Chronic Refractory Cough

Also known as: Chronic, refractory Cough / Refractory Chronic Cough / Refractory chronic cough (disorder) / Coughing / Cough / Coughing - function (qualifier value) / Cough (finding)

Drug	Drug Name	Drug Description
DB15097	Gefapixant	A P2X3 receptor antagonist that reduces the cough reflex in patients with refractory or unexplained chronic cough.
DB00327	Hydromorphone	An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.

Drug	Drug Name	Target	Type
DB15097	Gefapixant	P2X purinoceptor 3	target
DB15097	Gefapixant	P-glycoprotein 1	transporter
DB15097	Gefapixant	Multidrug and toxin extrusion protein 1	transporter
DB15097	Gefapixant	Multidrug and toxin extrusion protein 2	transporter
DB15097	Gefapixant	ATP-binding cassette sub-family G member 2	transporter
DB15097	Gefapixant	P2X purinoceptor 2	target
DB00327	Hydromorphone	Mu-type opioid receptor	target
DB00327	Hydromorphone	Delta-type opioid receptor	target
DB00327	Hydromorphone	Kappa-type opioid receptor	target
DB00327	Hydromorphone	Cytochrome P450 2C9	enzyme
DB00327	Hydromorphone	UDP-glucuronosyltransferase 1-3	enzyme
DB00327	Hydromorphone	UDP-glucuronosyltransferase 2B7	enzyme
DB00327	Hydromorphone	Serum albumin	carrier

Drug	Drug Name	Phase	Status	Count
DB00321	Amitriptyline	2	Recruiting	1
DB00476	Duloxetine	2	Recruiting	1
DB15097	Gefapixant	2	Completed	6
DB00844	Nalbuphine	2	Recruiting	1
DB12973	Serlopitant	2	Completed	1
DB00328	Indomethacin	3	Unknown Status	1
DB00338	Omeprazole	3	Unknown Status	1