Methylamine dehydrogenase light chain

Details

Name
Methylamine dehydrogenase light chain
Synonyms
  • 1.4.9.1
  • MADH
  • Methylamine dehydrogenase (amicyanin)
Gene Name
mauA
Organism
Paracoccus denitrificans
Amino acid sequence
>lcl|BSEQ0013036|Methylamine dehydrogenase light chain
MLGNFRFDDMVEKLSRRVAGQTSRRSVIGKLGTAMLGIGLVPLLPVDRRGRVSRANAADA
PAGTDPRAKWVPQDNDIQACDYWRHCSIDGNICDCSGGSLTNCPPGTKLATASWVASCYN
PTDGQSYLIAYRDCCGYNVSGRCPCLNTEGELPVYRPEFANDIIWCFGAEDDAMTYHCTI
SPIVGKAS
Number of residues
188
Molecular Weight
20392.855
Theoretical pI
6.45
GO Classification
Functions
amine dehydrogenase activity / methylamine dehydrogenase (amicyanin) activity
Processes
amine metabolic process
Components
outer membrane-bounded periplasmic space
General Function
Methylamine dehydrogenase (amicyanin) activity
Specific Function
Methylamine dehydrogenase carries out the oxidation of methylamine. Electrons are passed from methylamine dehydrogenase to amicyanin.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Periplasm
Gene sequence
>lcl|BSEQ0008270|72 bp
CTCGAGGCCGATAGGACCGGCTTCGCCTCGTTGCAGCAATACATGGCCAGCCGGAAGAAA
CAGGCGGCCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP22619
UniProtKB Entry NameDHML_PARDE
GenBank Protein ID150581
GenBank Gene IDM90098
General References
  1. Chistoserdov AY, Boyd J, Mathews FS, Lidstrom ME: The genetic organization of the mau gene cluster of the facultative autotroph Paracoccus denitrificans. Biochem Biophys Res Commun. 1992 May 15;184(3):1181-9. [Article]
  2. van Spanning RJ, Wansell CW, Reijnders WN, Oltmann LF, Stouthamer AH: Mutagenesis of the gene encoding amicyanin of Paracoccus denitrificans and the resultant effect on methylamine oxidation. FEBS Lett. 1990 Nov 26;275(1-2):217-20. [Article]
  3. Chen L, Mathews FS, Davidson VL, Huizinga EG, Vellieux FM, Hol WG: Three-dimensional structure of the quinoprotein methylamine dehydrogenase from Paracoccus denitrificans determined by molecular replacement at 2.8 A resolution. Proteins. 1992 Oct;14(2):288-99. [Article]
  4. Chen L, Durley R, Poliks BJ, Hamada K, Chen Z, Mathews FS, Davidson VL, Satow Y, Huizinga E, Vellieux FM, et al.: Crystal structure of an electron-transfer complex between methylamine dehydrogenase and amicyanin. Biochemistry. 1992 Jun 2;31(21):4959-64. [Article]
  5. Chen L, Durley RC, Mathews FS, Davidson VL: Structure of an electron transfer complex: methylamine dehydrogenase, amicyanin, and cytochrome c551i. Science. 1994 Apr 1;264(5155):86-90. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB08646TRW3-(2-AMINO-3-HYDROXY-PROPYL)-6-(N'-CYCLOHEXYL-HYDRAZINO)OCTAHYDRO-INDOL-7-OLexperimentalunknownDetails