The differential contribution of arginase and transamidinase to ornithine biosynthesis in two achromic human melanoma cell lines.
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Thomasset N, Quash GA, Dore JF
The differential contribution of arginase and transamidinase to ornithine biosynthesis in two achromic human melanoma cell lines.
FEBS Lett. 1982 Nov 1;148(1):63-6.
- PubMed ID
- 7173402 [ View in PubMed]
- Abstract
Cellular ornithine biosynthesis could be expected to play a significant role in putrescine formation and hence in growth. Two enzymes are involved in ornithine biosynthesis: arginase and transamidinase. These enzyme activities were studied in two human melanoma cell lines differing in their Km of diamine oxidase for putrescine and in their tumorigenicity in nude mice. Arginase activity accounts for the majority of ornithine formed in the highly tumorigenic cell line, while the majority of ornithine is derived from transamidinase action in the poorly tumorigenic cell line, with concomitant formation of methyl guanidine, a potent inhibitor of diamine oxidase.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ornithine Glycine amidinotransferase, mitochondrial Protein Humans UnknownNot Available Details