A quantitative atlas of mitotic phosphorylation.
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Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
A quantitative atlas of mitotic phosphorylation.
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.
- PubMed ID
- 18669648 [ View in PubMed]
- Abstract
The eukaryotic cell division cycle is characterized by a sequence of orderly and highly regulated events resulting in the duplication and separation of all cellular material into two newly formed daughter cells. Protein phosphorylation by cyclin-dependent kinases (CDKs) drives this cycle. To gain further insight into how phosphorylation regulates the cell cycle, we sought to identify proteins whose phosphorylation is cell cycle regulated. Using stable isotope labeling along with a two-step strategy for phosphopeptide enrichment and high mass accuracy mass spectrometry, we examined protein phosphorylation in a human cell line arrested in the G(1) and mitotic phases of the cell cycle. We report the identification of >14,000 different phosphorylation events, more than half of which, to our knowledge, have not been described in the literature, along with relative quantitative data for the majority of these sites. We observed >1,000 proteins with increased phosphorylation in mitosis including many known cell cycle regulators. The majority of sites on regulated phosphopeptides lie in [S/T]P motifs, the minimum required sequence for CDKs, suggesting that many of the proteins may be CDK substrates. Analysis of non-proline site-containing phosphopeptides identified two unique motifs that suggest there are at least two undiscovered mitotic kinases.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Tyrosine-protein kinase ABL1 P00519 Details NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial P56181 Details Dehydrogenase/reductase SDR family member 4 Q9BTZ2 Details Insulin receptor P06213 Details RAF proto-oncogene serine/threonine-protein kinase P04049 Details Transketolase P29401 Details Acetyl-CoA acetyltransferase, mitochondrial P24752 Details Creatine kinase B-type P12277 Details Pyruvate kinase PKM P14618 Details S-adenosylmethionine decarboxylase proenzyme P17707 Details Solute carrier family 12 member 6 Q9UHW9 Details Biotin--protein ligase P50747 Details NADH-cytochrome b5 reductase 3 P00387 Details D-3-phosphoglycerate dehydrogenase O43175 Details DNA ligase 3 P49916 Details Monocarboxylate transporter 7 O15403 Details Bifunctional glutamate/proline--tRNA ligase P07814 Details DNA ligase 1 P18858 Details Calcium-transporting ATPase type 2C member 1 P98194 Details Large neutral amino acids transporter small subunit 1 Q01650 Details Tryptophan--tRNA ligase, cytoplasmic P23381 Details Neutral amino acid transporter B(0) Q15758 Details Adrenodoxin, mitochondrial P10109 Details 5'-AMP-activated protein kinase subunit beta-1 Q9Y478 Details Cytosolic purine 5'-nucleotidase P49902 Details Solute carrier family 12 member 7 Q9Y666 Details Solute carrier family 12 member 2 P55011 Details Alanine--tRNA ligase, cytoplasmic P49588 Details S-adenosylmethionine synthase isoform type-2 P31153 Details GMP synthase [glutamine-hydrolyzing] P49915 Details Acetyl-coenzyme A synthetase, cytoplasmic Q9NR19 Details Ferritin heavy chain P02794 Details Retinoic acid receptor RXR-alpha P19793 Details Calmodulin P0DP23 Details Annexin A1 P04083 Details RAC-alpha serine/threonine-protein kinase P31749 Details Serine/threonine-protein kinase A-Raf P10398 Details Abelson tyrosine-protein kinase 2 P42684 Details cGMP-inhibited 3',5'-cyclic phosphodiesterase A Q14432 Details Histamine H1 receptor P35367 Details Monocarboxylate transporter 4 O15427 Details Neutral amino acid transporter A P43007 Details Isoleucine--tRNA ligase, cytoplasmic P41252 Details Receptor tyrosine-protein kinase erbB-2 P04626 Details Chromodomain-helicase-DNA-binding protein 1 O14646 Details Glyceraldehyde-3-phosphate dehydrogenase P04406 Details Methionine--tRNA ligase, cytoplasmic P56192 Details DNA polymerase alpha catalytic subunit P09884 Details Cationic amino acid transporter 2 P52569 Details Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 Details Solute carrier family 12 member 4 Q9UP95 Details Asparagine--tRNA ligase, cytoplasmic O43776 Details Choline-phosphate cytidylyltransferase A P49585 Details Acetyl-CoA carboxylase 1 Q13085 Details Serine/threonine-protein kinase B-raf P15056 Details Cytosolic phospholipase A2 P47712 Details Monocarboxylate transporter 1 P53985 Details 5'-AMP-activated protein kinase catalytic subunit alpha-1 Q13131 Details Retinoic acid-induced protein 3 Q8NFJ5 Details Cysteine--tRNA ligase, cytoplasmic P49589 Details Acetyl-CoA carboxylase 2 O00763 Details DNA polymerase alpha subunit B Q14181 Details Inosine-5'-monophosphate dehydrogenase 2 P12268 Details Pyrroline-5-carboxylate reductase 2 Q96C36 Details Biliverdin reductase A P53004 Details DNA topoisomerase 2-alpha P11388 Details Sodium/hydrogen exchanger 1 P19634 Details Epidermal growth factor receptor P00533 Details Activated CDC42 kinase 1 Q07912 Details 5'-AMP-activated protein kinase subunit beta-2 O43741 Details Glucocorticoid receptor P04150 Details Tyrosine-protein kinase Fyn P06241 Details Tyrosine-protein kinase Yes P07947 Details Ephrin type-A receptor 2 P29317 Details Perilipin-3 O60664 Details CTP synthase 1 P17812 Details Signal transducer and activator of transcription 5B P51692 Details DNA (cytosine-5)-methyltransferase 1 P26358 Details Solute carrier family 2, facilitated glucose transporter member 4 P14672 Details Calpastatin P20810 Details Hepatocyte growth factor receptor P08581 Details Growth factor receptor-bound protein 2 P62993 Details C-X-C chemokine receptor type 4 P61073 Details Mitogen-activated protein kinase 1 P28482 Details Cyclic AMP-responsive element-binding protein 1 P16220 Details Fatty acid synthase P49327 Details Apoptosis-inducing factor 1, mitochondrial O95831 Details DNA topoisomerase 1 P11387 Details Catenin beta-1 P35222 Details Thiopurine S-methyltransferase P51580 Details Long-chain-fatty-acid--CoA ligase 4 O60488 Details Calnexin P27824 Details Rho-associated protein kinase 1 Q13464 Details Mitogen-activated protein kinase 14 Q16539 Details Multidrug resistance protein 1 P08183 Details Mucin-2 Q02817 Details Transcription factor AP-1 P05412 Details Proton-coupled folate transporter Q96NT5 Details Choline transporter-like protein 1 Q8WWI5 Details Canalicular multispecific organic anion transporter 2 O15438 Details Mitogen-activated protein kinase 3 P27361 Details Glycogen synthase kinase-3 beta P49841 Details Canalicular multispecific organic anion transporter 1 Q92887 Details Cyclin-dependent kinase 1 P06493 Details Intercellular adhesion molecule 1 P05362 Details Nuclear factor NF-kappa-B p105 subunit P19838 Details Glucose-6-phosphate 1-dehydrogenase P11413 Details Phosphatidylserine synthase 1 P48651 Details Ras-related C3 botulinum toxin substrate 1 P63000 Details CD44 antigen P16070 Details Excitatory amino acid transporter 1 P43003 Details Heat shock protein HSP 90-alpha P07900 Details Protein kinase C alpha type P17252 Details cAMP-specific 3',5'-cyclic phosphodiesterase 4A P27815 Details Inositol monophosphatase 1 P29218 Details Inhibitor of nuclear factor kappa-B kinase subunit beta O14920 Details E3 ubiquitin-protein ligase XIAP P98170 Details Endoplasmin P14625 Details RAC-beta serine/threonine-protein kinase P31751 Details Phosphatidylethanolamine-binding protein 1 P30086 Details Multidrug resistance-associated protein 4 O15439 Details Glucose-6-phosphate isomerase P06744 Details Equilibrative nucleoside transporter 1 Q99808 Details Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial P33316 Details cGMP-inhibited 3',5'-cyclic phosphodiesterase B Q13370 Details Thymidine kinase, cytosolic P04183 Details cAMP-specific 3',5'-cyclic phosphodiesterase 4D Q08499 Details MAP kinase-activated protein kinase 2 P49137 Details Tubulin alpha-1C chain Q9BQE3 Details Tubulin alpha-4A chain P68366 Details Serine/threonine-protein phosphatase PP1-gamma catalytic subunit P36873 Details Methionine aminopeptidase 2 P50579 Details DNA repair protein XRCC4 Q13426 Details Fructose-bisphosphate aldolase A P04075 Details M-phase inducer phosphatase 2 P30305 Details Ras-related protein Rab-9A P51151 Details Poly [ADP-ribose] polymerase 1 P09874 Details Dual specificity protein kinase CLK1 P49759 Details Kinesin-like protein KIF11 P52732 Details Heat shock protein HSP 90-beta P08238 Details Cyclin-dependent kinase 7 P50613 Details ADP-ribose pyrophosphatase, mitochondrial Q9BW91 Details Keratin, type II cytoskeletal 8 P05787 Details Retinoblastoma-associated protein P06400 Details Synaptotagmin-like protein 4 Q96C24 Details Fibroblast growth factor receptor 3 P22607 Details Serpin B6 P35237 Details Pyridoxal-dependent decarboxylase domain-containing protein 1 Q6P996 Details Molybdenum cofactor sulfurase Q96EN8 Details Methylmalonic aciduria and homocystinuria type C protein Q9Y4U1 Details Methionine adenosyltransferase 2 subunit beta Q9NZL9 Details Phospholipase D1 Q13393 Details Peptidyl-glycine alpha-amidating monooxygenase P19021 Details Multifunctional protein ADE2 P22234 Details CAD protein P27708 Details Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 O94808 Details Glutamine--tRNA ligase P47897 Details N-acetyl-D-glucosamine kinase Q9UJ70 Details Phosphatidylserine synthase 2 Q9BVG9 Details Sphingomyelin phosphodiesterase 4 Q9NXE4 Details Peptidyl-prolyl cis-trans isomerase G Q13427 Details Histone deacetylase 1 Q13547 Details Histone deacetylase 2 Q92769 Details Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 Details Phosphatidylinositol 3-kinase regulatory subunit beta O00459 Details DNA-dependent protein kinase catalytic subunit P78527 Details Serine/threonine-protein kinase mTOR P42345 Details Nuclear factor NF-kappa-B p100 subunit Q00653 Details Superoxide dismutase [Cu-Zn] P00441 Details NF-kappa-B essential modulator Q9Y6K9 Details Protein kinase C delta type Q05655 Details DNA topoisomerase 2-beta Q02880 Details Carbonic anhydrase 9 Q16790 Details Ribonucleoside-diphosphate reductase subunit M2 P31350 Details Ephrin type-B receptor 4 P54760 Details Keratin, type II cytoskeletal 7 P08729 Details E3 ubiquitin-protein ligase UBR4 Q5T4S7 Details NAD-dependent protein deacetylase sirtuin-1 Q96EB6 Details Voltage-dependent anion-selective channel protein 1 P21796 Details Voltage-dependent anion-selective channel protein 2 P45880 Details Telomerase-binding protein EST1A Q86US8 Details Prostaglandin E synthase 3 Q15185 Details Gephyrin Q9NQX3 Details U1 small nuclear ribonucleoprotein A P09012 Details Protein S100-A11 P31949 Details Deoxycytidine kinase P27707 Details Focal adhesion kinase 1 Q05397 Details Pleckstrin homology domain-containing family A member 1 Q9HB21 Details Axin-1 O15169 Details Serine/threonine-protein kinase Chk1 O14757 Details Aurora kinase B Q96GD4 Details Disintegrin and metalloproteinase domain-containing protein 9 Q13443 Details Bcl-2-like protein 2 Q92843 Details Bcl2-associated agonist of cell death Q92934 Details Far upstream element-binding protein 1 Q96AE4 Details cAMP-dependent protein kinase type II-alpha regulatory subunit P13861 Details cAMP-dependent protein kinase type I-alpha regulatory subunit P10644 Details High mobility group protein B1 P09429 Details Mitogen-activated protein kinase kinase kinase 1 Q13233 Details Protein kinase C epsilon type Q02156 Details Heat shock protein beta-1 P04792 Details Centromere-associated protein E Q02224 Details Tumor necrosis factor receptor superfamily member 11A Q9Y6Q6 Details Signal transducer and activator of transcription 3 P40763 Details Ribosome-binding protein 1 Q9P2E9 Details Microtubule-associated protein 4 P27816 Details Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 P16615 Details Transmembrane anterior posterior transformation protein 1 homolog Q6NXT6 Details Induced myeloid leukemia cell differentiation protein Mcl-1 Q07820 Details Casein kinase I isoform epsilon P49674 Details Heat shock factor protein 1 Q00613 Details Histone deacetylase 4 P56524 Details Histone deacetylase 7 Q8WUI4 Details Integrin alpha-V P06756 Details DNA polymerase epsilon subunit 3 Q9NRF9 Details Cation-independent mannose-6-phosphate receptor P11717 Details Multidrug resistance-associated protein 5 O15440 Details Solute carrier organic anion transporter family member 4A1 Q96BD0 Details High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A O60658 Details High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B O95263 Details Steroid hormone receptor ERR1 P11474 Details Nuclear receptor coactivator 2 Q15596 Details Serine/threonine-protein kinase PLK1 P53350 Details Disintegrin and metalloproteinase domain-containing protein 17 P78536 Details Uracil-DNA glycosylase P13051 Details Mitogen-activated protein kinase 8 P45983 Details Dual specificity protein kinase TTK P33981 Details Endothelin-converting enzyme 1 P42892 Details Serine/threonine-protein kinase haspin Q8TF76 Details Inner centromere protein Q9NQS7 Details Serine/threonine-protein phosphatase PP1-alpha catalytic subunit P62136 Details 60S ribosomal protein L15 P61313 Details 60S ribosomal protein L19 P84098 Details 60S ribosomal protein L23a P62750 Details 60S ribosomal protein L3 P39023 Details Triosephosphate isomerase P60174 Details Cytochrome b-c1 complex subunit 6, mitochondrial P07919 Details Protein kinase C iota type P41743 Details Proteasome subunit alpha type-3 P25788 Details Proteasome subunit alpha type-4 P25789 Details Proteasome subunit alpha type-5 P28066 Details Casein kinase I isoform gamma-3 Q9Y6M4 Details STE20-like serine/threonine-protein kinase Q9H2G2 Details Dual specificity protein kinase CLK3 P49761 Details Nuclear receptor coactivator 5 Q9HCD5 Details Hydroxymethylglutaryl-CoA synthase, cytoplasmic Q01581 Details Geranylgeranyl transferase type-2 subunit beta P53611 Details Cyclin-dependent kinase 16 Q00536 Details Serine/threonine-protein kinase 26 Q9P289 Details Peroxisomal acyl-coenzyme A oxidase 1 Q15067 Details MKL/myocardin-like protein 1 Q969V6 Details Protein spire homolog 2 Q8WWL2 Details Cofilin-1 P23528 Details Rho-associated protein kinase 2 O75116 Details Ribosomal protein S6 kinase alpha-1 Q15418 Details Elongation factor 2 P13639 Details Alkaline phosphatase, placental type P05187 Details Tyrosine-protein kinase Lyn P07948 Details SRSF protein kinase 2 P78362 Details Calcium/calmodulin-dependent protein kinase type 1D Q8IU85 Details Glycylpeptide N-tetradecanoyltransferase 1 P30419 Details Afadin P55196 Details Interleukin-1 receptor-associated kinase 4 Q9NWZ3 Details CREB-binding protein Q92793 Details Mediator of RNA polymerase II transcription subunit 1 Q15648 Details Calcium/calmodulin-dependent protein kinase type II subunit gamma Q13555 Details Mothers against decapentaplegic homolog 2 Q15796 Details Protein arginine N-methyltransferase 3 O60678 Details Epsin-1 Q9Y6I3 Details Phosphoglycerate kinase 1 P00558 Details Phosphoglucomutase-1 P36871 Details Vimentin P08670 Details Uridine 5'-monophosphate synthase P11172 Details Cytochrome b5 type B O43169 Details Ras-related protein Rab-7a P51149 Details Cation-dependent mannose-6-phosphate receptor P20645 Details Poly(A) polymerase alpha P51003 Details 6-pyruvoyl tetrahydrobiopterin synthase Q03393 Details Inositol 1,4,5-trisphosphate receptor type 1 Q14643 Details Unconventional myosin-Ie Q12965 Details Ras-related protein Rab-5A P20339 Details Carboxypeptidase D O75976 Details Ubiquitin-like modifier-activating enzyme 1 P22314 Details Histone acetyltransferase KAT5 Q92993 Details Sorting nexin-3 O60493 Details FAD-linked sulfhydryl oxidase ALR P55789 Details SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 O60264 Details Uridine-cytidine kinase-like 1 Q9NWZ5 Details Spectrin beta chain, non-erythrocytic 1 Q01082 Details Spliceosome RNA helicase DDX39B Q13838 Details Ribosomal protein S6 kinase alpha-4 O75676 Details Kinesin-like protein KIF2C Q99661 Details Transient receptor potential cation channel subfamily M member 7 Q96QT4 Details Hepatocyte growth factor-regulated tyrosine kinase substrate O14964 Details Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Q9UL51 Details Peroxiredoxin-6 P30041 Details Sodium bicarbonate cotransporter 3 Q9Y6M7 Details Electroneutral sodium bicarbonate exchanger 1 Q2Y0W8 Details Myc proto-oncogene protein P01106 Details Hyaluronan mediated motility receptor O75330 Details Folate transporter 1 P41440 Details Sphingosine kinase 1 Q9NYA1 Details Proteasome subunit beta type-8 P28062 Details Discoidin domain-containing receptor 2 Q16832 Details Breakpoint cluster region protein P11274 Details Dual specificity mitogen-activated protein kinase kinase 2 P36507 Details Mitogen-activated protein kinase kinase kinase 2 Q9Y2U5 Details LIM domain kinase 1 P53667 Details RalA-binding protein 1 Q15311 Details 5'(3')-deoxyribonucleotidase, cytosolic type Q8TCD5 Details Transferrin receptor protein 1 P02786 Details Ribosomal protein S6 kinase alpha-3 P51812 Details Protein kinase C gamma type P05129 Details Protein kinase C zeta type Q05513 Details Membrane-associated progesterone receptor component 1 O00264 Details 5'-AMP-activated protein kinase catalytic subunit alpha-2 P54646 Details Inositol 1,4,5-trisphosphate receptor type 2 Q14571 Details Inositol 1,4,5-trisphosphate receptor type 3 Q14573 Details Cyclic AMP-dependent transcription factor ATF-1 P18846 Details Cyclic AMP-dependent transcription factor ATF-2 P15336 Details Cyclic AMP-dependent transcription factor ATF-7 P17544 Details Complement component 1 Q subcomponent-binding protein, mitochondrial Q07021 Details Intracellular hyaluronan-binding protein 4 Q5JVS0 Details Sodium/potassium-transporting ATPase subunit alpha-2 P50993 Details Sodium-dependent phosphate transporter 1 Q8WUM9 Details Transient receptor potential cation channel subfamily V member 6 Q9H1D0 Details Transient receptor potential cation channel subfamily V member 5 Q9NQA5 Details Histone H1.4 P10412 Details Casein kinase II subunit beta P67870 Details Sterol regulatory element-binding protein 1 P36956 Details Mitogen-activated protein kinase kinase kinase MLT Q9NYL2 Details Dihydropyrimidinase-related protein 2 Q16555 Details Alpha-enolase P06733 Details Protein PML P29590 Details Nucleolar and coiled-body phosphoprotein 1 Q14978 Details TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 Details Protein O-GlcNAcase O60502 Details Utrophin P46939 Details Proprotein convertase subtilisin/kexin type 9 Q8NBP7 Details Calsequestrin-2 O14958 Details Translationally-controlled tumor protein P13693 Details Calmodulin-2 P0DP24 Details Calmodulin-3 P0DP25 Details DNA-3-methyladenine glycosylase P29372 Details 60 kDa heat shock protein, mitochondrial P10809 Details 40S ribosomal protein S2 P15880 Details Heterogeneous nuclear ribonucleoproteins A2/B1 P22626 Details Heterogeneous nuclear ribonucleoprotein H P31943 Details Heterogeneous nuclear ribonucleoprotein H3 P31942 Details Heterogeneous nuclear ribonucleoprotein L P14866 Details Splicing factor, proline- and glutamine-rich P23246 Details Stress-induced-phosphoprotein 1 P31948 Details Eukaryotic translation initiation factor 6 P56537 Details Eukaryotic initiation factor 4A-I P60842 Details Hepatoma-derived growth factor P51858 Details Phosphoglycerate mutase 1 P18669 Details Ran-specific GTPase-activating protein P43487 Details Huntingtin P42858 Details Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Q8N1G2 Details Neural cell adhesion molecule L1 P32004 Details Cyclin-dependent kinase inhibitor 1 P38936 Details Eukaryotic translation initiation factor 3 subunit F O00303 Details Heterogeneous nuclear ribonucleoprotein K P61978 Details Heat shock 70 kDa protein 4 P34932 Details Heat shock protein 105 kDa Q92598 Details Nuclear migration protein nudC Q9Y266 Details Splicing factor 3A subunit 3 Q12874 Details Tumor protein D54 O43399 Details Tropomyosin alpha-1 chain P09493 Details Tropomyosin alpha-3 chain P06753 Details Ubiquitin carboxyl-terminal hydrolase 14 P54578 Details 14-3-3 protein theta P27348 Details Alpha-2-HS-glycoprotein P02765 Details Chromobox protein homolog 5 P45973 Details Keratin, type I cytoskeletal 9 P35527 Details Desmoplakin P15924 Details Inter-alpha-trypsin inhibitor heavy chain H1 P19827 Details KAT8 regulatory NSL complex subunit 3 Q9P2N6 Details Far upstream element-binding protein 2 Q92945 Details Cysteine and glycine-rich protein 1 P21291 Details Filamin-A P21333 Details Heterogeneous nuclear ribonucleoprotein D0 Q14103 Details Heterochromatin protein 1-binding protein 3 Q5SSJ5 Details Ras GTPase-activating-like protein IQGAP1 P46940 Details Nucleophosmin P06748 Details 60S ribosomal protein L14 P50914 Details 60S ribosomal protein L18 Q07020 Details 60S ribosomal protein L4 P36578 Details 40S ribosomal protein S17 P08708 Details 40S ribosomal protein S6 P62753 Details 40S ribosomal protein S8 P62241 Details Splicing factor 1 Q15637 Details Small nuclear ribonucleoprotein Sm D2 P62316 Details Transgelin-2 P37802 Details Zyxin Q15942 Details Serine/arginine-rich splicing factor 1 Q07955 Details Survival motor neuron protein B4DP61 Details Myosin-9 P35579 Details Probable ATP-dependent RNA helicase DDX5 P17844 Details Splicing factor 3B subunit 1 O75533 Details Elongation of very long chain fatty acids protein 5 Q9NYP7 Details Serine/threonine-protein kinase 3 Q13188 Details Serine/threonine-protein kinase 38 Q15208 Details Serine/threonine-protein kinase TAO1 Q7L7X3 Details Serine/threonine-protein kinase TAO3 Q9H2K8 Details Serine/threonine-protein kinase tousled-like 1 Q9UKI8 Details Serine/threonine-protein kinase tousled-like 2 Q86UE8 Details TRAF2 and NCK-interacting protein kinase Q9UKE5 Details Non-receptor tyrosine-protein kinase TNK1 Q13470 Details Serine/threonine-protein kinase ULK1 O75385 Details AP2-associated protein kinase 1 Q2M2I8 Details Calcium/calmodulin-dependent protein kinase kinase 1 Q8N5S9 Details Calcium/calmodulin-dependent protein kinase kinase 2 Q96RR4 Details Citron Rho-interacting kinase O14578 Details Dual specificity protein kinase CLK2 P49760 Details Dual specificity protein kinase CLK4 Q9HAZ1 Details Death-associated protein kinase 2 Q9UIK4 Details Interferon-induced, double-stranded RNA-activated protein kinase P19525 Details eIF-2-alpha kinase GCN2 Q9P2K8 Details Cyclin-G-associated kinase O14976 Details Glycogen synthase kinase-3 alpha P49840 Details Interleukin-1 receptor-associated kinase 1 P51617 Details Serine/threonine-protein kinase SIK3 Q9Y2K2 Details Serine/threonine-protein kinase LATS1 O95835 Details LIM domain kinase 2 P53671 Details Dual specificity mitogen-activated protein kinase kinase 6 P52564 Details Mitogen-activated protein kinase kinase kinase 11 Q16584 Details Mitogen-activated protein kinase kinase kinase 6 O95382 Details Mitogen-activated protein kinase kinase kinase kinase 2 Q12851 Details Mitogen-activated protein kinase kinase kinase kinase 4 O95819 Details Mitogen-activated protein kinase 4 P31152 Details Mitogen-activated protein kinase 7 Q13164 Details MAP kinase-activated protein kinase 5 Q8IW41 Details Serine/threonine-protein kinase MARK1 Q9P0L2 Details Serine/threonine-protein kinase MARK2 Q7KZI7 Details MAP/microtubule affinity-regulating kinase 3 P27448 Details CLIP-associating protein 1 Q7Z460 Details Megakaryocyte-associated tyrosine-protein kinase P42679 Details Maternal embryonic leucine zipper kinase Q14680 Details Misshapen-like kinase 1 Q8N4C8 Details MAP kinase-interacting serine/threonine-protein kinase 1 Q9BUB5 Details MAP kinase-interacting serine/threonine-protein kinase 2 Q9HBH9 Details Serine/threonine-protein kinase Nek1 Q96PY6 Details Serine/threonine-protein kinase Nek4 P51957 Details Serine/threonine-protein kinase Nek9 Q8TD19 Details Serine/threonine-protein kinase OSR1 O95747 Details Serine/threonine-protein kinase PAK 1 Q13153 Details Serine/threonine-protein kinase PAK 2 Q13177 Details Serine/threonine-protein kinase PAK 4 O96013 Details Cyclin-dependent kinase 17 Q00537 Details Phosphatidylinositol 4-kinase beta Q9UBF8 Details Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta O00750 Details Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 Details Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Q99640 Details Serine/threonine-protein kinase N1 Q16512 Details Serine/threonine-protein kinase N2 Q16513 Details Serine/threonine-protein kinase PLK4 O00444 Details Serine/threonine-protein kinase PRP4 homolog Q13523 Details Serine/threonine-protein kinase RIO1 Q9BRS2 Details Serine/threonine-protein kinase RIO2 Q9BVS4 Details Serine/threonine-protein kinase RIO3 O14730 Details Receptor-interacting serine/threonine-protein kinase 1 Q13546 Details Receptor-interacting serine/threonine-protein kinase 2 O43353 Details Serine/threonine-protein kinase SIK2 Q9H0K1 Details Serine/threonine-protein kinase 10 O94804 Details Serine/threonine-protein kinase 17A Q9UEE5 Details Histone-lysine N-methyltransferase EZH2 Q15910 Details Phospholipid transfer protein P55058 Details Exportin-1 O14980 Details POU domain, class 2, transcription factor 1 P14859 Details Mitogen-activated protein kinase 6 Q16659 Details NAD-dependent protein deacetylase sirtuin-2 Q8IXJ6 Details Dystrophin P11532 Details Solute carrier family 43 member 3 Q8NBI5 Details Peroxisome proliferator-activated receptor gamma coactivator 1-beta Q86YN6 Details Cytochrome b reductase 1 Q53TN4 Details ATP-citrate synthase P53396 Details Very long-chain acyl-CoA synthetase O14975 Details Sodium-coupled neutral amino acid transporter 1 Q9H2H9 Details Sodium-coupled neutral amino acid transporter 2 Q96QD8 Details DNA (cytosine-5)-methyltransferase 3A Q9Y6K1 Details Zinc transporter ZIP6 Q13433 Details Zinc transporter 1 Q9Y6M5 Details Zinc transporter ZIP3 Q9BRY0 Details Zinc transporter 6 Q6NXT4 Details Tyrosine-protein phosphatase non-receptor type 12 Q05209 Details V-type proton ATPase 116 kDa subunit a isoform 4 Q9HBG4 Details V-type proton ATPase 116 kDa subunit a isoform 2 Q9Y487 Details Caspase-4 P49662 Details Plasma membrane calcium-transporting ATPase 1 P20020 Details Plasma membrane calcium-transporting ATPase 2 Q01814 Details Caspase-9 P55211 Details Calcium-transporting ATPase type 2C member 2 O75185 Details Interleukin-6 receptor subunit beta P40189 Details Sphingosine kinase 2 Q9NRA0 Details Leucyl-cystinyl aminopeptidase Q9UIQ6 Details Cell surface hyaluronidase Q9UHN6 Details Molybdopterin synthase catalytic subunit O96007 Details Receptor protein-tyrosine kinase Q504U8 Details 3-ketoacyl-CoA thiolase, mitochondrial P42765 Details Serine/threonine-protein kinase ATR Q13535 Details P-selectin glycoprotein ligand 1 Q14242 Details Microphthalmia-associated transcription factor O75030 Details Eukaryotic translation initiation factor 4E-binding protein 1 Q13541 Details Lysine-specific histone demethylase 1A O60341 Details Signal transducer and activator of transcription 1-alpha/beta P42224 Details Proliferation marker protein Ki-67 P46013 Details G1/S-specific cyclin-D3 P30281 Details Histone acetyltransferase p300 Q09472 Details ELAV-like protein 1 Q15717 Details Dual specificity mitogen-activated protein kinase kinase 4 P45985 Details cAMP-dependent protein kinase type I-beta regulatory subunit P31321 Details CD276 antigen Q5ZPR3 Details Mucin-3A Q02505 Details Adenylate cyclase type 8 P40145 Details Adenylate cyclase type 6 O43306 Details Adenylate cyclase type 9 O60503 Details