Reaction: Tapentadol to 1 product

Reaction
Reaction type
N-demethylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Barbosa J, Faria J, Queiros O, Moreira R, Carvalho F, Dinis-Oliveira RJ: Comparative metabolism of tramadol and tapentadol: a toxicological perspective. Drug Metab Rev. 2016 Nov;48(4):577-592. doi: 10.1080/03602532.2016.1229788. Epub 2016 Sep 15. [Article]
  2. FDA Approved Drug Products: NUCYNTA (tapentadol) tablets for oral use C-II Initial U.S. (July 2023) [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2C9Not AvailableNot Availableimplied
Cytochrome P450 2C19Not AvailableNot Availableimplied