Claudin-16
Details
- Name
- Claudin-16
- Synonyms
- Paracellin-1
- PCLN-1
- PCLN1
- Gene Name
- CLDN16
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052292|Claudin-16 MTSRTPLLVTACLYYSYCNSRHLQQGVRKSKRPVFSHCQVPETQKTDTRHLSGARAGVCP CCHPDGLLATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWEC VTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEP YIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGM AGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMYA VDTRV
- Number of residues
- 305
- Molecular Weight
- 33836.11
- Theoretical pI
- Not Available
- GO Classification
- Functionsidentical protein binding / magnesium ion transmembrane transporter activity / structural molecule activityProcessescalcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules / cellular metal ion homeostasis / excretionComponentsbicellular tight junction / cell / integral component of membrane / plasma membrane
- General Function
- Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.
- Specific Function
- Identical protein binding
- Pfam Domain Function
- PMP22_Claudin (PF00822)
- Transmembrane Regions
- 74-94 151-171 186-206 240-260
- Cellular Location
- Cell junction
- Gene sequence
>lcl|BSEQ0052293|Claudin-16 (CLDN16) ATGACCTCCAGGACCCCACTGTTGGTTACAGCCTGTTTGTATTATTCTTACTGCAACTCA AGACACCTGCAGCAGGGCGTGAGAAAAAGTAAAAGACCAGTATTTTCACATTGCCAGGTA CCAGAAACACAGAAGACTGACACCCGCCACTTAAGTGGGGCCAGGGCTGGTGTCTGCCCA TGTTGCCATCCTGATGGGCTGCTTGCCACAATGAGGGATCTTCTTCAATACATCGCTTGC TTCTTTGCCTTTTTCTCTGCTGGGTTTTTGATTGTGGCCACCTGGACTGACTGTTGGATG GTGAATGCTGATGACTCTCTGGAGGTGAGCACAAAATGCCGAGGCCTCTGGTGGGAATGC GTCACAAATGCTTTTGATGGGATTCGCACCTGTGATGAGTACGATTCCATACTTGCGGAG CATCCCTTGAAGCTGGTGGTAACTCGAGCGTTGATGATTACTGCAGATATTCTAGCTGGG TTTGGATTTCTCACCCTGCTCCTTGGTCTTGACTGCGTGAAATTCCTCCCTGATGAGCCG TACATTAAAGTCCGCATCTGCTTTGTTGCTGGAGCCACGTTACTAATAGCAGGTACCCCA GGAATCATTGGCTCTGTGTGGTATGCTGTTGATGTGTATGTGGAACGTTCTACTTTGGTT TTGCACAATATATTTCTTGGTATCCAATATAAATTTGGTTGGTCCTGTTGGCTCGGAATG GCTGGGTCTCTGGGTTGCTTTTTGGCTGGAGCTGTTCTCACCTGCTGCTTATATCTTTTT AAAGATGTTGGACCTGAGAGAAACTATCCTTATTCCTTGAGGAAAGCCTATTCAGCCGCG GGTGTTTCCATGGCCAAGTCATACTCAGCCCCTCGCACAGAGACGGCCAAAATGTATGCT GTAGACACAAGGGTGTAA
- Chromosome Location
- 3
- Locus
- 3q28
- External Identifiers
Resource Link UniProtKB ID Q9Y5I7 UniProtKB Entry Name CLD16_HUMAN HGNC ID HGNC:2037 - General References
- Simon DB, Lu Y, Choate KA, Velazquez H, Al-Sabban E, Praga M, Casari G, Bettinelli A, Colussi G, Rodriguez-Soriano J, McCredie D, Milford D, Sanjad S, Lifton RP: Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science. 1999 Jul 2;285(5424):103-6. doi: 10.1126/science.285.5424.103. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Weber S, Hoffmann K, Jeck N, Saar K, Boeswald M, Kuwertz-Broeking E, Meij II, Knoers NV, Cochat P, Sulakova T, Bonzel KE, Soergel M, Manz F, Schaerer K, Seyberth HW, Reis A, Konrad M: Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene. Eur J Hum Genet. 2000 Jun;8(6):414-22. doi: 10.1038/sj.ejhg.5200475. [Article]
- Weber S, Schneider L, Peters M, Misselwitz J, Ronnefarth G, Boswald M, Bonzel KE, Seeman T, Sulakova T, Kuwertz-Broking E, Gregoric A, Palcoux JB, Tasic V, Manz F, Scharer K, Seyberth HW, Konrad M: Novel paracellin-1 mutations in 25 families with familial hypomagnesemia with hypercalciuria and nephrocalcinosis. J Am Soc Nephrol. 2001 Sep;12(9):1872-81. [Article]