Some properties of 5-hydroxytryptamine receptors in the hindquarters of the rat.

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Cooper M, Wyllie JH

Some properties of 5-hydroxytryptamine receptors in the hindquarters of the rat.

Br J Pharmacol. 1979 Sep;67(1):79-85.

PubMed ID

497523 [ View in PubMed

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Abstract

1 The rat hindquarter preparation, as described, responds with reproducible vasoconstriction to noradrenaline and tryptamines. 2 The receptors involved in these responses are distinct. 3 Evidence of heterogeneity of tryptamine receptors was not obtained. 4 The 5-hydroxytryptamine (5-HT) antagonists, methysergide and cyproheptadine, although very potent, displayed antagonism of a non-competitive type whereas a series of phenothiazines and phentolamine displayed competitive antagonism against 5-HT. 5 For the phenothiazines the order of increasing potency was promazine less than chlorpromazine less than triflupromazine.

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Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Triflupromazine	5-hydroxytryptamine receptor 2B	Protein	Humans	Yes	Antagonist	Details