Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3.
Article Details
- CitationCopy to clipboard
Drivas GT, Shih A, Coutavas EE, D'Eustachio P, Rush MG
Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3.
Oncogene. 1991 Jan;6(1):3-9.
- PubMed ID
- 1704119 [ View in PubMed]
- Abstract
The Polymerase Chain Reaction was used to amplify ras and ras-like sequences from two human cDNA libraries. Members corresponding to each of the three major ras-subfamilies (ras, rho, and rab/YPT) were identified. The one homologous to rab/YPT, referred to here as YL8, appears to be the human homolog of the recently reported Schizosaccharomyces pombe YPT3 gene. The YL8 gene could encode a guanine nucleotide binding protein of 216 amino acids with about 70% amino acid sequence identity to S. pombe YPT3, and is transcriptionally active in a variety of human cell lines.