Reaction: Zolpidem to 1 product
- Reaction
- Reaction type
- methyl-hydroxylation; oxidation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Reidy L, Nolan B, Ramos AR, Walls HC, Steele BW: Zolpidem urine excretion profiles and cross-reactivity with ELISA((R)) kits in subjects using Zolpidem or Ambien((R)) CR as a prescription sleep aid. J Anal Toxicol. 2011 Jun;35(5):294-301. [Article]
- Pichard L, Gillet G, Bonfils C, Domergue J, Thenot JP, Maurel P: Oxidative metabolism of zolpidem by human liver cytochrome P450S. Drug Metab Dispos. 1995 Nov;23(11):1253-62. [Article]
- Pharmacotherapy of Insomnia: Focus on Zolpidem Extended Release [File]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 3A4 Not Available Not Available confirmed Cytochrome P450 1A2 Not Available Not Available confirmed Cytochrome P450 2D6 Not Available Not Available confirmed