Reaction: Netarsudil to 1 product

Reaction
Reaction type
esterase hydrolysis
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Lin CW, Sherman B, Moore LA, Laethem CL, Lu DW, Pattabiraman PP, Rao PV, deLong MA, Kopczynski CC: Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. J Ocul Pharmacol Ther. 2017 Jun 13. doi: 10.1089/jop.2017.0023. [PubMed:28609185]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
CarboxylesteraseNot AvailableNot Availableconfirmed