Phenylethanolamine N-methyltransferase

Details

Name
Phenylethanolamine N-methyltransferase
Synonyms
  • 2.1.1.28
  • Noradrenaline N-methyltransferase
  • PNMTase
Gene Name
PNMT
Organism
Bovine
Amino acid sequence
>lcl|BSEQ0014025|Phenylethanolamine N-methyltransferase
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
Number of residues
283
Molecular Weight
30917.99
Theoretical pI
Not Available
GO Classification
Functions
phenylethanolamine N-methyltransferase activity
Processes
epinephrine biosynthetic process
General Function
Phenylethanolamine n-methyltransferase activity
Specific Function
Converts noradrenaline to adrenaline.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP10938
UniProtKB Entry NamePNMT_BOVIN
General References
  1. Baetge EE, Suh YH, Joh TH: Complete nucleotide and deduced amino acid sequence of bovine phenylethanolamine N-methyltransferase: partial amino acid homology with rat tyrosine hydroxylase. Proc Natl Acad Sci U S A. 1986 Aug;83(15):5454-8. [Article]
  2. Batter DK, D'Mello SR, Turzai LM, Hughes HB 3rd, Gioio AE, Kaplan BB: The complete nucleotide sequence and structure of the gene encoding bovine phenylethanolamine N-methyltransferase. J Neurosci Res. 1988 Mar;19(3):367-76. [Article]
  3. Weisberg EP, Batter DK, Brown WE, Kaplan BB: Purification and partial amino acid sequence of bovine adrenal phenylethanolamine N-methyltransferase: a comparison of nucleic acid and protein sequence data. J Neurosci Res. 1988 Mar;19(3):377-82. [Article]
  4. Wong DL, Yoo YS, Lau K, Schilling JW: Primary structure of bovine adrenal phenylethanolamine N-methyltransferase. Neuropsychopharmacology. 1990 Jun;3(3):175-80. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails