Cyclin-dependent kinase 6

Details

Name
Cyclin-dependent kinase 6
Synonyms
  • 2.7.11.22
  • CDKN6
  • Cell division protein kinase 6
  • Serine/threonine-protein kinase PLSTIRE
Gene Name
CDK6
Organism
Humans
Amino acid sequence
>lcl|BSEQ0016713|Cyclin-dependent kinase 6
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
Number of residues
326
Molecular Weight
36938.025
Theoretical pI
6.43
GO Classification
Functions
ATP binding / cyclin binding / cyclin-dependent protein serine/threonine kinase activity
Processes
astrocyte development / cell cycle arrest / cell dedifferentiation / cell division / dentate gyrus development / G1/S transition of mitotic cell cycle / generation of neurons / gliogenesis / hematopoietic stem cell differentiation / lateral ventricle development / mitotic cell cycle / negative regulation of cell cycle / negative regulation of cell differentiation / negative regulation of cell proliferation / negative regulation of cellular senescence / negative regulation of epithelial cell proliferation / negative regulation of myeloid cell differentiation / negative regulation of osteoblast differentiation / Notch signaling pathway / positive regulation of cell-matrix adhesion / positive regulation of fibroblast proliferation / positive regulation of gene expression / protein phosphorylation / regulation of cell motility / regulation of erythrocyte differentiation / regulation of gene expression / response to virus / T cell differentiation in thymus / type B pancreatic cell development
Components
centrosome / cyclin-dependent protein kinase holoenzyme complex / cytoplasm / cytosol / nucleoplasm / nucleus / ruffle
General Function
Cyclin-dependent protein serine/threonine kinase activity
Specific Function
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0016714|Cyclin-dependent kinase 6 (CDK6)
ATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGATCGGG
GAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTG
GCGTTGAAGCGCGTGCGGGTGCAGACCGGCGAGGAGGGCATGCCGCTCTCCACCATCCGC
GAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTGGTCAGGTTGTTT
GATGTGTGCACAGTGTCACGAACAGACAGAGAAACCAAACTAACTTTAGTGTTTGAACAT
GTCGATCAAGACTTGACCACTTACTTGGATAAAGTTCCAGAGCCTGGAGTGCCCACTGAA
ACCATAAAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCACACCGA
GTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAA
CTCGCTGACTTCGGCCTTGCCCGCATCTATAGTTTCCAGATGGCTCTAACCTCAGTGGTC
GTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACCCCCGTG
GATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGT
GGAAGTTCAGATGTTGATCAACTAGGAAAAATCTTGGACGTGATTGGACTCCCAGGAGAA
GAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAA
CCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGT
TTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACCCATACTTC
CAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACC
TCGGAGCTGAATACAGCCTGA
Chromosome Location
7
Locus
7q21-q22
External Identifiers
ResourceLink
UniProtKB IDQ00534
UniProtKB Entry NameCDK6_HUMAN
GenBank Protein ID36623
GenBank Gene IDX66365
GenAtlas IDCDK6
HGNC IDHGNC:1777
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03496Alvocidibexperimental, investigationalunknownDetails
DB07379(2S)-2-({6-[(3-Amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanolexperimentalunknownDetails
DB07795FisetinexperimentalunknownDetails
DB09073Palbociclibapproved, investigationalyesinhibitorDetails
DB11730Ribociclibapproved, investigationalyesantagonistinhibitorDetails
DB12001Abemaciclibapproved, investigationalyesinhibitorDetails