Reaction: Codeine to 1 product

Reaction
Reaction type
O-demethylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Caraco Y, Tateishi T, Guengerich FP, Wood AJ: Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity. Drug Metab Dispos. 1996 Jul;24(7):761-4. [PubMed:8818573]
  2. Vree TB, Verwey-van Wissen CP: Pharmacokinetics and metabolism of codeine in humans. Biopharm Drug Dispos. 1992 Aug;13(6):445-60. [PubMed:1391681]
  3. Cregg R, Russo G, Gubbay A, Branford R, Sato H: Pharmacogenetics of analgesic drugs. Br J Pain. 2013 Nov;7(4):189-208. doi: 10.1177/2049463713507439. [PubMed:26516523]
  4. Codeine FDA label [File]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2D6Not AvailableNot Availableimplied