Human proteasome subunits from 2-dimensional gels identified by partial sequencing.
Article Details
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Kristensen P, Johnsen AH, Uerkvitz W, Tanaka K, Hendil KB
Human proteasome subunits from 2-dimensional gels identified by partial sequencing.
Biochem Biophys Res Commun. 1994 Dec 30;205(3):1785-9.
- PubMed ID
- 7811265 [ View in PubMed]
- Abstract
Human proteasomes consist of 14 major subunits which can be resolved by two-dimensional polyacrylamide gel electrophoresis. Tryptic peptides from the subunits were sequenced. This allowed identification of all proteins in two-dimensional electrophoresis gels with proteasome subunits whose sequences are known from cDNA. The results also precisely define the specificity of a panel of subunit-specific monoclonal antibodies. A new proteasome subunit (Z) was discovered. In contrast, the putative subunit MECL-1 could not be detected in human placenta proteasomes.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Proteasome subunit beta type-5 P28074 Details Proteasome subunit beta type-2 P49721 Details Proteasome subunit alpha type-1 P25786 Details Proteasome subunit alpha type-2 P25787 Details Proteasome subunit alpha type-3 P25788 Details Proteasome subunit alpha type-4 P25789 Details Proteasome subunit alpha type-6 P60900 Details Proteasome subunit beta type-3 P49720 Details Proteasome subunit beta type-4 P28070 Details