Solute carrier organic anion transporter family member 4C1
Details
- Name
- Solute carrier organic anion transporter family member 4C1
- Synonyms
- OATP-H
- OATP-M1
- OATP4C1
- OATPX
- Organic anion transporter M1
- SLC21A20
- Solute carrier family 21 member 20
- Gene Name
- SLCO4C1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0012539|Solute carrier organic anion transporter family member 4C1 MKSAKGIENLAFVPSSPDILRRLSASPSQIEVSALSSDPQRENSQPQELQKPQEPQKSPE PSLPSAPPNVSEEKLRSLSLSEFEEGSYGWRNFHPQCLQRCNTPGGFLLHYCLLAVTQGI VVNGLVNISISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAF MIGLGALVFSLPQFFSGEYKLGSLFEDTCVTTRNSTSCTSSTSSLSNYLYVFILGQLLLG AGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGES TDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNA DVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFA ATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEP FAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPK VYYNCSCIERKTEITSTAETFGFEAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITV SILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYD NIKMAHMLVAISVTCKVITMFFNGFAIFLYKPPPSATDVSFHKENAVVTNVLAEQDLNKI VKEG
- Number of residues
- 724
- Molecular Weight
- 78947.525
- Theoretical pI
- 7.57
- GO Classification
- Functionssodium-independent organic anion transmembrane transporter activityProcessesanion transmembrane transport / cell differentiation / multicellular organismal development / sodium-independent organic anion transport / spermatogenesis / transmembrane transportComponentsbasolateral plasma membrane / extracellular exosome / integral component of plasma membrane / plasma membrane
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.
- Pfam Domain Function
- Transmembrane Regions
- 106-126 146-166 173-197 224-254 275-295 312-336 378-399 420-443 448-471 581-603 613-638 673-690
- Cellular Location
- Basolateral cell membrane
- Gene sequence
>lcl|BSEQ0012540|Solute carrier organic anion transporter family member 4C1 (SLCO4C1) ATGAAGAGCGCCAAAGGTATTGAGAACTTGGCTTTTGTCCCCTCCAGCCCAGACATCCTG CGCCGCTTGTCTGCGTCGCCCTCCCAAATCGAAGTCTCTGCCTTGTCCTCTGACCCCCAA AGAGAGAATTCTCAGCCACAGGAGCTTCAGAAGCCCCAGGAGCCCCAGAAGTCACCAGAG CCATCTCTGCCTTCAGCCCCTCCCAATGTCTCCGAAGAGAAGCTCCGGTCACTGTCGCTG TCCGAGTTTGAGGAGGGGTCTTACGGCTGGAGGAACTTCCATCCTCAATGTCTCCAGCGC TGCAACACACCTGGAGGCTTTCTGCTTCACTACTGCCTCTTGGCCGTCACGCAAGGTATT GTAGTTAATGGCCTAGTAAATATTAGCATTTCCACTGTTGAGAAGCGTTATGAAATGAAG AGTTCCCTGACTGGCCTGATTTCATCAAGCTACGATATTTCATTCTGTTTGTTGTCTTTA TTTGTATCATTCTTTGGTGAAAGAGGACATAAGCCGAGATGGCTTGCATTTGCAGCCTTT ATGATTGGACTGGGAGCACTTGTATTCTCATTGCCACAATTTTTCAGTGGAGAATATAAA TTGGGGTCTCTTTTTGAAGACACTTGTGTAACAACAAGGAATAGCACCAGTTGTACATCT TCAACTTCTTCACTTTCTAACTACTTGTATGTCTTCATCTTGGGACAACTATTGCTGGGG GCAGGAGGAACTCCTCTTTATACTCTGGGAACAGCCTTTCTTGATGATTCTGTGCCCACA CACAAGTCTTCTCTCTATATAGGAACCGGTTATGCTATGTCAATCTTAGGCCCTGCTATT GGCTATGTATTGGGAGGACAACTGCTAACCATATACATTGATGTTGCTATGGGAGAAAGC ACTGATGTCACTGAGGATGATCCGCGATGGTTGGGAGCTTGGTGGATTGGGTTTCTTCTA TCATGGATCTTTGCTTGGTCTTTAATAATACCTTTTTCTTGCTTTCCAAAACATTTACCA GGTACAGCAGAAATTCAAGCTGGAAAAACTTCCCAGGCTCATCAGAGTAATAGTAATGCA GATGTGAAATTTGGAAAAAGTATTAAAGATTTTCCAGCTGCTCTAAAGAATTTGATGAAG AATGCTGTCTTTATGTGTTTAGTTCTATCAACTTCTTCAGAAGCCTTAATTACTACTGGA TTTGCTACATTTTTACCTAAATTTATAGAAAATCAATTCGGATTGACATCCAGCTTCGCA GCTACTCTTGGAGGGGCTGTTTTAATTCCTGGAGCTGCTCTCGGTCAAATTTTAGGTGGC TTCCTTGTTTCAAAATTCAGAATGACATGTAAAAACACAATGAAGTTTGCACTGTTCACA TCTGGAGTTGCACTTACGCTGAGTTTTGTATTTATGTATGCCAAATGTGAAAATGAGCCA TTTGCTGGTGTATCTGAATCATATAATGGGACTGGAGAATTGGGAAACTTGATAGCCCCT TGTAATGCCAATTGTAACTGTTCGCGATCATATTATTATCCTGTCTGTGGAGATGGAGTC CAATATTTTTCTCCCTGCTTTGCAGGCTGTTCAAACCCAGTTGCACACAGGAAGCCAAAG GTATATTACAACTGTTCCTGTATTGAAAGGAAAACAGAAATAACATCCACTGCAGAAACT TTTGGTTTTGAAGCTAAAGCTGGAAAATGTGAAACTCATTGTGCGAAACTGCCCATATTC CTTTGCATTTTCTTTATTGTAATTATTTTTACCTTTATGGCCGGTACTCCTATAACTGTG TCTATCCTAAGGTGTGTTAATCACAGACAACGGTCCCTAGCCTTGGGAATACAATTTATG GTCCTTCGATTATTAGGGACAATTCCTGGACCAATTATATTTGGTTTCACAATAGACAGC ACATGTATTCTTTGGGATATAAATGATTGTGGAATTAAAGGAGCTTGCTGGATTTATGAT AACATCAAGATGGCCCATATGCTAGTAGCCATAAGTGTTACTTGTAAAGTTATCACCATG TTCTTCAATGGATTTGCAATCTTTTTGTATAAACCACCTCCATCAGCCACAGATGTGTCA TTTCATAAAGAGAATGCAGTTGTGACTAATGTTTTAGCAGAACAGGATCTCAACAAAATA GTAAAAGAAGGGTGA
- Chromosome Location
- 5
- Locus
- 5q21.2
- External Identifiers
Resource Link UniProtKB ID Q6ZQN7 UniProtKB Entry Name SO4C1_HUMAN GenBank Protein ID 33308060 GenBank Gene ID AF401643 HGNC ID HGNC:23612 - General References
- Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Chu XY, Bleasby K, Yabut J, Cai X, Chan GH, Hafey MJ, Xu S, Bergman AJ, Braun MP, Dean DC, Evers R: Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. J Pharmacol Exp Ther. 2007 May;321(2):673-83. doi: 10.1124/jpet.106.116517. Epub 2007 Feb 21. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00390 Digoxin approved unknown substrate Details DB01396 Digitoxin approved, investigational unknown inhibitor Details DB00279 Liothyronine approved, vet_approved unknown substrate Details DB01092 Ouabain approved unknown substrate Details DB01583 Liotrix approved unknown substrate Details DB00509 Dextrothyroxine approved, investigational unknown Details DB00563 Methotrexate approved unknown Details DB06335 Saxagliptin approved unknown substrate Details DB01137 Levofloxacin approved, investigational unknown inhibitor Details