Low affinity immunoglobulin epsilon Fc receptor
Details
- Name
- Low affinity immunoglobulin epsilon Fc receptor
- Synonyms
- BLAST-2
- C-type lectin domain family 4 member J
- CD23A
- CLEC4J
- Fc-epsilon-RII
- FCE2
- IGEBF
- Immunoglobulin E-binding factor
- Lymphocyte IgE receptor
- Gene Name
- FCER2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006736|Low affinity immunoglobulin epsilon Fc receptor MEEGQYSEIEELPRRRCCRRGTQIVLLGLVTAALWAGLLTLLLLWHWDTTQSLKQLEERA ARNVSQVSKNLESHHGDQMAQKSQSTQISQELEELRAEQQRLKSQDLELSWNLNGLQADL SSFKSQELNERNEASDLLERLREEVTKLRMELQVSSGFVCNTCPEKWINFQRKCYYFGKG TKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIGLRNLDLKGEFIWVDGSHV DYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRKLGAWVCDRLATCTPPASEGSAESM GPDSRPDPDGRLPTPSAPLHS
- Number of residues
- 321
- Molecular Weight
- 36468.49
- Theoretical pI
- 5.28
- GO Classification
- Functionscarbohydrate binding / integrin binding / metal ion bindingProcessesNotch signaling pathway / positive regulation of humoral immune response mediated by circulating immunoglobulin / positive regulation of killing of cells of other organism / positive regulation of nitric-oxide synthase activity / positive regulation of nitric-oxide synthase biosynthetic processComponentsexternal side of plasma membrane / extracellular exosome / integral component of plasma membrane / plasma membrane
- General Function
- Metal ion binding
- Specific Function
- Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
- Pfam Domain Function
- Lectin_C (PF00059)
- Transmembrane Regions
- 22-47
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0017110|Low affinity immunoglobulin epsilon Fc receptor (FCER2) ATGAATCCTCCAAGCCAGGAGATCGAGGAGCTTCCCAGGAGGCGGTGTTGCAGGCGTGGG ACTCAGATCGTGCTGCTGGGGCTGGTGACCGCCGCTCTGTGGGCTGGGCTGCTGACTCTG CTTCTCCTGTGGCACTGGGACACCACACAGAGTCTAAAACAGCTGGAAGAGAGGGCTGCC CGGAACGTCTCTCAAGTTTCCAAGAACTTGGAAAGCCACCACGGTGACCAGATGGCGCAG AAATCCCAGTCCACGCAGATTTCACAGGAACTGGAGGAACTTCGAGCTGAACAGCAGAGA TTGAAATCTCAGGACTTGGAGCTGTCCTGGAACCTGAACGGGCTTCAAGCAGATCTGAGC AGCTTCAAGTCCCAGGAATTGAACGAGAGGAACGAAGCTTCAGATTTGCTGGAAAGACTC CGGGAGGAGGTGACAAAGCTAAGGATGGAGTTGCAGGTGTCCAGCGGCTTTGTGTGCAAC ACGTGCCCTGAAAAGTGGATCAATTTCCAACGGAAGTGCTACTACTTCGGCAAGGGCACC AAGCAGTGGGTCCACGCCCGGTATGCCTGTGACGACATGGAAGGGCAGCTGGTCAGCATC CACAGCCCGGAGGAGCAGGACTTCCTGACCAAGCATGCCAGCCACACCGGCTCCTGGATT GGCCTTCGGAACTTGGACCTGAAGGGGGAGTTTATCTGGGTGGATGGGAGCCACGTGGAC TACAGCAACTGGGCTCCAGGGGAGCCCACCAGCCGGAGCCAGGGCGAGGACTGCGTGATG ATGCGGGGCTCCGGTCGCTGGAACGACGCCTTCTGCGACCGTAAGCTGGGCGCCTGGGTG TGCGACCGGCTGGCCACATGCACGCCGCCAGCCAGCGAAGGTTCCGCGGAGTCCATGGGA CCTGATTCAAGACCAGACCCTGACGGCCGCCTGCCCACCCCCTCTGCCCCTCTCCACTCT TGA
- Chromosome Location
- 19
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P06734 UniProtKB Entry Name FCER2_HUMAN GenBank Gene ID BC062591 GenAtlas ID FCER2 HGNC ID HGNC:3612 - General References
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- Kikutani H, Inui S, Sato R, Barsumian EL, Owaki H, Yamasaki K, Kaisho T, Uchibayashi N, Hardy RR, Hirano T, et al.: Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell. 1986 Dec 5;47(5):657-65. [Article]
- Ludin C, Hofstetter H, Sarfati M, Levy CA, Suter U, Alaimo D, Kilchherr E, Frost H, Delespesse G: Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor. EMBO J. 1987 Jan;6(1):109-14. [Article]
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- Yokota A, Kikutani H, Tanaka T, Sato R, Barsumian EL, Suemura M, Kishimoto T: Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression. Cell. 1988 Nov 18;55(4):611-8. [Article]
- Rose K, Turcatti G, Graber P, Pochon S, Regamey PO, Jansen KU, Magnenat E, Aubonney N, Bonnefoy JY: Partial characterization of natural and recombinant human soluble CD23. Biochem J. 1992 Sep 15;286 ( Pt 3):819-24. [Article]
- Lemieux GA, Blumenkron F, Yeung N, Zhou P, Williams J, Grammer AC, Petrovich R, Lipsky PE, Moss ML, Werb Z: The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10. J Biol Chem. 2007 May 18;282(20):14836-44. Epub 2007 Mar 27. [Article]
- Ivaldi C, Martin BR, Kieffer-Jaquinod S, Chapel A, Levade T, Garin J, Journet A: Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23. PLoS One. 2012;7(5):e37187. doi: 10.1371/journal.pone.0037187. Epub 2012 May 17. [Article]
- Padlan EA, Helm BA: Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23). Receptor. 1993 Winter;3(4):325-41. [Article]
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