Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population.
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Olschwang S, Laurent-Puig P, Vassal A, Salmon RJ, Thomas G
Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population.
Hum Genet. 1991 Feb;86(4):369-70.
- PubMed ID
- 1999338 [ View in PubMed]
- Abstract
We describe a simple method for characterizing a frequent polymorphism (that substitutes an arginine for a proline) in the coding sequence of the Tp53 gene in patients with colonic cancer and in a control population. We could find no evidence that this polymorphism is associated with a marked predisposition to colorectal cancer.