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Displaying drugs 1726 - 1750 of 1931 in total

XL765

XL765 is an orally available small molecule that has been shown in preclinical studies to selectively inhibit the activity of phosphoinositide-3 kinase (PI3K) and mammalian target of rapamycin (mTOR). It is being developed by Exelixis, Inc.
Investigational
Matched Description: … shown in preclinical studies to selectively inhibit the activity of phosphoinositide-3 kinase (PI3K) and …

CHF 4227

CHF 4227 is a new selective estrogen receptor modulator (SERM). The compound has a high receptor affinity and has shown promising efficacy in the prevention of bone loss in animal models of osteoporosis. Additionally, the compound has shown no uterotrophic activity suggesting a potential therapeutic advantage over drugs normally used...
Investigational
Matched Description: … The compound has a high receptor affinity and has shown promising efficacy in the prevention of bone …

TB-402

TB-402 is a human antibody binding to Factor VIII, which plays a crucial role in the coagulation of the blood. It is expected to be developed as a potential treatment to prevent blood clot formation in connection with certain types of heart arrhythmia, such as atrial fibrillation.
Investigational
Matched Description: … TB-402 is a human antibody binding to Factor VIII, which plays a crucial role in the coagulation of the …
Matched Categories: … Amino Acids, Peptides, and Proteins …

XmAb 2513

XmAb 2513 is a humanized monoclonal antibody that targets the antigen CD30, a molecule expressed on the surface of a number of tumor cell types. It has been investigated for the treatment of hodgkin’s lymphoma.
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins …

Icaridin

Icaridin, also known as Picaridin or hydroxy-ethyl isobutyl piperidine carboxylate, is a cyclic amine and a member of the piperidine chemical family. Piperidines are structural components of piperine, which is a plant extract from the genus _Piper _, or pepper. Icaridin has been commonly used as a topically-applied insect repellent...
Experimental
Matched Description: … Icaridin, also known as Picaridin or hydroxy-ethyl isobutyl piperidine carboxylate, is a cyclic amine and ... repellent by the Public Health Agency of Canada’s Canadian Advisory Committee on Tropical Medicine and ... insect repellent in various countries but was officially licensed for use in the United States in 2001 and …

Rexin G

Rexin-G is a tumor-targeted, injectable retroviral vector carrying a mutant form of the cyclin G1 gene. It is under development by Epeius Biotechnologies for the potential treatment of metastatic cancer. It is also being investigated for preventing SARSCOV-2 viral entry.
Investigational

Phenserine

Phenserine is under development by Axonyx, a US biopharmaceutical company that focuses on treatments for dementia. Phenserine is a next generation acetylcholinesterase (AChE) inhibitor indicated for the treatment of AD. Unlike currently marketed AChE inhibitors, it has a dual mechanism of action that also includes anti-amyloid activity, which may confer...
Investigational

NN344

NN344 is a neutral, soluble long-acting human insulin analogue with 24 hour coverage by once daily injection. NN344 has a very flat and predictable action profile. The product is intended for basal insulin treatment of diabetes mellitus.
Investigational
Matched Description: … NN344 has a very flat and predictable action profile. ... NN344 is a neutral, soluble long-acting human insulin analogue with 24 hour coverage by once daily injection …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

PI-166

PI-166 is a small organic compound with specific avidity to liver cancer cells. It has demonstrated the ability to reduce the growth of rat hepatomas, which is like human hepatomas, are resistant to established anti-cancer agents.
Investigational
Matched Description: … It has demonstrated the ability to reduce the growth of rat hepatomas, which is like human hepatomas, …

VPM4001

VPM4001 is an allogeneic vaccine for treatment of prostate carcinoma. It consists of irradiated human LNCaP cells that have been genetically modified to permanently secrete interferon-γ and interleukin-2 (LNCaP/IL-2/IFN-γ). Interferon-γ enhances presentation of tumour antigens, whereas interleukin-2 stimulates T cells.
Investigational
Matched Description: … interferon-γ and interleukin-2 (LNCaP/IL-2/IFN-γ). ... It consists of irradiated human LNCaP cells that have been genetically modified to permanently secrete …

SCIB1

SCIB1 is an investigational cancer vaccine being developed by Scancell Ltd. It is being investigated for the treatment of melanoma. It consists of plasmid DNA molecules that express a modified antibody in human cells, working to stimulate the patient's T cells to have a stronger reaction against melanoma cells.
Investigational
Matched Description: … It consists of plasmid DNA molecules that express a modified antibody in human cells, working to stimulate …

CEP-1347

CEP-1347 is a semi-synthetic compound shown to protect multiple nerve cell types from a variety of insults leading to programmed cell death (apoptosis) which could improve the survival of dopamine neurons prior to and after transplantation.
Investigational
Matched Description: … to programmed cell death (apoptosis) which could improve the survival of dopamine neurons prior to and …

AI-128

AI-128 is the first human demonstration of sustained release drug administration in the lung. AI-128 consists of slowly dissolving microspheres designed to control where drug particles go in the lung and how quickly they release their drug.
Investigational
Matched Description: … AI-128 is the first human demonstration of sustained release drug administration in the lung. ... consists of slowly dissolving microspheres designed to control where drug particles go in the lung and …

Dacetuzumab

Dacetuzumab has been used in trials studying the treatment of Multiple Myeloma, Non-Hodgkin Lymphoma, Leukemia, Lymphocytic, Chronic, and Lymphoma, Large B-Cell, Diffuse. It is a humanized anti-CD40 antibody and induces cytotoxicity in human multiple myeloma cells.
Investigational
Matched Description: … It is a humanized anti-CD40 antibody and induces cytotoxicity in human multiple myeloma cells. ... trials studying the treatment of Multiple Myeloma, Non-Hodgkin Lymphoma, Leukemia, Lymphocytic, Chronic, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

GI-101

GI-101 is a bi-specific fragment crystallizable region (Fc) fusion protein containing a cluster of differentiation 80 ectodomain as an N-terminal moiety and interleukin-2 variant as a C-terminal moiety conjugated with human immunoglobulin G4 Fc.
Investigational
Matched Description: … interleukin-2 variant as a C-terminal moiety conjugated with human immunoglobulin G4 Fc. ... region (Fc) fusion protein containing a cluster of differentiation 80 ectodomain as an N-terminal moiety and …

Mito-4509

Mito-4509 is a non-feminizing estrogen analog that could affect mitochondrial metabolic pathways. It is used to treat Parkinson's Disease, Alzheimer's Disease, Retinal Disorders and other neurologic Disorders.
Investigational
Matched Description: … It is used to treat Parkinson's Disease, Alzheimer's Disease, Retinal Disorders and other neurologic …

Sibrotuzumab

Sibrotuzumab is a humanized monoclonal antibody directed against fibroblast activation protein (FAP). It is used to treat cancer.
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins …

MLN8054

MLN8054 has been used in trials studying the treatment of Colon Neoplasm, Breast Neoplasm, Bladder Neoplasm, Pancreatic Neoplasm, and Advanced Malignancies.
Investigational
Matched Description: … trials studying the treatment of Colon Neoplasm, Breast Neoplasm, Bladder Neoplasm, Pancreatic Neoplasm, and …

SL017

SL017 formulated as a topical gel, has been combined with a widely available light source for permanent removal of unwanted hair and for treatment of actinic keratosis
Investigational
Matched Description: … gel, has been combined with a widely available light source for permanent removal of unwanted hair and …

Adecatumumab

Adecatumumab is a recombinant human monoclonal antibody of the IgG1 subclass with a binding specificity to epithelial cell adhesion molecule (EpCAM). EpCAM (CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, pancreatic and lung cancer.
Investigational
Matched Description: … Adecatumumab is a recombinant human monoclonal antibody of the IgG1 subclass with a binding specificity ... high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, pancreatic and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

SEA-BCMA

Investigational

Sar9, Met (O2)11-Substance P

Sar9, Met (O2)11-Substance P is a neurokinin-1 receptor agonist. It is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in the airways of humans and many other species.
Investigational
Matched Description: … the body, including in the airways of humans and many other species. ... It is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …

BBM-H803

BBM-H803 is a recombinant adeno-associated virus (AAV) based gene therapy drug for hemophilia A developed and manufactured by Belief BioMed. It consists of an adeno-associated virus vector containing an expression cassette of the human Factor VIII transgene.
Investigational
Matched Description: … It consists of an adeno-associated virus vector containing an expression cassette of the human Factor ... BBM-H803 is a recombinant adeno-associated virus (AAV) based gene therapy drug for hemophilia A developed and …

OMS906

OMS906 is a humanized Igg4 monoclonal antibody against mannan-binding lectin-associated serine protease-3 (MASP-3) currently being developed by Omeros.
Investigational

Pracinostat

Pracinostat is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in clinical trials, allowing oral dosing. Data demonstrate that Pracinostat is a potent and effective anti-tumor drug with potential as an oral therapy for a variety of human hematological and solid tumors.
Investigational
Matched Description: … therapy for a variety of human hematological and solid tumors. ... Data demonstrate that Pracinostat is a potent and effective anti-tumor drug with potential as an oral …
Displaying drugs 1726 - 1750 of 1931 in total