Oxygen-insensitive NAD(P)H nitroreductase
Details
- Name
- Oxygen-insensitive NAD(P)H nitroreductase
- Synonyms
- 1.-.-.-
- nfnB
- nfsI
- NR
- Gene Name
- nfsB
- Organism
- Enterobacter cloacae
- Amino acid sequence
>lcl|BSEQ0016966|Oxygen-insensitive NAD(P)H nitroreductase MDIISVALKRHSTKAFDASKKLTAEEAEKIKTLLQYSPSSTNSQPWHFIVASTEEGKARV AKSAAGTYVFNERKMLDASHVVVFCAKTAMDDAWLERVVDQEEADGRFNTPEAKAANHKG RTYFADMHRVDLKDDDQWMAKQVYLNVGNFLLGVGAMGLDAVPIEGFDAAILDEEFGLKE KGFTSLVVVPVGHHSVEDFNATLPKSRLPLSTIVTEC
- Number of residues
- 217
- Molecular Weight
- 23949.98
- Theoretical pI
- 5.61
- GO Classification
- Functionsoxidoreductase activity
- General Function
- Oxidoreductase activity
- Specific Function
- Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred.
- Pfam Domain Function
- Nitroreductase (PF00881)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0005921|654 bp ATGGATATCATTTCTGTCGCCCTGAAACGCCACTCTACCAAGGCGTTCGACGCAAGCAAA AAACTGACCGCGGAAGAAGCGGAAAAAATCAAAACCCTGCTGCAGTACAGCCCGTCCAGC ACCAACTCCCAGCCGTGGCACTTCATTGTAGCCAGCACCGAGGAAGGAAAAGCGCGCGTG GCGAAGTCCGCTGCGGGCACCTATGTGTTCAACGAACGCAAAATGCTGGATGCTTCCCAC GTGGTGGTGTTCTGCGCGAAAACCGCGATGGATGACGCCTGGCTGGAGCGCGTCGTGGAT CAGGAAGAGGCCGATGGCCGTTTCAACACGCCGGAAGCCAAAGCCGCAAACCATAAGGGC CGCACCTACTTCGCCGACATGCACCGCGTGGATCTGAAAGATGACGACCAGTGGATGGCG AAGCAGGTTTACCTGAACGTCGGCAACTTCCTGCTGGGCGTGGGCGCGATGGGTCTGGAC GCGGTACCAATTGAAGGTTTCGACGCCGCTATTCTCGACGAAGAGTTTGGCCTGAAAGAG AAAGGCTTCACCAGCCTGGTGGTGGTACCGGTTGGGCACCACAGCGTGGAAGATTTCAAC GCCACGCTGCCGAAATCTCGCCTGCCGCTGAGCACGATTGTGACCGAGTGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q01234 UniProtKB Entry Name NFSB_ENTCL GenBank Gene ID M63808 - General References
- Bryant C, Hubbard L, McElroy WD: Cloning, nucleotide sequence, and expression of the nitroreductase gene from Enterobacter cloacae. J Biol Chem. 1991 Mar 5;266(7):4126-30. [Article]
- Bryant C, DeLuca M: Purification and characterization of an oxygen-insensitive NAD(P)H nitroreductase from Enterobacter cloacae. J Biol Chem. 1991 Mar 5;266(7):4119-25. [Article]
- Haynes CA, Koder RL, Miller AF, Rodgers DW: Structures of nitroreductase in three states: effects of inhibitor binding and reduction. J Biol Chem. 2002 Mar 29;277(13):11513-20. Epub 2002 Jan 22. [Article]