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Displaying drugs 1851 - 1875 of 1930 in total

Tridolgosir

An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.
Experimental
Matched Description: … Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity. …

LNP-nCoVsaRNA Vaccine

LNP-nCoVsaRNA is a purified, synthetic mRNA vaccine candidate encoding the S glycoprotein of SARS-CoV-2, which is used primarily by the virus to attach to and invade human cells. The vaccine was developed in and tested by the Medical Research Council Clinical Trials Unit at UCL in the UK, and jointly...
Investigational
Matched Description: … invade human cells. ... the UK, and jointly funded by UK Research and Innovation. ... candidate encoding the S glycoprotein of SARS-CoV-2, which is used primarily by the virus to attach to and …

TTP889

TTP889, an orally bioavailable selective inhibitor of the intrinsic coagulation pathway, is being developed as an anticoagulant for the treatment of thromboembolic disorders. TTP889 is the only known selective small molecule inhibitor of Factor IX, a key enzyme of the intrinsic pathway of the blood coagulation system. TTP889 has proven...
Investigational
Matched Description: … TTP889 has proven to be effective in preventing clot formation in several animal models of human disease …

Ceramide NP

Ceramide NP is a lipid molecule included in a group of lipid molecules called ceramides. Ceramides are major lipid components in the stratum corneum of the human skin. Ceramide 3 consists of a phytosphingosine backbone N-acylated with a saturated fatty acid (stearic acid) . It is widely used as a...
Experimental
Matched Description: … Ceramides are major lipid components in the stratum corneum of the human skin. ... It is widely used as a moisturizer in various cosmetic and personal products. …

ZEN-012

ZEN-012 is a novel small molecule and the first anti-cancer drug in development involving two mechanisms of action: tubulin and topoisomerase II inhibition. ZEN-012 also expresses additional modes of action such as pro-apoptotic and anti-angiogenic properties. It is developed for the treatment of solid tumors.
Investigational
Matched Description: … of action: tubulin and topoisomerase II inhibition. ... ZEN-012 is a novel small molecule and the first anti-cancer drug in development involving two mechanisms ... ZEN-012 also expresses additional modes of action such as pro-apoptotic and anti-angiogenic properties …

1D09C3

1D09C3, a monoclonal antibody against lymphoid cancers, is an anti-MHC (major histocompatibility complex) class II monoclonal antibody. The antibody was isolated in collaboration with MorphoSys from its HuCAL(R) library of human antibodies. 1D09C3 binds to certain cell surface receptors, selectively killing activated, proliferating MHC class II-positive tumor cells, which include...
Investigational
Matched Description: … The antibody was isolated in collaboration with MorphoSys from its HuCAL(R) library of human antibodies ... T-cell lymphomas. 1D09C3 has been shown to induce programmed cell death and does not require a functioning ... selectively killing activated, proliferating MHC class II-positive tumor cells, which include those in B-cell and …

Fenretinide

A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.
Investigational
Matched Description: … A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at …

VIR201

is an experimental therapeutic vaccine currently in clinical trial. The aim of therapeutic vaccines is to augment the body's immune response to HIV and to delay or prevent progression to AIDS.
Investigational
Matched Description: … The aim of therapeutic vaccines is to augment the body's immune response to HIV and to delay or prevent …

Grapiprant

Grapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic acid known to be prostaglandin receptor antagonists. This type of molecules is currently in development for veterinary patients. This class...
Investigational
Vet approved
Matched Description: … Grapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. ... These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic …

Tarenflurbil

Tarenflurbil is an investigational drug that was studied in patients with mild Alzheimer's disease. It is a selective amyloid lowering agent (SALA) that reduces levels of the toxic peptide amyloid beta 42 (Aβ42) in cultured human cells and in animal models. Aβ42 is the primary initiator of neurotoxicity and amyloid...
Investigational
Matched Description: … cells and in animal models. ... amyloid lowering agent (SALA) that reduces levels of the toxic peptide amyloid beta 42 (Aβ42) in cultured human ... Aβ42 is the primary initiator of neurotoxicity and amyloid plaque development in the brains of Alzheimer's …
Matched Categories: … Gamma Secretase Inhibitors and Modulators …

Selamectin

Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in dogs as well as prevent heartworms, fleas, ear mites, hookworms, and roundworms in cats. It also removes 2 types of...
Vet approved
Matched Description: … It is structurally related to ivermectin and milbemycin. Selamectin is not approved for human use. ... Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections ... heartworms, fleas, ear mites, hookworms, and roundworms in cats. …

Covid-19 Coronavirus Artificial Antigen Presenting Cell Vaccine

Through analysis of potential immunogenic targets of the SARS-Cov2 genome, a synthetic ‘minigene’ was developed using domains of viral structural proteins and a polyprotein protease. Specifically, the COVID-19 infection relies on the binding of the Spike protein to an ACEII receptor, and with the described approach, the vaccine uses these...
Investigational
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials ... the SARS-Cov2 genome, a synthetic ‘minigene’ was developed using domains of viral structural proteins and ... Specifically, the COVID-19 infection relies on the binding of the Spike protein to an ACEII receptor, and …

Tenocyclidine

Tenocyclidine (TCP, thienyl cyclohexylpiperidine) is a dissociative anesthetic drug with stimulant and hallucinogenic effects. It is more potent than phencyclidine and hence, this drug was classified under the schedule 1 in 1970.
Experimental
Illicit
Investigational
Matched Description: … Tenocyclidine (TCP, thienyl cyclohexylpiperidine) is a dissociative anesthetic drug with stimulant and ... It is more potent than phencyclidine and hence, this drug was classified under the schedule 1 in 1970 …

Morniflumate

Morniflumate is a non-steroidal anti-inflammatory drug with antipyretic properties. It is the morpholinoethyl ester of niflumic acid . In one study, post morniflumate ingestion, physical examination and clinical symptoms of those with bronchitis showed improvement .
Experimental
Matched Description: … In one study, post morniflumate ingestion, physical examination and clinical symptoms of those with bronchitis …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells

Human olfactory mucosa-derived mesenchymal stem cells (OM-MSCs) reside in an accessible location of the nasal cavity and have properties of multipotency and high proliferation, which contributes to high potential for regenerative medicine. In humans, OM-MSCs are derived from the olfactory mucosa which is collected in vivo through rhinoscopy techniques and...
Investigational
Matched Description: … Human olfactory mucosa-derived mesenchymal stem cells (OM-MSCs) reside in an accessible location of the ... nasal cavity and have properties of multipotency and high proliferation, which contributes to high potential ... for OM-MSC collection, isolation, and therapeutic application. …

Mycobacterium w. Vaccine

The Mycobacterium w (M.w) vaccine is a heat-killed suspension derived from a non-pathogenic mycobacterium: mycobacterium indicus pranii. As an immunotherapy, M.w is used against leprosy; the compound also shares antigens with M. tuberculosis. Its use has shown clinical improvement, rapid bacterial clearance, and enhanced immune responses to Mycobacterium leprae antigens....
Investigational
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials ... It has protective efficacy against M. tuberculosis and M. leprae. ... M.w immunization activates macrophages and lymphocytes upon administration. …

Sennosides

Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation[FDA Label] and empty the large intestine before surgery. The medication is taken by mouth or via the rectum[FDA Label]. It typically begins working in minutes when given by rectum and within twelve hours when given...
Experimental
Matched Description: … laxative medication, has recently proven effective in inhibiting the ribonuclease H (RNase H) activity of human ... also known as senna glycoside or senna) is a medication used to treat constipation[FDA Label][L771] and ... It typically begins working in minutes when given by rectum and within twelve hours when given by mouth …
Matched Mixtures name: … Senna and Docusate Sodium ... Senna and Docusate Sodium ... Docusate Sodium and Senna …
Matched Salts name: … Sennosides A and B …
Matched Categories: … Alimentary Tract and Metabolism ... Herbs and Natural Products …

Tunicamycin

Tunicamycin is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P HexNAc-1-P family of enzymes. One member of this family is the enzyme GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis in eukaryotes. Tunicamycin blocks...
Experimental
Matched Description: … Tunicamycin is produced by Streptomyces clavuligerus and Streptomyces lysosuperficus bacteria along with ... Tunicamycin blocks N-linked glycosylation (N-glycans) resulting in cell cycle arrest at the G1 phase in human …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

NNZ-2591

NNZ-2591 (cyclo-L-glycyl-L-2-allylproline) is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human insulin-like growth factor 1 (IGF-1), that has been chemically modified to increase its half-life, stability, and oral bioavailability. It is currently under development by Neuren Pharmaceuticals for the symptomatic treatment of Angelman, Phelan-McDermid, and...
Investigational
Matched Description: … A189390] is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human ... It was granted Orphan Drug Designation by the FDA in October 2019[L11103] and was granted a patent by ... under development by Neuren Pharmaceuticals for the symptomatic treatment of Angelman, Phelan-McDermid, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Ularitide

Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is involved in regulating blood pressure and the excretion of water and sodium from the kidneys. Urodilatin is produced in the kidney and excreted into the urine, and thus exists in low levels naturally in the...
Investigational
Matched Description: … Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is ... involved in regulating blood pressure and the excretion of water and sodium from the kidneys. ... Urodilatin is produced in the kidney and excreted into the urine, and thus exists in low levels naturally …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

CoronaVac

CoronaVac, previously known as PiCoVacc, is a SARS-CoV-2 purified, inactivated, and adsorbed vaccine candidate developed by SinoVac Biotech Corporation . It was developed by propagating the SARS-CoV-2 CN2 strain inside Vero Cells and inactivating it with B-propiolactone[A219481;A219758]. In preclinical trials, PiCoVacc induced SARS-CoV-2-specific neutralizing antibodies in rats, mice, and the...
Investigational
Matched Description: … As of August 2020, the vaccine is being tested in numerous human clinical trials assessing its safety ... and immunogenicity. ... CoronaVac, previously known as PiCoVacc, is a SARS-CoV-2 purified, inactivated, and adsorbed vaccine …

2G7

2G7 is an anti-TGF-beta monoclonal antibody developed by Genentech.
Investigational

Alkaline Phosphatase

Alkaline Phosphatase (AP) is an oral treatment and has a very favorable side-effect profile. AP only acts locally in the colon to reduce the continuous inflammation of the colon by endotoxin from Gram-negative bacteria and extracellular ATP in UC patients.
Investigational
Matched Description: … Alkaline Phosphatase (AP) is an oral treatment and has a very favorable side-effect profile. ... the colon to reduce the continuous inflammation of the colon by endotoxin from Gram-negative bacteria and …
Matched Categories: … Enzymes and Coenzymes …

Chromic citrate

Experimental

RG2417

RG2417 is a proprietary formulation of uridine, a biological compound essential for the synthesis of DNA and RNA, the basic hereditary material found in all cells, and numerous other factors essential for cell metabolism. Uridine is synthesized by the mitochondria, the power plant of the human cell responsible for energy...
Investigational
Matched Description: … Uridine is synthesized by the mitochondria, the power plant of the human cell responsible for energy ... RNA, the basic hereditary material found in all cells, and numerous other factors essential for cell ... RG2417 is a proprietary formulation of uridine, a biological compound essential for the synthesis of DNA and …
Displaying drugs 1851 - 1875 of 1930 in total