Acyclovir sodiumProduct ingredient for Acyclovir

Name
Acyclovir sodium
Drug Entry
Acyclovir

Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis10,11,12,13,14,15. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old.13

Acyclovir was granted FDA approval on 29 March 1982.12

Accession Number
DBSALT000004
Structure
Thumb
Synonyms
Aciclovir sodium
UNII
927L42J563
CAS Number
69657-51-8
Weight
Average: 247.1865
Monoisotopic: 247.068133886
Chemical Formula
C8H10N5NaO3
InChI Key
RMLUKZWYIKEASN-UHFFFAOYSA-M
InChI
InChI=1S/C8H11N5O3.Na/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14;/h3,14H,1-2,4H2,(H3,9,11,12,15);/q;+1/p-1
IUPAC Name
sodium 9-[(2-hydroxyethoxy)methyl]-2-imino-3,9-dihydro-2H-purin-6-olate
SMILES
[Na+].OCCOCN1C=NC2=C1NC(=N)N=C2[O-]
External Links
PubChem Compound
23665721
ChemSpider
45865
ChEMBL
CHEMBL1200380
Wikipedia
Aciclovir
Predicted Properties
PropertyValueSource
Water Solubility5.69 mg/mLALOGPS
logP-1.2ALOGPS
logP-1.2ChemAxon
logS-1.6ALOGPS
pKa (Strongest Acidic)6.11ChemAxon
pKa (Strongest Basic)4.97ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area118.58 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity76.2 m3·mol-1ChemAxon
Polarizability21.16 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon