Ceramide NP

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Ceramide NP
Accession Number
DB14111  (DB11258)
Type
Small Molecule
Groups
Experimental
Description

Ceramide NP is a lipid molecule included in a group of lipid molecules called ceramides. Ceramides are major lipid components in the stratum corneum of the human skin. Ceramide 3 consists of a phytosphingosine backbone N-acylated with a saturated fatty acid (stearic acid) 2. It is widely used as a moisturizer in various cosmetic and personal products. Together with ceramide 1, they synergistically improve the skin barrier function in humans 1,2.

Structure
Thumb
Synonyms
  • Cer(t18:0/18:1n-9)
  • Ceramide 3
  • Ceramide III
  • Ceramide IIIb
  • Cytomide IIIa
  • Cytomide IIIb
  • N-(9Z-octadecenoyl)-4-hydroxysphinganine
  • N-(9Z-octadecenoyl)phytosphingosine
  • N-octadecanoylphytosphingosine
  • N-oleoylphytosphingosine
  • N-oloeoyl-4-hydroxysphinganine
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Cellapy A RepairLotion0.05 1/200mLTopicalGm Holdings Co., Ltd2014-10-22Not applicableUs
Cellapy A Repair CreamCream0.1 1/100mLTopicalGm Holdings Co., Ltd2014-10-15Not applicableUs
JNH Ato-Care Super Barried ATO-SerumLiquid1.5 mg/50mLTopicalDaeduck Lab Co., Ltd.2012-08-24Not applicableUs
Sonatural Deep Moisture Cerafocus Enhance CeramideCream1.5 g/50mLTopicalSonatural Global Co.,ltd2017-03-02Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Energy Boosting TonerCeramide NP (0.01 g/100mL) + Adenosine (0.04 g/100mL) + Tremella fuciformis whole (0.1 g/100mL)LiquidTopicalAri&j Inc2017-07-05Not applicableUs
Moisture BoundCeramide NP (0.01 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL) + Tremella fuciformis whole (0.1 g/100mL)CreamTopicalAri&j Inc2017-07-05Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Cellapy A RepairCeramide NP (0.05 1/200mL)LotionTopicalGm Holdings Co., Ltd2014-10-22Not applicableUs
Cellapy A Repair CreamCeramide NP (0.1 1/100mL)CreamTopicalGm Holdings Co., Ltd2014-10-15Not applicableUs
Energy Boosting TonerCeramide NP (0.01 g/100mL) + Adenosine (0.04 g/100mL) + Tremella fuciformis whole (0.1 g/100mL)LiquidTopicalAri&j Inc2017-07-05Not applicableUs
JNH Ato-Care Super Barried ATO-SerumCeramide NP (1.5 mg/50mL)LiquidTopicalDaeduck Lab Co., Ltd.2012-08-24Not applicableUs
Moisture BoundCeramide NP (0.01 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL) + Tremella fuciformis whole (0.1 g/100mL)CreamTopicalAri&j Inc2017-07-05Not applicableUs
Sonatural Deep Moisture Cerafocus Enhance CeramideCeramide NP (1.5 g/50mL)CreamTopicalSonatural Global Co.,ltd2017-03-02Not applicableUs
Categories
UNII
4370DF050B
CAS number
100403-19-8
Weight
Average: 581.967
Monoisotopic: 581.53830977
Chemical Formula
C36H71NO4
InChI Key
ATGQXSBKTQANOH-UWVGARPKSA-N
InChI
InChI=1S/C36H71NO4/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-35(40)37-33(32-38)36(41)34(39)30-28-26-24-22-20-16-14-12-10-8-6-4-2/h17-18,33-34,36,38-39,41H,3-16,19-32H2,1-2H3,(H,37,40)/b18-17-/t33-,34+,36-/m0/s1
IUPAC Name
(9Z)-N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]octadec-9-enamide
SMILES
CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Huang HC, Chang TM: Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin. Int J Dermatol. 2008 Aug;47(8):812-9. doi: 10.1111/j.1365-4632.2008.03687.x. [PubMed:18717861]
  2. Choi SM, Lee BM: Safety and risk assessment of ceramide 3 in cosmetic products. Food Chem Toxicol. 2015 Oct;84:8-17. doi: 10.1016/j.fct.2015.07.012. Epub 2015 Jul 21. [PubMed:26206496]
  3. Kucharekova M, Schalkwijk J, Van De Kerkhof PC, Van De Valk PG: Effect of a lipid-rich emollient containing ceramide 3 in experimentally induced skin barrier dysfunction. Contact Dermatitis. 2002 Jun;46(6):331-8. [PubMed:12190621]
External Links
ChemSpider
29320046
ChEBI
85204

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LotionTopical0.05 1/200mL
CreamTopical0.1 1/100mL
LiquidTopical
LiquidTopical1.5 mg/50mL
CreamTopical
CreamTopical1.5 g/50mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility9.71e-05 mg/mLALOGPS
logP9.05ALOGPS
logP10.52ChemAxon
logS-6.8ALOGPS
pKa (Strongest Acidic)13.27ChemAxon
pKa (Strongest Basic)-1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area89.79 Å2ChemAxon
Rotatable Bond Count32ChemAxon
Refractivity176.49 m3·mol-1ChemAxon
Polarizability77.39 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on June 21, 2018 11:23 / Updated on May 01, 2019 11:57