Mixed lineage kinase activity of indolocarbazole analogues.
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Murakata C, Kaneko M, Gessner G, Angeles TS, Ator MA, O'Kane TM, McKenna BA, Thomas BA, Mathiasen JR, Saporito MS, Bozyczko-Coyne D, Hudkins RL
Mixed lineage kinase activity of indolocarbazole analogues.
Bioorg Med Chem Lett. 2002 Jan 21;12(2):147-50.
- PubMed ID
- 11755341 [ View in PubMed]
- Abstract
The MLK1-3 activity for a series of analogues of the indolocarbazole K-252a is reported. Addition of 3,9-bis-alkylthiomethyl groups to K-252a results in potent and selective MLK inhibitors. The in vitro and in vivo survival promoting activity of bis-isopropylthiomethyl-K-252a (16, CEP-11004/KT-8138) is reported.