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Identification
NameThiamine
Accession NumberDB00152  (NUTR00009, APRD00552, EXPT03222)
TypeSmall Molecule
GroupsApproved, Nutraceutical, Vet Approved
DescriptionThiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.
Structure
Thumb
Synonyms
3-(4-AMINO-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium
Aneurin
Antiberiberi factor
Thiamin
Thiamine
thiamine(1+)
thiamine(1+) ion
thiaminium
Vitamin B1
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
BetaxinSolution100 mgIntramuscular; IntravenousHospira, Inc.2002-06-01Not applicableCanada
Betaxin Liq 100mg/mlLiquid100 mgIntramuscular; IntravenousSanofi1936-12-312001-08-10Canada
Thiamiject Injection - Liq Im IV 100mg/mlLiquid100 mgIntramuscular; IntravenousOmega Laboratories Ltd1998-07-16Not applicableCanada
Thiamine HCl Inj 100mg/mlLiquid100 mgIntramuscular; IntravenousKripps Pharmacy Ltd.1979-12-31Not applicableCanada
Thiamine HCl Injection - Liq 100mg/mlLiquid100 mgIntramuscular; IntravenousFaulding Consumer, Inc.1998-04-302001-07-30Canada
Thiamine Hydrochloride Inj 100mg/mlLiquid100 mgIntramuscularSaanich Pharmacy1988-12-311997-02-20Canada
Thiamine Hydrochloride Injection USP, 100mg/mlLiquid100 mgIntramuscular; IntravenousAlveda Pharmaceuticals IncNot applicableNot applicableCanada
Thiamine Hydrochloride Injection, USPLiquid100 mgIntramuscular; IntravenousSterimax Inc2001-05-01Not applicableCanada
Vitamin B1Solution100 mgIntramuscular; IntravenousMylan Pharmaceuticals1994-12-312015-11-03Canada
Vitamin B1Solution100 mgIntramuscular; IntravenousSandoz Canada Incorporated1989-12-312016-10-24Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ThiamineInjection, solution100 mg/mLIntramuscular; IntravenousCardinal Health2000-09-01Not applicableUs
ThiamineInjection, solution100 mg/mLIntramuscular; IntravenousFresenius Kabi2000-09-01Not applicableUs
Thiamine HydrochlorideInjection, solution100 mg/mLIntramuscular; IntravenousGeneral Injectables & Vaccines2013-08-21Not applicableUs
Thiamine HydrochlorideInjection, solution100 mg/mLIntramuscular; IntravenousPhysicians Total Care, Inc.2001-04-18Not applicableUs
Thiamine HydrochlorideInjection, solution100 mg/mLIntramuscular; IntravenousGeneral Injectables & Vaccines2010-09-012017-01-20Us
Thiamine HydrochlorideInjection, solution100 mg/mLIntramuscular; IntravenousMylan Institutional2013-06-04Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acti-thiamine Caplet 100mgTablet100 mgOralActi Form Ltd.1991-12-312005-03-21Canada
B-1 Caps 500mgCapsule500 mgOralTwin Laboratories Inc.1995-12-311999-11-10Canada
B1 400mg Ctr TabTablet, extended release400 mgOralBioenergy Inc.1979-12-311998-06-03Canada
B1 Tab 100mgTablet100 mgOralVita Health Products Inc1979-12-312002-07-31Canada
Bewon ElixirLiquid.05 mgOralLaboratoires Charton Laboratories1995-12-311999-01-16Canada
Bewon Elixir 0.05mg/mlElixir.05 mgOralWyeth Ayerst Canada Inc.1994-12-311998-01-28Canada
Thiamine HCl Tab 100mgTablet100 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada
Thiamine HCl Tab 25mgTablet25 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312000-08-17Canada
Thiamine HCl Tab 50mgTablet50 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada
Thiamine Hydrochloride Inj 100mg/ml USPLiquid100 mgIntramuscular; IntravenousDavid Bull Laboratories (Pty) Ltd.1991-12-311998-08-13Canada
Vit B1 Ctr Srt 100mgTablet, extended release100 mgOralBioenergy Inc.1981-12-311998-06-03Canada
Vita-amine Cap 100mgCapsule100 mgOralLes Laboratoires Vachon Inc.1991-12-311997-08-08Canada
Vitamin B-1 100 Mg TabletsTablet100 mgOralGeneral Nutrition Canada Inc.1997-05-062007-08-01Canada
Vitamin B-1 Thiamine HCl 100mgCapsule100 mgOralAlbi Naturals1999-04-302009-07-15Canada
Vitamin B1 100 mgCapsule100 mgOralFlora Manufacturing And Distributing Ltd.2002-03-152004-08-04Canada
Vitamin B1 100mgTablet100 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Vitamin B1 100mg TabletTablet100 mgOralNutricorp International2000-01-242009-08-05Canada
Vitamin B1 Tab 100mgTablet100 mgOralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1978-12-312002-07-29Canada
Vitamin B1 Tab 100mgTablet100 mgOralShoppers Drug Mart Inc.1980-12-311997-08-15Canada
Vitamin B1 Tab 100mg USPTablet100 mgOralPharmavite1987-12-311998-09-08Canada
Vitamin B1 Tab 100mg USPTablet100 mgOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312001-07-06Canada
Vitamin B1 Tab 2mg USPTablet2 mgOralLab Gernetic Int Ltee1985-12-311997-02-21Canada
Vitamin B1 Tablets 100mgTablet100 mgOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada
Vitamine B1 100 Mg - TabletTablet100 mgOralNobel Pharm Enr.1995-12-312001-10-15Canada
Vitamine B1 Tab 100mg USPTablet100 mgOralLaboratoire Lalco Inc.1986-12-312002-09-05Canada
Unapproved/Other Products Not Available
International Brands
NameCompany
Betalin SEli Lilly
BiamineNot Available
Brand mixtures
NameLabellerIngredients
Acti-MN + B1 + C CapletActi Form Ltd.
Active FeGm Pharmaceuticals
AlertonicOdan Laboratories Ltd
Allbee With C 550 CapWhitehall Robins Inc.
Allbee With Vitamin C CapWhitehall Robins Inc.
Alsimine W Vitamins A DAlsi Cie Ltee
Am CapsNew Vision Nutritionals Company
AntlervironClassical Remedia Ltd
AppedrineChattem, Inc.
B 50 CapsulesRheingold Food International Ltd.
B 6 PlusAnabolic Laboratories Inc.
B C Antistress CapLes Laboratoires Bio SantÉ Inc.
B Complex 25mg Vitamin SupplementGarden State Nutritionals
B Complex 50 Vitamin CapBioforce Canada Inc.
B Complex 50+ CapletHealth Wise Nutrition Inc.
B Complex 500 TabNobel Pharm Enr.
B Complex Plus C 300mg TabNutricorp International
B Complex TabletsGolden Neo Life Diamite International, Limited
B Complex W C and B12 InjE L Stickley And Co Ltd.
B Complex W C Forte CapEverest Pharmaceuticals Ltd.
B Complex W Vit C W Non-med Yeast&liver TabPharmavite
B Complex W Vitamin C Fortis CapShoppers Drug Mart Inc.
B Complex With C 300mgVita Health Products Inc
B Complex With C 300mg TabPharmavite
B Complex With C 550mgVita Health Products Inc
B Compound 50mg TabGahler Enterprises Ltd.
B Plus C 300 mgVita Health Products Inc
B Plus C 300mg Timed ReleaseVita Health Products Inc
B Stress C + Iron & ViteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
B Totum 500Desbergers LtÉe, Division Of Technilab Inc.
B VirolRolmex International Inc.
B Vitamin Compound With B12 ThunasThuna Herbal Remedies Ltd.
B With C 500 CapPharmetics (2011) Inc.
B-100 CapsNow Foods
B-100 Complex TabletsViva Pharmaceutical Inc.
B-100 Hi Potency B Vitamins TabNatrol, Inc.
B-100 Vitamin SupplementGarden State Nutritionals
B-50 ComplexVita Health Products Inc
B-50 Complex TabVita Health Products Inc
B-50 Hi Potency B Vitamins TabNatrol, Inc.
B-comboPerdido Key Health And Wellness Inc
B-complexEnrich International
B-complex 100Great Earth Companies, Inc.
B-complex 50Great Earth Companies, Inc.
B-complex TabNatures Sunshine Products, Inc.
B-complex TabletsShaklee Corporation
B-complex With Vitamin C, Biotin, Folic AcidWn Pharmaceuticals Ltd.
B-complex-50 TabJr Carlson Labs Inc
B-plexWn Pharmaceuticals Ltd.
B-plex 100Merit Pharmaceuticals
B-plus - TabChampion's Choice Advanced Nutrition Inc.
B50 B Complex TabNutristar Health Products (1987) Inc.
B50 ComplexPreferred Nutrition Inc.
B6 Plus TabVita Health Products Inc
BacminMarnel Pharmaceuticals, Llc
Balanced B 125 SrtAnabolic Laboratories Inc.
Balanced B-100 B-complex Vitamins TabPharmavite
Balanced B-100 Timed ReleasePharmavite
Balanced B-50 B-complex Vitamins TabPharmavite
Balanced B-50 B-complex Vitamins, Timed RelePharmavite
Balanced B-50 ComplexLeiner Health Products
Balanced B-complex Vit + Vit C&e TabPharmavite
Balanced B100Hall Laboratories, Ltd.
Balanced B50 ComplexHall Laboratories, Ltd.
Beautel Supplement De Vitamines Et MineralNobel Pharm Enr.
Beminal W C Fortis InjAyerst Laboratories
Beminal With C Fortis CapWyeth Ayerst Canada Inc.
Beminal With C Fortis PwsWyeth Ayerst Canada Inc.
Bev 29 TabBeverly International Nutrition
Bev B-150Beverly International Nutrition
Biovim TabLe Naturiste J.M.B. Inc.
BiovitaIldong Pharmaceutical Co., Ltd.
Bugs Bunny and Friends Multiple VitaminsBayer Inc Consumer Care
Bugs Bunny Chew Multi Vit Plus IronMiles Inc. Pharmaceutical Division
C-B ComplexAvacare, Division Of Jeunique International Inc.
C-forcePrairie Naturals
C-nate DHACenturion Labs
C.R.T. X Multivitamin & Mineral Powder MixMetaform Ltd.
Cal M TabAnabolic Laboratories Inc.
Carbassist TabletsWyeth Ltd.
Cc IIAdded Dimensions
Cda-21 Vitamins With Non-medicinal Probiotic ComplexRx Vitamins Inc.
Cedevita Plus Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Cedevita Sugar-free Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Chela Potassium PlusNu Life Nutrition Ltd.
Chela-chromium 200Nu Life Nutrition Ltd.
Chela-manganese 50 PlusNu Life Nutrition Ltd.
Chew.multiple Vits.with Extra C for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vit Plus Iron for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vitamins for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vitamins Plus Extra CRandle Pharmaceutical Inc.
Chewable Multiple Vitamins Plus Iron TabRandle Pharmaceutical Inc.
Chewable Multiple Vitamins TabRandle Pharmaceutical Inc.
Chewable MultivitaminsWn Pharmaceuticals Ltd.
Chewable Multivitamins Plus IronWn Pharmaceuticals Ltd.
Children Choice Multivit Chewable TabSwiss Herbal Remedies Ltd.
Children Choice Multivitamin W Iron Chew TabSwiss Herbal Remedies Ltd.
Children's Chewable Multi Vit W IronShoppers Drug Mart Inc.
Children's Chewable Multi VitaminsShoppers Drug Mart Inc.
Children's Chewable Multi Vitamins With Iron TabletsVita Health Products Inc
Children's Chewable Multi-vitaminWn Pharmaceuticals Ltd.
Children's Chewable Multi-vitamin Complete With MineralsWn Pharmaceuticals Ltd.
Children's Chewable Multiple Vit.plus IronStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple Vitamins - TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple Vitamins (chewable Tablets)Pharmetics (2011) Inc.
Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets)Pharmetics (2011) Inc.
Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets)Pharmetics (2011) Inc.
Children's Vitamins ChewableVita Health Products Inc
Children's Vitamins W Iron ChewableVita Health Products Inc
Childrens Chew Multi Vitamin TabNutristar Health Products (1987) Inc.
Childrens Chewable Multiple VitaminsKsl Pharmaceuticals
Childrens Chewable Multiple Vitamins Plus FeKsl Pharmaceuticals
Childrens Chewable Multiple Vitamins TabPharmavite
Childrens Chewable MultivitaminsRandle Pharmaceutical Inc.
Childrens Chewable Multivitamins W IronRandle Pharmaceutical Inc.
Childrens Chewable Vitamin TabPharmetics (2011) Inc.
Childrens Chewable VitaminsD.C. Labs Limited
Childrens Multiple Vit and Min Chew TabCountry Health Laboratories Ltd.
Chromease TabAnabolic Laboratories Inc.
Citranatal DHAMission Pharmacal
Citranatal RxMission Pharmacal
Complete Mega BGahler Enterprises Ltd.
Complete Multivitamins and Minerals Tablets Timed ReleasePharmetics (2011) Inc.
Complex 5 - PwrAst Research
Complex-75Frega Inc.
Complexe B 75mgPharmalab Inc.
Complexe B Compose 75Les Laboratoires Bio SantÉ Inc.
Complexe B-75Frega Inc.
Concept DHAUs Pharmaceutical Corporation
Concept ObUs Pharmaceutical Corporation
Croq-vit Pour EnfantsNutrivac Ltee
CyroplexTherapeutic Foods Co.
D'pantothenic Acid-B1-B2 TabHealth Thru Herbs Inc.
Daily Energy Brand B-complexEnzymatic Therapy, Inc.
Derma-forcePrairie Naturals
Dexatrim TabletsChattem, Inc.
Dia-viteR & D Laboratories Inc.
DiaplexNephro Tech, Inc.
Dynam Ampoule Et TabletCardinaux Enrg Les Produits Naturels
E.S.T. ComplexAbundance Marketing Ltd.
Efferlife Multivitamins and MineralsNaturale Science Inc.
Enbrace HrJaymac Pharmaceuticals, Llc
EnlyteJaymac Pharmaceuticals Llc
Enviroflex - TabEnviro Tech International Canada
EscaviteGm Pharmaceuticals
Essential B TabletsGeneral Nutrition Canada Inc.
Everyday Multiple VitaminsD.C. Labs Limited
Everyday Multiple Vitamins With IronD.C. Labs Limited
Extra P.N. Vitamin-mineral Drink MixChanges International
Feminique W Iron and Calcium TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Ferra Naka Plus VitaminsNaka Sales Ltd.
Flinstones Multiple Plus IronMiles Inc. Pharmaceutical Division
Flintstones Multiple VitaminsBayer Inc Consumer Care
Flintstones Multiple Vitamins Plus IronBayer Inc Consumer Care
Flintstones Multiple Vitamins TabMiles Inc. Pharmaceutical Division
Flintstones W Extra C TabMiles Inc. Pharmaceutical Division
Floradix Formula LiqFlora Manufacturing And Distributing Ltd.
Floravit - SyrFlora Manufacturing And Distributing Ltd.
FlorivaBon Geo Pharmaceuticals, Inc.
Floriva PlusBon Geo Pharmaceuticals, Inc.
Foltabs PrenatalMidlothian Laboratories
For Kids Only Chewable Multivit. Plus IronKsl Pharmaceuticals
For Kids Only Chewable Multivitamins - TabKsl Pharmaceuticals
Formula D.S.Golden Pride International
Formula Fm Vitamins & Minerals TabMetagenics, Inc.
Formula LfNumark Laboratories, Inc.
Formula Pro-BBalance Plus, Inc.
Fortamines 10 CapsulesRougier Pharma Division Of Ratiopharm Inc
Fortamines-10 ComprimesRougier Pharma Division Of Ratiopharm Inc
Fortaplex InjKripps Pharmacy Ltd.
Fortistress TabSantÉ Naturelle (Ag) LtÉe
Forty Plus Vitamin SupplementGarden State Nutritionals
G.A.S. ComplexAbundance Marketing Ltd.
Garfield Chewable Multivits Plus Iron TabWhitehall Robins Inc.
Gemvites Jr Tab ChewablePharmavite Laboratories (1987) Inc.
Geritol LiquidGlaxosmithkline Inc
Gestamine ComprimesLab Nadeau LtÉe, Division Of Technilab Inc.
Gesticare DHAJazz Pharmaceuticals Commercial Corp.
Glyco-aide TabAvant Garde, Les SupplÉments
Harvest Of Values All B Complex TabHillestad Pharmaceuticals Usa
Healthy Mamabe Well Rounded Be Well RoundedMATERNAL SCIENCE, LLC
Hemarexin AmpLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
Hemarexin Liquid and Drinkable AmpoulesSabex Inc
Hemarexin TabLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
Hemenatal OBWh Nutritionals, Llc
Hi Potency B Complex W Chelated MineralsKlaire Labs Inc.
Hi Potency B52 B Complex TabCountry Health Laboratories Ltd.
Hi Potency Balanced B-100 Complex - TabLeiner Health Products
Hi Potency Stress B Tension With CLee Adams Laboratories
High Potency Vitamin B Complex + C TabVita Health Products Inc
Hill.viteHillestad Pharmaceuticals Usa
Hormodausse Plus Calc Et D TabLaboratoires Charton Laboratories
Hypo Vites TabPharmetics (2011) Inc.
Iberet 500Abbott
Inatal AdvanceNnodum Pharmaceuticals
Inatal UltraNnodum Pharmaceuticals
Infa Drops MultivitaminsVita Health Products Inc
Infant Multivitamin DropsGeneral Nutrition Canada Inc.
Infantol DropsChurch & Dwight Company, Inc.
Insur-all Vitamin SupplementGarden State Nutritionals
Integra PlusUs Pharmaceutical Corporation
Iron 25mg With Vit B-cmplx, Vit C, Cu & MoQuest Vitamins A Div Of Purity Life Health Products
Iron Polysaccharides Folic Acid DHAVirtus Pharmaceuticals
Kanga Sport Vitamins B & C Plus MineralsLacombe Drugs (1992) Ltd
Kanga-B Vitamin B Group + CLacombe Drugs (1992) Ltd
Kanga-kid Multi-vitamin & MineralLacombe Drugs (1992) Ltd
Kanga-kid Vitamins & IronLacombe Drugs (1992) Ltd
Kanga-V Multivitamins & MineralsLacombe Drugs (1992) Ltd
Kenwood Liquid SupplementKenwood Laboratories (Division Of Bradley Pharmaceuticals)
Kid's Choice Children's Chewable Vitamins - TabVita Health Products Inc
Kids Stuff TabletsVita Health Products Inc
Kids Stuff With Iron TabletsVita Health Products Inc
Kimchi Vitamin Chewable MultivitaminTobico
KindervitesHerbalife International Of America
Leritone JuniorInstitut De Recherche Biologique Yves Ponroy Canada Inc.
Lipo-B-C TabMetagenics, Inc.
Liqui B ComplexTwin Laboratories Inc.
Liqui B Complex PlusTwin Laboratories Inc.
Liqui Infant VitaminsTwin Laboratories Inc.
Liqui VitaTwin Laboratories Inc.
Liquid B Complex 50Jamieson Laboratories Ltd
Livron Plus AmpouleMedic Laboratory LtÉe
Livron Plus TabMedic Laboratory LtÉe
Low Potency B Complex TabFlora Manufacturing And Distributing Ltd.
Lysamine Diet Supp Amp-tabWelcker Lyster Ltd., Division Of Technilab Inc.
M.V.I. 12Aventis Pharma Ltd.
M.V.I. PaediatricAventis Pharma Ltd.
M.V.I. PediatricHospira Worldwide, Inc.
Maltlevol 12 LiqCarter Horner Corp.
Maltlevol LiqCarter Horner Corp.
Maxi 10 TabDesbergers LtÉe, Division Of Technilab Inc.
Maxi 6 LiqDesbergers LtÉe, Division Of Technilab Inc.
Mega 13 Multivitamin FormulaVita Health Products Inc
Megavites TabIcn Pharmaceuticals
Meplex T 750Medic Laboratory LtÉe
MethaverSterling Knight Pharmaceuticals, Llc
Mini-B TabTwin Laboratories Inc.
Mor-vites TabPharmetics (2011) Inc.
Multi - N.T.O.x Formula - TabAbundance Marketing Ltd.
Multi 12 InjectionSandoz Canada Incorporated
Multi BSeroyal International Inc.
Multi Enfants TabVitalab
Multi Nt-OXAbundance Marketing Ltd.
Multi RolRolmex International Inc.
Multi Vitamin - MineralEnrich International
Multi Vitamin & MineralsWn Pharmaceuticals Ltd.
Multi Vitamin and FluorideLibertas Pharma, Inc.
Multi Vitamin Drops With FluorideSeton Pharmaceuticals
Multi Vitamin Drops With Fluoride and IronSeton Pharmaceuticals
Multi Vitamin Drops With Fluoride With IronStratus Pharmaceuticals
Multi Vitamin Plus IronWn Pharmaceuticals Ltd.
Multi Vitamin With FluorideQualitest
Multi Vitamin-mineral FormulaVita Health Products Inc
Multi Vitamin, Iron and FluorideMayne Pharma
Multi Vitamines - LiqLand Art Inc.
Multi Vitamins & MineralsWn Pharmaceuticals Ltd.
Multi Vite Liq AdultPharmetics (2011) Inc.
Multi Vite Liq JuniorPharmetics (2011) Inc.
Multi-11Sandoz Canada Incorporated
Multi-12 PediatricSabex Inc
Multi-12/k1 PediatricSandoz Canada Incorporated
Multi-vit With FluorideA S Medication Solutions
Multi-vit With Fluoride and IronQualitest
Multi-vitaminLLC Federal Solutions
Multi-vitamin Dietary SupplementGarden State Nutritionals
Multi-vitamin Drops With Fluoride and IronMethod Pharmaceuticals
Multi-vitamin FluorideStratus Pharmaceuticals
Multi-vitamin Fluoride and Iron DropsBoca Pharmacal, Inc.
Multi-vitamin Fluoride DropsH.J. Harkins Company
Multi-vitamin With FluorideGolden State Medical Supply
Multi-vitamines Enfants ComprimeHerbes Universelles Inc.
Multi-vitaminsWn Pharmaceuticals Ltd.
Multi-vitamins With MineralsWn Pharmaceuticals Ltd.
Multiple Vitamin Plus Minerals TabHall Laboratories, Ltd.
Multiple Vitamin TabAdams Laboratories
Multiple VitaminsGfr Pharma Ltd.
Multiple Vitamins and Minerals TabRandle Pharmaceutical Inc.
Multiple Vitamins Plus Iron for WomenPharmetics (2011) Inc.
Multiple Vitamins Plus Iron TabHall Laboratories, Ltd.
Multiple Vitamins TabHall Laboratories, Ltd.
Multiple Vitamins W Iron TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins W Minerals TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins With IronStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins With Minerals TabletsPharmetics (2011) Inc.
MultisolLes Laboratoires Vachon Inc.
Multivit-liqPharmalab Inc.
MultivitaminLaboratoires Confab Inc
Multivitamin With FluorideSancilio & Company Inc.
MultivitaminesRolmex International Inc.
Multivitamines Et MinerauxLe Groupe M. Vachon Inc.
Multivitamines Plus Fer Pour Enfants (chewable Tablets)Laboratoire Lalco Inc.
Multivitamines Pour Enfants (chewable Tablets)Laboratoire Lalco Inc.
MultivitaminsVita Health Products Inc
Multivitamins for ChildrenQuest Vitamins A Div Of Purity Life Health Products
Multivitamins W IronRandle Pharmaceutical Inc.
MvcSancilio & Company Inc.
Mvc-fluorideSancilio & Company Inc.
Myhephron Dialysis and Stress SupplementMartin Ekwealor Pharmaceu
Mynephrocaps Dialysis/stress Vitamin SupplementMartin Ekwealor Pharmaceuticals, Inc.
Nata KompleteWh Nutritionals, Llc
NatafortMission Pharmacal
NataviteSchein Pharmaceutical Canada Inc.
Neo Bex ElixirNeolab Inc
Neo Vites TabNeolab Inc
Neo-bexNeolab Inc
Neo-bex InjectableBrostel Inc.
Neo-vites & Minerals TabNeolab Inc
NephrocapsCardinal Health
Nutrifer Plus TabletsWyeth Ayerst Canada Inc.
Nutrilite Double XNutrilite, A Division Of Access Business Group, Llc
Nutrol-B-complexRolmex International Inc.
O-cal Fa MultivitaminPharmics, Inc.
O-cal Prenatal VitaminPharmics, Inc.
OnccorSimone Protective Pharmaceuticals, Inc.
One A Day Advance AdultsBayer Inc Consumer Care
One A Day Advance Adults 50+Bayer Inc Consumer Care
One A Day Advance FemBayer Inc Consumer Care
One A Day TabCountry Health Laboratories Ltd.
Opti-manganese + B1 + C CapletNu Life Nutrition Ltd.
Orange Flavored Crystal Chews TabJeunique International Inc.
Orifer FSanofi Aventis
Original Bioscal Forte Multi-vitamin Supplement CapsulesCarram Inc.
Orti BSeroyal International Inc.
P.N.P. Vitamin DrinkChanges International
P.R.O. ComplexAbundance Marketing Ltd.
Paramettes Chewable Multivitamins Plus IronWyeth Ayerst Canada Inc.
Paramettes Chewable Multivits With Iron TabWhitehall Robins Inc.
Paramettes Multivits Plus Iron Tab (teens)Whitehall Robins Inc.
Paramettes SyrupWyeth Ayerst Canada Inc.
Penta-thion PwrSabex Inc
Permathene-12 - CapletCca Industries, Inc
Phosthenine Vitamines Et Fer (ampoules Buvable)Laboratoires Cortunon Inc.
Phytofortis + Calcium A-DPhyto Health Corporation
Phytoplex B LiqPhyto Health Corporation
PhytopureLaboratoire Lalco Inc.
PM CapsNew Vision Nutritionals Company
PNF-FirstAcella Pharmaceuticals, LLC
Pnv Ferrous Fumarate Docusate Folic AcidVirtus Pharmaceuticals
Pnv Prenatal Plus MultivitaminSancilio & Company Inc.
Pnv Prenatal VitaminSancilio & Company Inc.
Pnv Prenatal Vitamin Plus Vitamin ASancilio & Company Inc.
Pnv-selectAcella Pharmaceuticals, LLC
Poly-VI-sol DropsMead Johnson Nutritionals
Polymine Avec Zinc Et CuivreLes Laboratoires Vachon Inc.
Prefera Ob Plus DHAAlaven Pharmaceutical
PreferaobMeda Pharmaceuticals Ltd
Preferaob Plus DHAAlaven Pharmaceutical
PregvitDuchesnay Inc.
Pregvit Folic 4Duchesnay Inc.
Pregvit Folic 5Duchesnay Inc.
Prenatal 19Nationwide Laboratories
Prenatal Mega AntioxidantUsana Health Services, Inc.
Prenatal PlusBlenheim Pharmacal, Inc.
Prenatal Plus IronMajor
Prenatal Vitamins Plusbryant ranch prepack
Prenatal Vitamins Plus Low IronPatrin Pharma
Prenate EliteAvion Pharmaceuticals, Llc
Prenate StarAvion Pharmaceuticals, Llc
PreplusVirtus Pharmaceuticals
PretabVirtus Pharmaceuticals
Prevital TabBio Vita
Purevit Dualfe PlusPure Tek Corporation
Q.T. Vitamin and Mineral Drink MixGarden State Nutritionals
Reaphirm Plant Source DHAEverett Laboratories, Inc.
Reno CapsNnodum Pharmaceuticals
ReplaviteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Revit Plus CapIcn Pharmaceuticals
Revit TabIcn Pharmaceuticals
Revitex Ampoules Et ComprimesLes Produits Gerbex Inc.
Revival 1 TabBio Vita
Right Choice A.M. Multi Formula - CapletBody Wise International Llc
Se-natal 19Seton Pharmaceuticals
Se-natal 19 ChewableSeton Pharmaceuticals
Se-natal OneSeton Pharmaceuticals
Se-tan PlusSeton Pharmaceuticals
Sibergin B - CapPharmavite
Somarexin and C 1000Laboratoire Lalco Inc.
Somavit Brand Vitamins and Minerals ComplexSoma Health Products
Sopalamine/3b Plus CTechnilab Pharma Inc.
Sopalamine/3b TabTechnilab Pharma Inc.
Spectrum 2 CapNf Formulas Inc.
Stress B & C CapletHealth Wise Nutrition Inc.
Stress B Capsules With Vitamin CRheingold Food International Ltd.
Stress B Complex With C, E & IronPharmavite
Stress B With 1000 Mg Vitamin CHolista Health (Canada) Inc.
Stress B&c TabBioforce Canada Inc.
Stress Complex 600 Avec Vit E Cuivre ZincFrega Inc.
Stress Ctr SrtBioenergy Inc.
Stress FormulaVita Health Products Inc
Stress Formula + IronVita Health Products Inc
Stress Formula B-comp + 500mg Vit C TabQuest Vitamins A Div Of Purity Life Health Products
Stress Formula Multi-B Comp + 500mg Vit C CapQuest Vitamins A Div Of Purity Life Health Products
Stress Formula Multivitamin Tablets USPLeiner Health Products
Stress Formula TabNatures Sunshine Products, Inc.
Stress Formula Vit B With C ComplexWatkins Incorporated
Stress Forte Plus Lipotropic FactorsDouglas Laboratories
Stress TabVita Health Products Inc
Stress TabletsD.C. Labs Limited
Stress Vitamin B With C Complex TabletsPurity Life Health Products A Division Of Sunopta Inc.
StressmatesTwin Laboratories Inc.
Strovite Forte CapletEverett Laboratories, Inc.
Strovite One CapletsEverett Laboratories, Inc.
Sun-rype VitaburstSun Rype Products Ltd.
Super B Compound W 500mg Vit CGahler Enterprises Ltd.
Super Charged EnergySimone Protective Pharmaceuticals, Inc.
Super Daily No 2W.R. Enterprises Inc.
Super PantoplexNu Life Nutrition Ltd.
Super Stress CapsulesRheingold Food International Ltd.
Super Stress Mega B Plus 1000mg Vit C TabQuest Vitamins A Div Of Purity Life Health Products
Super Vitalex Ampoule BuvableCarmaran LtÉe
Super-pote Vitamin SupplementGarden State Nutritionals
Supplement De Multivitamines Infusion Arome Fruits RougesYves Rocher Inc.
Supravite 10ml AmpouleNobel Pharm Enr.
Supravite Bouteille 250mlNobel Pharm Enr.
Supravite C 1000Nobel Pharm Enr.
Supravite Pour EnfantsPharmalab Inc.
Supravite Stress Avec Vit EPharmalab Inc.
Supravite Stress Avec Vit E Cuivre Et ZincPharmalab Inc.
Supravite Stress Avec Vit E Et FerPharmalab Inc.
Surbex 500 FilmtabAbbott
Surbex-500 With IronAbbott
Surbex-500 With ZincAbbott
Swical-energy-2Les Laboratoires Swisse Inc.
Synergistic Manganese CapsulesQuest Vitamins A Div Of Purity Life Health Products
T.R.I. B-plex SrcAnabolic Laboratories Inc.
Tandem ObUs Pharmaceutical Corporation
Tandem PlusUs Pharmaceutical Corporation
Tender Age Multi VitaminsJamieson Laboratories Ltd
Thiamine HCl 100mg W C 20mgGahler Enterprises Ltd.
Time Release B 100 Compound - TabletHealth Wise Nutrition Inc.
Timed Release B Complex 100 SrtJamieson Laboratories Ltd
Timed Release B-complex 100Great Earth Companies, Inc.
Timed Release B-complex 50Great Earth Companies, Inc.
Tini-cal AmpoulesPharmetics (2011) Inc.
Toni Com LiqVitalab
Tonicol Et A-D-C Ampoules/comprimesDistributions Multi Pro Inc.
Tonimol Cap LiqHerbes Universelles Inc.
TriadvanceTrigen Laboratories, Inc.
Tricare PrenatalMedecor Pharma, Llc
Trinatal GtTrigen Laboratories, Inc.
Twin Ultra Liquid Fruit Punch FlavorTwin Laboratories Inc.
Twin Ultra Liquid Grape FlavorTwin Laboratories Inc.
Twin Ultra Liquid Lemon-lime FlavorTwin Laboratories Inc.
Twin Ultra Liquid Orange FlavorTwin Laboratories Inc.
Ultra EnerforceNutribon (1986) Inc.
Ultra HrNatural Organics Inc.
Usana Megavitamin Tablets - TabUsana Health Sciences, Inc.
V-natalVirtus Pharmaceuticals
Vasodyn TabNutri Dyn Products Ltd.
Viamon Ampoules Et ComprimesLab Nadeau LtÉe, Division Of Technilab Inc.
Vigem 12 LiquidPharmavite Laboratories (1987) Inc.
Vigo Multivitamins Drops/lozengeAshbury Research Corporation
Vimeral TabIcn Pharmaceuticals
Virt-bal DHA PlusVirtus Pharmaceuticals
Virt-capsVirtus Pharmaceuticals
Virt-PNVirtus Pharmaceuticals
Virt-vite PlusVirtus Pharmaceuticals
Vit B Complex CtrBioenergy Inc.
Vit B Complex Plus Vit C 550mgHall Laboratories, Ltd.
Vit-HA Multi Vitamin and Zinc SupplementRheingold Food International Ltd.
Vita B + C 500 TabLaboratoire Romilo
Vita B Complex TabNutrimetics International (Canada) Inc.
Vita Day TabJamieson Laboratories Ltd
Vita-BNutri Dyn Products Ltd.
Vita-B-75 CapLes Laboratoires Vachon Inc.
Vita-worth B-complex TabletsGeneral Nutrition Canada Inc.
Vitabanks Vitamin TabVitabank Inc.
Vitachrom GcNikken Usa, Incorporated
Vitaday TabPharmetics (2011) Inc.
VitafantLes Laboratoires Vachon Inc.
Vitafer - LiqFrega Inc.
Vitaflex Dietary SuplementHome Shopping Network Direct
Vitafol CapletEverett Laboratories, Inc.
Vitafol Ob CapletExeltis Usa, Inc.
Vitafol OneEverett Laboratories, Inc.
Vitafol PlusEverett Laboratories, Inc.
Vitafol UltraEverett Laboratories, Inc.
Vitalife - CapsuleHolista Health (Canada) Inc.
Vitamin and Mineral Supplement - LiqTechnilab Pharma Inc.
Vitamin B + C CapFinlandia Consultants
Vitamin B ComplexMylan Institutional
Vitamin B Complex + C 300mg CapRandle Pharmaceutical Inc.
Vitamin B Complex + C 600mg TabRandle Pharmaceutical Inc.
Vitamin B Complex 100 TabBioforce Canada Inc.
Vitamin B Complex 50Gfr Pharma Ltd.
Vitamin B Complex Plus 300mg Vitamin CHall Laboratories, Ltd.
Vitamin B Complex Plus C 300mg Timed ReleaseVita Health Products Inc
Vitamin B Complex SupplAvacare, Division Of Jeunique International Inc.
Vitamin B Complex TabNutristar Health Products (1987) Inc.
Vitamin B Complex W C 300mg TabLee Adams Laboratories
Vitamin B Complex W C TabAlbi Imports Ltd.
Vitamin B Compound TabNutrilite, A Division Of Access Business Group, Llc
Vitamin B Compound W C Tab 500mgAdams Laboratories
Vitamin B Compound W Vit C 250mg TabSwiss Herbal Remedies Ltd.
Vitamin B Compound With Vitamin C Fortis Capsule DtcD.C. Labs Limited
Vitamin B Cpd W Vit C TabIcn Pharmaceuticals
Vitamin B TabletsWeider Health Products
Vitamine 110 LiqFrega Inc.
Vitamine Du Groupe B Plus Fer - LiqPharmalab Inc.
Vitamines Pour Bebes Et EnfantsHerbes Universelles Inc.
Vitamins ChewableStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Vitamins W Iron ChewableStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Vitogen B Stress C Vit E Zinc & CopStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Vitogen B Stress C600Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.
VP-heme OBVirtus Pharmaceuticals
Vtb Vitamin and Mineral SupplementGarden State Nutritionals
Women's FormulaPro Ma Systems
Zoo ChewsHall Laboratories, Ltd.
Salts
Name/CASStructureProperties
Cocarboxylase
136-08-3
ThumbNot applicableDBSALT002217
Thiamine Hydrochloride
67-03-8
Thumb
  • InChI Key: DPJRMOMPQZCRJU-UHFFFAOYSA-M
  • Monoisotopic Mass: 336.057837322
  • Average Mass: 337.269
DBSALT000205
Thiamine mononitrate
532-43-4
Thumb
  • InChI Key: UIERGBJEBXXIGO-UHFFFAOYSA-N
  • Monoisotopic Mass: 327.100124747
  • Average Mass: 327.359
DBSALT001495
Categories
UNIIX66NSO3N35
CAS number59-43-8
WeightAverage: 265.355
Monoisotopic: 265.112306876
Chemical FormulaC12H17N4OS
InChI KeyJZRWCGZRTZMZEH-UHFFFAOYSA-N
InChI
InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1
IUPAC Name
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium
SMILES
CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N
Pharmacology
IndicationFor the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.
Structured Indications Not Available
PharmacodynamicsThiamine is a vitamin with antioxidant, erythropoietic, cognition-and mood-modulatory, antiatherosclerotic, putative ergogenic, and detoxification activities. Thiamine has been found to protect against lead-induced lipid peroxidation in rat liver and kidney. Thiamine deficiency results in selective neuronal death in animal models. The neuronal death is associated with increased free radical production, suggesting that oxidative stress may play an important early role in brain damage associated with thiamine deficiency. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Inhibition of endothelial cell proliferation may also promote atherosclerosis. Endothelial cells in culture have been found to have a decreased proliferative rate and delayed migration in response to hyperglycemic conditions. Thiamine has been shown to inhibit this effect of glucose on endothelial cells.
Mechanism of actionIt is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiamine is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives. There are five known natural thiamine phosphate derivatives: thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), and the recently discovered adenosine thiamine triphosphate (AThTP), and adenosine thiamine diphosphate. Each derivative has unique functions, however, most are involved as coenzymes.
TargetKindPharmacological actionActionsOrganismUniProt ID
Thiamin pyrophosphokinase 1Proteinyes
ligand
HumanQ9H3S4 details
Thiamine transporter 1Proteinunknown
binder
HumanO60779 details
Related Articles
AbsorptionAbsorbed mainly from duodenum, by both active and passive processes
Volume of distributionNot Available
Protein binding90-94%
Metabolism

Hepatic

Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityThiamine toxicity is uncommon; as excesses are readily excreted, although long-term supplementation of amounts larger than 3 gram have been known to cause toxicity. Oral mouse LD50 = 8224 mg/kg, oral rat LD50 = 3710 mg/kg.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Thiamine MetabolismMetabolicSMP00076
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug InteractionsNo interactions found.
Food InteractionsNot Available
References
Synthesis Reference

Nobuyuki Kitamori, Masaya Maeno, Seiji Izuhara, “Granules of thiamine salt and the production thereof.” U.S. Patent US4702919, issued July, 1974.

US4702919
General References
  1. Slater PV: Multi-level preparation for nursing impact on nursing practice. Aust Nurses J. 1978 Jun;7(11):40-3. [PubMed:249270 ]
  2. Kopriva V, Bilkovic R, Licko T: [Tumours of the small intestine (author's transl)]. Cesk Gastroenterol Vyz. 1977 Dec;31(8):549-53. [PubMed:603941 ]
  3. Beissel J: [The role of right catheterization in valvular prosthesis surveillance (author's transl)]. Ann Cardiol Angeiol (Paris). 1977 Dec;26(6):587-9. [PubMed:606152 ]
  4. Lonsdale D, Shamberger RJ, Audhya T: Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study. Neuro Endocrinol Lett. 2002 Aug;23(4):303-8. [PubMed:12195231 ]
  5. Lonsdale D: A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives. Evid Based Complement Alternat Med. 2006 Mar;3(1):49-59. [PubMed:16550223 ]
External Links
ATC CodesA11DA01
AHFS Codes
  • 88:08.00
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.2 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableHIV-1 Infections / Human Immunodeficiency Virus (HIV) Infections / Mycobacterium avium complex infection1
1CompletedBasic ScienceBeriberi1
1CompletedDiagnosticHealthy Volunteers1
1CompletedPreventionHIV/AIDS1
1CompletedTreatmentCancers / Metastases1
1Not Yet RecruitingBasic ScienceAging / Mineral deficiency / Vitamin Deficiency1
1, 2CompletedTreatmentShock, Septic1
1, 2SuspendedTreatmentSchizoaffective Disorders / Schizophrenia1
2CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentCancer, Breast1
2CompletedTreatmentCardiac Surgical Procedures / Coronary Artery Bypass1
2CompletedTreatmentDiabetes / Heart Failure (HF)1
2Not Yet RecruitingTreatmentAcidosis, Respiratory / Cardiac Arrest / Shock / Thiamin Deficiency1
2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2Unknown StatusTreatmentCritically Ill / Respiratory Failure1
2, 3CompletedTreatmentAcidosis, Respiratory1
2, 3CompletedTreatmentCardiovascular Diseases / Chronic Kidney Disease (CKD) / Mortality1
3CompletedPreventionComplications, Pregnancy / Human Immunodeficiency Virus (HIV) Infections1
3CompletedTreatmentAnemias1
3CompletedTreatmentChronic Heart Failure (CHF)1
3CompletedTreatmentDiarrheal Illnesses / Growth Faltering / Respiratory Illness1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis, Pulmonary1
3CompletedTreatmentHydatidiform Mole1
3TerminatedTreatmentHyperemesis Gravidarum1
3Unknown StatusNot AvailableAnemias / Low Birth Weight / Neonatal Mortality1
3Unknown StatusTreatmentAlzheimer Disease / Down Syndrome (DS)1
4CompletedHealth Services ResearchAcidosis, Respiratory / Aids / Human Immunodeficiency Virus (HIV) Infections / Lipodystrophies1
4CompletedTreatmentDiabetic Peripheral Neuropathic Pain1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentPregnancy1
4RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4RecruitingTreatmentWernicke-Korsakoff syndrome1
4WithdrawnTreatmentNephritis / Proteinuria / Systemic Lupus Erythematosus (SLE)1
Not AvailableCompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedPreventionNeural Tube Defects (NTDs)1
Not AvailableCompletedTreatmentAcute Respiratory Failure1
Not AvailableCompletedTreatmentHeart Failure (HF)1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections2
Not AvailableCompletedTreatmentThyrotoxicosis1
Not AvailableNot Yet RecruitingTreatmentMetastatic Breast Cancer (MBC) / Stage 4 Breast Cancer1
Not AvailableRecruitingTreatmentTemporomandibular Joint Disorder1
Not AvailableUnknown StatusTreatmentSciatica Due to Intervertebral Disc Disorder1
Not AvailableWithdrawnPreventionHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableWithdrawnTreatmentDiabetes Complications / Diabetes Mellitus (DM) / Peripheral Neuropathy1
Pharmacoeconomics
Manufacturers
  • Eli lilly and co
  • Abraxis pharmaceutical products
  • Akorn inc
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia and critical care
  • Bel mar laboratories inc
  • Dell laboratories inc
  • Hospira inc
  • Luitpold pharmaceuticals inc
  • Parke davis div warner lambert co
  • Watson laboratories inc
  • Wyeth ayerst laboratories
Packagers
Dosage forms
FormRouteStrength
TabletOral100 mg
ElixirOral
CapsuleOral500 mg
Tablet, extended releaseOral
InjectionIntramuscular
Injection, solutionIntramuscular; Intravenous
Tablet, extended releaseOral400 mg
Powder, for solutionIntramuscular; Intravenous
Powder, for solutionIntravenous
SolutionIntramuscular; Intravenous100 mg
LiquidOral.05 mg
ElixirOral.05 mg
GranuleOral
TabletOral
Capsule, delayed release pelletsOral
SyrupOral
LiquidIntramuscular; Intravenous
Tablet, effervescentOral
LiquidIntravenous
Injection, powder, lyophilized, for solutionIntravenous
Liquid; tabletOral
Solution / dropsOral
SolutionIntravenous
LiquidOral
SolutionOral
Tablet, chewableOral
SolutionIntramuscular; Intravenous
PowderOral
Tablet, coatedOral
KitOral
Capsule, extended releaseOral
LiquidIntramuscular; Intravenous100 mg
TabletOral25 mg
TabletOral50 mg
Injection, solutionIntramuscular; Intravenous100 mg/mL
LiquidIntramuscular100 mg
Capsule; liquidOral
LozengeOral
Kit
Tablet, extended releaseOral100 mg
CapsuleOral100 mg
CapsuleOral
Capsule, gelatin coatedOral
Capsule, liquid filledOral
InjectionIntravenous
TabletOral2 mg
Tablet, film coatedOral
Prices
Unit descriptionCostUnit
Thiamine 100 mg/ml vial8.61USD ml
Infuvite pediatric vial2.58USD ml
Vitamin B-1 100 mg/ml1.64USD ml
Thiamiject 100 mg/ml1.24USD ml
Thiamine Hcl 100 mg/ml1.24USD ml
Thiamine hcl powder0.73USD g
Thiamine 100 mg tablet0.21USD tablet
Thiamine 500 mg tablet0.18USD tablet
Vitamin b-1 250 mg tablet0.06USD tablet
Vitamin b-1 100 mg tablet0.05USD tablet
Thiamine 250 mg tablet0.03USD tablet
CVS Pharmacy vitamin b-1 100 mg tablet0.02USD tablet
Vitamin b-1 50 mg tablet0.02USD tablet
Thiamine hcl 50 mg tablet0.01USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point248 dec °CPhysProp
water solubility5E+005 mg/LMERCK INDEX (1996); approx.
Predicted Properties
PropertyValueSource
Water Solubility0.0153 mg/mLALOGPS
logP-2.1ALOGPS
logP-3.1ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)15.5ChemAxon
pKa (Strongest Basic)5.54ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area75.91 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity73.4 m3·mol-1ChemAxon
Polarizability28.14 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.7976
Blood Brain Barrier+0.933
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.5593
P-glycoprotein inhibitor INon-inhibitor0.9814
P-glycoprotein inhibitor IINon-inhibitor0.8504
Renal organic cation transporterNon-inhibitor0.7559
CYP450 2C9 substrateNon-substrate0.842
CYP450 2D6 substrateNon-substrate0.7591
CYP450 3A4 substrateNon-substrate0.7256
CYP450 1A2 substrateNon-inhibitor0.58
CYP450 2C9 inhibitorNon-inhibitor0.7521
CYP450 2D6 inhibitorNon-inhibitor0.7523
CYP450 2C19 inhibitorNon-inhibitor0.7397
CYP450 3A4 inhibitorNon-inhibitor0.8019
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7795
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.8999
BiodegradationNot ready biodegradable0.86
Rat acute toxicity2.4577 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9415
hERG inhibition (predictor II)Non-inhibitor0.6221
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MSNot Available
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-000i-0109000000-48864f31ba475645654bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-05o1-9200000000-2ec0f3e9e364cffde16eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-0aou-9000000000-0184506492d9f5b68b97View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-03di-0090000000-872150be83cbd75d8ecfView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-0002-0930000000-ecf71c75bdea859139d5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-0002-0900000000-4d9113fdc633fb1ccbb5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-0002-0900000000-4a8016299623af0c3027View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negativesplash10-0002-1900000000-773912c9f325c419c77dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-014i-0390000000-95f3ca57c95542bdc7e7View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-00di-0900000000-e079d1fc1e06396dc524View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positivesplash10-00di-0900000000-ebb16d4f204f291b9a3aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positivesplash10-00e9-4900000000-ad4d4779d76b9edb7ec5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positivesplash10-001i-9600000000-b631eed5be831527fc17View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-00di-0900000000-50f2f613f576814eb627View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-002b-0900000000-2f184bbfec6bc0ef00c6View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-001i-9000000000-35bc744495a2570a565fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-00di-1900000000-d8a7ac327273c32b4524View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0002-0920000000-ca80ef6513c61be5b5e9View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
1D NMR13C NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,1H] 2D NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as thiamines. These are compounds containing a thiamine moiety, which is structurally characterized by a 3-[(4-Amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-5-yl backbone.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDiazines
Sub ClassPyrimidines and pyrimidine derivatives
Direct ParentThiamines
Alternative Parents
Substituents
  • Thiamine
  • 4,5-disubstituted 1,3-thiazole
  • Aminopyrimidine
  • Imidolactam
  • Azole
  • Thiazole
  • Heteroaromatic compound
  • Azacycle
  • Alcohol
  • Organopnictogen compound
  • Primary amine
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Organic nitrogen compound
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Amine
  • Organic cation
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
ligand
General Function:
Thiamine diphosphokinase activity
Specific Function:
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.
Gene Name:
TPK1
Uniprot ID:
Q9H3S4
Molecular Weight:
27265.05 Da
References
  1. Pylypchuk SIu, Parkhomenko IuM, Protasova ZS, Vovk AI, Donchenko HV: [Interaction of rat brain thiamine kinase with thiamine and its derivatives]. Ukr Biokhim Zh (1999). 2001 Mar-Apr;73(2):51-6. [PubMed:11642045 ]
  2. Melnick J, Lis E, Park JH, Kinsland C, Mori H, Baba T, Perkins J, Schyns G, Vassieva O, Osterman A, Begley TP: Identification of the two missing bacterial genes involved in thiamine salvage: thiamine pyrophosphokinase and thiamine kinase. J Bacteriol. 2004 Jun;186(11):3660-2. [PubMed:15150256 ]
  3. Bellyei S, Szigeti A, Boronkai A, Szabo Z, Bene J, Janaky T, Barna L, Sipos K, Minik O, Kravjak A, Ohmacht R, Melegh B, Zavodszky P, Than GN, Sumegi B, Bohn H, Than NG: Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK). Placenta. 2005 Jan;26(1):34-46. [PubMed:15664409 ]
  4. de Jong L, Meng Y, Dent J, Hekimi S: Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans. Genetics. 2004 Oct;168(2):845-54. [PubMed:15514058 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Thiamine uptake transmembrane transporter activity
Specific Function:
High-affinity transporter for the intake of thiamine.
Gene Name:
SLC19A2
Uniprot ID:
O60779
Molecular Weight:
55399.49 Da
References
  1. Liberman MC, Tartaglini E, Fleming JC, Neufeld EJ: Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotype. J Assoc Res Otolaryngol. 2006 Sep;7(3):211-7. Epub 2006 Apr 27. [PubMed:16642288 ]
  2. Diaz GA, Banikazemi M, Oishi K, Desnick RJ, Gelb BD: Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome. Nat Genet. 1999 Jul;22(3):309-12. [PubMed:10391223 ]
  3. Fleming JC, Tartaglini E, Steinkamp MP, Schorderet DF, Cohen N, Neufeld EJ: The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter. Nat Genet. 1999 Jul;22(3):305-8. [PubMed:10391222 ]
  4. Labay V, Raz T, Baron D, Mandel H, Williams H, Barrett T, Szargel R, McDonald L, Shalata A, Nosaka K, Gregory S, Cohen N: Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness. Nat Genet. 1999 Jul;22(3):300-4. [PubMed:10391221 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP4B1
Uniprot ID:
P13584
Molecular Weight:
58990.64 Da
References
  1. Liu S, Stromberg A, Tai HH, Moscow JA: Thiamine transporter gene expression and exogenous thiamine modulate the expression of genes involved in drug and prostaglandin metabolism in breast cancer cells. Mol Cancer Res. 2004 Aug;2(8):477-87. [PubMed:15328374 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. [PubMed:12089365 ]
  2. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. [PubMed:12606755 ]
  2. Sinclair CJ, Chi KD, Subramanian V, Ward KL, Green RM: Functional expression of a high affinity mammalian hepatic choline/organic cation transporter. J Lipid Res. 2000 Nov;41(11):1841-8. [PubMed:11060354 ]
  3. Green RM, Lo K, Sterritt C, Beier DR: Cloning and functional expression of a mouse liver organic cation transporter. Hepatology. 1999 May;29(5):1556-62. [PubMed:10216142 ]
  4. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:
SLC22A5
Uniprot ID:
O76082
Molecular Weight:
62751.08 Da
References
  1. Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. [PubMed:11160873 ]
  2. Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. [PubMed:10454528 ]
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Drug created on June 13, 2005 07:24 / Updated on February 24, 2017 10:31