Calcium/calmodulin-dependent protein kinase type II subunit gamma
Details
- Name
- Calcium/calmodulin-dependent protein kinase type II subunit gamma
- Synonyms
- 2.7.11.17
- CaM kinase II subunit gamma
- CAMK
- CAMK-II
- CAMKG
- Gene Name
- CAMK2G
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008324|Calcium/calmodulin-dependent protein kinase type II subunit gamma MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLER EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQI LESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGY LSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT VTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKL KGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPL QTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKARSPEGRSSRDRTAPSAGMQPQPSL CSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFE NLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDG KWLNVHYHCSGAPAAPLQ
- Number of residues
- 558
- Molecular Weight
- 62608.655
- Theoretical pI
- 7.89
- GO Classification
- FunctionsATP binding / calcium-dependent protein serine/threonine phosphatase activity / calmodulin binding / calmodulin-dependent protein kinase activity / protein homodimerization activityProcessesactivation of MAPKK activity / axon guidance / calcium ion transport / cellular response to heat / cytokine-mediated signaling pathway / epidermal growth factor receptor signaling pathway / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / G1/S transition of mitotic cell cycle / innate immune response / insulin receptor signaling pathway / insulin secretion / interferon-gamma-mediated signaling pathway / MAPK cascade / neurotrophin TRK receptor signaling pathway / protein autophosphorylation / protein dephosphorylation / protein oligomerization / Ras protein signal transduction / regulation of calcium ion transport / regulation of cellular response to heat / regulation of relaxation of cardiac muscle / regulation of skeletal muscle adaptation / small GTPase mediated signal transduction / synaptic transmission / vascular endothelial growth factor receptor signaling pathwayComponentscytosol / endocytic vesicle membrane / membrane / neuronal postsynaptic density / nucleoplasm / plasma membrane / sarcoplasmic reticulum membrane
- General Function
- Protein homodimerization activity
- Specific Function
- Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Sarcoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0008323|1584 bp ATGGCCACCACCGCCACCTGCACACGTTTCACCGACGACTACCAGCTCTTCGAGGAGCTT GGCAAGGGTGCTTTCTCTGTGGTCCGCAGGTGTGTGAAGAAAACCCCCACGCAGGAGTAC GCAGCAAAAATCATCAATACCAAGAAATTGTCTGCCCGGGATCACCAGAAACTAGAACGT GAGGCTCGGATATGTCGACTTCTGAAACATCCAAACATCGTGCGCCTCCATGACAGTATT TCTGAAGAAGGGTTTCACTACCTCGTGTTTGACCTTGTTACCGGCGGGGAGCTGTTTGAA GACATTGTGGCCAGAGAGTACTACAGTGAAGCAGATGCCAGCCACTGTATACATCAGATT CTGGAGAGTGTTAACCACATCCACCAGCATGACATCGTCCACAGGGACCTGAAGCCTGAG AACCTGCTGCTGGCGAGTAAATGCAAGGGTGCCGCCGTCAAGCTGGCTGATTTTGGCCTA GCCATCGAAGTACAGGGAGAGCAGCAGGCTTGGTTTGGTTTTGCTGGCACCCCAGGTTAC TTGTCCCCTGAGGTCTTGAGGAAAGATCCCTATGGAAAACCTGTGGATATCTGGGCCTGC GGGGTCATCCTGTATATCCTCCTGGTGGGCTATCCTCCCTTCTGGGATGAGGATCAGCAC AAGCTGTATCAGCAGATCAAGGCTGGAGCCTATGATTTCCCATCACCAGAATGGGACACG GTAACTCCTGAAGCCAAGAACTTGATCAACCAGATGCTGACCATAAACCCAGCAAAGCGC ATCACGGCTGACCAGGCTCTCAAGCACCCGTGGGTCTGTCAACGATCCACGGTGGCATCC ATGATGCATCGTCAGGAGACTGTGGAGTGTTTGCGCAAGTTCAATGCCCGGAGAAAACTG AAGGGTGCCATCCTCACGACCATGCTTGTCTCCAGGAACTTCTCAGTTGGCAGGCAGAGC TCCGCCCCCGCCTCGCCTGCCGCGAGCGCCGCCGGCCTGGCCGGGCAAGCTGCCAAAAGC CTATTGAACAAGAAGTCGGATGGCGGTGTCAAGAAAAGGAAGTCGAGTTCCAGCGTGCAC CTAATGGAGCCACAAACCACTGTGGTACACAACGCTACAGATGGGATCAAGGGCTCCACA GAGAGCTGCAACACCACCACAGAAGATGAGGACCTCAAAGTGCGAAAACAGGAGATCATT AAGATTACAGAACAGCTGATTGAAGCCATCAACAATGGGGACTTTGAGGCCTACACGAAG ATTTGTGATCCAGGCCTCACTTCCTTTGAGCCTGAGGCCCTTGGTAACCTCGTGGAGGGG ATGGATTTCCATAAGTTTTACTTTGAGAATCTCCTGTCAAAGAACAGCAAGCCTATCCAT ACCACCATCCTAAACCCACACGTCCACGTGATTGGGGAGGACGCAGCGTGCATCGCCTAC ATCCGCCTCACCCAGTACATCGACGGGCAGGGTCGGCCTCGCACCAGCCAGTCAGAAGAG ACCCGGGTCTGGCACCGTCGGGATGGCAAGTGGCTCAATGTCCACTATCACTGCTCAGGG GCCCCTGCCGCACCGCTGCAGTGA
- Chromosome Location
- Not Available
- Locus
- 10q22
- External Identifiers
Resource Link UniProtKB ID Q13555 UniProtKB Entry Name KCC2G_HUMAN GenBank Protein ID 21707842 GenBank Gene ID BC034044 HGNC ID HGNC:1463 - General References
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