Tumor necrosis factor receptor superfamily member 11A
Details
- Name
- Tumor necrosis factor receptor superfamily member 11A
- Synonyms
- ODFR
- Osteoclast differentiation factor receptor
- RANK
- Receptor activator of NF-KB
- Gene Name
- TNFRSF11A
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006732|Tumor necrosis factor receptor superfamily member 11A MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKC TTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHW SQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGK RVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGK ALTANLWHWINEACGRLSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMC YPDQGGVCQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQL LFLTEPGSKSTPPFSEPLEVGENDSLSQCFTGTQSTVGSESCNCTEPLCRTDWTPMSSEN YLQKEVDSGHCPHWAASPSPNWADVCTGCRNPPGEDCEPLVGSPKRGPLPQCAYGMGLPP EEEASRTEARDQPEDGADGRLPSSARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVM NFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLRE PEKASRPVQEQGGAKA
- Number of residues
- 616
- Molecular Weight
- 66033.365
- Theoretical pI
- 5.0
- GO Classification
- Functionscytokine binding / metal ion binding / receptor activity / transmembrane signaling receptor activity / tumor necrosis factor-activated receptor activityProcessesadaptive immune response / apoptotic signaling pathway / cell-cell signaling / circadian temperature homeostasis / inflammatory response / lymph node development / mammary gland alveolus development / monocyte chemotaxis / ossification / osteoclast differentiation / positive regulation of cell proliferation / positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling / positive regulation of fever generation by positive regulation of prostaglandin secretion / positive regulation of JUN kinase activity / positive regulation of NF-kappaB transcription factor activity / positive regulation of sequence-specific DNA binding transcription factor activity / regulation of apoptotic process / response to cytokine / response to interleukin-1 / response to lipopolysaccharide / response to radiation / response to tumor necrosis factor / signal transduction / TNFSF11-mediated signaling pathway / tumor necrosis factor-mediated signaling pathwayComponentsexternal side of plasma membrane / integral component of plasma membrane / plasma membrane
- General Function
- Tumor necrosis factor-activated receptor activity
- Specific Function
- Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
- Pfam Domain Function
- TNFR_c6 (PF00020)
- Transmembrane Regions
- 213-233
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012417|Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A) ATGGCCCCGCGCGCCCGGCGGCGCCGCCCGCTGTTCGCGCTGCTGCTGCTCTGCGCGCTG CTCGCCCGGCTGCAGGTGGCTTTGCAGATCGCTCCTCCATGTACCAGTGAGAAGCATTAT GAGCATCTGGGACGGTGCTGTAACAAATGTGAACCAGGAAAGTACATGTCTTCTAAATGC ACTACTACCTCTGACAGTGTATGTCTGCCCTGTGGCCCGGATGAATACTTGGATAGCTGG AATGAAGAAGATAAATGCTTGCTGCATAAAGTTTGTGATACAGGCAAGGCCCTGGTGGCC GTGGTCGCCGGCAACAGCACGACCCCCCGGCGCTGCGCGTGCACGGCTGGGTACCACTGG AGCCAGGACTGCGAGTGCTGCCGCCGCAACACCGAGTGCGCGCCGGGCCTGGGCGCCCAG CACCCGTTGCAGCTCAACAAGGACACAGTGTGCAAACCTTGCCTTGCAGGCTACTTCTCT GATGCCTTTTCCTCCACGGACAAATGCAGACCCTGGACCAACTGTACCTTCCTTGGAAAG AGAGTAGAACATCATGGGACAGAGAAATCCGATGCGGTTTGCAGTTCTTCTCTGCCAGCT AGAAAACCACCAAATGAACCCCATGTTTACTTGCCCGGTTTAATAATTCTGCTTCTCTTC GCGTCTGTGGCCCTGGTGGCTGCCATCATCTTTGGCGTTTGCTATAGGAAAAAAGGGAAA GCACTCACAGCTAATTTGTGGCACTGGATCAATGAGGCTTGTGGCCGCCTAAGTGGAGAT AAGGAAATGTGA
- Chromosome Location
- 18
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9Y6Q6 UniProtKB Entry Name TNR11_HUMAN GenBank Gene ID AF018253 GenAtlas ID TNFRSF11A HGNC ID HGNC:11908 - General References
- Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature. 1997 Nov 13;390(6656):175-9. [Article]
- Sirinian C, Papanastasiou AD, Zarkadis IK, Kalofonos HP: Alternative splicing generates a truncated isoform of human TNFRSF11A (RANK) with an altered capacity to activate NF-kappaB. Gene. 2013 Aug 1;525(1):124-9. doi: 10.1016/j.gene.2013.04.075. Epub 2013 May 7. [Article]
- Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Yano K, Morinaga T, Higashio K: RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem Biophys Res Commun. 1998 Dec 18;253(2):395-400. [Article]
- Wong BR, Josien R, Lee SY, Vologodskaia M, Steinman RM, Choi Y: The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. J Biol Chem. 1998 Oct 23;273(43):28355-9. [Article]
- Wada T, Nakashima T, Oliveira-dos-Santos AJ, Gasser J, Hara H, Schett G, Penninger JM: The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med. 2005 Apr;11(4):394-9. Epub 2005 Mar 6. [Article]
- Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
- Hughes AE, Ralston SH, Marken J, Bell C, MacPherson H, Wallace RG, van Hul W, Whyte MP, Nakatsuka K, Hovy L, Anderson DM: Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Nat Genet. 2000 Jan;24(1):45-8. [Article]
- Guerrini MM, Sobacchi C, Cassani B, Abinun M, Kilic SS, Pangrazio A, Moratto D, Mazzolari E, Clayton-Smith J, Orchard P, Coxon FP, Helfrich MH, Crockett JC, Mellis D, Vellodi A, Tezcan I, Notarangelo LD, Rogers MJ, Vezzoni P, Villa A, Frattini A: Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am J Hum Genet. 2008 Jul;83(1):64-76. doi: 10.1016/j.ajhg.2008.06.015. [Article]