Loprazolam

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Loprazolam
Accession Number
DB13643
Type
Small Molecule
Groups
Experimental
Description

Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent nocturnal awakenings. Loprazolam is recommended as a short-term therapy only, due to adverse events associated with the drug including dependence and withdrawal symptoms. It is a positive modulator of GABA-A receptor that enhances the inhibitory neurotransmission. It is not an FDA-approved drug.

Structure
Thumb
Synonyms
  • Triazulenone
External IDs
RU-31158 FREE BASE
Categories
UNII
759N8462G8
CAS number
61197-73-7
Weight
Average: 464.904
Monoisotopic: 464.136366275
Chemical Formula
C23H21ClN6O3
InChI Key
UTEFBSAVJNEPTR-RGEXLXHISA-N
InChI
InChI=1S/C23H21ClN6O3/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24/h2-7,12,14H,8-11,13H2,1H3/b19-14-
IUPAC Name
(4Z)-9-(2-chlorophenyl)-4-[(4-methylpiperazin-1-yl)methylidene]-12-nitro-2,5,8-triazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),5,8,11,13-pentaen-3-one
SMILES
[H]\C(N1CCN(C)CC1)=C1\N=C2CN=C(C3=CC=CC=C3Cl)C3=C(C=CC(=C3)N(=O)=O)N2C1=O

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Loprazolam.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Loprazolam.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Loprazolam.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Loprazolam.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Loprazolam.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Loprazolam is combined with Alaproclate.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Loprazolam.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Loprazolam.Approved, Illicit
AllopregnanoloneThe risk or severity of adverse effects can be increased when Allopregnanolone is combined with Loprazolam.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Loprazolam.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Alphaprodine is combined with Loprazolam.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Loprazolam.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Loprazolam.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Loprazolam.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Loprazolam.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Loprazolam.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Loprazolam.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Loprazolam.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Loprazolam.Investigational, Vet Approved
AzelastineLoprazolam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Loprazolam is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Loprazolam.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Benperidol is combined with Loprazolam.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Loprazolam.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Loprazolam.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Loprazolam is combined with Brexpiprazole.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Loprazolam.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Loprazolam.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when Bromisoval is combined with Loprazolam.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Bromperidol is combined with Loprazolam.Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Loprazolam.Approved, Investigational, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Loprazolam.Approved, Investigational
BuprenorphineLoprazolam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Loprazolam.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Loprazolam.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Loprazolam.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Loprazolam is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Loprazolam.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Loprazolam.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Loprazolam.Approved, Illicit, Vet Approved
CanertinibThe risk or severity of adverse effects can be increased when Canertinib is combined with Loprazolam.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Loprazolam.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Loprazolam.Illicit, Investigational, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Loprazolam is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Loprazolam.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Loprazolam.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Loprazolam.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Loprazolam.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Loprazolam.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Loprazolam.Approved, Investigational, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Loprazolam is combined with Chlorzoxazone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Loprazolam.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Loprazolam is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Loprazolam is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Loprazolam is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Loprazolam.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Loprazolam is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Clonidine.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Loprazolam is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Loprazolam.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Clothiapine is combined with Loprazolam.Experimental
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Loprazolam.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Loprazolam.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Loprazolam.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Loprazolam.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Loprazolam is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Loprazolam.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Dapoxetine.Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Deramciclane is combined with Loprazolam.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Loprazolam.Approved
DesipramineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Loprazolam.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Loprazolam.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Loprazolam.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Loprazolam.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Loprazolam.Approved, Investigational
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Loprazolam.Approved, Illicit, Vet Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Diethyl ether is combined with Loprazolam.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Loprazolam is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Loprazolam.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Loprazolam.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Loprazolam.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Loprazolam is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Loprazolam.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Loprazolam.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Loprazolam.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Loprazolam is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Loprazolam.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Loprazolam.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Loprazolam.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Loprazolam.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Loprazolam.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Loprazolam.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Loprazolam.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Ecopipam is combined with Loprazolam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Loprazolam is combined with Efavirenz.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Eltanolone is combined with Loprazolam.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Loprazolam.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Loprazolam is combined with Entacapone.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Loprazolam is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Loprazolam.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Loprazolam.Approved
EthanolLoprazolam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Loprazolam.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Loprazolam is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Loprazolam is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Loprazolam.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Ethyl chloride is combined with Loprazolam.Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Loprazolam.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Loprazolam.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Loprazolam.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Loprazolam.Investigational, Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Loprazolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Loprazolam.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Loprazolam is combined with Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Loprazolam.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Loprazolam is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Loprazolam.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Loprazolam.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Loprazolam is combined with Flibanserin.Approved
FluanisoneThe risk or severity of adverse effects can be increased when Loprazolam is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Loprazolam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Loprazolam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Loprazolam.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Loprazolam.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Loprazolam.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Loprazolam.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when Loprazolam is combined with Fluticasone propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Loprazolam.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Loprazolam is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Loprazolam.Approved, Illicit, Investigational
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Loprazolam.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Loprazolam is combined with Gabapentin Enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Loprazolam.Approved, Illicit, Investigational
GepironeThe risk or severity of adverse effects can be increased when Gepirone is combined with Loprazolam.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Loprazolam.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Loprazolam.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Loprazolam.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Loprazolam.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Loprazolam.Approved, Illicit, Investigational
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Loprazolam.Approved
HydrocodoneLoprazolam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Loprazolam.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Loprazolam.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Loprazolam is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Indalpine.Investigational, Withdrawn
IndiplonThe risk or severity of adverse effects can be increased when Indiplon is combined with Loprazolam.Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Loprazolam.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Loprazolam.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Loprazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Loprazolam.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Loprazolam is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Loprazolam.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Loprazolam is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Loprazolam.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Loprazolam is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Loprazolam.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Loprazolam.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Loprazolam.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Loprazolam.Illicit
LoratadineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Loprazolam.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Loprazolam is combined with Lormetazepam.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Loprazolam.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Loprazolam.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Loprazolam.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Maprotiline.Approved
MebicarThe risk or severity of adverse effects can be increased when Mebicar is combined with Loprazolam.Experimental
MeclizineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Meclizine.Approved
MedazepamThe risk or severity of adverse effects can be increased when Medazepam is combined with Loprazolam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Loprazolam.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Loprazolam.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Loprazolam.Approved, Investigational
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Loprazolam.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Loprazolam.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Meptazinol is combined with Loprazolam.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Loprazolam.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Loprazolam is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Loprazolam.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Loprazolam.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Loprazolam.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Loprazolam.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Loprazolam is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Loprazolam.Approved
MethotrimeprazineLoprazolam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Loprazolam.Approved, Investigational, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Loprazolam is combined with Methsuximide.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Loprazolam.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Loprazolam.Approved
MetyrosineLoprazolam may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Loprazolam.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Loprazolam is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Loprazolam.Approved, Investigational
MirtazapineLoprazolam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Loprazolam.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Loprazolam.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Loprazolam.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Loprazolam.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Loprazolam is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Loprazolam.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Loprazolam.Approved, Vet Approved
NorfluraneThe risk or severity of adverse effects can be increased when Norflurane is combined with Loprazolam.Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Loprazolam.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Loprazolam.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Loprazolam.Approved
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Loprazolam.Approved, Illicit
OrphenadrineLoprazolam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Loprazolam.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Loprazolam.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Oxethazaine is combined with Loprazolam.Approved, Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Loprazolam.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Loprazolam.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Loprazolam.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Loprazolam.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Loprazolam.Approved
ParaldehydeLoprazolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ParoxetineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Paroxetine.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when Loprazolam is combined with Penfluridol.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Loprazolam.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Loprazolam.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Loprazolam.Approved
PerazineThe risk or severity of adverse effects can be increased when Perazine is combined with Loprazolam.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Loprazolam.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Loprazolam.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Loprazolam.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Phenazocine is combined with Loprazolam.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Phenibut is combined with Loprazolam.Experimental
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Loprazolam.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Phenoperidine is combined with Loprazolam.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Loprazolam.Approved
PhenytoinThe risk or severity of adverse effects can be increased when Loprazolam is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Loprazolam.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Loprazolam.Approved, Investigational
PipotiazineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Pipotiazine.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when Piritramide is combined with Loprazolam.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Loprazolam is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Loprazolam is combined with Pomalidomide.Approved
PramipexoleLoprazolam may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Loprazolam.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Loprazolam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Loprazolam.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Loprazolam.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Loprazolam is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Loprazolam.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Loprazolam.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Loprazolam.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Promethazine.Approved
PropanididThe risk or severity of adverse effects can be increased when Propanidid is combined with Loprazolam.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Loprazolam.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Loprazolam.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Loprazolam.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Protriptyline.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Proxibarbal is combined with Loprazolam.Experimental
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Loprazolam.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Loprazolam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Loprazolam.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Raclopride is combined with Loprazolam.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Loprazolam is combined with Ramelteon.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Loprazolam.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Loprazolam.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Loprazolam.Approved, Investigational
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Loprazolam.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Ritanserin is combined with Loprazolam.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Loprazolam.Vet Approved
RopiniroleLoprazolam may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Loprazolam.Approved
RotigotineLoprazolam may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Loprazolam.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Loprazolam.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Sepranolone is combined with Loprazolam.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Loprazolam.Approved, Investigational, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Loprazolam.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Loprazolam.Approved
StiripentolThe risk or severity of adverse effects can be increased when Loprazolam is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Loprazolam.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Loprazolam.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when Sultopride is combined with Loprazolam.Experimental
SuvorexantLoprazolam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Tandospirone is combined with Loprazolam.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Loprazolam.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Loprazolam is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Loprazolam.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Loprazolam.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Tetrahydropalmatine is combined with Loprazolam.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Loprazolam.Investigational
ThalidomideLoprazolam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Loprazolam.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Loprazolam.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Loprazolam.Approved, Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Loprazolam.Approved
TiagabineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Tiapride is combined with Loprazolam.Approved, Investigational
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Loprazolam.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Tilidine.Experimental
TizanidineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Loprazolam is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Loprazolam is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Loprazolam.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Loprazolam.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Loprazolam.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Loprazolam.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Loprazolam.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Tricaine methanesulfonate is combined with Loprazolam.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Trichloroethylene is combined with Loprazolam.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Loprazolam.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when Trifluperidol is combined with Loprazolam.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Loprazolam.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Triprolidine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Loprazolam.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Veralipride is combined with Loprazolam.Experimental
VigabatrinThe risk or severity of adverse effects can be increased when Loprazolam is combined with Vigabatrin.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Loprazolam is combined with Vinyl ether.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Loprazolam.Approved
XenonThe risk or severity of adverse effects can be increased when Xenon is combined with Loprazolam.Experimental
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Loprazolam.Vet Approved
YohimbineThe therapeutic efficacy of Loprazolam can be decreased when used in combination with Yohimbine.Approved, Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Loprazolam.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Loprazolam is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Loprazolam is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Loprazolam.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Loprazolam.Vet Approved
ZolpidemLoprazolam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Loprazolam is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Loprazolam.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Loprazolam.Approved, Investigational
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Loprazolam.Approved, Investigational
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
3033860
PubChem Substance
347829308
ChemSpider
2298440
ChEBI
135754
ChEMBL
CHEMBL2107448
ATC Codes
N05CD11 — Loprazolam

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0917 mg/mLALOGPS
logP2.8ALOGPS
logP2.68ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)19.13ChemAxon
pKa (Strongest Basic)8.06ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area97.33 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity126.87 m3·mol-1ChemAxon
Polarizability48.07 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzodiazepines
Sub Class
1,4-benzodiazepines
Direct Parent
1,4-benzodiazepines
Alternative Parents
Alpha amino acids and derivatives / Nitroaromatic compounds / Chlorobenzenes / N-methylpiperazines / Aryl chlorides / Imidazolinones / Vinylogous amides / Trialkylamines / Ketimines / Organic oxoazanium compounds
show 10 more
Substituents
1,4-benzodiazepine / Alpha-amino acid or derivatives / Nitroaromatic compound / N-methylpiperazine / N-alkylpiperazine / Halobenzene / Chlorobenzene / Piperazine / Aryl chloride / Imidazolinone
show 35 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on June 23, 2017 14:45 / Updated on December 01, 2017 16:43