Controlling the elongation phase of transcription with P-TEFb.
Article Details
- CitationCopy to clipboard
Peterlin BM, Price DH
Controlling the elongation phase of transcription with P-TEFb.
Mol Cell. 2006 Aug 4;23(3):297-305.
- PubMed ID
- 16885020 [ View in PubMed]
- Abstract
The positive transcription elongation factor b (P-TEFb) is a cyclin-dependent kinase that controls the elongation phase of transcription by RNA polymerase II (RNAPII). This process is made possible by the reversal of effects of negative elongation factors that include NELF and DSIF. In complex organisms, elongation control is critical for the regulated expression of most genes. In those organisms, the function of P-TEFb is influenced negatively by HEXIM proteins and 7SK snRNA and positively by a variety of recruiting factors. Phylogenetic analyses of the components of the human elongation control machinery indicate that the number of mechanisms utilized to regulate P-TEFb function increased as organisms developed more complex developmental patterns.