Phospholipase A2

Details

Name
Phospholipase A2
Synonyms
  • 3.1.1.4
  • Group IB phospholipase A2
  • Phosphatidylcholine 2-acylhydrolase 1B
  • PLA2
  • PLA2A
  • PPLA2
Gene Name
PLA2G1B
Organism
Humans
Amino acid sequence
>lcl|BSEQ0019511|Phospholipase A2
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPV
DELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNC
DRNAAICFSKAPYNKAHKNLDTKKYCQS
Number of residues
148
Molecular Weight
16359.535
Theoretical pI
7.91
GO Classification
Functions
bile acid binding / calcium ion binding / calcium-dependent phospholipase A2 activity / phospholipase A2 activity / receptor binding
Processes
actin filament organization / activation of MAPK activity / activation of phospholipase A2 activity / antibacterial humoral response / arachidonic acid secretion / cellular response to insulin stimulus / defense response to Gram-positive bacterium / fatty acid biosynthetic process / glucose transport / glycerophospholipid biosynthetic process / innate immune response in mucosa / interleukin-8 production / intracellular signal transduction / leukotriene biosynthetic process / multicellular organismal lipid catabolic process / neutrophil chemotaxis / neutrophil mediated immunity / phosphatidic acid biosynthetic process / phosphatidylcholine acyl-chain remodeling / phosphatidylcholine metabolic process / phosphatidylethanolamine acyl-chain remodeling / phosphatidylglycerol acyl-chain remodeling / phosphatidylinositol acyl-chain remodeling / phosphatidylserine acyl-chain remodeling / phospholipid metabolic process / positive regulation of calcium ion transport into cytosol / positive regulation of DNA replication / positive regulation of fibroblast proliferation / positive regulation of immune response / positive regulation of NF-kappaB transcription factor activity / positive regulation of protein secretion / positive regulation of transcription from RNA polymerase II promoter / signal transduction / small molecule metabolic process
Components
cell surface / extracellular region / extracellular space / secretory granule
General Function
Receptor binding
Specific Function
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0019512|Phospholipase A2 (PLA2G1B)
ATGAAACTCCTTGTGCTAGCTGTGCTGCTCACAGTGGCCGCCGCCGACAGCGGCATCAGC
CCTCGGGCCGTGTGGCAGTTCCGCAAAATGATCAAGTGCGTGATCCCGGGGAGTGACCCC
TTCTTGGAATACAACAACTACGGCTGCTACTGTGGCTTGGGGGGCTCAGGCACCCCCGTG
GATGAACTGGACAAGTGCTGCCAGACACATGACAACTGCTATGACCAGGCCAAGAAGCTG
GACAGCTGTAAATTTCTGCTGGACAACCCGTACACCCACACCTATTCATACTCGTGCTCT
GGCTCGGCAATCACCTGTAGCAGCAAAAACAAAGAGTGTGAGGCCTTCATTTGCAACTGC
GACCGCAACGCTGCCATCTGCTTTTCAAAAGCTCCATATAACAAGGCACACAAGAACCTG
GACACCAAGAAGTATTGTCAGAGTTGA
Chromosome Location
12
Locus
12q23-q24.1
External Identifiers
ResourceLink
UniProtKB IDP04054
UniProtKB Entry NamePA21B_HUMAN
GenBank Protein ID190013
GenBank Gene IDM21054
HGNC IDHGNC:9030
General References
  1. Seilhamer JJ, Randall TL, Yamanaka M, Johnson LK: Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung. DNA. 1986 Dec;5(6):519-27. [PubMed:3028739]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039]
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  5. Grataroli R, Dijkman R, Dutilh CE, van der Ouderaa F, De Haas GH, Figarella C: Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region. Eur J Biochem. 1982 Feb;122(1):111-7. [PubMed:7060561]
  6. Verheij HM, Westerman J, Sternby B, De Haas GH: The complete primary structure of phospholipase A2 from human pancreas. Biochim Biophys Acta. 1983 Sep 14;747(1-2):93-9. [PubMed:6349696]
  7. Xu W, Yi L, Feng Y, Chen L, Liu J: Structural insight into the activation mechanism of human pancreatic prophospholipase A2. J Biol Chem. 2009 Jun 12;284(24):16659-66. doi: 10.1074/jbc.M808029200. Epub 2009 Mar 18. [PubMed:19297324]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02210Hexane-1,6-DiolexperimentalunknownDetails
DB04552Niflumic acidexperimentalyesinhibitorDetails
DB02795P-Anisic AcidexperimentalunknownDetails
DB035651-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-PhosphoethanolamineexperimentalunknownDetails
DB03587PyruvaldehydeexperimentalunknownDetails
DB03633Lpc-EtherexperimentalunknownDetails
DB02938Heptanoic Acidexperimental, investigationalunknownDetails
DB02659Cholic AcidapprovedunknownDetails
DB07657PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTERexperimentalunknownDetails
DB078361-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOLexperimentalunknownDetails
DB02448N-Tridecanoic AcidexperimentalunknownDetails
DB00795SulfasalazineapprovedunknownantagonistDetails
DB09061Cannabidiolapproved, investigationalunknownDetails
DB14011NabiximolsinvestigationalunknownDetails
DB14009Medical Cannabisexperimental, investigationalunknownDetails