB00535CefdinirSolute carrier family 22 member 8transporter
DB01066CefditorenPenicillin-binding protein 1Atarget
DB01066CefditorenPenicillin-binding protein 2Btarget
DB00671CefiximePenicillin-binding protein 2target
DB00671CefiximeSolute carrier family 22 member 5transporter
DB00671CefiximeSolute carrier family 15 member 1transporter
DB00671CefiximeSolute carrier family 15 member 2transporter
DB01416CefpodoximePeptidoglycan synthase FtsItarget
DB01150CefprozilPenicillin-binding protein 1Atarget
DB01150CefprozilPenicillin-binding protein 2xtarget
DB01150CefprozilPenicillin-binding protein 2Btarget
DB01415CeftibutenSolute carrier family 15 member 1transporter
DB01415CeftibutenSolute carrier family 15 member 2transporter
DB01415CeftibutenPeptidoglycan synthase FtsItarget
DB01415CeftibutenPenicillin-binding protein 1Atarget
DB01415CeftibutenPenicillin-binding protein 1Btarget
DB01415CeftibutenPenicillin-binding protein 2target
DB01415CeftibutenSolute carrier family 22 member 6transporter
DB01415CeftibutenSolute carrier family 22 member 8transporter
DB01211Clarithromycin50S ribosomal protein L10target
DB01211ClarithromycinCytochrome P450 3A4enzyme
DB01211ClarithromycinCytochrome P450 2C19enzyme
DB01211ClarithromycinCytochrome P450 3A5enzyme
DB01211ClarithromycinCytochrome P450 3A7enzyme
DB01211ClarithromycinMultidrug resistance protein 1transporter
DB01211ClarithromycinSolute carrier family 22 member 7transporter
DB01211ClarithromycinCytochrome P450 1A2enzyme
DB01211ClarithromycinPotassium voltage-gated channel subfamily H member 2target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B1target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B3target
DB01190Clindamycin50S ribosomal protein L10target
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190Clindamycin23S rRNAtarget
DB00417PhenoxymethylpenicillinPenicillin-binding protein 1Atarget
DB00417PhenoxymethylpenicillinMecA PBP2' (penicillin binding protein 2')target
DB00417PhenoxymethylpenicillinD-alanyl-D-alanine carboxypeptidase DacBtarget
DB00417PhenoxymethylpenicillinPenicillin acylasetarget
DB00417PhenoxymethylpenicillinSolute carrier family 15 member 1target
DrugDrug NamePhaseStatusCount