Observation of an unprecedented Cu Bis-His site: crystal structure of the H129V mutant of nitrite reductase.
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Ellis MJ, Antonyuk SV, Strange RW, Sawers G, Eady RR, Hasnain SS
Observation of an unprecedented Cu Bis-His site: crystal structure of the H129V mutant of nitrite reductase.
Inorg Chem. 2004 Nov 29;43(24):7591-3.
- PubMed ID
- 15554622 [ View in PubMed]
- Abstract
Copper nitrite reductases contain both an electron-transfer type 1 Cu site and a catalytic type 2 Cu site. We have mutated one of the type 2 copper ligating histidines to observe the effect on catalytic turnover. This mutation has created a unique site where Cu is ligated by 2 His Nepsilon2 atoms alone.