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Displaying drugs 4101 - 4125 of 4179 in total

Thiamine

Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays...
Approved
Investigational
Nutraceutical
Vet approved
Matched Description: … It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. ... Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients ... and the nervous and digestive systems. …
Matched Salts cas: … 59-43-8 ... 67-03-8 …
Matched Mixtures name: … Cavan Alpha ... Prenate Star ... Iron Polysaccharides Folic Acid DHA …
Matched Categories: … Alimentary Tract and Metabolism ... Diet, Food, and Nutrition …
Matched Products: … BEVIGEN 250 MG TABLET, 20 ADET ... VI-PLEX B1 200 MG/2 ML AMPUL, 3 ADET …

Zidovudine

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator...
Approved
Matched Description: … It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves ... Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia ... modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid …
Matched Mixtures name: … LAMIVUDINE, NEVIRAPINE AND ZIDOVUDINE TABLETS (150/200/300 mg) ... LAMIVUDINA 150 MG + ZIDOVUDINA 300 MG + NEVIRAPINA 200 MG TABLETAS CUBIERTAS ... LAMIVUDINA 150 MG + ZIDOVUDINA 300 MG + NEVIRAPINA 200 MG TABLETAS CUBIERTAS …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleic Acid Synthesis Inhibitors ... zidovudine and lamivudine ... zidovudine, lamivudine and abacavir ... zidovudine, lamivudine and nevirapine …
Matched Products: … RETROVİR 200 MG/20 ML IV İNFÜZYONLUK ÇÖZELTİ, 5 ADET ... ZIDOVUDINA 200 MG CAPSULAS …

Zopiclone

Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate-like properties.
Approved
Matched Categories: … Benzodiazepine hypnotics and sedatives ... Hypnotics and Sedatives ... Zopiclone and prodrugs ... Sleep Initiation and Maintenance Disorders ... Miscellaneous Anxiolytics Sedatives and Hypnotics …
Matched Products: … IMOVANE 7.5 MG FİLM KAPLI TABLET, 20 ADET …

Linaclotide

Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist.[A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin derived from Escherichia coli, the first natural ligand...
Approved
Matched Synonyms: … L-TYROSINE, L-CYSTEINYL-L-CYSTEINYL-L-.ALPHA. …
Matched Iupac: … dodecaazatetracyclo[22.22.4.2^{16,33}.0^{7,11}]dopentacontan-38-yl]formamido}-3-(4-hydroxyphenyl)propanoic acid …
Matched Description: … Linaclotide is a synthetic 14-amino acid cyclic peptide [A260271] and first-in-class guanylate cyclase-C ... [A260271] It gained EMA and Health Canada approval on November 26, 2012 [L47216] and December 3, 2013 ... [A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Alimentary Tract and Metabolism …

Dactinomycin

A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin...
Approved
Investigational
Matched Synonyms: … DILACTONE ACTINOMYCIN D ACID …
Matched Description: … It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Nucleic Acid Synthesis Inhibitors ... Cytotoxic Antibiotics and Related Substances …

(4S)-5-[[(2S)-1-[[(2S)-1-Amino-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-4-benzamido-5-oxopentanoic acid

Experimental
Matched Name: … yl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-4-benzamido-5-oxopentanoic acid …
Matched Iupac: … ethyl]carbamoyl}-2-{4-[difluoro(phosphono)methyl]phenyl}ethyl]carbamoyl}-4-(phenylformamido)butanoic acid …

Rovanersen

Investigational
Matched Synonyms: … )-sp-c-(p(s))-sp-a-(p(s))-sp-c-(p(r))-sp-a-(p(s))-sp-g-(p(s))-sp-ram-rcm-rum-rum-(p(s))-sp-rcm) ... Dna,d(rgm-(p(s))-sp-rgm-rcm-ram-rcm-(p(s))-sp-a-(p(s))-sp-a-(p(s))-sp-g-(p(s))-sp-g-(p(s))-sp-g-(p(s) …

Lexanersen

Lexanersen is an antisense oligonucleotide under investigation for use as a disease-modifying therapy in Huntington's disease.
Investigational
Matched Synonyms: … ))-sp-t-(p(s))-sp-a-(p(s))-sp-g-(p(r))-sp-a-(p(s))-sp-t-(p(s))-sp-rgm-ram-rgm-rgm-(p(s))-sp-rgm) ... Dna, d(rgm-(p(s))-sp-rum-rgm-rcm-ram-(p(s))-sp-c-(p(s))-sp-a-(p(s))-sp-c-(p(s))-sp-a-(p(s))-sp-g-(p(s …

S-(2-{[N-(2-HYDROXY-4-{[HYDROXY(OXIDO)PHOSPHINO]OXY}-3,3-DIMETHYLBUTANOYL)-BETA-ALANYL]AMINO}ETHYL) HEXANETHIOATE

Experimental
Matched Name: … S-(2-{[N-(2-HYDROXY-4-{[HYDROXY(OXIDO)PHOSPHINO]OXY}-3,3-DIMETHYLBUTANOYL)-BETA-ALANYL]AMINO}ETHYL) HEXANETHIOATE …
Matched Iupac: … [(2-{[2-(hexanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy]phosphinic acid …

1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione

Experimental
Matched Name: … 1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione …

(3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol

Experimental
Matched Name: … 9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8- …
Matched Iupac: … (2R,6S,7R)-4,4-difluoro-7-(4-hydroxyphenyl)-10-(methoxymethyl)-8-oxatricyclo[7.4.0.0^{2,6}]trideca-1( …

19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one

Experimental
Matched Name: … 4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8( …
Matched Iupac: … 18-(cyclopropylamino)-2,8,16,17,19,20-hexaazatetracyclo[12.5.2.1^{3,7}.0^{17,21}]docosa-1(20),3(22),4,6,14 …

5-hydroxy-4-(7-methoxy-1,1-dioxido-2H-1,2,4-benzothiadiazin-3-yl)-2-(3-methylbutyl)-6-phenylpyridazin-3(2H)-one

Experimental
Matched Name: … 5-hydroxy-4-(7-methoxy-1,1-dioxido-2H-1,2,4-benzothiadiazin-3-yl)-2-(3-methylbutyl)-6-phenylpyridazin …

(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime

Experimental
Matched Name: … (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime …
Matched Iupac: … (3Z)-1-[(6-fluoro-2,4-dihydro-1,3-benzodioxin-8-yl)methyl]-3-(hydroxyimino)-4-phenyl-2,3-dihydro-1H-indol …

Doxorubicin

Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed...
Approved
Investigational
Matched Synonyms: … -8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione ... (8S-cis)-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy …
Matched Iupac: … (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl …
Matched Description: … [A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain ... Hodgkin’s lymphoma, multiple myeloma, sarcoma, and pediatric cancers. ... generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and …
Matched Salts cas: … 111266-55-8 …
Matched Categories: … Anthracyclines and Related Substances ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances ... CHOP-R chemotherapy regimen …
Matched Products: … GRANA ... Adriblastin 200 mg Stechampulle ... CAELYX CONCENTRATE FOR INFUSION 2MG/ML (20MG/VIAL) …

Clarithromycin

Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug...
Approved
Matched Description: … Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the ... translation and protein assembly process. ... Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration …
Matched Salts cas: … 848130-51-8 …
Matched Mixtures name: … Lansoprazole, Amoxicillin, and Clarithromycin ... Lansoprazole, Amoxicillin and Clarithromycin ... Lansoprazole, Amoxicillin and Clarithromycin …
Matched Categories: … Drugs for Acid Related Disorders ... Alimentary Tract and Metabolism ... Erythromycin and similars ... Macrolides, Lincosamides and Streptogramins ... Metabolic Side Effects of Drugs and Substances …
Matched Products: … KLACID (R) MR ... Ran-clarithromycin ... Monoclarium Prolonged Release Capsule 200 mg …

3-{[(2,2-dioxido-1,3-dihydro-2-benzothien-5-yl)amino]methylene}-5-(1,3-oxazol-5-yl)-1,3-dihydro-2H-indol-2-one

Experimental
Matched Name: … 3-{[(2,2-dioxido-1,3-dihydro-2-benzothien-5-yl)amino]methylene}-5-(1,3-oxazol-5-yl)-1,3-dihydro-2H-indol …

(5S)-1-benzyl-3-(1,1-dioxido-1,2-benzisothiazol-3-yl)-4-hydroxy-5-(1-methylethyl)-1,5-dihydro-2H-pyrrol-2-one

Experimental
Matched Name: … (5S)-1-benzyl-3-(1,1-dioxido-1,2-benzisothiazol-3-yl)-4-hydroxy-5-(1-methylethyl)-1,5-dihydro-2H-pyrrol …

(3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime

Experimental
Matched Name: … (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime …
Matched Iupac: … (3E)-5-fluoro-1-[(6-fluoro-2,4-dihydro-1,3-benzodioxin-8-yl)methyl]-3-(hydroxyimino)-2,3-dihydro-1H-indol …

Phylloquinone

Vitamin K1, also called phylloquinone or phytonadione, is a fat soluble vitamin.[L33319,L33345] Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates precursors to coagulation factors II, VII, IX, and X.[A234264,A234195,A234259] It is indicated in the treatment of coagulation disorders due to faulty formation of coagulation factors II,...
Approved
Investigational
Matched Synonyms: … alpha-Phylloquinone …
Matched Description: … precursors to coagulation factors II, VII, IX, and X. ... [L33319,L33345] Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates ... the treatment of coagulation disorders due to faulty formation of coagulation factors II, VII, IX, and …
Matched Mixtures name: … Vitamin D2 and K1 ... NUTRILITE CHILDREN MULTIVITAMIN AND IRON CHEWABLE TABLET ... Omega-3 Rx Complete …
Matched Categories: … Blood and Blood Forming Organs ... Diet, Food, and Nutrition …

(11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE

Experimental
Matched Name: … (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B] …
Matched Iupac: … (1-methanesulfonylpiperidin-4-yl)-10-(piperazin-1-yl)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8) …

(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime

Experimental
Matched Name: … (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime …
Matched Iupac: … (3Z)-1-[(6-fluoro-2,4-dihydro-1,3-benzodioxin-8-yl)methyl]-3-(hydroxyimino)-4-[(1E)-2-phenylethenyl]- …

8-Benzyl-2-Hydroperoxy-2-(4-Hydroxy-Benzyl)-6-(4-Hydroxy-Phenyl)-2h-Imidazo[1,2-a]Pyrazin-3-One

Experimental
Matched Name: … 8-Benzyl-2-Hydroperoxy-2-(4-Hydroxy-Benzyl)-6-(4-Hydroxy-Phenyl)-2h-Imidazo[1,2-a]Pyrazin-3-One …
Matched Iupac: … (2S)-8-benzyl-2-hydroperoxy-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-2H,3H-imidazo[1,2-a]pyrazin …

(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

Experimental
Matched Name: … (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4- …
Matched Iupac: … (2R,3R,4S,5R)-2-(6-amino-8-{[(3,4-dichlorophenyl)methyl]amino}-9H-purin-9-yl)-5-(hydroxymethyl)oxolane …

(3-EXO)-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8,8-DIMETHYL-8-AZONIABICYCLO[3.2.1]OCTANE

Experimental
Matched Name: … (3-EXO)-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8,8-DIMETHYL-8-AZONIABICYCLO[3.2.1]OCTANE …
Matched Iupac: … [3.2.1]octan-8-ium ... (1R,3R,5S)-8,8-dimethyl-3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yloxy}-8-azabicyclo …
Displaying drugs 4101 - 4125 of 4179 in total