Gastric inhibitory polypeptide
Details
- Name
- Gastric inhibitory polypeptide
- Synonyms
- GIP
- Glucose-dependent insulinotropic polypeptide
- Incretin hormone
- Gene Name
- GIP
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052780|Gastric inhibitory polypeptide MVATKTFALLLLSLFLAVGLGEKKEGHFSALPSLPVGSHAKVSSPQPRGPRYAEGTFISD YSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQREARALELASQANRKEEEAVEPQSSPA KNPSDEDLLRDLLIQELLACLLDQTNLCRLRSR
- Number of residues
- 153
- Molecular Weight
- 17107.37
- Theoretical pI
- Not Available
- GO Classification
- Functionsgastric inhibitory polypeptide receptor binding / glucagon receptor binding / hormone activityProcessesadenylate cyclase-activating G protein-coupled receptor signaling pathway / adult locomotory behavior / digestive system development / endocrine pancreas development / exploration behavior / female pregnancy / gastric inhibitory peptide signaling pathway / long-term synaptic potentiation / memory / positive regulation of cAMP-mediated signaling / positive regulation of glucagon secretion / positive regulation of glucose transmembrane transport / positive regulation of insulin secretion / regulation of fatty acid biosynthetic process / regulation of insulin secretion / response to acidic pH / response to amino acid / response to axon injury / response to glucose / response to lipid / response to organic cyclic compound / response to peptide hormone / response to selenium ion / response to starvation / response to xenobiotic stimulus / sensory perception of pain / signal transduction / triglyceride homeostasisComponentsendoplasmic reticulum lumen / extracellular region / extracellular space / neuronal cell body / secretory granule lumen
- General Function
- Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
- Specific Function
- Gastric inhibitory polypeptide receptor binding
- Pfam Domain Function
- Hormone_2 (PF00123)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0052781|Gastric inhibitory polypeptide (GIP) ATGGTGGCCACGAAGACCTTTGCTCTGCTGCTGCTGTCCCTGTTCCTGGCAGTGGGACTA GGAGAGAAGAAAGAGGGTCACTTCAGCGCTCTCCCCTCCCTGCCTGTTGGATCTCATGCT AAGGTGAGCAGCCCTCAACCTCGAGGCCCCAGGTACGCGGAAGGGACTTTCATCAGTGAC TACAGTATTGCCATGGACAAGATTCACCAACAAGACTTTGTGAACTGGCTGCTGGCCCAA AAGGGGAAGAAGAATGACTGGAAACACAACATCACCCAGAGGGAGGCTCGGGCGCTGGAG CTGGCCAGTCAAGCTAATAGGAAGGAGGAGGAGGCAGTGGAGCCACAGAGCTCCCCAGCC AAGAACCCCAGCGATGAAGATTTGCTGCGGGACTTGCTGATTCAAGAGCTGTTGGCCTGC TTGCTGGATCAGACAAACCTCTGCAGGCTCAGGTCTCGGTGA
- Chromosome Location
- 17
- Locus
- 17q21.32
- External Identifiers
Resource Link UniProtKB ID P09681 UniProtKB Entry Name GIP_HUMAN HGNC ID HGNC:4270 - General References
- Not Available