Amphetamine aspartate monohydrateProduct ingredient for Amphetamine
- Name
- Amphetamine aspartate monohydrate
- Drug Entry
- Amphetamine
Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 and first synthesized by 1927. After being proven to reduce drug-induced anesthesia and produce arousal and insomnia, amphetamine racemic mix was registered by Smith, Kline and French in 1935. Amphetamine structure presents one chiral center and it exists in the form of dextro- and levo-isomers.1 The first product of Smith, Kline and French was approved by the FDA on 1976.12
During World War II, amphetamine was used to promote wakefulness in the soldiers. This use derived into a large overproduction of amphetamine and all the surplus after the war finalized ended up in the black market, producing the initiation of the illicit abuse.1
- Accession Number
- DBSALT001501
- Structure
Structure for Amphetamine aspartate monohydrate (DBSALT001501)
- Synonyms
- Amfetamine aspartate monohydrate
- UNII
- O1ZPV620O4
- CAS Number
- 851591-76-9
- Weight
- Average: 421.538
Monoisotopic: 421.257671239 - Chemical Formula
- C22H35N3O5
- InChI Key
- DAWXRFCLWKUCNS-MNTSKLTCSA-N
- InChI
- InChI=1S/2C9H13N.C4H7NO4.H2O/c2*1-8(10)7-9-5-3-2-4-6-9;5-2(4(8)9)1-3(6)7;/h2*2-6,8H,7,10H2,1H3;2H,1,5H2,(H,6,7)(H,8,9);1H2/t;;2-;/m..0./s1
- IUPAC Name
- (2S)-2-aminobutanedioic acid bis(1-phenylpropan-2-amine) hydrate
- SMILES
- O.N[C@@H](CC(O)=O)C(O)=O.CC(N)CC1=CC=CC=C1.CC(N)CC1=CC=CC=C1
- External Links
- ChemSpider
- 32700563
- Wikipedia
- Amphetamine_aspartate_monohydrate
- Predicted Properties
Property Value Source Water Solubility 1.74 mg/mL ALOGPS logP 1.85 ALOGPS logP 1.8 Chemaxon logS -1.9 ALOGPS pKa (Strongest Basic) 10.01 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 26.02 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 43.71 m3·mol-1 Chemaxon Polarizability 16.18 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon