FAD-linked sulfhydryl oxidase ALR
Details
- Name
- FAD-linked sulfhydryl oxidase ALR
- Synonyms
- 1.8.3.2
- ALR
- Augmenter of liver regeneration
- Hepatopoietin
- HERV1
- HPO
- Gene Name
- GFER
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009501|FAD-linked sulfhydryl oxidase ALR MAAPGERGRFHGGNLFFLPGGARSEMMDDLATDARGRGAGRRDAAASASTPAQAPTSDSP VAEDASRRRPCRACVDFKTWMRTQQKRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDL PTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLCRNHPDTRTRACFTQWLCHLHNEVNRK LGKPDFDCSKVDERWRDGWKDGSCD
- Number of residues
- 205
- Molecular Weight
- 23448.95
- Theoretical pI
- Not Available
- GO Classification
- Functionsflavin adenine dinucleotide binding / protein disulfide oxidoreductase activity / thiol oxidase activityProcessescellular protein metabolic process / protein targeting to mitochondrionComponentscytoplasm / extracellular region / mitochondrial intermembrane space / mitochondrion
- General Function
- Thiol oxidase activity
- Specific Function
- Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
- Pfam Domain Function
- Evr1_Alr (PF04777)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion intermembrane space
- Gene sequence
>lcl|BSEQ0013200|FAD-linked sulfhydryl oxidase ALR (GFER) ATGGCGGCGCCCGGCGAGCGGGGCCGCTTCCACGGCGGGAACCTCTTCTTCCTGCCGGGG GGCGCGCGCTCCGAGATGATGGACGACCTGGCGACCGACGCGCGGGGCCGGGGCGCGGGG CGGAGAGACGCGGCCGCCTCGGCCTCGACGCCAGCCCAGGCGCCGACCTCCGATTCTCCT GTCGCCGAGGACGCCTCCCGGAGGCGGCCGTGCCGGGCCTGCGTCGACTTCAAGACGTGG ATGCGGACGCAGCAGAAGCGGGACACCAAGTTTAGGGAGGACTGCCCGCCGGATCGCGAG GAACTGGGCCGCCACAGCTGGGCTGTCCTCCACACCCTGGCCGCCTACTACCCCGACCTG CCCACCCCAGAACAGCAGCAAGACATGGCCCAGTTCATACATTTATTTTCTAAGTTTTAC CCCTGTGAGGAGTGTGCTGAAGACCTAAGAAAAAGGCTGTGCAGGAACCACCCAGACACC CGCACCCGGGCATGCTTCACACAGTGGCTGTGCCACCTGCACAATGAAGTGAACCGCAAG CTGGGCAAGCCTGACTTCGACTGCTCAAAAGTGGATGAGCGCTGGCGCGACGGCTGGAAG GATGGCTCCTGTGACTAG
- Chromosome Location
- 16
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P55789 UniProtKB Entry Name ALR_HUMAN HGNC ID HGNC:4236 - General References
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