[Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration hepatitis].
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Cheng J, Zhong Y
[Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration hepatitis].
Zhonghua Gan Zang Bing Za Zhi. 2000 Feb;8(1):12-4.
- PubMed ID
- 10712775 [ View in PubMed]
- Abstract
OBJECTIVE: To clone the human genomic DNA of augmenter of liver regeneration (ALR) and specify the intron-exon structure. METHODS: Using human ALR cDNA sequence as a reference and BLAST path as a nucleotide homology search tool, GenBank has been searched for ALR homologous genomic DNA sequence. The intron-exon sequences were defined by the Breathnath-Chambon rule. RESULTS: The coding sequence of human ALR consists of 3 exons, and is similar to murine ALR genomic DNA structure. The human ALR genomic DNA is 1813 nt long and codes a protein of 125 amino acid residues. CONCLUSION: Human genomic DNA of ALR consists of 3 exons and 2 introns.