Flavin mononucleotide

Identification

Name
Flavin mononucleotide
Accession Number
DB03247  (EXPT01458)
Type
Small Molecule
Groups
Approved, Investigational
Description

A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.

Structure
Thumb
Synonyms
  • FMN
  • riboflavin 5'-(dihydrogen phosphate)
  • riboflavin 5'-monophosphate
  • riboflavin 5'-phosphate
  • Riboflavin monophosphate
  • Riboflavin phosphate
  • Riboflavin-5-phosphate
  • riboflavine dihydrogen phosphate
  • Vitamin B2 (riboflavin-5-phosphate)
  • Vitamin B2 phosphate
Product Ingredients
IngredientUNIICASInChI Key
Riboflavin 5'-phosphate sodium20RD1DZH996184-17-4LQVGUKOCMOKKJU-QPVGXXQTSA-M
Riboflavin 5'-phosphate sodium anhydrous957E53WV42130-40-5OHSHFZJLPYLRIP-BMZHGHOISA-M
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
M.V.I. AdultKitHospira, Inc.2004-01-302018-05-01Us
M.V.I. AdultKitHospira, Inc.2004-01-30Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Beminal Fortis ElxFlavin mononucleotide (.625 mg) + Cyanocobalamin (.45 mcg) + Dexpanthenol (.534 mg) + Nicotinamide (2.5 mg) + Pyridoxine (.05 mg) + Thiamine (1.25 mg)ElixirOralWhitehall Robins Inc.1993-12-311996-09-09Canada
Gtf Support CapletFlavin mononucleotide (5 mg) + Chromium (200 mcg) + Niacin (20 mg) + Calcium pantothenate (5 mg) + Thiamine hydrochloride (7 mg)TabletOralNu Life Nutrition Ltd.1997-08-152005-03-15Canada
Kanga Sport Vitamins B & C Plus MineralsRiboflavin 5'-phosphate sodium anhydrous (14 mg) + Ascorbic acid (1000 mg) + Biotin (180 mcg) + Cyanocobalamin (10 mcg) + Magnesium cation (50 mg) + Nicotinamide (50 mg) + Calcium pantothenate (35 mg) + Potassium cation (34 mg) + Pyridoxine hydrochloride (10 mg) + Thiamine (14 mg)Tablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-B Vitamin B Group + CRiboflavin 5'-phosphate sodium anhydrous (15 mg) + Ascorbic acid (1000 mg) + Biotin (150 mcg) + Cyanocobalamin (10 mcg) + Nicotinamide (50 mg) + Calcium pantothenate (35 mg) + Pyridoxine hydrochloride (10 mg) + Thiamine (15 mg)Tablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-kid Multi-vitamin & MineralRiboflavin 5'-phosphate sodium anhydrous (1.6 mg) + Ascorbic acid (50 mg) + Beta carotene (1600 unit) + Biotin (50 mcg) + Cyanocobalamin (2 mcg) + Ferrous sulfate (4 mg) + Folic Acid (0.1 mg) + Magnesium cation (50 mg) + Nicotinamide (15 mg) + Calcium pantothenate (5 mg) + Pyridoxine hydrochloride (1 mg) + Thiamine (1 mg) + Vitamin E (10 unit)Tablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kenwood Liquid SupplementRiboflavin 5'-phosphate sodium (4.27 mg) + Ascorbic acid (155 mg) + Ergocalciferol (400 unit) + Manganese (1 mg) + Nicotinamide (60 mg) + Calcium pantothenate (5.7 mg) + Potassium cation (5 mg) + Pyridoxine hydrochloride (1.26 mg) + Thiamine hydrochloride (6.62 mg) + Vitamin A palmitate (10000 unit)LiquidOralKenwood Laboratories (Division Of Bradley Pharmaceuticals)Not applicableNot applicableCanada
Mvc 9 Plus 3 InjRiboflavin 5'-phosphate sodium (3.6 mg) + Ascorbic acid (100 mg) + Biotin (60 mcg) + Cyanocobalamin (5 mcg) + D-alpha-Tocopherol acetate (10 unit) + Dexpanthenol (15 mg) + Ergocalciferol (200 unit) + Folic Acid (.4 mg) + Nicotinamide (40 mg) + Pyridoxine hydrochloride (4 mg) + Thiamine hydrochloride (3 mg) + Vitamin A (3300 unit)LiquidIntravenousLyphomed, Division Of Fujisawa Canada Inc.1984-12-311996-09-10Canada
Mvc 9+4 InjRiboflavin 5'-phosphate sodium (1.4 mg) + Ascorbic acid (80 mg) + Biotin (20 mcg) + Cyanocobalamin (1 mcg) + D-alpha-Tocopherol acetate (7 unit) + Dexpanthenol (5 mg) + Ergocalciferol (400 unit) + Folic Acid (.14 mg) + Nicotinamide (17 mg) + Phylloquinone (0.2 mg) + Pyridoxine (1 mg) + Thiamine hydrochloride (1.2 mg) + Vitamin A (2300 unit)LiquidIntravenousLyphomed Canada Inc.1990-12-311996-09-09Canada
Nrg Plus LiqFlavin mononucleotide (7.5 mg) + Biotin (100 mcg) + Cholecalciferol (400 unit) + Choline (50 mg) + Cyanocobalamin (14 mcg) + Dexpanthenol (15 mg) + Ferric ammonium citrate (15 mg) + Inositol (50 mg) + Nicotinamide (45 mg) + Potassium Iodide (.1 mg) + Potassium cation (200 mg) + Pyridoxine hydrochloride (3 mg) + Thiamine mononitrate (4.5 mg) + Vitamin A palmitate (5000 unit)LiquidOralJeunique International Inc.1998-02-172006-07-20Canada
Pediatric Infuvite Multiple VitaminsRiboflavin 5'-phosphate sodium (1.4 mg/4mL) + Ascorbic acid (80 mg/4mL) + Biotin (20 ug/1mL) + Cholecalciferol (400 [iU]/4mL) + Cyanocobalamin (1 ug/1mL) + D-alpha-Tocopherol acetate (7 [iU]/4mL) + Dexpanthenol (5 mg/4mL) + Folic Acid (140 ug/1mL) + Nicotinamide (17 mg/4mL) + Phylloquinone (0.2 mg/4mL) + Pyridoxine hydrochloride (1 mg/4mL) + Thiamine hydrochloride (1.2 mg/4mL) + Vitamin A palmitate (2300 [iU]/4mL)KitSandoz2004-01-29Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
BumP DHAFlavin mononucleotide (2 mg/1) + Cobamamide (500 mg/1) + Flavin adenine dinucleotide (1 mg/1) + Iron (15 mg/1) + Leucovorin (1 mg/1) + Levomefolate magnesium (1 mg/1) + Magnesium oxide (125 mg/1) + NADH (25 ug/1) + Omega-3 fatty acids (300 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxal Phosphate (5 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Zinc glycinate (15 1/1)CapsuleOralCenturion Labs2017-03-242017-04-19Us
Multi Vitamin Drops with FluorideRiboflavin 5'-phosphate sodium (.6 mg/mL) + Ascorbic acid (35 mg/mL) + Cholecalciferol (400 [iU]/mL) + Cyanocobalamin (2 ug/mL) + D-alpha-Tocopherol acetate (5 [iU]/mL) + Nicotinamide (8 mg/mL) + Pyridoxine hydrochloride (.4 mg/mL) + Sodium fluoride (.25 mg/mL) + Thiamine hydrochloride (.5 mg/mL) + Vitamin A palmitate (1500 [iU]/mL)Solution / dropsOralSeton Pharmaceuticals2014-04-182017-09-30Us
Multi Vitamin Drops with FluorideRiboflavin 5'-phosphate sodium (.6 mg/mL) + Ascorbic acid (35 mg/mL) + Cholecalciferol (400 [iU]/mL) + Cyanocobalamin (2 ug/mL) + D-alpha-Tocopherol acetate (5 [iU]/mL) + Nicotinamide (8 mg/mL) + Pyridoxine hydrochloride (.4 mg/mL) + Sodium fluoride (.5 mg/mL) + Thiamine hydrochloride (.5 mg/mL) + Vitamin A palmitate (1500 [iU]/mL)Solution / dropsOralSeton Pharmaceuticals2014-04-182017-12-22Us
Multi Vitamin Drops with Fluoride and IronRiboflavin 5'-phosphate sodium (.6 mg/mL) + Ascorbic acid (35 mg/mL) + Cholecalciferol (400 [iU]/mL) + D-alpha-Tocopherol acetate (5 [iU]/mL) + Ferrous sulfate (10 mg/mL) + Nicotinamide (8 mg/mL) + Pyridoxine hydrochloride (.4 mg/mL) + Sodium fluoride (.25 mg/mL) + Thiamine hydrochloride (.5 mg/mL) + Vitamin A palmitate (1500 [iU]/mL)Solution / dropsOralSeton Pharmaceuticals2014-04-182017-12-22Us
Multi-Vit with FluorideRiboflavin 5'-phosphate sodium (.6 mg/mL) + Ascorbic acid (35 mg/mL) + Cholecalciferol (400 [iU]/mL) + Cyanocobalamin (2 ug/mL) + Nicotinamide (8 mg/mL) + Pyridoxine hydrochloride (.4 mg/mL) + Sodium fluoride (.5 mg/mL) + Thiamine hydrochloride (.5 mg/mL) + Vitamin A palmitate (1500 [iU]/mL) + Vitamin E (5 [iU]/mL)SolutionOralPar Pharmaceutical1997-06-192021-03-31Us
Multi-Vit with FluorideRiboflavin 5'-phosphate sodium (.6 mg/mL) + Ascorbic acid (35 mg/mL) + Cholecalciferol (400 [iU]/mL) + Cyanocobalamin (2 ug/mL) + Nicotinamide (8 mg/mL) + Pyridoxine hydrochloride (.4 mg/mL) + Sodium fluoride (.25 mg/mL) + Thiamine hydrochloride (.5 mg/mL) + Vitamin A palmitate (1500 [iU]/mL) + Vitamin E (5 [iU]/mL)SolutionOralPar Pharmaceutical1997-04-182021-03-31Us
Multi-Vit with Fluoride and IronRiboflavin 5'-phosphate sodium (.6 mg/mL) + Ascorbic acid (35 mg/mL) + Cholecalciferol (400 [iU]/mL) + Ferrous sulfate (10 mg/mL) + Nicotinamide (8 mg/mL) + Pyridoxine hydrochloride (.4 mg/mL) + Sodium fluoride (.25 mg/mL) + Thiamine hydrochloride (.5 mg/mL) + Vitamin A palmitate (1500 [iU]/mL) + Vitamin E (5 [iU]/mL)SolutionOralPar Pharmaceutical1998-01-072021-02-28Us
Multi-Vitamin Drops with Fluoride and IronRiboflavin 5'-phosphate sodium (.6 mg/mL) + Ascorbic acid (35 mg/mL) + Cholecalciferol (400 [iU]/mL) + D-alpha-Tocopherol acetate (5 [iU]/mL) + Ferrous sulfate (10 mg/mL) + Nicotinamide (8 mg/mL) + Pyridoxine hydrochloride (.4 mg/mL) + Sodium fluoride (.25 mg/mL) + Thiamine hydrochloride (.5 mg/mL) + Vitamin A palmitate (1500 [iU]/mL)LiquidOralMethod Pharmaceuticals2017-02-24Not applicableUs
Multi-Vitamin with FluorideRiboflavin 5'-phosphate sodium (.6 mg/mL) + Ascorbic acid (35 mg/mL) + Cholecalciferol (400 [iU]/mL) + Cyanocobalamin (2 ug/mL) + D-alpha-Tocopherol acetate (5 [iU]/mL) + Nicotinamide (8 mg/mL) + Pyridoxine hydrochloride (.4 mg/mL) + Sodium fluoride (.5 mg/mL) + Thiamine hydrochloride (.5 mg/mL) + Vitamin A palmitate (1500 [iU]/mL)LiquidOralMethod Pharmaceuticals2017-02-24Not applicableUs
Multi-Vitamin with FluorideRiboflavin 5'-phosphate sodium (.6 mg/mL) + Ascorbic acid (35 mg/mL) + Cholecalciferol (400 [iU]/mL) + Cyanocobalamin (2 ug/mL) + D-alpha-Tocopherol acetate (5 [iU]/mL) + Nicotinamide (8 mg/mL) + Pyridoxine hydrochloride (.4 mg/mL) + Sodium fluoride (.25 mg/mL) + Thiamine hydrochloride (.5 mg/mL) + Vitamin A palmitate (1500 [iU]/mL)LiquidOralMethod Pharmaceuticals2017-02-24Not applicableUs
Categories
Not Available
UNII
7N464URE7E
CAS number
146-17-8
Weight
Average: 456.3438
Monoisotopic: 456.104614802
Chemical Formula
C17H21N4O9P
InChI Key
FVTCRASFADXXNN-SCRDCRAPSA-N
InChI
InChI=1S/C17H21N4O9P/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29)/t11-,12+,14-/m0/s1
IUPAC Name
{[(2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-2H,3H,4H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy}phosphonic acid
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(O)=O)C1=NC(=O)NC(=O)C1=N2

Pharmacology

Indication
Not Available
Associated Conditions
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UTrimethylamine dehydrogenaseNot AvailableMethylophilus methylotrophus
URubredoxin-oxygen oxidoreductaseNot AvailableDesulfovibrio gigas
URiboflavin biosynthesis protein RibFNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UMorphinone reductaseNot AvailablePseudomonas putida
UNADPH-flavin oxidoreductaseNot AvailableVibrio harveyi
URibosomal protein S6 kinase alpha-4Not AvailableHuman
UPhenazine biosynthesis protein PhzGNot AvailablePseudomonas fluorescens
UHydroxyacid oxidase 2Not AvailableHuman
UNAD(P)H dehydrogenase (quinone)Not AvailableDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
UFlavodoxin-1Not AvailableEscherichia coli (strain K12)
UIsopentenyl-diphosphate delta-isomeraseNot AvailableBacillus subtilis (strain 168)
UNADH dehydrogenaseNot AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
UFMN-binding proteinNot AvailableDesulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
UNitroreductase family proteinNot AvailableBacillus cereus (strain ATCC 14579 / DSM 31)
UNADPH--cytochrome P450 reductaseNot AvailableHuman
UPhosphopantothenoylcysteine decarboxylaseNot AvailableHuman
UPhzGNot AvailablePseudomonas aeruginosa
UFerredoxin-dependent glutamate synthase 2Not AvailableSynechocystis sp. (strain PCC 6803 / Kazusa)
UPyridoxine/pyridoxamine 5'-phosphate oxidaseNot AvailableEscherichia coli (strain K12)
UFlavodoxinNot AvailableClostridium beijerinckii
UOxygen-insensitive NAD(P)H nitroreductaseNot AvailableEscherichia coli (strain K12)
UChorismate synthaseNot AvailableStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
U2,4-dienoyl-CoA reductase [NADPH]Not AvailableEscherichia coli (strain K12)
UDihydroorotate dehydrogenase A (fumarate)Not AvailableLactococcus lactis subsp. cremoris
UFlavin reductase (NADPH)Not AvailableHuman
UHydroxyacid oxidase 1Not AvailableHuman
UPyridoxine-5'-phosphate oxidaseNot AvailableHuman
UMajor NAD(P)H-flavin oxidoreductaseNot AvailableVibrio fischeri
URiboflavin kinaseNot AvailableHuman
UOxygen-insensitive NADPH nitroreductaseNot AvailableEscherichia coli (strain K12)
UNitric oxide synthase, brainNot AvailableHuman
UDihydroorotate dehydrogenase (quinone)Not AvailableEscherichia coli (strain K12)
UDihydropyrimidine dehydrogenase [NADP(+)]Not AvailableHuman
UDihydroorotate dehydrogenase (quinone), mitochondrialNot AvailableHuman
UPentaerythritol tetranitrate reductaseNot AvailableEnterobacter cloacae
UFMN-dependent NADH-azoreductaseNot AvailableSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
UEpidermin decarboxylaseNot AvailableStaphylococcus epidermidis
UFMN-dependent NADH-azoreductaseNot AvailableEscherichia coli (strain K12)
UChorismate synthaseNot AvailableHelicobacter pylori (strain ATCC 700392 / 26695)
UFlavodoxinNot AvailableNostoc sp. (strain PCC 7120 / UTEX 2576)
UFlavodoxinNot AvailableDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
UFlavodoxinNot AvailableSynechococcus elongatus (strain PCC 7942)
UPutative uncharacterized proteinNot AvailableStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
UPutative monooxygenase MoxCNot AvailableBacillus subtilis (strain 168)
UtRNA-dihydrouridine synthaseNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UProtein NrdINot AvailableBacillus subtilis (strain 168)
UProbable aromatic acid decarboxylaseNot AvailableEscherichia coli O157:H7
U(S)-mandelate dehydrogenaseNot AvailablePseudomonas putida
UFMN-dependent NADPH-azoreductaseNot AvailableBacillus subtilis (strain 168)
UFlavodoxinNot AvailableHelicobacter pylori (strain J99 / ATCC 700824)
USerine/threonine-protein kinase Sgk1Not AvailableHuman
UOxygen-insensitive NAD(P)H nitroreductaseNot AvailableEnterobacter cloacae
UNitric oxide reductaseNot AvailableMoorella thermoacetica (strain ATCC 39073)
UIsopentenyl-diphosphate delta-isomeraseNot AvailableThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
PathwayCategory
Arginine and Proline MetabolismMetabolic
Prolinemia Type IIDisease
Hyperprolinemia Type IDisease
Carnosinuria, carnosinemiaDisease
sulfur metabolism (isethionate)Metabolic
sulfur metabolism (methanesulfonate)Metabolic
Flavin biosynthesisMetabolic
pyrimidine metabolism Metabolic
Vitamin B6 Metabolism Metabolic
Vitamin B6 MetabolismMetabolic
Riboflavin MetabolismMetabolic
Pantothenate and CoA BiosynthesisMetabolic
Pyrimidine MetabolismMetabolic
Prolidase Deficiency (PD)Disease
Sulfur Metabolism (Propanesulfonate)Metabolic
Pyrimidine MetabolismMetabolic
Vitamin B6 MetabolismMetabolic
Riboflavin MetabolismMetabolic
Pyrimidine MetabolismMetabolic
sulfur metabolism (propanesulfonate)Metabolic
sulfur metabolism (ethanesulfonate)Metabolic
Arginine and Proline MetabolismMetabolic
Nitric Oxide Signaling PathwaySignaling
GABA-Transaminase DeficiencyDisease
Hyperprolinemia Type IIDisease
Ureidopropionase DeficiencyDisease
Carnosinuria, carnosinemiaDisease
Creatine deficiency, guanidinoacetate methyltransferase deficiencyDisease
Hyperornithinemia with gyrate atrophy (HOGA)Disease
Sulfur MetabolismMetabolic
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
Human Metabolome Database
HMDB0001520
KEGG Compound
C00061
PubChem Compound
643976
PubChem Substance
46507603
ChemSpider
559060
BindingDB
50421345
ChEBI
17621
ChEMBL
CHEMBL1201794
HET
FMN
Wikipedia
Flavin_mononucleotide
PDB Entries
1ag9 / 1ahn / 1akq / 1akr / 1akt / 1aku / 1akv / 1akw / 1al7 / 1al8
show 967 more

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2, 3Unknown StatusTreatmentKeratoconus1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
ElixirOral
CapsuleOral
TabletOral
Tablet, effervescentOral
Kit
Solution / dropsOral
SolutionOral
LiquidIntravenous
LiquidOral
Kit
Injection, solutionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.668 mg/mLALOGPS
logP-0.78ALOGPS
logP-1ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)1.57ChemAxon
pKa (Strongest Basic)0.68ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count11ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area201.58 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity107.14 m3·mol-1ChemAxon
Polarizability42.19 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.9125
Blood Brain Barrier-0.7057
Caco-2 permeable-0.6779
P-glycoprotein substrateSubstrate0.7661
P-glycoprotein inhibitor INon-inhibitor0.7188
P-glycoprotein inhibitor IINon-inhibitor0.9704
Renal organic cation transporterNon-inhibitor0.9373
CYP450 2C9 substrateNon-substrate0.7163
CYP450 2D6 substrateNon-substrate0.821
CYP450 3A4 substrateSubstrate0.523
CYP450 1A2 substrateNon-inhibitor0.6006
CYP450 2C9 inhibitorNon-inhibitor0.8359
CYP450 2D6 inhibitorNon-inhibitor0.8907
CYP450 2C19 inhibitorNon-inhibitor0.6667
CYP450 3A4 inhibitorNon-inhibitor0.7421
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8922
Ames testNon AMES toxic0.716
CarcinogenicityNon-carcinogens0.8096
BiodegradationNot ready biodegradable0.9737
Rat acute toxicity2.4314 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9468
hERG inhibition (predictor II)Inhibitor0.584
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , NegativeLC-MS/MSsplash10-0002-9000200000-bc07cc2b3950f70a9db3
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0002-9000200000-bc07cc2b3950f70a9db3
1H NMR Spectrum1D NMRNot Applicable
[1H,1H] 2D NMR Spectrum2D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as flavin nucleotides. These are nucleotides containing a flavin moiety. Flavin is a compound that contains the tricyclic isoalloxazine ring system, which bears 2 oxo groups at the 2- and 4-positions.
Kingdom
Organic compounds
Super Class
Nucleosides, nucleotides, and analogues
Class
Flavin nucleotides
Sub Class
Not Available
Direct Parent
Flavin nucleotides
Alternative Parents
Flavins / Quinoxalines / Pyrimidones / Monoalkyl phosphates / Pyrazines / Benzenoids / Vinylogous amides / Heteroaromatic compounds / Secondary alcohols / Lactams
show 6 more
Substituents
Flavin nucleotide / Flavin / Isoalloxazine / Diazanaphthalene / Pteridine / Quinoxaline / Monoalkyl phosphate / Pyrimidone / Pyrazine / Organic phosphoric acid derivative
show 20 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
flavin mononucleotide (CHEBI:17621)

Targets

Kind
Protein
Organism
Methylophilus methylotrophus
Pharmacological action
Unknown
General Function
Trimethylamine dehydrogenase activity
Specific Function
Not Available
Gene Name
tmd
Uniprot ID
P16099
Uniprot Name
Trimethylamine dehydrogenase
Molecular Weight
81628.615 Da
Kind
Protein
Organism
Desulfovibrio gigas
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Catalyzes the four-electron reduction of one oxygen molecule to two water molecules.
Gene Name
roo
Uniprot ID
Q9F0J6
Uniprot Name
Rubredoxin-oxygen oxidoreductase
Molecular Weight
44796.045 Da
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
Riboflavin kinase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q9WZW1
Uniprot Name
Riboflavin biosynthesis protein
Molecular Weight
33613.56 Da
Kind
Protein
Organism
Pseudomonas putida
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Not Available
Gene Name
morB
Uniprot ID
Q51990
Uniprot Name
Morphinone reductase
Molecular Weight
41249.71 Da
Kind
Protein
Organism
Vibrio harveyi
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction.
Gene Name
frp
Uniprot ID
Q56691
Uniprot Name
NADPH-flavin oxidoreductase
Molecular Weight
26309.475 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Ribosomal protein s6 kinase activity
Specific Function
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor REL...
Gene Name
RPS6KA4
Uniprot ID
O75676
Uniprot Name
Ribosomal protein S6 kinase alpha-4
Molecular Weight
85605.025 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Pseudomonas fluorescens
Pharmacological action
Unknown
General Function
Pyridoxamine-phosphate oxidase activity
Specific Function
Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. Probably catalyzes the...
Gene Name
phzG
Uniprot ID
Q51793
Uniprot Name
Phenazine biosynthesis protein PhzG
Molecular Weight
24934.955 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Very-long-chain-(s)-2-hydroxy-acid oxidase activity
Specific Function
Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.
Gene Name
HAO2
Uniprot ID
Q9NYQ3
Uniprot Name
Hydroxyacid oxidase 2
Molecular Weight
38838.35 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Pharmacological action
Unknown
General Function
Nad(p)h dehydrogenase (quinone) activity
Specific Function
It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone stat...
Gene Name
Not Available
Uniprot ID
Q9RYU4
Uniprot Name
NAD(P)H dehydrogenase (quinone)
Molecular Weight
21297.875 Da
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Fmn binding
Specific Function
Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase.
Gene Name
fldA
Uniprot ID
P61949
Uniprot Name
Flavodoxin-1
Molecular Weight
19736.735 Da
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
Gene Name
fni
Uniprot ID
P50740
Uniprot Name
Isopentenyl-diphosphate delta-isomerase
Molecular Weight
37220.19 Da
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Nadh dehydrogenase activity
Specific Function
Can oxidize either NADH or NADPH with a preference for NADH. Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6...
Gene Name
nox
Uniprot ID
Q60049
Uniprot Name
NADH dehydrogenase
Molecular Weight
22730.15 Da
Kind
Protein
Organism
Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Pharmacological action
Unknown
General Function
Pyridoxamine-phosphate oxidase activity
Specific Function
Functions as a redox protein with a potential of -325 mV.
Gene Name
Not Available
Uniprot ID
Q46604
Uniprot Name
FMN-binding protein
Molecular Weight
13137.025 Da
Kind
Protein
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q81EW9
Uniprot Name
Nitroreductase family protein
Molecular Weight
22822.865 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Gene Name
POR
Uniprot ID
P16435
Uniprot Name
NADPH--cytochrome P450 reductase
Molecular Weight
76689.12 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Phosphopantothenoylcysteine decarboxylase activity
Specific Function
Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.
Gene Name
PPCDC
Uniprot ID
Q96CD2
Uniprot Name
Phosphopantothenoylcysteine decarboxylase
Molecular Weight
22394.965 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Pseudomonas aeruginosa
Pharmacological action
Unknown
General Function
Pyridoxamine-phosphate oxidase activity
Specific Function
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Gene Name
phzG
Uniprot ID
O69755
Uniprot Name
Phenazine biosynthesis protein
Molecular Weight
24268.005 Da
Kind
Protein
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Not Available
Gene Name
gltS
Uniprot ID
P55038
Uniprot Name
Ferredoxin-dependent glutamate synthase 2
Molecular Weight
169497.705 Da
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Pyridoxamine-phosphate oxidase activity
Specific Function
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Gene Name
pdxH
Uniprot ID
P0AFI7
Uniprot Name
Pyridoxine/pyridoxamine 5'-phosphate oxidase
Molecular Weight
25544.975 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Clostridium beijerinckii
Pharmacological action
Unknown
General Function
Fmn binding
Specific Function
Low-potential electron donor to a number of redox enzymes.
Gene Name
Not Available
Uniprot ID
P00322
Uniprot Name
Flavodoxin
Molecular Weight
15332.225 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Nad(p)h nitroreductase activity
Specific Function
Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinon...
Gene Name
nfsB
Uniprot ID
P38489
Uniprot Name
Oxygen-insensitive NAD(P)H nitroreductase
Molecular Weight
23904.99 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
Unknown
General Function
Chorismate synthase activity
Specific Function
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves ...
Gene Name
aroC
Uniprot ID
P0A2Y7
Uniprot Name
Chorismate synthase
Molecular Weight
42871.475 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Nadph dehydrogenase activity
Specific Function
Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-2- enoyl-CoA.
Gene Name
fadH
Uniprot ID
P42593
Uniprot Name
2,4-dienoyl-CoA reductase [NADPH]
Molecular Weight
72677.545 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Lactococcus lactis subsp. cremoris
Pharmacological action
Unknown
General Function
Dihydroorotate dehydrogenase (fumarate) activity
Specific Function
Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
Gene Name
pyrDA
Uniprot ID
Q53ZE5
Uniprot Name
Dihydroorotate dehydrogenase A (fumarate)
Molecular Weight
34209.99 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Riboflavin reductase (nadph) activity
Specific Function
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone)....
Gene Name
BLVRB
Uniprot ID
P30043
Uniprot Name
Flavin reductase (NADPH)
Molecular Weight
22119.215 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Very-long-chain-(s)-2-hydroxy-acid oxidase activity
Specific Function
Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octano...
Gene Name
HAO1
Uniprot ID
Q9UJM8
Uniprot Name
Hydroxyacid oxidase 1
Molecular Weight
40923.945 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Pyridoxamine-phosphate oxidase activity
Specific Function
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Gene Name
PNPO
Uniprot ID
Q9NVS9
Uniprot Name
Pyridoxine-5'-phosphate oxidase
Molecular Weight
29987.79 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Vibrio fischeri
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction. Major FMN reductase. It is capable of using both NADH and NADPH as elect...
Gene Name
Not Available
Uniprot ID
P46072
Uniprot Name
Major NAD(P)H-flavin oxidoreductase
Molecular Weight
24720.685 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Riboflavin kinase activity
Specific Function
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (...
Gene Name
RFK
Uniprot ID
Q969G6
Uniprot Name
Riboflavin kinase
Molecular Weight
17623.08 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Oxidoreductase activity, acting on nad(p)h, nitrogenous group as acceptor
Specific Function
Reduction of nitroaromatic compounds using NADH. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major component of the oxygen-insensitive...
Gene Name
nfsA
Uniprot ID
P17117
Uniprot Name
Oxygen-insensitive NADPH nitroreductase
Molecular Weight
26800.375 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Tetrahydrobiopterin binding
Specific Function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. P...
Gene Name
NOS1
Uniprot ID
P29475
Uniprot Name
Nitric oxide synthase, brain
Molecular Weight
160969.095 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Fmn binding
Specific Function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Gene Name
pyrD
Uniprot ID
P0A7E1
Uniprot Name
Dihydroorotate dehydrogenase (quinone)
Molecular Weight
36774.185 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Protein homodimerization activity
Specific Function
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Gene Name
DPYD
Uniprot ID
Q12882
Uniprot Name
Dihydropyrimidine dehydrogenase [NADP(+)]
Molecular Weight
111400.32 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Ubiquinone binding
Specific Function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Gene Name
DHODH
Uniprot ID
Q02127
Uniprot Name
Dihydroorotate dehydrogenase (quinone), mitochondrial
Molecular Weight
42866.93 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Enterobacter cloacae
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Not Available
Gene Name
onr
Uniprot ID
P71278
Uniprot Name
Pentaerythritol tetranitrate reductase
Molecular Weight
39488.93 Da
Kind
Protein
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Pharmacological action
Unknown
General Function
Oxidoreductase activity, acting on other nitrogenous compounds as donors
Specific Function
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity.
Gene Name
azoR
Uniprot ID
P63462
Uniprot Name
FMN-dependent NADH-azoreductase
Molecular Weight
21627.63 Da
Kind
Protein
Organism
Staphylococcus epidermidis
Pharmacological action
Unknown
General Function
Lyase activity
Specific Function
Catalyzes the removal of two reducing equivalents (oxidative decarboxylation) from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond.
Gene Name
epiD
Uniprot ID
P30197
Uniprot Name
Epidermin decarboxylase
Molecular Weight
20824.89 Da
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
Specific Function
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl ...
Gene Name
azoR
Uniprot ID
P41407
Uniprot Name
FMN-dependent NADH-azoreductase
Molecular Weight
21657.47 Da
Kind
Protein
Organism
Helicobacter pylori (strain ATCC 700392 / 26695)
Pharmacological action
Unknown
General Function
Fmn binding
Specific Function
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves ...
Gene Name
aroC
Uniprot ID
P56122
Uniprot Name
Chorismate synthase
Molecular Weight
40099.6 Da
Kind
Protein
Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Pharmacological action
Unknown
General Function
Fmn binding
Specific Function
Low-potential electron donor to a number of redox enzymes.
Gene Name
isiB
Uniprot ID
P0A3D9
Uniprot Name
Flavodoxin
Molecular Weight
18963.675 Da
Kind
Protein
Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Pharmacological action
Unknown
General Function
Iron ion binding
Specific Function
Low-potential electron donor to a number of redox enzymes.
Gene Name
Not Available
Uniprot ID
P00323
Uniprot Name
Flavodoxin
Molecular Weight
15823.215 Da
Kind
Protein
Organism
Synechococcus elongatus (strain PCC 7942)
Pharmacological action
Unknown
General Function
Fmn binding
Specific Function
Low-potential electron donor to a number of redox enzymes.
Gene Name
isiB
Uniprot ID
P10340
Uniprot Name
Flavodoxin
Molecular Weight
18777.495 Da
Kind
Protein
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q8DW21
Uniprot Name
Uncharacterized protein
Molecular Weight
22384.165 Da
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
Unknown
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Specific Function
May play a role in methionine degradation. May play a role in a sulfur salvage pathway.
Gene Name
moxC
Uniprot ID
O34974
Uniprot Name
Putative monooxygenase MoxC
Molecular Weight
49410.955 Da
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
Trna dihydrouridine synthase activity
Specific Function
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
Gene Name
Not Available
Uniprot ID
Q9WXV1
Uniprot Name
tRNA-dihydrouridine synthase
Molecular Weight
35149.495 Da
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Probably involved in ribonucleotide reductase function.
Gene Name
nrdI
Uniprot ID
P50618
Uniprot Name
Protein NrdI
Molecular Weight
14602.575 Da
Kind
Protein
Organism
Escherichia coli O157:H7
Pharmacological action
Unknown
General Function
Prenyltransferase activity
Specific Function
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase C (By similarity). Involved in the decarboxylation and detoxificati...
Gene Name
ecdB
Uniprot ID
P69772
Uniprot Name
Probable UbiX-like flavin prenyltransferase
Molecular Weight
21469.72 Da
Kind
Protein
Organism
Pseudomonas putida
Pharmacological action
Unknown
General Function
Fmn binding
Specific Function
Reduction of (S)-mandelate to benzoylformate.
Gene Name
mdlB
Uniprot ID
P20932
Uniprot Name
(S)-mandelate dehydrogenase
Molecular Weight
43436.53 Da
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADPH, but not NADH, as an electron donor for its activity.
Gene Name
azr
Uniprot ID
O07529
Uniprot Name
FMN-dependent NADPH-azoreductase
Molecular Weight
18903.755 Da
Kind
Protein
Organism
Helicobacter pylori (strain J99 / ATCC 700824)
Pharmacological action
Unknown
General Function
Fmn binding
Specific Function
Low-potential electron donor to a number of redox enzymes.
Gene Name
fldA
Uniprot ID
Q9ZK53
Uniprot Name
Flavodoxin
Molecular Weight
17473.305 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Sodium channel regulator activity
Specific Function
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell gr...
Gene Name
SGK1
Uniprot ID
O00141
Uniprot Name
Serine/threonine-protein kinase Sgk1
Molecular Weight
48941.96 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Enterobacter cloacae
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred.
Gene Name
nfsB
Uniprot ID
Q01234
Uniprot Name
Oxygen-insensitive NAD(P)H nitroreductase
Molecular Weight
23949.98 Da
Kind
Protein
Organism
Moorella thermoacetica (strain ATCC 39073)
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Has nitric oxide reductase activity in combination with Hrb; probably involved in nitrosative stress protection.
Gene Name
fprA
Uniprot ID
Q9FDN7
Uniprot Name
Nitric oxide reductase
Molecular Weight
44296.64 Da
Kind
Protein
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
Gene Name
fni
Uniprot ID
Q746I8
Uniprot Name
Isopentenyl-diphosphate delta-isomerase
Molecular Weight
35900.305 Da

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Gene Name
POR
Uniprot ID
P16435
Uniprot Name
NADPH--cytochrome P450 reductase
Molecular Weight
76689.12 Da

Drug created on June 13, 2005 07:24 / Updated on August 02, 2018 07:58