Mechanisms of action of intravenous immunoglobulins.
Article Details
- CitationCopy to clipboard
Baerenwaldt A, Biburger M, Nimmerjahn F
Mechanisms of action of intravenous immunoglobulins.
Expert Rev Clin Immunol. 2010 May;6(3):425-34. doi: 10.1586/eci.10.9.
- PubMed ID
- 20441428 [ View in PubMed]
- Abstract
Intravenous immunoglobulin (IVIg) has been used for nearly three decades as an efficient anti-inflammatory therapeutic regimen in a growing number of autoimmune diseases. Despite this their success in clinical application, the mechanism of action of IVIg therapy remains elusive. During the last few years, several mechanisms dependent on either the IgG variable or constant fragment have been proposed to explain the potent immunomodulatory activity of IVIg. This review will discuss which molecular and cellular pathways might be involved in the anti-inflammatory activity of IVIg and for which types of autoimmune diseases they might be relevant.
DrugBank Data that Cites this Article
- Drug Targets