Displaying drugs 6601 - 6625 of 8033 in total
ZYCOV-D
The ZYCOV-D vaccine candidate was developed by Cadila Healthcare Ltd. based in India . The vaccine was developed using a DNA vaccine platform with a non-replicating and non-integrating plasmid carrying the gene of interest . Once the plasmid DNA is introduced into host cells and the viral protein is translated,...
Investigational
Matched Description: … As of August, 2020 the candidate is in Phase II clinical trials[A219758]. ... using a DNA vaccine platform with a non-replicating and non-integrating plasmid carrying the gene of ... is translated, it elicits a strong immune response, stimulating the humoral and cellular components of …
DDP-225
DDP225 is both a noradrenaline reuptake inhibitor and a serotonin type 3 receptor (5-HT3) antagonist. Noradrenaline and serotonin are neurotransmitters that are known to be involved in the control of the gastrointestinal system. The unique combination of noradrenaline reuptake inhibition and 5-HT3 antagonism in one orally delivered compound represents a...
Investigational
Matched Description: … Noradrenaline and serotonin are neurotransmitters that are known to be involved in the control of the ... The unique combination of noradrenaline reuptake inhibition and 5-HT3 antagonism in one orally delivered …
CTS-21166
CTS-21166 is a small-molecule beta-secretase inhibitor, which is being developed as a disease-modifying treatment for Alzheimer's disease. CTS-21166 is the only BACE1 inhibitor that has passed Phase I clinical trial thus far. In 2008, CoMentis revealed this small compound as a transition-state analog inhibitor (structure is currently undisclosed) with excellent...
Investigational
Matched Description: … these have met the requirements of an ideal oral drug candidate. ... excellent properties in brain penetration, selectivity, metabolic stability, and oral availability; all of …
Loprazolam
Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent nocturnal awakenings. Loprazolam is recommended as a short-term therapy only, due to adverse events associated with the drug including dependence...
Experimental
Matched Description: … It is a positive modulator of GABA-A receptor that enhances the inhibitory neurotransmission. ... It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or …
VPM1002
The bacille Calmette-Guérin (BCG) vaccine protects against severe extrapulmonary forms of tuberculosis (TB) but does not adequately protect against pulmonary TB -- the most prevalent form of TB. This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary TB in newborns and TB recurrence in adults...
Investigational
Matched Description: … (TB) but does not adequately protect against pulmonary TB -- the most prevalent form of TB. ... The bacille Calmette-Guérin (BCG) vaccine protects against severe extrapulmonary forms of tuberculosis ... BCG Prague as it has a better safety profile than some other BCG versions due to the lack of the RD2 …
(R)-Rolipram
The (R)-enantiomer of rolipram, it is a phosphodiesterase inhibitor with antidepressant properties.
Experimental
Matched Description: … The (R)-enantiomer of rolipram, it is a phosphodiesterase inhibitor with antidepressant properties. …
Homocysteine
Homocysteine is a thiol-containing amino acid formed by a demethylation of methionine.
Experimental
Matched Description: … Homocysteine is a thiol-containing amino acid formed by a demethylation of methionine. …
NCX 701
Nitroparacetamol (NCX-701) is a newly synthesized nitric oxide-releasing derivative of paracetamol.
Investigational
Matched Description: … Nitroparacetamol (NCX-701) is a newly synthesized nitric oxide-releasing derivative of paracetamol. …
99mTc-glucarate
99mTc-glucarate(GLA) is an agent for non-invasive detection of breast tumours.
Investigational
Matched Description: … 99mTc-glucarate(GLA) is an agent for non-invasive detection of breast tumours. …
Transcrocetinate
Vitamin A-analog that increases diffusivity of oxygen in aqueous solutions, including plasma.
Investigational
Matched Description: … Vitamin A-analog that increases diffusivity of oxygen in aqueous solutions, including plasma. …
N-chlorotaurine
N-chlorotaurine is an inhibitor of inducible nitric oxide synthase and IkappaB kinase.
Investigational
Matched Description: … N-chlorotaurine is an inhibitor of inducible nitric oxide synthase and IkappaB kinase. …
Vixotrigine
Vixotrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
Investigational
Matched Description: … Vixotrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression. …
Radafaxine
Radafaxine has been used in trials studying the treatment of Depressive Disorder, Major.
Investigational
Matched Description: … Radafaxine has been used in trials studying the treatment of Depressive Disorder, Major. …
Alvelestat
Alvelestat has been investigated for the basic science of Chronic Obstructive Pulmonary Disease.
Investigational
Matched Description: … Alvelestat has been investigated for the basic science of Chronic Obstructive Pulmonary Disease. …
Avagacestat
Avagacestat has been investigated for the basic science and treatment of Alzheimer Disease.
Investigational
Matched Description: … Avagacestat has been investigated for the basic science and treatment of Alzheimer Disease. …
Flumatinib
Flumatinib has been used in trials studying the treatment of Myelogenous Leukemia, Chronic.
Investigational
Matched Description: … Flumatinib has been used in trials studying the treatment of Myelogenous Leukemia, Chronic. …
Decoglurant
Decoglurant has been used in trials studying the treatment of Major Depressive Disorder.
Investigational
Matched Description: … Decoglurant has been used in trials studying the treatment of Major Depressive Disorder. …
Ozagrel
Ozagrel has been used in trials studying the treatment of Dry Eye Syndromes.
Investigational
Matched Description: … Ozagrel has been used in trials studying the treatment of Dry Eye Syndromes. …
BMS-777607
BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.
Investigational
Matched Description: … BMS-777607 has been investigated for the basic science of Malignant Solid Tumour. …
L-Baclofen
L-Baclofen has been used in trials studying the treatment of Trigeminal Neuralgia.
Investigational
Matched Description: … L-Baclofen has been used in trials studying the treatment of Trigeminal Neuralgia. …
ATU-027
Atu027 has been used in trials studying the treatment of Advanced Solid Tumors.
Investigational
Matched Description: … Atu027 has been used in trials studying the treatment of Advanced Solid Tumors. …
Bunazosin
Bunazosin has been used in trials studying the treatment of High Blood Pressure.
Investigational
Matched Description: … Bunazosin has been used in trials studying the treatment of High Blood Pressure. …
Temefos
Diphos has been used in trials studying the treatment of Plasmodium Falciparum Malaria.
Investigational
Matched Description: … Diphos has been used in trials studying the treatment of Plasmodium Falciparum Malaria. …
Tanezumab
Tanezumab has been investigated for the treatment of Osteoarthritis, Knee and Neuralgia, Postherpetic.
Investigational
Matched Description: … Tanezumab has been investigated for the treatment of Osteoarthritis, Knee and Neuralgia, Postherpetic …
DSM-265
DSM265 has been used in trials studying the prevention and treatment of Malaria.
Investigational
Matched Description: … DSM265 has been used in trials studying the prevention and treatment of Malaria. …
Displaying drugs 6601 - 6625 of 8033 in total