Crystal structure of the catalytic domain of human matrix metalloproteinase 10.
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Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B
Crystal structure of the catalytic domain of human matrix metalloproteinase 10.
J Mol Biol. 2004 Feb 20;336(3):707-16.
- PubMed ID
- 15095982 [ View in PubMed]
- Abstract
The catalytic domain of matrix metalloproteinase-10 (MMP-10) has been expressed in Escherichia coli and its crystal structure solved at 2.1 A resolution. The availability of this structure allowed us to critically examine the small differences existing between the catalytic domains of MMP-3 and MMP-10, which show the highest sequence identity among all MMPs. Furthermore, the binding mode of N-isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid (NNGH), which is one of the most known commercial inhibitors of MMPs, is described for the first time.