Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.
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Hein H, Schluter C, Kulke R, Christophers E, Schroder JM, Bartels J
Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.
Biochem Biophys Res Commun. 1997 Aug 28;237(3):537-42.
- PubMed ID
- 9299399 [ View in PubMed]
- Abstract
Eotaxin is an eosinophil specific beta-chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. Its expression is stimulus- and cell-specific. We here describe the genomic organisation (3 exons of 132, 112 and 542 bp and 2 introns of 1211 and 378 bp) and sequence including 3 kb of DNA from the immediate 5' upstream region of the human eotaxin gene. Among the regulatory promoter elements potentially regulating eotaxin gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-1, a NF-kappa-B like consensus sequence and gamma-interferon- as well as glucocorticoid response elements.