An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice.
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Manzaneque JM, Navarro JF
An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice.
Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21(1):11-5.
- PubMed ID
- 10222441 [ View in PubMed]
- Abstract
Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist. Although the antiaggressive action of neuroleptic drugs is well known, the effects of zuclopenthixol on agonistic interactions have not been explored and there are no studies comparing acute and subchronic effects of this compound on aggression in rodents. In this work, we examined the action of zuclopenthixol (0.025-0.4 mg/kg), administered acutely or subchronically for 10 days, on agonistic behavior elicited by isolation in male mice. Individually housed mice were exposed to anosmic "standard opponents" 30 min after the drug administration, and encounters were videotaped and evaluated using an ethologically based analysis. After acute treatment, zuclopenthixol (0.2 and 0.4 mg/kg)-treated animals exhibited ethopharmacological profiles characterized by a decrease in offensive behaviors without impairment of motor activity (0.2 mg/kg). In contrast, the antiaggressive action of the highest dose used (0.4 mg/kg) was accompanied by a marked increase of immobility. After subchronic treatment, no tolerance to zuclopenthixol antiaggressive or motor activity was observed. Overall, this behavioral profile is similar to that observed with other typical neuroleptics.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Zuclopenthixol Dopamine D1 receptor Protein Humans YesAntagonistDetails Zuclopenthixol Dopamine D5 receptor Protein Humans YesAntagonistDetails