Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension.

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Mohta M, Janani SS, Sethi AK, Agarwal D, Tyagi A

Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension.

Anaesthesia. 2010 Dec;65(12):1200-5. doi: 10.1111/j.1365-2044.2010.06559.x.

PubMed ID

21182601 [ View in PubMed

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Abstract

This study compared the effects of intravenous infusions of phenylephrine and mephentermine on the prevention of maternal hypotension and neonatal outcome in patients receiving spinal anaesthesia for caesarean section. Sixty ASA 1-2 patients with term, uncomplicated singleton pregnancy undergoing caesarean section under spinal anaesthesia were randomly divided into two groups of 30 each, to receive a prophylactic intravenous infusion of either phenylephrine or mephentermine. The incidence of hypotension was statistically similar in the two groups. However, in patients receiving phenylephrine, 7 (23%) developed bradycardia and 6 (20%), reactive hypertension. Neonatal outcome, in terms of Apgar scores and umbilical artery pH, was similar in both the groups. To conclude, phenylephrine and mephentermine infusions are equally effective in preventing post spinal hypotension in patients undergoing caesarean section and are associated with a similar neonatal outcome.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Mephentermine	Alpha adrenergic receptor (Protein Group)	Protein group	Humans	Yes	Agonist	Details
Mephentermine	Beta adrenergic receptor (Protein Group)	Protein group	Humans	Unknown	Agonist	Details