60S ribosomal protein L11

Details

Name
60S ribosomal protein L11
Synonyms
  • CLL-associated antigen KW-12
Gene Name
RPL11
Organism
Humans
Amino acid sequence
>lcl|BSEQ0007351|60S ribosomal protein L11
MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSF
GIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYD
PSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK
Number of residues
178
Molecular Weight
20252.235
Theoretical pI
10.14
GO Classification
Functions
poly(A) RNA binding / RNA binding / rRNA binding / structural constituent of ribosome
Processes
cellular protein metabolic process / gene expression / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / protein localization to nucleus / protein targeting / ribosomal large subunit assembly / ribosomal large subunit biogenesis / rRNA processing / SRP-dependent cotranslational protein targeting to membrane / translation / translational elongation / translational initiation / translational termination / viral life cycle / viral process / viral transcription
Components
cytoplasm / cytosol / cytosolic large ribosomal subunit / extracellular exosome / membrane / nucleolus
General Function
Structural constituent of ribosome
Specific Function
Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0017242|60S ribosomal protein L11 (RPL11)
ATGGCGCAGGATCAAGGTGAAAAGGAGAACCCCATGCGGGAACTTCGCATCCGCAAACTC
TGTCTCAACATCTGTGTTGGGGAGAGTGGAGACAGACTGACGCGAGCAGCCAAGGTGTTG
GAGCAGCTCACAGGGCAGACCCCTGTGTTTTCCAAAGCTAGATACACTGTCAGATCCTTT
GGCATCCGGAGAAATGAAAAGATTGCTGTCCACTGCACAGTTCGAGGGGCCAAGGCAGAA
GAAATCTTGGAGAAGGGTCTAAAGGTGCGGGAGTATGAGTTAAGAAAAAACAACTTCTCA
GATACTGGAAACTTTGGTTTTGGGATCCAGGAACACATCGATCTGGGTATCAAATATGAC
CCAAGCATTGGTATCTACGGCCTGGACTTCTATGTGGTGCTGGGTAGGCCAGGTTTCAGC
ATCGCAGACAAGAAGCGCAGGACAGGCTGCATTGGGGCCAAACACAGAATCAGCAAAGAG
GAGGCCATGCGCTGGTTCCAGCAGAAGTATGATGGGATCATCCTTCCTGGCAAATAA
Chromosome Location
1
Locus
1p36.1-p35
External Identifiers
ResourceLink
UniProtKB IDP62913
UniProtKB Entry NameRL11_HUMAN
GenBank Protein ID495126
GenBank Gene IDX79234
HGNC IDHGNC:10301
General References
  1. Mishin VP, Filipenko ML, Muravlev AI, Karpova GG, Mertvetsov NP: [Cloning and determination of the primary structure of DNA complementary to the mRNA of human ribosomal protein L11]. Bioorg Khim. 1995 Feb;21(2):158-60. [PubMed:7748210]
  2. Voronina EN, Kolokol'tsova TD, Nechaeva EA, Filipenko ML: [Structural and functional analysis of the human ribosomal protein L11 gene]. Mol Biol (Mosk). 2003 May-Jun;37(3):425-35. [PubMed:12815950]
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  4. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC: A map of 75 human ribosomal protein genes. Genome Res. 1998 May;8(5):509-23. [PubMed:9582194]
  5. Odintsova TI, Muller EC, Ivanov AV, Egorov TA, Bienert R, Vladimirov SN, Kostka S, Otto A, Wittmann-Liebold B, Karpova GG: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. J Protein Chem. 2003 Apr;22(3):249-58. [PubMed:12962325]
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  7. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976]
  8. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861]
  9. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [PubMed:21269460]
  10. Bienvenut WV, Sumpton D, Martinez A, Lilla S, Espagne C, Meinnel T, Giglione C: Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-alpha-acetylation features. Mol Cell Proteomics. 2012 Jun;11(6):M111.015131. doi: 10.1074/mcp.M111.015131. Epub 2012 Jan 5. [PubMed:22223895]
  11. Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12449-54. doi: 10.1073/pnas.1210303109. Epub 2012 Jul 18. [PubMed:22814378]
  12. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [PubMed:24275569]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB07374AnisomycinexperimentalunknownDetails
DB02494Alpha-Hydroxy-Beta-Phenyl-Propionic AcidexperimentalunknownDetails
DB08437PuromycinexperimentalunknownDetails