Identification
NameThiamine
Accession NumberDB00152  (NUTR00009, APRD00552, EXPT03222)
TypeSmall Molecule
GroupsApproved, Nutraceutical, Vet Approved
Description

Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.

Structure
Thumb
Synonyms
3-(4-AMINO-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium
Aneurin
Antiberiberi factor
Thiamin
Thiamine
thiamine(1+)
thiamine(1+) ion
thiaminium
Vitamin B1
External IDs Not Available
Product Ingredients
IngredientUNIICASInChI KeyDetails
Thiamine HydrochlorideM572600E5P 67-03-8DPJRMOMPQZCRJU-UHFFFAOYSA-MDetails
Thiamine mononitrate8K0I04919X 532-43-4UIERGBJEBXXIGO-UHFFFAOYSA-NDetails
Product Images
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
BetaxinSolution100 mgIntramuscular; IntravenousHospira, Inc.2002-06-01Not applicableCanada
Betaxin Liq 100mg/mlLiquid100 mgIntramuscular; IntravenousSanofi1936-12-312001-08-10Canada
Thiamiject Injection - Liq Im IV 100mg/mlLiquid100 mgIntramuscular; IntravenousOmega Laboratories Ltd1998-07-16Not applicableCanada
Thiamine HCl Inj 100mg/mlLiquid100 mgIntramuscular; IntravenousKripps Pharmacy Ltd.1979-12-31Not applicableCanada
Thiamine HCl Injection - Liq 100mg/mlLiquid100 mgIntramuscular; IntravenousFaulding Consumer, Inc.1998-04-302001-07-30Canada
Thiamine Hydrochloride Inj 100mg/mlLiquid100 mgIntramuscularSaanich Pharmacy1988-12-311997-02-20Canada
Thiamine Hydrochloride Injection USP, 100mg/mlLiquid100 mgIntramuscular; IntravenousAlveda Pharmaceuticals IncNot applicableNot applicableCanada
Thiamine Hydrochloride Injection, USPLiquid100 mgIntramuscular; IntravenousSterimax Inc2001-05-01Not applicableCanada
Vitamin B1Solution100 mgIntramuscular; IntravenousSandoz Canada Incorporated1989-12-31Not applicableCanada
Vitamin B1Solution100 mgIntramuscular; IntravenousMylan Pharmaceuticals1994-12-312015-11-03Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ThiamineInjection, solution100 mg/mLIntramuscular; IntravenousFresenius Kabi2000-09-01Not applicableUs
ThiamineInjection, solution100 mg/mLIntramuscular; IntravenousCardinal Health2000-09-01Not applicableUs
Thiamine HydrochlorideInjection, solution100 mg/mLIntramuscular; IntravenousPhysicians Total Care, Inc.2001-04-18Not applicableUs
Thiamine HydrochlorideInjection, solution100 mg/mLIntramuscular; IntravenousGeneral Injectables & Vaccines2010-09-012017-01-20Us
Thiamine HydrochlorideInjection, solution100 mg/mLIntramuscular; IntravenousMylan Institutional2013-06-04Not applicableUs
Thiamine HydrochlorideInjection, solution100 mg/mLIntramuscular; IntravenousGeneral Injectables & Vaccines2013-08-21Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acti-thiamine Caplet 100mgTablet100 mgOralActi Form Ltd.1991-12-312005-03-21Canada
B-1 Caps 500mgCapsule500 mgOralTwin Laboratories Inc.1995-12-311999-11-10Canada
B1 400mg Ctr TabTablet, extended release400 mgOralBioenergy Inc.1979-12-311998-06-03Canada
B1 Tab 100mgTablet100 mgOralVita Health Products Inc1979-12-312002-07-31Canada
Bewon ElixirLiquid.05 mgOralLaboratoires Charton Laboratories1995-12-311999-01-16Canada
Bewon Elixir 0.05mg/mlElixir.05 mgOralWyeth Ayerst Canada Inc.1994-12-311998-01-28Canada
Thiamine HCl Tab 100mgTablet100 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada
Thiamine HCl Tab 25mgTablet25 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312000-08-17Canada
Thiamine HCl Tab 50mgTablet50 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada
Thiamine Hydrochloride Inj 100mg/ml USPLiquid100 mgIntramuscular; IntravenousDavid Bull Laboratories (Pty) Ltd.1991-12-311998-08-13Canada
Vit B1 Ctr Srt 100mgTablet, extended release100 mgOralBioenergy Inc.1981-12-311998-06-03Canada
Vita-amine Cap 100mgCapsule100 mgOralLes Laboratoires Vachon Inc.1991-12-311997-08-08Canada
Vitamin B-1 100 Mg TabletsTablet100 mgOralGeneral Nutrition Canada Inc.1997-05-062007-08-01Canada
Vitamin B-1 Thiamine HCl 100mgCapsule100 mgOralAlbi Naturals1999-04-302009-07-15Canada
Vitamin B1 100 mgCapsule100 mgOralFlora Manufacturing And Distributing Ltd.2002-03-152004-08-04Canada
Vitamin B1 100mgTablet100 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Vitamin B1 100mg TabletTablet100 mgOralNutricorp International2000-01-242009-08-05Canada
Vitamin B1 Tab 100mgTablet100 mgOralShoppers Drug Mart Inc.1980-12-311997-08-15Canada
Vitamin B1 Tab 100mgTablet100 mgOralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1978-12-312002-07-29Canada
Vitamin B1 Tab 100mg USPTablet100 mgOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312001-07-06Canada
Vitamin B1 Tab 100mg USPTablet100 mgOralPharmavite1987-12-311998-09-08Canada
Vitamin B1 Tab 2mg USPTablet2 mgOralLab Gernetic Int Ltee1985-12-311997-02-21Canada
Vitamin B1 Tablets 100mgTablet100 mgOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada
Vitamine B1 100 Mg - TabletTablet100 mgOralNobel Pharm Enr.1995-12-312001-10-15Canada
Vitamine B1 Tab 100mg USPTablet100 mgOralLaboratoire Lalco Inc.1986-12-312002-09-05Canada
Unapproved/Other Products Not Available
International Brands
NameCompany
Betalin SEli Lilly
BiamineNot Available
Brand mixtures
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Acti-MN + B1 + C CapletTabletOralActi Form Ltd.1991-12-312005-03-21Canada
Active FETabletOralGm Pharmaceuticals2013-11-11Not applicableUs
Adult Infuvite Multiple VitaminsInjection, solutionIntravenousSandoz2005-05-18Not applicableUs
AlertonicElixirOralOdan Laboratories Ltd1995-12-31Not applicableCanada
Allbee With C 550 CapCapsuleOralWhitehall Robins Inc.1994-12-312003-08-01Canada
Allbee With Vitamin C CapCapsuleOralWhitehall Robins Inc.1994-12-312000-07-26Canada
Alsimine W Vitamins A DCapsule; LiquidOralAlsi Cie Ltee1978-12-312003-05-21Canada
Am CapsCapsuleOralNew Vision Nutritionals Company1998-10-012002-11-20Canada
AntlervironCapsuleOralClassical Remedia LtdNot applicableNot applicableCanada
AppedrineTabletOralChattem, Inc.1975-12-312004-07-08Canada
B 50 CapsulesCapsuleOralRheingold Food International Ltd.1987-12-312007-07-26Canada
B 6 PlusTabletOralAnabolic Laboratories Inc.1967-12-312004-03-15Canada
B C Antistress CapCapsuleOralLes Laboratoires Bio SantÉ Inc.1992-12-311996-09-10Canada
B Complex 25mg Vitamin SupplementTabletOralGarden State Nutritionals1998-08-312000-06-07Canada
B Complex 50 Vitamin CapCapsuleOralBioforce Canada Inc.1994-12-311997-07-22Canada
B Complex 50+ CapletTabletOralHealth Wise Nutrition Inc.1994-12-312002-07-18Canada
B Complex 500 TabTabletOralNobel Pharm Enr.1981-12-311998-08-14Canada
B Complex Plus C 300mg TabTabletOralNutricorp International2000-08-012009-08-05Canada
B Complex TabletsTabletOralGolden Neo Life Diamite International, Limited1979-12-312000-08-06Canada
B Complex W C and B12 InjLiquidIntramuscular; IntravenousE L Stickley And Co Ltd.1963-12-311996-09-09Canada
B Complex W C Forte CapCapsuleOralEverest Pharmaceuticals Ltd.1980-12-311999-07-14Canada
B Complex W Vit C W Non-med Yeast&liver TabTabletOralPharmavite1991-12-311997-09-04Canada
B Complex W Vitamin C Fortis CapCapsuleOralShoppers Drug Mart Inc.1984-12-311998-08-14Canada
B Complex With C 300mgCapsuleOralVita Health Products Inc1985-12-312008-08-05Canada
B Complex With C 300mg TabTabletOralPharmavite1987-12-312005-07-15Canada
B Complex With C 550mgCapsuleOralVita Health Products Inc1990-12-312002-07-31Canada
B Compound 50mg TabTabletOralGahler Enterprises Ltd.1987-12-312009-09-28Canada
B Plus C 300mg Timed ReleaseTablet, extended releaseOralVita Health Products Inc1981-12-312008-08-05Canada
B Stress C + Iron & ViteTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1990-12-312004-07-26Canada
B Totum 500TabletOralDesbergers LtÉe, Division Of Technilab Inc.1966-12-311999-09-17Canada
B VirolElixirOralRolmex International Inc.1975-12-312008-07-09Canada
B Vitamin Compound With B12 ThunasLiquidOralThuna Herbal Remedies Ltd.1984-05-312002-10-16Canada
B With C 500 CapCapsuleOralPharmetics (2011) Inc.1995-12-312006-07-27Canada
B-100 CapsCapsuleOralNow Foods2005-05-192008-07-11Canada
B-100 Complex TabletsTablet, extended releaseOralViva Pharmaceutical Inc.2001-06-052009-12-18Canada
B-100 Hi Potency B Vitamins TabTabletOralNatrol, Inc.1994-12-312009-05-07Canada
B-100 Vitamin SupplementTablet, extended releaseOralGarden State Nutritionals1998-09-222000-06-07Canada
B-50 ComplexTabletOralVita Health Products Inc1977-12-312004-07-26Canada
B-50 Complex TabTabletOralVita Health Products Inc1988-12-311998-07-22Canada
B-50 Hi Potency B Vitamins TabTabletOralNatrol, Inc.1994-12-312006-09-26Canada
B-ComboInjectionIntramuscularPerdido Key Health And Wellness Inc2015-11-23Not applicableUs
B-complexTabletOralEnrich International1999-11-112001-09-28Canada
B-complex 100TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
B-complex 50TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
B-complex TabTabletOralNatures Sunshine Products, Inc.1995-12-312009-08-07Canada
B-complex TabletsTabletOralShaklee Corporation1983-12-312000-01-24Canada
B-complex With Vitamin C, Biotin, Folic AcidTabletOralWn Pharmaceuticals Ltd.2001-11-232009-09-28Canada
B-complex-50 TabTabletOralJr Carlson Labs Inc1998-10-252005-09-15Canada
B-plexTabletOralWn Pharmaceuticals Ltd.1999-10-202000-01-28Canada
B-plex 100Injection, solutionIntramuscular; IntravenousMerit Pharmaceuticals2012-01-01Not applicableUs
B-plus - TabTabletOralChampion's Choice Advanced Nutrition Inc.1997-06-111999-08-28Canada
B50 B Complex TabTabletOralNutristar Health Products (1987) Inc.1983-12-311996-09-09Canada
B50 ComplexCapsuleOralPreferred Nutrition Inc.2003-10-292005-08-04Canada
B6 Plus TabTabletOralVita Health Products Inc1979-12-312002-08-01Canada
BacminTablet, coatedOralMarnel Pharmaceuticals, Llc2000-04-01Not applicableUs
Balanced B 125 SrtTablet, extended releaseOralAnabolic Laboratories Inc.1981-12-311996-10-02Canada
Balanced B-100 B-complex Vitamins TabTabletOralPharmavite1991-12-312003-07-30Canada
Balanced B-100 Timed ReleaseTabletOralPharmavite2000-10-242005-07-15Canada
Balanced B-50 B-complex Vitamins TabTabletOralPharmavite1995-12-312000-08-24Canada
Balanced B-50 B-complex Vitamins, Timed ReleTabletOralPharmavite1995-12-312006-07-05Canada
Balanced B-50 ComplexTabletOralLeiner Health ProductsNot applicableNot applicableCanada
Balanced B-complex Vit + Vit C&e TabTabletOralPharmavite1991-12-312006-07-05Canada
Balanced B100TabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Balanced B50 ComplexTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Beminal W C Fortis InjPowder, for solutionIntramuscular; IntravenousAyerst Laboratories1951-12-311996-09-10Canada
Beminal With C Fortis CapCapsuleOralWyeth Ayerst Canada Inc.1994-12-312001-08-03Canada
Beminal With C Fortis PwsPowder, for solutionIntravenousWyeth Ayerst Canada Inc.1994-12-312000-08-02Canada
Bev 29 TabTabletOralBeverly International Nutrition1987-12-311998-08-01Canada
Bev B-150TabletOralBeverly International Nutrition1986-12-311998-08-01Canada
Biovim TabTabletOralLe Naturiste J.M.B. Inc.1977-12-312008-07-31Canada
BiovitaGranuleOralIldong Pharmaceutical Co., Ltd.2015-06-03Not applicableUs
Bugs Bunny and Friends Multiple VitaminsTabletOralBayer Inc Consumer Care1996-12-312004-04-15Canada
Bugs Bunny Chew Multi Vit Plus IronTabletOralMiles Inc. Pharmaceutical Division1983-12-311996-09-09Canada
C-B ComplexTabletOralAvacare, Division Of Jeunique International Inc.1984-12-311996-09-09Canada
C-forceCapsuleOralPrairie Naturals1997-04-012002-06-21Canada
C-Nate DHACapsule, gelatin coatedOralCenturion Labs2013-01-01Not applicableUs
C.R.T. X Multivitamin & Mineral Powder MixPowderOralMetaform Ltd.1998-12-082001-07-23Canada
Cal M TabTabletOralAnabolic Laboratories Inc.1978-12-312004-03-15Canada
Carbassist TabletsTabletOralWyeth Ltd.1978-12-312006-07-24Canada
Cc IIPowderOralAdded Dimensions1997-03-262006-09-25Canada
Cda-21 Vitamins With Non-medicinal Probiotic ComplexCapsuleOralRx Vitamins Inc.2006-08-012007-10-25Canada
Cedevita Plus Vitamin SupplementPowderOralPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.Not applicableNot applicableCanada
Cedevita Sugar-free Vitamin SupplementPowderOralPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.Not applicableNot applicableCanada
Central-vite 18 EssentialTabletOralVita Health Products Inc1998-04-242002-07-31Canada
Century CompleteTabletOralVita Health Products Inc1998-03-172002-07-31Canada
Chela Potassium PlusTabletOralNu Life Nutrition Ltd.1988-12-312000-03-03Canada
Chela-chromium 200TabletOralNu Life Nutrition Ltd.1986-12-312000-03-03Canada
Chela-manganese 50 PlusTabletOralNu Life Nutrition Ltd.1987-12-312000-03-03Canada
Chew.multiple Vits.with Extra C for ChildrenTabletOralRandle Pharmaceutical Inc.1996-09-191999-09-03Canada
Chewable Multiple Vit Plus Iron for ChildrenTabletOralRandle Pharmaceutical Inc.1996-09-191999-09-03Canada
Chewable Multiple Vitamins for ChildrenTabletOralRandle Pharmaceutical Inc.1996-09-191999-09-03Canada
Chewable Multiple Vitamins Plus Extra CTabletOralRandle Pharmaceutical Inc.1993-12-311999-09-03Canada
Chewable Multiple Vitamins Plus Iron TabTabletOralRandle Pharmaceutical Inc.1993-12-311999-09-03Canada
Chewable Multiple Vitamins TabTabletOralRandle Pharmaceutical Inc.1993-12-311999-09-03Canada
Chewable MultivitaminsTabletOralWn Pharmaceuticals Ltd.2002-05-312008-07-17Canada
Chewable Multivitamins Plus IronTabletOralWn Pharmaceuticals Ltd.2002-05-312007-08-07Canada
Children Choice Multivit Chewable TabTabletOralSwiss Herbal Remedies Ltd.1990-12-312009-08-04Canada
Children Choice Multivitamin W Iron Chew TabTabletOralSwiss Herbal Remedies Ltd.1991-12-312009-08-04Canada
Children's Chewable Multi Vit W IronTabletOralShoppers Drug Mart Inc.1982-12-311997-08-15Canada
Children's Chewable Multi VitaminsTabletOralShoppers Drug Mart Inc.1982-12-311997-08-15Canada
Children's Chewable Multi Vitamins With Iron TabletsTabletOralVita Health Products Inc1998-05-202008-08-05Canada
Children's Chewable Multi-vitaminTabletOralWn Pharmaceuticals Ltd.2000-03-012007-08-07Canada
Children's Chewable Multi-vitamin Complete With MineralsTabletOralWn Pharmaceuticals Ltd.2000-03-012001-07-18Canada
Children's Chewable Multiple Vit.plus IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-10-102002-07-31Canada
Children's Chewable Multiple Vitamins - TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-10-102002-07-31Canada
Children's Chewable Multiple Vitamins (chewable Tablets)TabletOralPharmetics (2011) Inc.1999-08-162009-07-30Canada
Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets)TabletOralPharmetics (2011) Inc.1999-08-162009-07-30Canada
Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets)TabletOralPharmetics (2011) Inc.1999-08-162009-07-30Canada
Children's Vitamins ChewableTabletOralVita Health Products Inc1990-12-312002-07-31Canada
Children's Vitamins W Iron ChewableTabletOralVita Health Products Inc1990-12-312002-07-31Canada
Childrens Chew Multi Vitamin TabTabletOralNutristar Health Products (1987) Inc.1983-12-311996-09-09Canada
Childrens Chewable Multiple VitaminsTabletOralKsl Pharmaceuticals1994-12-311999-08-12Canada
Childrens Chewable Multiple Vitamins Plus FeTabletOralKsl Pharmaceuticals1994-12-312000-08-29Canada
Childrens Chewable Multiple Vitamins TabTabletOralPharmavite1987-12-312000-08-24Canada
Childrens Chewable MultivitaminsTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Childrens Chewable Multivitamins W IronTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Childrens Chewable Vitamin TabTabletOralPharmetics (2011) Inc.1993-12-312006-07-27Canada
Childrens Chewable VitaminsTabletOralD.C. Labs Limited1974-12-312003-07-11Canada
Childrens Multiple Vit and Min Chew TabTabletOralCountry Health Laboratories Ltd.1982-12-312008-07-17Canada
Chromease TabTabletOralAnabolic Laboratories Inc.1981-12-312004-03-15Canada
CitraNatal DHATabletOralMission Pharmacal2007-11-20Not applicableUs
CitraNatal RxTabletOralMission Pharmacal2014-08-11Not applicableUs
Complete Mega BTabletOralGahler Enterprises Ltd.1985-12-312001-07-26Canada
Complete Multivitamins and Minerals for ChildrenTabletOralQuest Vitamins A Div Of Purity Life Health Products2001-01-312004-06-29Canada
Complete Multivitamins and Minerals Tablets Timed ReleaseTablet, extended releaseOralPharmetics (2011) Inc.1999-07-262009-07-30Canada
Complex 5 - PwrPowderOralAst Research1996-03-151998-08-10Canada
Complex-75CapsuleOralFrega Inc.1990-12-311999-08-06Canada
Complexe B 75mgTabletOralPharmalab Inc.1994-12-312001-07-30Canada
Complexe B Compose 75TabletOralLes Laboratoires Bio SantÉ Inc.1983-12-311996-09-10Canada
Complexe B-75TabletOralFrega Inc.1998-06-292008-02-13Canada
Concept DHACapsule, liquid filledOralUs Pharmaceutical Corporation2009-06-24Not applicableUs
Concept OBCapsuleOralUs Pharmaceutical Corporation2009-01-01Not applicableUs
Croq-vit Pour EnfantsTabletOralNutrivac Ltee1987-12-311996-09-09Canada
CyroplexTabletOralTherapeutic Foods Co.1987-12-312003-07-16Canada
D'pantothenic Acid-B1-B2 TabTabletOralHealth Thru Herbs Inc.1985-12-312001-06-21Canada
Daily Energy Brand B-complexCapsuleOralEnzymatic Therapy, Inc.2004-01-012008-07-25Canada
Derma-forceCapsuleOralPrairie Naturals1997-04-012006-09-20Canada
Dexatrim TabletsTabletOralChattem, Inc.1996-09-092005-06-29Canada
Dia-viteTabletOralR & D Laboratories Inc.1997-08-132003-07-16Canada
DiaplexTabletOralNephro Tech, Inc.2002-07-102004-07-23Canada
Dynam Ampoule Et TabletLiquid; TabletOralCardinaux Enrg Les Produits Naturels1989-12-311996-09-09Canada
E.S.T. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Efferlife Multivitamins and MineralsTablet, effervescentOralNaturale Science Inc.2001-10-012006-10-10Canada
Enviroflex - TabTabletOralEnviro Tech International Canada1997-09-151999-07-26Canada
EscaviteTablet, chewableOralGm Pharmaceuticals2012-02-01Not applicableUs
Essential B TabletsTabletOralGeneral Nutrition Canada Inc.1997-04-182006-08-03Canada
Everyday Multiple VitaminsTabletOralD.C. Labs Limited1972-12-312003-07-11Canada
Everyday Multiple Vitamins With IronTabletOralD.C. Labs Limited1972-12-312003-07-11Canada
Extra P.N. Vitamin-mineral Drink MixPowderOralChanges InternationalNot applicableNot applicableCanada
Feminique W Iron and Calcium TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1992-12-311998-08-13Canada
Ferra Naka Plus VitaminsLiquidOralNaka Sales Ltd.1999-05-052001-07-23Canada
Flinstones Multiple Plus IronTabletOralMiles Inc. Pharmaceutical Division1971-12-311996-09-09Canada
Flintstones Multiple VitaminsTabletOralBayer Inc Consumer Care1995-12-312004-06-28Canada
Flintstones Multiple Vitamins Plus IronTabletOralBayer Inc Consumer Care1995-12-312004-06-28Canada
Flintstones Multiple Vitamins TabTabletOralMiles Inc. Pharmaceutical Division1970-12-311996-09-09Canada
Flintstones W Extra C TabTabletOralMiles Inc. Pharmaceutical Division1981-12-311996-09-09Canada
Floradix Formula LiqLiquidOralFlora Manufacturing And Distributing Ltd.1979-12-312002-06-05Canada
Floravit - SyrSyrupOralFlora Manufacturing And Distributing Ltd.1995-05-282009-08-05Canada
FlorivaTablet, chewableOralBon Geo Pharmaceuticals, Inc.2015-09-10Not applicableUs
Floriva PlusSolution / dropsOralBon Geo Pharmaceuticals, Inc.2015-12-28Not applicableUs
Foltabs PrenatalTabletOralMidlothian Laboratories2009-01-01Not applicableUs
For Kids Only Chewable Multivit. Plus IronTabletOralKsl Pharmaceuticals1996-12-312002-07-31Canada
For Kids Only Chewable Multivitamins - TabTabletOralKsl Pharmaceuticals1996-12-312002-07-31Canada
Formula BCapsuleOralBalance Plus, Inc.2000-04-192004-08-17Canada
Formula D.S.TabletOralGolden Pride InternationalNot applicableNot applicableCanada
Formula Fm Vitamins & Minerals TabTabletOralMetagenics, Inc.1997-01-272001-10-05Canada
Formula LfTabletOralNumark Laboratories, Inc.2003-12-152009-07-31Canada
Formula Pro-BCapsuleOralBalance Plus, Inc.2000-03-082004-08-17Canada
Fortamines 10 CapsulesCapsuleOralRougier Pharma Division Of Ratiopharm Inc1974-12-311999-09-27Canada
Fortamines-10 ComprimesTabletOralRougier Pharma Division Of Ratiopharm Inc1979-12-312003-09-22Canada
Fortaplex InjLiquidIntramuscular; IntravenousKripps Pharmacy Ltd.1979-12-31Not applicableCanada
Fortistress TabTabletOralSantÉ Naturelle (Ag) LtÉe1993-12-312001-07-06Canada
Forty Plus Vitamin SupplementTabletOralGarden State Nutritionals1998-10-162000-06-07Canada
G.A.S. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Garfield Chewable Multivits Plus Iron TabTabletOralWhitehall Robins Inc.1993-12-312000-07-26Canada
Gemvites Jr Tab ChewableTabletOralPharmavite Laboratories (1987) Inc.1969-12-311999-10-19Canada
Geritol LiquidLiquidOralGlaxosmithkline Inc1992-12-312002-07-31Canada
Gestamine ComprimesTabletOralLab Nadeau LtÉe, Division Of Technilab Inc.1957-12-311999-09-28Canada
Gesticare DHAKitJazz Pharmaceuticals Commercial Corp.2008-10-01Not applicableUs
Glyco-aide TabTabletOralAvant Garde, Les SupplÉments1995-12-311998-07-08Canada
Harvest Of Values All B Complex TabTabletOralHillestad Pharmaceuticals Usa1997-09-242009-09-22Canada
healthy mamaBE WELL ROUNDED BE WELL ROUNDEDTablet, film coatedOralMATERNAL SCIENCE, LLC2013-07-09Not applicableUs
Hemarexin AmpLiquidOralLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.1958-12-311999-01-22Canada
Hemarexin Liquid and Drinkable AmpoulesLiquidOralSabex Inc1997-08-192009-11-26Canada
Hemarexin TabTabletOralLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.1997-12-172004-08-03Canada
HemeNatal OBTabletOralWh Nutritionals, Llc2012-03-08Not applicableUs
Hi Potency B Complex W Chelated MineralsTabletOralKlaire Labs Inc.1984-12-312004-01-19Canada
Hi Potency B52 B Complex TabTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Hi Potency Balanced B-100 Complex - TabTabletOralLeiner Health ProductsNot applicableNot applicableCanada
Hi Potency Stress B Tension With CTabletOralLee Adams Laboratories1982-12-312010-08-05Canada
High Potency Vitamin B Complex + C TabTabletOralVita Health Products Inc1996-10-112004-07-26Canada
Hill.viteTabletOralHillestad Pharmaceuticals Usa2001-11-142009-09-22Canada
Hormodausse Plus Calc Et D TabTabletOralLaboratoires Charton Laboratories1988-12-311999-01-16Canada
Hypo Vites TabTabletOralPharmetics (2011) Inc.1977-12-312006-07-27Canada
Iberet 500Tablet, extended releaseOralAbbott1965-12-312007-07-31Canada
Inatal AdvanceTablet, coatedOralNnodum Pharmaceuticals2005-06-10Not applicableUs
INATAL UltraTablet, coatedOralNnodum Pharmaceuticals2005-06-20Not applicableUs
Infa Drops MultivitaminsLiquidOralVita Health Products Inc1998-05-202002-07-31Canada
Infant Multivitamin DropsSolution / dropsOralGeneral Nutrition Canada Inc.2002-10-202005-08-05Canada
Infantol DropsSolution / dropsOralChurch & Dwight Company, Inc.1988-12-312008-07-30Canada
Infuvite Adult Multiple VitaminsInjection, solutionIntravenousSandoz2005-05-18Not applicableUs
Insur-all Vitamin SupplementTabletOralGarden State Nutritionals1998-10-162000-06-07Canada
Integra PlusCapsuleOralUs Pharmaceutical Corporation2009-04-27Not applicableUs
Iron 25mg With Vit B-cmplx, Vit C, Cu & MoCapsuleOralQuest Vitamins A Div Of Purity Life Health Products1996-07-232002-07-29Canada
Iron Polysaccharides Folic Acid DHATablet, film coatedOralVirtus Pharmaceuticals2013-12-202017-08-11Us
Kanga Sport Vitamins B & C Plus MineralsTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-B Vitamin B Group + CTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-kid Multi-vitamin & MineralTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-kid Vitamins & IronTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-V Multivitamins & MineralsTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kenwood Liquid SupplementLiquidOralKenwood Laboratories (Division Of Bradley Pharmaceuticals)Not applicableNot applicableCanada
Kid's Choice Children's Chewable Vitamins - TabTabletOralVita Health Products Inc1998-04-162002-07-31Canada
Kids Stuff TabletsTabletOralVita Health Products Inc1998-04-202002-07-31Canada
Kids Stuff With Iron TabletsTabletOralVita Health Products Inc1998-04-202002-07-31Canada
Kimchi Vitamin chewable multivitaminTablet, chewableOralTobico2010-03-18Not applicableUs
KindervitesSolution / dropsOralHerbalife International Of America1984-12-312002-09-17Canada
L.G.I.T.CapsuleOralMorinda Canada1999-12-152001-07-23Canada
Leritone JuniorCapsuleOralInstitut De Recherche Biologique Yves Ponroy Canada Inc.1998-12-072004-12-23Canada
Lipo-B-C TabTabletOralMetagenics, Inc.1989-12-311996-10-02Canada
Liqui B ComplexLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liqui B Complex PlusLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liqui Infant VitaminsLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liqui VitaLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liquid B Complex 50LiquidOralJamieson Laboratories Ltd1985-12-311997-08-13Canada
Livron Plus AmpouleLiquidOralMedic Laboratory LtÉe1980-12-311996-09-09Canada
Livron Plus TabTabletOralMedic Laboratory LtÉe1980-12-311996-09-09Canada
Low Potency B Complex TabTabletOralFlora Manufacturing And Distributing Ltd.1983-12-311999-10-18Canada
Lysamine Diet Supp Amp-tabLiquid; TabletOralWelcker Lyster Ltd., Division Of Technilab Inc.1983-12-311999-09-17Canada
M.V.I. 12LiquidIntravenousAventis Pharma Ltd.1992-12-312002-07-29Canada
M.V.I. PaediatricLiquidIntravenousAventis Pharma Ltd.1988-12-312002-07-29Canada
M.V.I. PediatricInjection, powder, lyophilized, for solutionIntravenousHospira Worldwide, Inc.1983-04-06Not applicableUs
Maltlevol 12 LiqLiquidOralCarter Horner Corp.1978-12-312002-02-07Canada
Maltlevol LiqLiquidOralCarter Horner Corp.1980-12-312005-03-21Canada
MangadynTabletOralNutri Dyn Products Ltd.1982-12-311997-08-22Canada
Maxi 10 TabTabletOralDesbergers LtÉe, Division Of Technilab Inc.1979-12-311999-09-17Canada
Maxi 6 LiqLiquidOralDesbergers LtÉe, Division Of Technilab Inc.1980-12-311999-09-17Canada
Medi Msm (methyl Sulfonyl Methane)PowderTopicalMbg Inc (Korea Institute of Science Development)2016-09-162017-09-16Us
Mega 13 Multivitamin FormulaCapsuleOralVita Health Products Inc1988-12-311998-07-22Canada
Megavites TabTabletOralIcn Pharmaceuticals1973-12-312005-04-26Canada
Meplex T 750TabletOralMedic Laboratory LtÉe1966-12-311996-09-09Canada
MethaverCapsuleOralSterling Knight Pharmaceuticals, Llc2015-11-24Not applicableUs
Mini-B TabTabletOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Mor-vites TabTabletOralPharmetics (2011) Inc.1992-12-312006-07-27Canada
Multi - N.T.O.x Formula - TabTabletOralAbundance Naturally LtdNot applicableNot applicableCanada
Multi 12 InjectionLiquidIntravenousSandoz Canada Incorporated1994-12-31Not applicableCanada
Multi BTabletOralSeroyal International Inc.1988-12-312009-07-06Canada
Multi Enfants TabTabletOralVitalab1992-12-311997-07-22Canada
Multi Nt-OXTabletOralAbundance Marketing Ltd.1999-02-012001-07-10Canada
Multi RolLiquid; TabletOralRolmex International Inc.1975-12-311997-08-08Canada
Multi Vitamin - MineralTabletOralEnrich International1999-11-112001-09-28Canada
Multi Vitamin & MineralsTabletOralWn Pharmaceuticals Ltd.2002-01-042008-07-17Canada
Multi Vitamin and FluorideSolution / dropsOralLibertas Pharma, Inc.2011-05-21Not applicableUs
Multi Vitamin Drops with FluorideSolution / dropsOralSeton Pharmaceuticals2014-04-18Not applicableUs
Multi Vitamin Drops with Fluoride and IronSolution / dropsOralSeton Pharmaceuticals2014-04-18Not applicableUs
Multi Vitamin Drops with Fluoride with IronLiquidOralStratus Pharmaceuticals2014-09-01Not applicableUs
Multi Vitamin Plus IronTabletOralWn Pharmaceuticals Ltd.2002-03-132009-09-28Canada
Multi Vitamin with FluorideTablet, chewableOralQualitest2009-10-092016-10-13Us
Multi Vitamin-mineral FormulaTabletOralVita Health Products Inc1997-04-031998-01-16Canada
Multi Vitamin, Iron and FluorideSolution / dropsOralMayne Pharma2011-05-212019-10-31Us
Multi Vitamines - LiqLiquidOralLand Art Inc.1995-12-312008-06-26Canada
Multi Vitamins & MineralsTabletOralWn Pharmaceuticals Ltd.2000-01-122001-04-12Canada
Multi Vite Liq AdultLiquidOralPharmetics (2011) Inc.1981-12-312001-07-26Canada
Multi Vite Liq JuniorLiquidOralPharmetics (2011) Inc.1981-12-312001-07-26Canada
Multi-11SolutionIntravenousSandoz Canada Incorporated2002-01-28Not applicableCanada
Multi-12 PediatricLiquidIntravenousSabex Inc1998-04-092009-11-26Canada
Multi-12/k1 PediatricLiquidIntravenousSandoz Canada Incorporated2000-11-07Not applicableCanada
Multi-Vit with FluorideSolutionOralA S Medication Solutions1997-04-182017-06-20Us
Multi-Vit with Fluoride and IronSolutionOralQualitest1998-01-07Not applicableUs
Multi-VitaminLiquidOralLLC Federal Solutions2013-08-12Not applicableUs
Multi-vitamin Dietary SupplementTabletOralGarden State Nutritionals1998-09-222000-06-07Canada
Multi-Vitamin Drops with Fluoride and IronLiquidOralMethod Pharmaceuticals2017-02-24Not applicableUs
Multi-Vitamin FluorideLiquidOralStratus Pharmaceuticals2014-09-01Not applicableUs
Multi-Vitamin Fluoride and Iron DropsSolutionOralBoca Pharmacal, Inc.2011-04-202015-12-29Us
Multi-Vitamin Fluoride DropsSolutionOralH.J. Harkins Company2011-05-04Not applicableUs
Multi-Vitamin With FluorideTablet, chewableOralGolden State Medical Supply2010-12-17Not applicableUs
Multi-vitamines Enfants ComprimeTabletOralHerbes Universelles Inc.1997-09-292009-07-15Canada
Multi-vitaminsTabletOralWn Pharmaceuticals Ltd.1999-12-222008-07-17Canada
Multi-vitamins With MineralsTabletOralWn Pharmaceuticals Ltd.2001-04-122009-09-28Canada
Multiple Vitamin Plus Minerals TabTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Multiple Vitamin TabTabletOralAdams Laboratories1983-12-312009-12-02Canada
Multiple VitaminsTabletOralGfr Pharma Ltd.2002-10-102007-07-20Canada
Multiple Vitamins & Minerals TabletsTabletOralPharmetics (2011) Inc.2002-12-182006-07-27Canada
Multiple Vitamins and Minerals TabTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Multiple Vitamins Plus Iron for WomenTabletOralPharmetics (2011) Inc.1999-08-162006-07-27Canada
Multiple Vitamins Plus Iron TabTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Multiple Vitamins TabTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Multiple Vitamins W Minerals TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1976-12-312002-07-31Canada
Multiple Vitamins With IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1987-12-312002-07-31Canada
Multiple Vitamins With Minerals TabletsTabletOralPharmetics (2011) Inc.1999-07-162009-07-30Canada
MultisolLiquidOralLes Laboratoires Vachon Inc.1979-12-311997-02-06Canada
Multivit Et Fer Ampoules Et ComprimesLiquid; TabletOralNobel Pharm Enr.1988-12-311998-08-14Canada
Multivit-liqLiquidOralPharmalab Inc.1995-12-311997-08-08Canada
MultivitaminTabletOralLaboratoires Confab IncNot applicableNot applicableCanada
Multivitamin Drops with FluorideSolution / dropsOralSancilio & Company, Inc.2017-04-10Not applicableUs
MultiVitamin Drops with Fluoride and IronLiquidOralSancilio & Company, Inc.2017-08-24Not applicableUs
Multivitamin with fluorideTablet, chewableOralA S Medication Solutions2011-12-202017-06-20Us
MultivitaminesTabletOralRolmex International Inc.1998-05-112007-07-09Canada
Multivitamines Et MinerauxTabletOralLe Groupe M. Vachon Inc.Not applicableNot applicableCanada
Multivitamines Et Mineraux Junior RegulierTabletOralLaboratoire Riva Inc1996-10-082008-07-30Canada
Multivitamines Et Mineraux Reguliers / Regular Multivitamins and MineralsTabletOralVita Health Products Inc1998-10-062004-07-26Canada
Multivitamines Plus Fer Pour Enfants (chewable Tablets)TabletOralLaboratoire Lalco Inc.1998-07-032002-09-05Canada
Multivitamines Pour Enfants (chewable Tablets)TabletOralLaboratoire Lalco Inc.1998-07-032002-09-05Canada
Multivitamins and Minerals - CompleteTabletOralVita Health Products Inc2000-02-012006-07-31Canada
Multivitamins and Multiminerals Formula Regular TabletTabletOralPharmetics (2011) Inc.2001-11-222009-07-30Canada
Multivitamins for ChildrenTabletOralQuest Vitamins A Div Of Purity Life Health Products2001-01-312004-06-29Canada
Multivitamins W IronTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
MvcTablet, chewableOralSancilio & Company Inc.2009-12-20Not applicableUs
MVC-FluorideTablet, chewableOralSancilio & Company Inc.2011-12-07Not applicableUs
Myhephron Dialysis and Stress SupplementCapsuleOralMartin Ekwealor Pharmaceu2016-08-01Not applicableUs
Mynephrocaps Dialysis/stress Vitamin SupplementCapsuleOralMartin Ekwealor Pharmaceuticals, Inc.2013-12-16Not applicableUs
N.E.U. ComplexTabletOralAbundance Marketing Ltd.2000-12-042004-06-30Canada
Nata KompleteTabletOralWh Nutritionals, Llc2011-06-252016-12-06Us
NataFortTabletOralMission Pharmacal2011-08-25Not applicableUs
NataviteTabletOralSchein Pharmaceutical Canada Inc.1997-07-292004-07-26Canada
Neo Bex ElixirElixirOralNeolab Inc1984-12-311997-08-12Canada
Neo Vites TabTabletOralNeolab Inc1979-12-311997-08-12Canada
Neo-bexTabletOralNeolab Inc1987-12-312005-08-02Canada
Neo-bex InjectableSolutionIntramuscular; IntravenousBrostel Inc.1951-12-31Not applicableCanada
Neo-vites & Minerals TabTabletOralNeolab Inc1987-12-311997-08-12Canada
NephrocapsCapsule, liquid filledOralCardinal Health2010-01-14Not applicableUs
Nutrifer Plus TabletsTabletOralWyeth Ayerst Canada Inc.1994-12-311999-09-23Canada
Nutrilite Double XTabletOralNutrilite, A Division Of Access Business Group, Llc2002-12-152008-06-24Canada
Nutrol-B-complexTabletOralRolmex International Inc.1999-06-282008-07-09Canada
O-Cal FA multivitaminTabletOralPharmics, Inc.1970-01-15Not applicableUs
O-Cal Prenatal VitaminTabletOralPharmics, Inc.2002-01-23Not applicableUs
OnccorTabletOralSimone Protective Pharmaceuticals, Inc.Not applicableNot applicableCanada
One A Day Advance AdultsTabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance Adults 50+TabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance FemTabletOralBayer Inc Consumer Care1999-03-012001-02-22Canada
One A Day TabTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Opti-manganese + B1 + C CapletTabletOralNu Life Nutrition Ltd.1991-12-312005-03-15Canada
Orange Flavored Crystal Chews TabTabletOralJeunique International Inc.1998-02-172006-07-20Canada
Orifer FTabletOralSanofi Aventis1995-12-312007-11-22Canada
Original Bioscal Forte Multi-vitamin Supplement CapsulesCapsuleOralCarram Inc.1997-05-071999-07-30Canada
Orti BCapsuleOralSeroyal International Inc.1983-12-312008-10-09Canada
P.N.P. Vitamin DrinkLiquidOralChanges InternationalNot applicableNot applicableCanada
P.R.O. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Paramettes Chewable Multivitamins Plus IronTabletOralWyeth Ayerst Canada Inc.1994-12-312000-08-02Canada
Paramettes Chewable Multivits With Iron TabTabletOralWhitehall Robins Inc.1994-12-311996-09-09Canada
Paramettes Multivits Plus Iron Tab (teens)TabletOralWhitehall Robins Inc.1993-12-311996-09-09Canada
Paramettes SyrupSyrupOralWyeth Ayerst Canada Inc.1994-12-312002-07-31Canada
Pediatric Infuvite Multiple VitaminsInjection, solutionIntravenousSandoz2001-02-21Not applicableUs
Pediatric Infuvite Multiple Vitamins for InfusionInjection, solutionIntravenousSandoz2001-02-21Not applicableUs
Penta-thion PwrPowderOralSabex Inc1994-12-312008-08-07Canada
Permathene-12 - CapletTabletOralCca Industries, Inc1995-12-312000-12-14Canada
Phosthenine Vitamines Et Fer (ampoules Buvable)LiquidOralLaboratoires Cortunon Inc.1997-01-232007-07-23Canada
Phytofortis + Calcium A-DLiquid; TabletOralPhyto Health Corporation1983-12-312003-11-27Canada
Phytoplex B LiqLiquidOralPhyto Health Corporation1973-12-312004-08-30Canada
PhytopureCapsuleOralLaboratoire Lalco Inc.1993-12-312001-10-15Canada
PM CapsCapsuleOralNew Vision Nutritionals Company1998-10-012002-11-20Canada
PNV Ferrous Fumarate Docusate Folic AcidTabletOralVirtus Pharmaceuticals2014-04-22Not applicableUs
PNV Prenatal Plus MultivitaminTabletOralClinical Solutions Wholsesale2013-04-012017-07-03Us
PNV Prenatal VitaminTablet, chewableOralSancilio & Company Inc.2011-12-20Not applicableUs
PNV Prenatal Vitamin Plus Vitamin ATabletOralSancilio & Company Inc.2012-12-07Not applicableUs
PNV-FirstTablet, coatedOralAcella Pharmaceuticals, LLC2013-05-17Not applicableUs
PNV-SelectTablet, film coatedOralAcella Pharmaceuticals, LLC2009-11-02Not applicableUs
Poly-VI-sol DropsLiquidOralMead Johnson Nutritionals1986-12-312000-09-11Canada
Polymine Avec Zinc Et CuivreTabletOralLes Laboratoires Vachon Inc.1985-12-312007-07-12Canada
Potassium Plus Vit B ComplexTabletOralAnabolic Laboratories Inc.1981-12-311996-10-02Canada
Prefera OB plus DHATabletOralAlaven Pharmaceutical2009-04-01Not applicableUs
PreferaOBTablet, coatedOralMeda Pharmaceuticals Ltd2015-04-28Not applicableUs
PreferaOB plus DHATabletOralAlaven Pharmaceutical2010-11-15Not applicableUs
PregvitTabletOralDuchesnay Inc.2003-08-252016-07-05Canada
Pregvit Folic 4TabletOralDuchesnay Inc.Not applicableNot applicableCanada
Pregvit Folic 5TabletOralDuchesnay Inc.2006-03-172016-07-05Canada
PreNatal 19Tablet, coatedOralNationwide Laboratories2013-06-01Not applicableUs
Prenatal Mega AntioxidantTabletOralUsana Health Services, Inc.2012-04-11Not applicableUs
Prenatal PlusTablet, film coatedOralBlenheim Pharmacal, Inc.2010-12-09Not applicableUs65162 0668 50 nlmimage10 120e0910
Prenatal Plus IronTablet, film coatedOralMajor2011-06-07Not applicableUs
PreNatal Vitamins PlusTabletOralbryant ranch prepack2011-04-15Not applicableUs
Prenatal Vitamins Plus Low IronTabletOralPatrin Pharma2013-04-01Not applicableUs39328 0106 10 nlmimage10 df476fdb
Prenatal, DHAKitPure Tek Corporation2017-08-10Not applicableUs
Prenate EliteTablet, coatedOralAvion Pharmaceuticals, Llc2012-08-06Not applicableUs
Prenate StarTablet, coatedOralAvion Pharmaceuticals, Llc2014-06-05Not applicableUs
PrePLUSTabletOralVirtus Pharmaceuticals2014-04-04Not applicableUs
PreQue 10TabletOralActavis Pharma Company2011-11-01Not applicableUs
PreTABTabletOralVirtus Pharmaceuticals2014-04-092017-08-08Us
Prevital TabTabletOralBio Vita1991-12-312000-07-20Canada
PureVit DualFe PlusCapsuleOralPure Tek Corporation2011-06-01Not applicableUs
Q.T. Vitamin and Mineral Drink MixPowderOralGarden State NutritionalsNot applicableNot applicableCanada
Reaphirm Plant Source DHACapsule, gelatin coatedOralEverett Laboratories, Inc.2011-12-05Not applicableUs
Reno CapsCapsuleOralNnodum Pharmaceuticals2008-11-30Not applicableUs63044 0622 01 nlmimage10 7d3cbea5
ReplaviteTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1999-10-202002-07-31Canada
Revit Plus CapCapsuleOralIcn Pharmaceuticals1972-12-311998-08-13Canada
Revit TabTabletOralIcn Pharmaceuticals1980-12-311998-08-13Canada
Revitex Ampoules Et ComprimesLiquid; TabletOralLes Produits Gerbex Inc.1988-12-312005-06-29Canada
Revival 1 TabTabletOralBio Vita1991-12-311999-08-12Canada
Right Choice A.M. Multi Formula - CapletTabletOralBody Wise International LlcNot applicableNot applicableCanada
Se-Natal 19TabletOralSeton Pharmaceuticals2009-07-01Not applicableUs
Se-Natal 19 ChewableTablet, chewableOralSeton Pharmaceuticals2009-07-01Not applicableUs
Se-Natal OneTabletOralSeton Pharmaceuticals2009-04-162016-10-13Us
Se-Tan PLUSCapsule, gelatin coatedOralSeton Pharmaceuticals2009-10-01Not applicableUs
Sibergin B - CapCapsuleOralPharmavite1996-09-031998-09-08Canada
Somarexin and C 1000Liquid; TabletOralLaboratoire Lalco Inc.1977-12-312008-07-29Canada
Somavit Brand Vitamins and Minerals ComplexTabletOralSoma Health Products2000-01-152005-08-26Canada
Sopalamine/3b Plus CTabletOralTechnilab Pharma Inc.1987-12-312001-09-05Canada
Sopalamine/3b TabTabletOralTechnilab Pharma Inc.1987-12-312001-09-05Canada
Spectrum 2 CapCapsuleOralNf Formulas Inc.1988-12-312008-06-26Canada
Stress B & C CapletTabletOralHealth Wise Nutrition Inc.1995-12-311998-08-25Canada
Stress B Capsules With Vitamin CCapsuleOralRheingold Food International Ltd.1987-12-312007-07-26Canada
Stress B Complex With C, E & IronTabletOralPharmavite1999-10-312005-07-15Canada
Stress B With 1000 Mg Vitamin CTabletOralHolista Health (Canada) Inc.2002-11-132008-07-17Canada
Stress B&c TabTabletOralBioforce Canada Inc.1985-12-311997-04-04Canada
Stress Complex 600 Avec Vit E Cuivre ZincTabletOralFrega Inc.1995-12-312008-02-13Canada
Stress Ctr SrtTablet, extended releaseOralBioenergy Inc.1979-12-311998-06-03Canada
Stress FormulaTabletOralVita Health Products Inc1998-05-202005-07-20Canada
Stress Formula + IronTabletOralVita Health Products Inc1998-05-202006-07-31Canada
Stress Formula B-comp + 500mg Vit C TabTabletOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312002-07-29Canada
Stress Formula Multi-B Comp + 500mg Vit C CapCapsuleOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312001-07-06Canada
Stress Formula Multivitamin Tablets USPTabletOralLeiner Health ProductsNot applicableNot applicableCanada
Stress Formula TabTabletOralNatures Sunshine Products, Inc.1986-12-312009-09-09Canada
Stress Formula Vit B With C ComplexTabletOralWatkins Incorporated1985-12-312000-01-15Canada
Stress Forte Plus Lipotropic FactorsTabletOralDouglas Laboratories1995-12-312009-09-29Canada
Stress TabTabletOralVita Health Products Inc1981-12-312005-07-20Canada
Stress TabletsTabletOralD.C. Labs Limited1981-12-312003-07-11Canada
Stress Vitamin B With C Complex TabletsTabletOralPurity Life Health Products A Division Of Sunopta Inc.2002-06-012007-07-26Canada
StressmatesTabletOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Strovite Forte CapletTablet, coatedOralEverett Laboratories, Inc.1996-10-01Not applicableUs
Strovite One CapletsTabletOralEverett Laboratories, Inc.2001-05-04Not applicableUs
Sun-rype VitaburstLiquidOralSun Rype Products Ltd.2004-08-102008-03-13Canada
Super B Compound W 500mg Vit CTabletOralGahler Enterprises Ltd.1986-12-312000-08-01Canada
Super Charged EnergyPowderOralSimone Protective Pharmaceuticals, Inc.Not applicableNot applicableCanada
Super Daily No 2TabletOralW.R. Enterprises Inc.1990-12-312003-07-30Canada
Super PantoplexTabletOralNu Life Nutrition Ltd.1987-12-312000-03-03Canada
Super Stress CapsulesCapsuleOralRheingold Food International Ltd.1987-12-311997-08-22Canada
Super Stress Mega B Plus 1000mg Vit C TabTabletOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312001-07-06Canada
Super Vitalex Ampoule BuvableLiquidOralCarmaran LtÉe1984-12-312001-08-31Canada
Super-pote Vitamin SupplementTabletOralGarden State Nutritionals1998-09-252000-06-07Canada
Supplement De Multivitamines Infusion Arome Fruits RougesKitOralYves Rocher Inc.1999-10-182000-08-08Canada
Supravite 10ml AmpouleLiquidOralNobel Pharm Enr.1991-12-312002-09-06Canada
Supravite Bouteille 250mlLiquidOralNobel Pharm Enr.2002-10-312008-07-29Canada
Supravite C 1000Liquid; TabletOralNobel Pharm Enr.1981-12-312002-09-06Canada
Supravite Pour EnfantsTabletOralPharmalab Inc.1985-12-312008-07-14Canada
Supravite Stress Avec Vit ETabletOralPharmalab Inc.1985-12-311997-08-08Canada
Supravite Stress Avec Vit E Cuivre Et ZincTabletOralPharmalab Inc.1985-12-311997-08-08Canada
Supravite Stress Avec Vit E Et FerTabletOralPharmalab Inc.1985-12-311997-08-08Canada
Surbex 500 FilmtabTabletOralAbbott1979-12-312008-06-06Canada
Surbex-500 With IronTabletOralAbbott1986-12-312008-06-06Canada
Surbex-500 With ZincTabletOralAbbott1986-12-312008-06-06Canada
Swical-energy-2LiquidOralLes Laboratoires Swisse Inc.1997-06-092006-02-14Canada
Synergistic Manganese CapsulesCapsuleOralQuest Vitamins A Div Of Purity Life Health Products1996-08-151999-08-08Canada
T.R.I. B-plex SrcCapsule, extended releaseOralAnabolic Laboratories Inc.1979-12-312004-03-15Canada
Tandem OBCapsuleOralUs Pharmaceutical Corporation2006-06-17Not applicableUs
Tandem PlusCapsuleOralUs Pharmaceutical Corporation2006-06-17Not applicableUs
Tender Age Multi VitaminsLiquidOralJamieson Laboratories Ltd1982-12-312000-09-08Canada
Thiamine HCl 100mg W C 20mgTabletOralGahler Enterprises Ltd.1987-12-312005-08-15Canada
Time Release B 100 Compound - TabletTabletOralHealth Wise Nutrition Inc.1996-10-222002-07-18Canada
Timed Release B Complex 100 SrtTablet, extended releaseOralJamieson Laboratories Ltd1994-12-311997-08-13Canada
Timed Release B-complex 100Tablet, extended releaseOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Timed Release B-complex 50Tablet, extended releaseOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Tini-cal AmpoulesLiquidOralPharmetics (2011) Inc.1966-12-312001-07-26Canada
Toni Com LiqLiquidOralVitalab1990-12-312009-07-14Canada
Tonicol Et A-D-C Ampoules/comprimesLiquid; TabletOralDistributions Multi Pro Inc.1988-12-311999-07-21Canada
Tonimol Cap LiqCapsule; LiquidOralHerbes Universelles Inc.1978-12-312009-07-15Canada
TriAdvanceTabletOralTrigen Laboratories, Inc.2010-09-102017-09-16Us
Tricare PrenatalTablet, coatedOralMedecor Pharma, Llc2002-11-11Not applicableUs
Trinatal GTTabletOralTrigen Laboratories, Inc.2011-07-052017-09-13Us
Twin Ultra Liquid Fruit Punch FlavorLiquidOralTwin Laboratories Inc.1995-12-312002-09-11Canada
Twin Ultra Liquid Grape FlavorLiquidOralTwin Laboratories Inc.1995-12-312007-08-01Canada
Twin Ultra Liquid Lemon-lime FlavorLiquidOralTwin Laboratories Inc.1995-12-312005-08-30Canada
Twin Ultra Liquid Orange FlavorLiquidOralTwin Laboratories Inc.1995-12-312002-09-11Canada
Ultra EnerforceLiquidOralNutribon (1986) Inc.2002-01-292005-02-16Canada
Ultra HrTabletOralNatural Organics Inc.Not applicableNot applicableCanada
Usana Megavitamin Tablets - TabTabletOralUsana Health Sciences, Inc.1996-12-302000-09-11Canada
Vasodyn TabTabletOralNutri Dyn Products Ltd.1978-12-311998-08-13Canada
Viamon Ampoules Et ComprimesLiquid; TabletOralLab Nadeau LtÉe, Division Of Technilab Inc.1977-12-311999-09-28Canada
Vigem 12 LiquidLiquidOralPharmavite Laboratories (1987) Inc.1958-12-311999-10-19Canada
Vigo Multivitamins Drops/lozengeLozengeOralAshbury Research CorporationNot applicableNot applicableCanada
Vimeral TabTabletOralIcn Pharmaceuticals1979-12-312005-04-26Canada
Virt-CapsCapsule, gelatin coatedOralVirtus Pharmaceuticals2014-04-012017-08-11Us
Virt-PnTablet, coatedOralVirtus Pharmaceuticals2012-07-122017-08-09Us
Virt-Vite PlusTabletOralVirtus Pharmaceuticals2014-01-142017-08-11Us
Vit B Complex CtrTablet, extended releaseOralBioenergy Inc.1979-12-311998-06-03Canada
Vit B Complex Plus Vit C 550mgCapsuleOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Vit-HA Multi Vitamin and Zinc SupplementTabletOralRheingold Food International Ltd.1994-12-312007-07-26Canada
Vita B + C 500 TabTabletOralLaboratoire Romilo1993-12-311999-08-18Canada
Vita B Complex TabTabletOralNutrimetics International (Canada) Inc.1985-12-312000-07-19Canada
Vita Day TabTabletOralJamieson Laboratories Ltd1993-12-311997-08-13Canada
Vita-BTabletOralNutri Dyn Products Ltd.1984-12-311997-08-22Canada
Vita-B-75 CapCapsuleOralLes Laboratoires Vachon Inc.1989-12-311998-09-28Canada
Vita-worth B-complex TabletsTabletOralGeneral Nutrition Canada Inc.1997-04-182005-08-05Canada
Vitabanks Vitamin TabTabletOralVitabank Inc.1990-12-311997-05-30Canada
Vitachrom GcTabletOralNikken Usa, Incorporated2000-08-302007-10-01Canada
Vitaday TabTabletOralPharmetics (2011) Inc.1977-12-311999-08-13Canada
VitafantTabletOralLes Laboratoires Vachon Inc.1994-12-312008-07-09Canada
Vitafer - LiqLiquidOralFrega Inc.1995-12-311997-12-10Canada
Vitaflex Dietary SuplementTabletOralHome Shopping Network DirectNot applicableNot applicableCanada
Vitafol CapletCapsuleOralEverett Laboratories, Inc.1985-05-01Not applicableUs
Vitafol OB CapletTabletOralExeltis Usa, Inc.2002-12-02Not applicableUs
Vitafol OneCapsule, gelatin coatedOralEverett Laboratories, Inc.2011-06-13Not applicableUs
Vitafol PlusCapsule, liquid filledOralEverett Laboratories, Inc.2012-04-23Not applicableUs
Vitafol UltraCapsule, liquid filledOralExeltis Usa, Inc.2013-09-23Not applicableUs
Vitalife - CapsuleCapsuleOralHolista Health (Canada) Inc.1996-11-132002-08-06Canada
Vitamin and Mineral Supplement - LiqLiquidOralTechnilab Pharma Inc.1998-05-252005-08-05Canada
Vitamin B + C CapCapsuleOralFinlandia Consultants1990-12-311997-12-02Canada
Vitamin B ComplexInjectionIntravenousMylan Institutional2013-05-10Not applicableUs
Vitamin B Complex + C 300mg CapCapsuleOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Vitamin B Complex + C 600mg TabTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Vitamin B Complex 100 TabTabletOralBioforce Canada Inc.1994-12-311997-04-04Canada
Vitamin B Complex 50TabletOralGfr Pharma Ltd.2002-10-102004-06-15Canada
Vitamin B Complex Plus 300mg Vitamin CTabletOralHall Laboratories, Ltd.1996-11-282003-09-11Canada
Vitamin B Complex Plus C 300mg Timed ReleaseTablet, extended releaseOralVita Health Products Inc1998-10-062009-08-06Canada
Vitamin B Complex SupplTabletOralAvacare, Division Of Jeunique International Inc.1985-12-312006-07-20Canada
Vitamin B Complex TabTabletOralNutristar Health Products (1987) Inc.1981-12-311996-09-09Canada
Vitamin B Complex W C 300mg TabTabletOralLee Adams Laboratories1982-12-312009-12-02Canada
Vitamin B Complex W C TabTabletOralAlbi Imports Ltd.1979-12-312004-09-24Canada
Vitamin B Compound TabTabletOralNutrilite, A Division Of Access Business Group, Llc1982-12-311996-09-09Canada
Vitamin B Compound W C Tab 500mgTabletOralAdams Laboratories1979-12-312009-10-21Canada
Vitamin B Compound W Vit C 250mg TabTabletOralSwiss Herbal Remedies Ltd.1972-12-312003-09-10Canada
Vitamin B Compound With Vitamin C Fortis Capsule DtcCapsuleOralD.C. Labs Limited1973-12-312005-07-19Canada
Vitamin B Cpd W Vit C TabTabletOralIcn Pharmaceuticals1978-12-312005-04-26Canada
Vitamin B TabletsTabletOralWeider Health Products1985-12-311999-09-09Canada
Vitamine 110 LiqLiquidOralFrega Inc.1993-12-312008-07-09Canada
Vitamine Du Groupe B Plus Fer - LiqLiquidOralPharmalab Inc.1995-12-312008-07-14Canada
Vitamines Pour Bebes Et EnfantsLiquidOralHerbes Universelles Inc.1978-12-312009-07-15Canada
Vitogen B Compound W C Fortis CapsulesCapsuleOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1972-12-311997-10-14Canada
Vitogen B Stress C Vit E Zinc & CopTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1984-12-312002-07-31Canada
Vitogen B Stress C600TabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1981-12-312002-07-31Canada
Vitogen Multiple Vitamins TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1966-12-311997-10-14Canada
Vitogen Multiple Vitamins W IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1976-12-311997-10-14Canada
Vitreat Chewable Vitamin TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1972-12-311997-08-08Canada
Vitreat Chewable Vitamins Plus IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1977-12-311997-08-08Canada
VP-heme OBTablet, film coatedOralVirtus Pharmaceuticals2013-10-14Not applicableUs
Vtb Vitamin and Mineral SupplementTabletOralGarden State NutritionalsNot applicableNot applicableCanada
Women's FormulaTabletOralPro Ma Systems1998-10-312007-09-25Canada
Zoo ChewsTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Categories
UNIIX66NSO3N35
CAS number59-43-8
WeightAverage: 265.355
Monoisotopic: 265.112306876
Chemical FormulaC12H17N4OS
InChI KeyJZRWCGZRTZMZEH-UHFFFAOYSA-N
InChI
InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1
IUPAC Name
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium
SMILES
CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N
Pharmacology
Indication

For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.

Structured Indications Not Available
Pharmacodynamics

Thiamine is a vitamin with antioxidant, erythropoietic, cognition-and mood-modulatory, antiatherosclerotic, putative ergogenic, and detoxification activities. Thiamine has been found to protect against lead-induced lipid peroxidation in rat liver and kidney. Thiamine deficiency results in selective neuronal death in animal models. The neuronal death is associated with increased free radical production, suggesting that oxidative stress may play an important early role in brain damage associated with thiamine deficiency. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Inhibition of endothelial cell proliferation may also promote atherosclerosis. Endothelial cells in culture have been found to have a decreased proliferative rate and delayed migration in response to hyperglycemic conditions. Thiamine has been shown to inhibit this effect of glucose on endothelial cells.

Mechanism of action

It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiamine is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives. There are five known natural thiamine phosphate derivatives: thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), and the recently discovered adenosine thiamine triphosphate (AThTP), and adenosine thiamine diphosphate. Each derivative has unique functions, however, most are involved as coenzymes.

TargetKindPharmacological actionActionsOrganismUniProt ID
Thiamin pyrophosphokinase 1Proteinyes
ligand
HumanQ9H3S4 details
Thiamine transporter 1Proteinunknown
binder
HumanO60779 details
Related Articles
Absorption

Absorbed mainly from duodenum, by both active and passive processes

Volume of distributionNot Available
Protein binding

90-94%

Metabolism

Hepatic

Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
Toxicity

Thiamine toxicity is uncommon; as excesses are readily excreted, although long-term supplementation of amounts larger than 3 gram have been known to cause toxicity. Oral mouse LD50 = 8224 mg/kg, oral rat LD50 = 3710 mg/kg.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Thiamine MetabolismMetabolicSMP00076
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions No interactions found.
Food InteractionsNot Available
References
Synthesis Reference

Nobuyuki Kitamori, Masaya Maeno, Seiji Izuhara, "Granules of thiamine salt and the production thereof." U.S. Patent US4702919, issued July, 1974.

US4702919
General References
  1. Slater PV: Multi-level preparation for nursing impact on nursing practice. Aust Nurses J. 1978 Jun;7(11):40-3. [PubMed:249270 ]
  2. Kopriva V, Bilkovic R, Licko T: [Tumours of the small intestine (author's transl)]. Cesk Gastroenterol Vyz. 1977 Dec;31(8):549-53. [PubMed:603941 ]
  3. Beissel J: [The role of right catheterization in valvular prosthesis surveillance (author's transl)]. Ann Cardiol Angeiol (Paris). 1977 Dec;26(6):587-9. [PubMed:606152 ]
  4. Lonsdale D, Shamberger RJ, Audhya T: Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study. Neuro Endocrinol Lett. 2002 Aug;23(4):303-8. [PubMed:12195231 ]
  5. Lonsdale D: A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives. Evid Based Complement Alternat Med. 2006 Mar;3(1):49-59. [PubMed:16550223 ]
External Links
ATC CodesA11DA01 — Thiamine (vit b1)
AHFS Codes
  • 88:08.00
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.2 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections / Infection, Human Immunodeficiency Virus I / Mycobacterium avium complex infection1
1CompletedBasic ScienceBeriberi1
1CompletedDiagnosticHealthy Volunteers1
1CompletedPreventionHIV/AIDS1
1CompletedTreatmentCancers / Metastases1
1Not Yet RecruitingBasic ScienceAging / Mineral deficiency / Vitamin Deficiency1
1RecruitingTreatmentAcidosis, Respiratory / Shock, Septic / Thiamine Deficiency1
1, 2CompletedTreatmentShock, Septic1
1, 2SuspendedTreatmentSchizoaffective Disorders / Schizophrenic Disorders1
2CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentCancer, Breast1
2CompletedTreatmentCardiac Surgical Procedures / Coronary Artery Bypass Graft1
2CompletedTreatmentCritically Ill / Respiratory Failure1
2CompletedTreatmentDiabetes / Heart Failure, Unspecified1
2Enrolling by InvitationTreatmentSepsis1
2RecruitingTreatmentAcidosis, Respiratory / Cardiac Arrest / Shock / Thiamin Deficiency1
2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2, 3CompletedTreatmentAcidosis, Respiratory1
2, 3CompletedTreatmentCardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / Mortality1
3CompletedPreventionComplications, Pregnancy / Human Immunodeficiency Virus (HIV) Infections1
3CompletedTreatmentAnemias1
3CompletedTreatmentChronic Heart Failure (CHF)1
3CompletedTreatmentDiarrheal Illnesses / Growth Faltering / Respiratory Illness1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis, Pulmonary1
3CompletedTreatmentHydatidiform Mole1
3TerminatedTreatmentHyperemesis Gravidarum1
3Unknown StatusNot AvailableAnemias / Low Birth Weight / Neonatal Mortality1
3Unknown StatusTreatmentAlzheimer's Disease (AD) / Down Syndrome (DS)1
4CompletedHealth Services ResearchAcidosis, Respiratory / Aids / Human Immunodeficiency Virus (HIV) Infections / Lipodystrophies1
4CompletedTreatmentDiabetic Peripheral Neuropathic Pain1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentPregnancy1
4RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4RecruitingTreatmentWernicke-Korsakoff syndrome1
4WithdrawnTreatmentNephritis / Proteinuria / Systemic Lupus Erythematosus (SLE)1
Not AvailableCompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedPreventionNeural Tube Defects (NTDs)1
Not AvailableCompletedTreatmentAcute Respiratory Failure1
Not AvailableCompletedTreatmentHeart Failure, Unspecified1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections2
Not AvailableCompletedTreatmentThyrotoxicosis1
Not AvailableNot Yet RecruitingTreatmentBreast Cancer Metastatic / Metastatic Breast Cancer (MBC)1
Not AvailableRecruitingTreatmentTemporomandibular Joint Disorders1
Not AvailableUnknown StatusTreatmentSciatica Due to Intervertebral Disc Disorder1
Not AvailableWithdrawnPreventionHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableWithdrawnTreatmentDiabetes Complications / Diabetes Mellitus (DM) / Peripheral Neuropathy1
Pharmacoeconomics
Manufacturers
  • Eli lilly and co
  • Abraxis pharmaceutical products
  • Akorn inc
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia and critical care
  • Bel mar laboratories inc
  • Dell laboratories inc
  • Hospira inc
  • Luitpold pharmaceuticals inc
  • Parke davis div warner lambert co
  • Watson laboratories inc
  • Wyeth ayerst laboratories
Packagers
Dosage forms
FormRouteStrength
TabletOral100 mg
ElixirOral
CapsuleOral500 mg
Tablet, extended releaseOral
InjectionIntramuscular
Injection, solutionIntramuscular; Intravenous
Tablet, extended releaseOral400 mg
Powder, for solutionIntramuscular; Intravenous
Powder, for solutionIntravenous
SolutionIntramuscular; Intravenous100 mg
LiquidOral.05 mg
ElixirOral.05 mg
GranuleOral
TabletOral
SyrupOral
LiquidIntramuscular; Intravenous
Kit
Tablet, effervescentOral
Tablet, chewableOral
LiquidIntravenous
Injection, powder, lyophilized, for solutionIntravenous
PowderTopical
Liquid; tabletOral
Solution / dropsOral
SolutionIntravenous
LiquidOral
SolutionOral
SolutionIntramuscular; Intravenous
Injection, solutionIntravenous
PowderOral
Tablet, coatedOral
KitOral
Capsule, extended releaseOral
LiquidIntramuscular; Intravenous100 mg
TabletOral25 mg
TabletOral50 mg
Injection, solutionIntramuscular; Intravenous100 mg/mL
LiquidIntramuscular100 mg
Capsule; liquidOral
LozengeOral
Tablet, extended releaseOral100 mg
CapsuleOral100 mg
CapsuleOral
Capsule, gelatin coatedOral
Capsule, liquid filledOral
InjectionIntramuscular; Intravenous
InjectionIntravenous
TabletOral2 mg
Tablet, film coatedOral
Prices
Unit descriptionCostUnit
Thiamine 100 mg/ml vial8.61USD ml
Infuvite pediatric vial2.58USD ml
Vitamin B-1 100 mg/ml1.64USD ml
Thiamiject 100 mg/ml1.24USD ml
Thiamine Hcl 100 mg/ml1.24USD ml
Thiamine hcl powder0.73USD g
Thiamine 100 mg tablet0.21USD tablet
Thiamine 500 mg tablet0.18USD tablet
Vitamin b-1 250 mg tablet0.06USD tablet
Vitamin b-1 100 mg tablet0.05USD tablet
Thiamine 250 mg tablet0.03USD tablet
CVS Pharmacy vitamin b-1 100 mg tablet0.02USD tablet
Vitamin b-1 50 mg tablet0.02USD tablet
Thiamine hcl 50 mg tablet0.01USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)248 dec °CPhysProp
water solubility5E+005 mg/LMERCK INDEX (1996); approx.
Predicted Properties
PropertyValueSource
Water Solubility0.0153 mg/mLALOGPS
logP-2.1ALOGPS
logP-3.1ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)15.5ChemAxon
pKa (Strongest Basic)5.54ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area75.91 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity73.4 m3·mol-1ChemAxon
Polarizability28.14 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.7976
Blood Brain Barrier+0.933
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.5593
P-glycoprotein inhibitor INon-inhibitor0.9814
P-glycoprotein inhibitor IINon-inhibitor0.8504
Renal organic cation transporterNon-inhibitor0.7559
CYP450 2C9 substrateNon-substrate0.842
CYP450 2D6 substrateNon-substrate0.7591
CYP450 3A4 substrateNon-substrate0.7256
CYP450 1A2 substrateNon-inhibitor0.58
CYP450 2C9 inhibitorNon-inhibitor0.7521
CYP450 2D6 inhibitorNon-inhibitor0.7523
CYP450 2C19 inhibitorNon-inhibitor0.7397
CYP450 3A4 inhibitorNon-inhibitor0.8019
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7795
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.8999
BiodegradationNot ready biodegradable0.86
Rat acute toxicity2.4577 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9415
hERG inhibition (predictor II)Non-inhibitor0.6221
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MSNot Available
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-000i-0109000000-48864f31ba475645654bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-05o1-9200000000-2ec0f3e9e364cffde16eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-0aou-9000000000-0184506492d9f5b68b97View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-03di-0090000000-872150be83cbd75d8ecfView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-0002-0930000000-ecf71c75bdea859139d5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-0002-0900000000-4d9113fdc633fb1ccbb5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-0002-0900000000-4a8016299623af0c3027View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negativesplash10-0002-1900000000-773912c9f325c419c77dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-014i-0390000000-95f3ca57c95542bdc7e7View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-00di-0900000000-e079d1fc1e06396dc524View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positivesplash10-00di-0900000000-ebb16d4f204f291b9a3aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positivesplash10-00e9-4900000000-ad4d4779d76b9edb7ec5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positivesplash10-001i-9600000000-b631eed5be831527fc17View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-00di-0900000000-50f2f613f576814eb627View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-002b-0900000000-2f184bbfec6bc0ef00c6View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-001i-9000000000-35bc744495a2570a565fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-00di-1900000000-d8a7ac327273c32b4524View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0002-0920000000-ca80ef6513c61be5b5e9View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-03di-0090000000-872150be83cbd75d8ecfView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
1D NMR13C NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,1H] 2D NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as thiamines. These are compounds containing a thiamine moiety, which is structurally characterized by a 3-[(4-Amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-5-yl backbone.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDiazines
Sub ClassPyrimidines and pyrimidine derivatives
Direct ParentThiamines
Alternative ParentsAminopyrimidines and derivatives / 4,5-disubstituted thiazoles / Imidolactams / Heteroaromatic compounds / Azacyclic compounds / Primary amines / Primary alcohols / Organopnictogen compounds / Hydrocarbon derivatives / Organic cations
SubstituentsThiamine / 4,5-disubstituted 1,3-thiazole / Aminopyrimidine / Imidolactam / Azole / Thiazole / Heteroaromatic compound / Azacycle / Alcohol / Organopnictogen compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptorsthiamine (CHEBI:18385 ) / Water-soluble vitamins (C00378 ) / a vitamin (THIAMINE )

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
ligand
General Function:
Thiamine diphosphokinase activity
Specific Function:
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.
Gene Name:
TPK1
Uniprot ID:
Q9H3S4
Uniprot Name:
Thiamin pyrophosphokinase 1
Molecular Weight:
27265.05 Da
References
  1. Pylypchuk SIu, Parkhomenko IuM, Protasova ZS, Vovk AI, Donchenko HV: [Interaction of rat brain thiamine kinase with thiamine and its derivatives]. Ukr Biokhim Zh (1999). 2001 Mar-Apr;73(2):51-6. [PubMed:11642045 ]
  2. Melnick J, Lis E, Park JH, Kinsland C, Mori H, Baba T, Perkins J, Schyns G, Vassieva O, Osterman A, Begley TP: Identification of the two missing bacterial genes involved in thiamine salvage: thiamine pyrophosphokinase and thiamine kinase. J Bacteriol. 2004 Jun;186(11):3660-2. [PubMed:15150256 ]
  3. Bellyei S, Szigeti A, Boronkai A, Szabo Z, Bene J, Janaky T, Barna L, Sipos K, Minik O, Kravjak A, Ohmacht R, Melegh B, Zavodszky P, Than GN, Sumegi B, Bohn H, Than NG: Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK). Placenta. 2005 Jan;26(1):34-46. [PubMed:15664409 ]
  4. de Jong L, Meng Y, Dent J, Hekimi S: Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans. Genetics. 2004 Oct;168(2):845-54. [PubMed:15514058 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Thiamine uptake transmembrane transporter activity
Specific Function:
High-affinity transporter for the intake of thiamine.
Gene Name:
SLC19A2
Uniprot ID:
O60779
Uniprot Name:
Thiamine transporter 1
Molecular Weight:
55399.49 Da
References
  1. Liberman MC, Tartaglini E, Fleming JC, Neufeld EJ: Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotype. J Assoc Res Otolaryngol. 2006 Sep;7(3):211-7. Epub 2006 Apr 27. [PubMed:16642288 ]
  2. Diaz GA, Banikazemi M, Oishi K, Desnick RJ, Gelb BD: Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome. Nat Genet. 1999 Jul;22(3):309-12. [PubMed:10391223 ]
  3. Fleming JC, Tartaglini E, Steinkamp MP, Schorderet DF, Cohen N, Neufeld EJ: The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter. Nat Genet. 1999 Jul;22(3):305-8. [PubMed:10391222 ]
  4. Labay V, Raz T, Baron D, Mandel H, Williams H, Barrett T, Szargel R, McDonald L, Shalata A, Nosaka K, Gregory S, Cohen N: Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness. Nat Genet. 1999 Jul;22(3):300-4. [PubMed:10391221 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP4B1
Uniprot ID:
P13584
Uniprot Name:
Cytochrome P450 4B1
Molecular Weight:
58990.64 Da
References
  1. Liu S, Stromberg A, Tai HH, Moscow JA: Thiamine transporter gene expression and exogenous thiamine modulate the expression of genes involved in drug and prostaglandin metabolism in breast cancer cells. Mol Cancer Res. 2004 Aug;2(8):477-87. [PubMed:15328374 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Uniprot Name:
Solute carrier family 22 member 2
Molecular Weight:
62579.99 Da
References
  1. Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. [PubMed:12089365 ]
  2. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Uniprot Name:
Solute carrier family 22 member 1
Molecular Weight:
61153.345 Da
References
  1. Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. [PubMed:12606755 ]
  2. Sinclair CJ, Chi KD, Subramanian V, Ward KL, Green RM: Functional expression of a high affinity mammalian hepatic choline/organic cation transporter. J Lipid Res. 2000 Nov;41(11):1841-8. [PubMed:11060354 ]
  3. Green RM, Lo K, Sterritt C, Beier DR: Cloning and functional expression of a mouse liver organic cation transporter. Hepatology. 1999 May;29(5):1556-62. [PubMed:10216142 ]
  4. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:
SLC22A5
Uniprot ID:
O76082
Uniprot Name:
Solute carrier family 22 member 5
Molecular Weight:
62751.08 Da
References
  1. Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. [PubMed:11160873 ]
  2. Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. [PubMed:10454528 ]
Drug created on June 13, 2005 07:24 / Updated on September 01, 2017 10:24