Response regulator RamR
Details
- Name
- Response regulator RamR
- Synonyms
- Transcriptional activator RamR
- Gene Name
- ramR
- Organism
- Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
- Amino acid sequence
>lcl|BSEQ0052784|Response regulator RamR MGEMVRIAVVHDEKLLRSALVQLLRSDDTLDVSSHCLDADGPELSAALPADVCVVDGECL TGPEDAGAGRLRARYGDRLVVLATAKRPGVLRRAFDGGALGLVDKNAPAHRLITAVHTVA RGERFLDETLTVALLKGAEMPLTTRELGVLTLASQGAPIAEIAARLHLSRGTVRNYMATA VRKVGARNRVDAIRIVQSAGWT
- Number of residues
- 202
- Molecular Weight
- 21489.545
- Theoretical pI
- Not Available
- GO Classification
- FunctionsDNA bindingProcessesregulation of transcription, DNA-templated
- General Function
- A transcription factor required for aerial hyphae formation on rich medium (PubMed:12100547, PubMed:12453210). Activates transcription of ramC. Might be part of a two-component regulatory system (PubMed:12453210). Binds the promoter of ramC (PubMed:12100547, PubMed:12453210). Non-phosphorylated protein cooperatively binds multiple sites in the ramC promoter. Has not been seen to autophosphorylate using the small molecule phosphodonors phosphoramidate, acetyl phosphate or carbamoyl phosphate (PubMed:16051268). Upon low expression suppresses the bald (bld, no aerial hyphae) phenotype of citA but not bldJ mutants; higher expression also suppresses the bldJ mutant as well as several other bld mutations, inducing SapB production even on media where SapB is normally not produced (PubMed:12453210). Expression of the ram locus (ramA, ramB and ramR) induces rapid aerial mycelium formation in S.lividans (PubMed:8206859). Overexpression suppresses the no aerial hyphae phenotype of a chaplin-negative strain, probably by inducing expression of SapB (PubMed:17462011). Overexpression of RamR show there are about 280 genes having at least a threefold increase or fourfold decrease in RNA abundance versus wild-type including gene cluster SCO4072-SCO4075 (PubMed:16925552).
- Specific Function
- Dna binding
- Pfam Domain Function
- GerE (PF00196)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0052785|Response regulator RamR (ramR) GTGGGGGAGATGGTTCGTATTGCCGTGGTGCACGACGAGAAGCTGCTGCGGTCGGCACTG GTGCAACTGCTCAGATCCGACGACACGCTGGACGTGTCCTCGCACTGCCTCGACGCCGAC GGTCCGGAGCTGAGTGCGGCATTGCCCGCCGACGTCTGTGTCGTGGACGGAGAGTGCCTG ACGGGGCCGGAAGACGCGGGAGCCGGACGCCTGCGGGCCCGGTACGGGGACCGGCTCGTG GTCCTCGCGACCGCCAAGCGGCCGGGAGTGCTGCGCCGGGCGTTCGACGGGGGCGCCCTC GGGCTGGTCGACAAGAACGCCCCGGCCCACCGGCTGATCACCGCCGTGCACACGGTCGCC CGGGGCGAACGCTTCCTGGACGAGACGCTCACCGTGGCCCTGCTGAAGGGTGCGGAGATG CCGCTGACCACGAGGGAACTGGGCGTGCTGACCCTGGCTTCCCAGGGGGCGCCGATCGCC GAGATCGCGGCGCGCCTGCACCTGTCCCGGGGGACGGTCCGCAACTACATGGCCACGGCG GTCCGGAAGGTGGGTGCCCGCAACCGCGTCGACGCGATCCGCATCGTGCAGAGCGCCGGC TGGACCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q7AKE4 UniProtKB Entry Name RAMR_STRCO - General References
- Not Available