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Displaying drugs 3851 - 3875 of 4889 in total
Experimental
Matched Name: … 3-Amino-4,5-Dihydroxy-Cyclohex-1-Enecarboxylate …
Matched Iupac: … (3S,4R,5R)-3-amino-4,5-dihydroxycyclohex-1-ene-1-carboxylate …
Experimental
Matched Name: … 5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine …
Matched Iupac: … 5H,6H-benzo[h]cinnolin-3-amine …
Experimental
Matched Name: … (1R)-3-chloro-1-phenylpropan-1-ol …
Matched Iupac: … (1R)-3-chloro-1-phenylpropan-1-ol …
Experimental
Matched Name: … D-phenylalanyl-N-(3-methylbenzyl)-L-prolinamide …
Matched Iupac: … (2S)-1-[(2R)-2-amino-3-phenylpropanoyl]-N-[(3-methylphenyl)methyl]pyrrolidine-2-carboxamide …
Experimental
Matched Name: … N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE …
Matched Iupac: … 3-oxo-N-[(3S)-2-oxooxolan-3-yl]dodecanamide …
Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms. Alprazolam's adverse...
Approved
Illicit
Investigational
Matched Iupac: … 12-chloro-3-methyl-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene …
Matched Description: … ketoconazole and itraconazole. ... Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders. ... [L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like …
Matched Categories: … Benzodiazepines and benzodiazepine derivatives ... Hypnotics and Sedatives …
Matched Products: … XANAX 1 MG TABLET, 30 ADET ... STABINA 1 MG TABLET, 30 ADET ... XANAX 0,5 MG TABLET, 30 ADET …
Pabinafusp alfa is under investigation in clinical trial NCT03568175 (A Study of JR-141 in Patients With Mucopolysaccharidosis II).
Investigational
Matched Synonyms: … HUMAN-MUS MUSCULUS MONOCLONAL JR-141 .GAMMA.1-CHAIN) FUSION PROTEIN WITH PEPTIDE (SYNTHETIC 2-AMINO ACID
Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestosterone (DHT), a primary hormonal...
Approved
Investigational
Matched Synonyms: … (5α,17β)-N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide ... α,α,α,α',α',α'-hexafluoro-3-oxo-4-aza-5α-androst-1-ene-17β-carboxy-2',5'-xylidide …
Matched Description: … hormonal mediator that plays a role in the development and enlargement of the prostate gland. ... 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and ... [A1909] Type I and II 5α-reductase enzymes convert testosterone into dihydrotestosterone (DHT), a primary …
Matched Mixtures name: … Dutasteride and tamsulosin hydrochloride ... Dutasteride and Tamsulosin Hydrochloride ... Dutasteride and tamsulosin hydrochloride
Matched Categories: … tamsulosin and dutasteride ... Genito Urinary System and Sex Hormones ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … RESTAD 0,5 MG YUMUŞAK KAPSÜL, 30 KAPSÜL ... AVODART 0,5 MG YUMUSAK KAPSUL, 30 ADET ... DUTAPROS 0,5 MG YUMUSAK KAPSUL, 30 ADET …
TAK-733 has been used in trials studying the treatment of Advanced Metastatic Melanoma, Advanced Nonhematologic Malignancies, and Advanced Non-hematologic Malignancies.
Investigational
Matched Synonyms: … (3H,8H)-DIONE ... -4,7(3H,8H)-dione ... (R)-3-(2,3-DIHYDROXYPROPYL)-6-FLUORO-5-(2-FLUORO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO(2,3-D)PYRIMIDINE-4,7 …
Matched Iupac: … 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methyl-3H,4H,7H,8H-pyrido[2,3 …
Matched Description: … trials studying the treatment of Advanced Metastatic Melanoma, Advanced Nonhematologic Malignancies, and
Inavolisib (GDC-0077) is under investigation in clinical trial NCT03006172 (To Evaluate the Safety, Tolerability, and Pharmacokinetics of GDC-0077 Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer).
Investigational
Matched Synonyms: … (2S)-2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl)-5,6-dihydroimidazo(1,2-D)(1,4)benzoxazepin- ... propanamide, 2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl)-5,6-dihydroimidazo(1,2-D)(1,4)benzoxazepin …
Matched Iupac: … (2S)-2-({4-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-9-oxa-3,6-diazatricyclo[8.4.0.0^{2,6}] …
Matched Description: … Endocrine and Targeted Therapies in Participants With Breast Cancer). ... GDC-0077) is under investigation in clinical trial NCT03006172 (To Evaluate the Safety, Tolerability, and ... Pharmacokinetics of GDC-0077 Single Agent in Participants With Solid Tumors and in Combination With …
Matched Categories: … Phosphoinositide-3 Kinase Inhibitors …
SB-218078 is a specific inhibitor of CHK1.
Investigational
Matched Synonyms: … 9,10,11,12-tetrahydro-9,12-epoxy-1h-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1,3 ... 9,12-epoxy-1h-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1,3(2h)-dione, 9,10,11,12 …
Matched Iupac: … 2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaene-3,5
Matched Salts name: … SB-218078 hydrochloride
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities...
Approved
Matched Synonyms: … (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate ... 3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate …
Matched Iupac: … 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Description: … Amlodipine is commonly used in the treatment of high blood pressure and angina. ... dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and ... Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), …
Matched Mixtures name: … AMLODIPIN VALS BETA 5/80 ... AMLODIPIN VALS BETA 5/80 ... AMLODIPIN VALS BETA 5/80 …
Matched Categories: … ACE Inhibitors and Calcium Channel Blockers ... Angiotensin II Antagonists and Calcium Channel Blockers ... Calcium Channel Blockers and Diuretics ... Calcium-Regulating Hormones and Agents ... nebivolol and amlodipine …
Matched Products: … TENSIVASK 30 ... AMLOHEX 5 MG TABLET, 30 ADET ... SAMLODEX 5 MG TABLET,30 ADET …
Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II. It is typically given to patients who cannot be managed with the standard first line therapy, metformin. Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and...
Approved
Matched Synonyms: … 1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea ... 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea …
Matched Description: … cells, raising intracellular potassium and calcium ion concentrations. ... [L8117] A formulation with metformin was granted FDA approval on on 31 July 2000.[L8120] ... ] Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta
Matched Mixtures name: … DUPLAX 500 MG/5 MG FILM KAPLI TABLET, 30 ADET ... DUPLAX 500 MG/2.5 MG FILM KAPLI TABLET, 30 ADET ... DUPLAX 250 MG/1.25 MG FILM KAPLI TABLET, 30 ADET …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … DIYABEN 3,5 MG TABLET, 30 ADET ... MANINIL 3.5 ... GLIBENCLAMID AL 3.5
Desmethylprodine, a derivative of meperidine, is an opioid analgesic with the potency of morphine. It has been listed as a Schedule I controlled drug in the United States, and thus is not used clinically. It is known to be a designer drug, synthesized in 1977, for the purpose of recreational...
Experimental
Illicit
Matched Synonyms: … 3-Demethylprodine …
Matched Description: … It has been listed as a Schedule I controlled drug in the United States, and thus is not used clinically …
Matched Salts name: … Desmethylprodine hydrochloride
Matched Categories: … Acids, Heterocyclic ... Isonipecotic Acids
Experimental
Matched Synonyms: … 3-Amino-4-hydroxytoluene …
Queuine is a derivative of 7-Deazaguanine. Bacteria possess the exclusive ability to synthesize queuine, which is then salvaged and passed on to plants and animals. Quantities of queuine have been found in tomatoes, wheat, coconut water, and milk from humans, cows, and goats. Humans salvage and recover queuine from either...
Experimental
Nutraceutical
Matched Synonyms: … 7-(3,4-trans-4,5-cis-dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanine …
Matched Iupac: … (1R,2S,5S)-5-[({4-hydroxy-2-imino-1H,2H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}methyl)amino]cyclopent-3-ene- …
Matched Description: … queuine to queuosine by placing it in the wobble position (anticodon) of several tRNAs including aspartic acid ... and goats. ... plants and animals. …
Experimental
Matched Name: … 1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea …
Matched Iupac: … 3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-(4-chlorophenyl)urea …
Experimental
Matched Name: … N-Methyl-N-[3-(6-Phenyl[1,2,4]Triazolo[4,3-B]Pyridazin-3-Yl)Phenyl]Acetamide …
Matched Iupac: … N-methyl-N-(3-{6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl}phenyl)acetamide …
Experimental
Matched Name: … 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide …
Matched Iupac: … 6-chloro-N-(pyrimidin-5-yl)-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzoxazole-7-carboxamide …
Experimental
Matched Name: … S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE …
Matched Iupac: … (2S)-3-(4-fluorophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide …
Experimental
Matched Name: … N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE …
Matched Iupac: … N-[(2R)-4-(4-hydroxyphenyl)butan-2-yl]-2-(2-phenyl-1H-indol-3-yl)acetamide …
Experimental
Matched Name: … 2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[2-METHYL-4-ISOXAZOLYL]-PHENOL …
Matched Iupac: … 4-{3,5-dimethyl-4-[3-(3-methyl-1,2-oxazol-5-yl)propoxy]phenyl}-2-methyl-1,3-oxazole …
Olutasidenib (FT-2102) is a selective and potent isocitrate dehydrogenase-1 (IDH1) inhibitor approved by the FDA in December 2022.[L44256,L44261] It is indicated for the treatment of relapsed or refractory acute myeloid leukemia (AML) in patients with a susceptible IDH1 mutation as determined by an FDA-approved test. IDH1 mutations are common in...
Approved
Investigational
Matched Synonyms: … (s)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2- ... 2-pyridinecarbonitrile, 5-(((1s)-1-(6-chloro-1,2-dihydro-2-oxo-3-quinolinyl)ethyl)amino)-1,6-dihydro- ... 5-(((1s)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2 …
Matched Iupac: … 5-{[(1S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-1-methyl-6-oxo-1,6-dihydropyridine-2 …
Matched Description: … and gliomas (NCT03684811). ... Olutasidenib (FT-2102) is a selective and potent isocitrate dehydrogenase-1 (IDH1) inhibitor approved ... in different types of cancer, such as gliomas, AML, intrahepatic cholangiocarcinoma, chondrosarcoma, and
Experimental
Matched Name: … 4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one …
Matched Iupac: … 4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one …
Experimental
Matched Name: … 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one …
Matched Iupac: … 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-2-one …
Displaying drugs 3851 - 3875 of 4889 in total