Thyroxine 5-deiodinase
Details
- Name
- Thyroxine 5-deiodinase
- Synonyms
- 1.21.99.3
- 5DIII
- DIOIII
- ITDI3
- TXDI3
- Type 3 DI
- Type III iodothyronine deiodinase
- Gene Name
- DIO3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051588|Thyroxine 5-deiodinase MPRQATSRLVVGEGEGSQGASGPAATMLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLW LLDFLCIRKHFLGRRRRGQPEPEVELNSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHG QKLDFFKQAHEGGPAPNSEVVLPDGFQSQHILDYAQGNRPLVLNFGSCTUPPFMARMSAF QRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCA LVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGAR PRRV
- Number of residues
- 304
- Molecular Weight
- 33947.175
- Theoretical pI
- Not Available
- GO Classification
- Functionsthyroxine 5-deiodinase activity / thyroxine 5'-deiodinase activityProcessesapoptotic process / hormone biosynthetic process / positive regulation of multicellular organism growth / retinal cone cell development / thyroid hormone catabolic process / thyroid hormone generationComponentsendosome membrane / integral component of membrane / plasma membrane
- General Function
- Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
- Specific Function
- Thyroxine 5'-deiodinase activity
- Pfam Domain Function
- T4_deiodinase (PF00837)
- Transmembrane Regions
- 45-67
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0051589|Thyroxine 5-deiodinase (DIO3) ATGCCTCGCCAGGCCACGTCGCGGTTGGTGGTCGGAGAGGGCGAGGGGTCCCAGGGGGCT TCGGGGCCTGCAGCCACCATGCTCCGCTCCCTGCTGCTTCACTCCTTGAGGCTCTGCGCC CAGACCGCCTCGTGCCTCGTGCTCTTCCCGCGCTTCCTCGGCACGGCCTTCATGCTCTGG CTTCTCGATTTCTTGTGTATCCGCAAGCATTTCCTGGGCCGCCGCCGCCGGGGGCAGCCC GAGCCCGAAGTGGAGCTCAACAGTGAAGGCGAGGAGGTGCCTCCCGATGACCCGCCCATC TGCGTGTCCGACGACAACCGCCTGTGCACCCTGGCGTCGCTCAAGGCGGTGTGGCATGGC CAGAAGTTGGATTTCTTCAAGCAGGCGCACGAGGGCGGTCCGGCGCCCAACTCCGAGGTG GTTCTGCCCGACGGCTTCCAGAGCCAGCACATCCTCGACTACGCGCAAGGGAACCGCCCG CTGGTTCTCAATTTCGGCAGCTGCACCTGACCACCGTTCATGGCGCGCATGAGCGCCTTC CAGCGCCTGGTCACTAAGTACCAGCGCGACGTCGACTTCCTCATCATCTACATCGAGGAA GCGCACCCCTCCGACGGCTGGGTCACCACGGACTCTCCCTACATCATCCCACAGCACCGG AGCCTGGAGGACCGGGTCAGCGCAGCGAGGGTACTGCAGCAAGGTGCACCCGGCTGCGCT CTGGTCCTCGACACCATGGCCAACTCCAGCAGCTCGGCCTATGGCGCCTACTTCGAGCGT CTCTATGTCATCCAGAGTGGCACTATTATGTACCAGGGCGGCCGTGGCCCCGACGGCTAC CAGGTCTCTGAGCTGCGCACTTGGTTGGAACGCTATGATGAGCAACTGCACGGCGCTCGG CCCCGGAGGGTGTAA
- Chromosome Location
- 14
- Locus
- 14q32.31
- External Identifiers
Resource Link UniProtKB ID P55073 UniProtKB Entry Name IOD3_HUMAN HGNC ID HGNC:2885 - General References
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- Kuiper GG, Klootwijk W, Visser TJ: Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference. Endocrinology. 2003 Jun;144(6):2505-13. doi: 10.1210/en.2003-0084. [Article]
- Baqui M, Botero D, Gereben B, Curcio C, Harney JW, Salvatore D, Sorimachi K, Larsen PR, Bianco AC: Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. J Biol Chem. 2003 Jan 10;278(2):1206-11. doi: 10.1074/jbc.M210266200. Epub 2002 Nov 4. [Article]
- Sagar GD, Gereben B, Callebaut I, Mornon JP, Zeold A, Curcio-Morelli C, Harney JW, Luongo C, Mulcahey MA, Larsen PR, Huang SA, Bianco AC: The thyroid hormone-inactivating deiodinase functions as a homodimer. Mol Endocrinol. 2008 Jun;22(6):1382-93. doi: 10.1210/me.2007-0490. Epub 2008 Mar 20. [Article]