Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C.
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Shirai T, Shiojiri S, Ito H, Yamamoto S, Kusumoto H, Deyashiki Y, Maruyama I, Suzuki K
Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C.
J Biochem. 1988 Feb;103(2):281-5.
- PubMed ID
- 2836377 [ View in PubMed]
- Abstract
The gene coding for human thrombomodulin, a thrombin receptor on endothelial cells and a cofactor for the activation of anticoagulant protein C zymogen, was isolated from a human genomic library by employing human thrombomodulin cDNA as a probe. The nucleotide sequences of the gene and the adjacent 5' and 3' flanking regions were then determined. The nucleotide sequence of this gene with approximately 3.7 kilobase pairs was identical to that of the cDNA, indicating that the gene for human thrombomodulin is free of introns. Hybridization data showed that there is only a single thrombomodulin gene in the human genome.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Drotrecogin alfa Thrombomodulin Protein Humans UnknownNot Available Details - Polypeptides
Name UniProt ID Thrombomodulin P07204 Details