Protrudin induces neurite formation by directional membrane trafficking.
Article Details
- CitationCopy to clipboard
Shirane M, Nakayama KI
Protrudin induces neurite formation by directional membrane trafficking.
Science. 2006 Nov 3;314(5800):818-21.
- PubMed ID
- 17082457 [ View in PubMed]
- Abstract
Guanosine triphosphatases of the Rab family are key regulators of membrane trafficking, with Rab11 playing a specific role in membrane recycling. We identified a mammalian protein, protrudin, that promoted neurite formation through interaction with the guanosine diphosphate (GDP)-bound form of Rab11. Phosphorylation of protrudin by extracellular signal-regulated kinase (ERK) in response to nerve growth factor promoted protrudin association with Rab11-GDP. Down-regulation of protrudin by RNA interference induced membrane extension in all directions and inhibited neurite formation. Thus, protrudin regulates Rab11-dependent membrane recycling to promote the directional membrane trafficking required for neurite formation.